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Rebeca Gracia et al.
Clinical toxicology (Philadelphia, Pa.), 50(8), 743-748 (2012-08-16)
Fomepizole has been utilized with remarkable success for ethylene glycol and methanol poisonings in children and adults. However, very little information is available regarding the safe and effective use of fomepizole in pregnancy. The goal of this research was to
Raido Paasma et al.
Clinical toxicology (Philadelphia, Pa.), 50(9), 823-831 (2012-09-21)
INTRODUCTION. Thorough prognostic and metabolic studies of methanol poisonings are scarce. Our aims were to evaluate the factors associated with sequelae and death from methanol poisoning, to develop a simple risk-assessment chart to evaluate factors associated with sequelae and death
Kelly M Tart et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 21(3), 268-272 (2011-06-03)
To describe the clinical experience and therapeutic use of fomepizole (4-methylpyrazole [4-MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity. All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the
Gayle Hann et al.
BMJ case reports, 2012, doi:10-doi:10 (2012-05-19)
This case report describes the presentation and management of a 2-year-old child who ingested a potentially fatal amount of ethylene glycol (EG). There are few published cases worldwide of EG poisoning in children managed with fomepizole. All cases described in
Mohan S Maddur et al.
Clinical reviews in allergy & immunology, 58(2), 213-228 (2019-06-05)
Natural antibodies (nAbs) are most commonly defined as immunoglobulins present in the absence of pathological conditions or deliberate immunizations. Occurrence of nAbs in germ- and antigen-free mice suggest that their production is driven, at least in part, by self-antigens. Accordingly
Knut Erik Hovda et al.
Clinical toxicology (Philadelphia, Pa.), 49(6), 478-484 (2011-08-10)
Fomepizole is the antidote of choice in toxic alcohol poisonings. Potential side effects from frequent use of fomepizole were studied in a patient admitted 154 times with ethylene glycol (EG) poisoning. The intra-individual correlation between the serum-ethylene glycol (serum-EG) and
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.
Huang W, Booth DM, Cane MC, et al.
Gut, 63(8), 1313-1324 (2014)
Zi-Long Li et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 52(2), 180-189 (2017-02-10)
The aim of this study was to examine the effect of alcohol on the decidualization of human endometrial stromal cells during early pregnancy. During in vitro decidualization, human endometrial stromal cells were treated with alcohol, 4-methylpyrazole hydrochloride (FPZ), the inhibitor
María Elena Quintanilla et al.
Alcohol (Fayetteville, N.Y.), 45(8), 751-762 (2011-08-06)
The main goal of this study was to investigate the ability of an ethanol dose (1g/kg) administered intraperitoneally to induce conditioned place preference (CPP) and/or conditioned place aversion (CPA) in two lines of rats selectively bred for their high (UChB)
Jessica H Hartman et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1976-1983 (2012-07-19)
We are the first to report allosterism during styrene oxidation by recombinant CYP2E1 and human liver microsomes. At low styrene concentrations, oxidation is inefficient because of weak binding to CYP2E1 (K(s) = 830 μM). A second styrene molecule then binds
Graham A Tipples et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 30(3), 233-238 (2004-05-12)
Rubella virus generally causes a mild fever, rash illness similar in clinical presentation to infections by other viruses including measles and parvovirus B19. Rubella infections in pregnant women in the first trimester carry a high risk of congenital rubella syndrome
When is it appropriate to treat ethylene glycol intoxication with fomepizole alone without hemodialysis?
Gregory K Buller et al.
Seminars in dialysis, 24(4), 441-442 (2011-08-02)
So-Hyun Kim et al.
Journal of clinical biochemistry and nutrition, 48(3), 214-221 (2011-05-13)
The ameliorating effects of Mango (Mangifera indica L.) flesh and peel samples on plasma ethanol level were investigated using a mouse model. Mango fruit samples remarkably decreased mouse plasma ethanol levels and increased the activities of alcohol dehydrogenase and acetaldehyde
J G Schier et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 923-929 (2013-11-26)
Diethylene glycol (DEG) mass poisoning is a persistent public health problem. Unfortunately, there are no human biological data on DEG and its suspected metabolites in poisoning. If present and associated with poisoning, the evidence for use of traditional therapies such
Paul G Thomes et al.
Autophagy, 9(1), 63-73 (2012-10-24)
Acute and chronic ethanol administration increase autophagic vacuole (i.e., autophagosome; AV) content in liver cells. This enhancement depends on ethanol oxidation. Here, we used parental (nonmetabolizing) and recombinant (ethanol-metabolizing) Hep G2 cells to identify the ethanol metabolite that causes AV
Kenneth E McMartin et al.
Clinical toxicology (Philadelphia, Pa.), 50(5), 375-383 (2012-05-05)
Fomepizole, a potent inhibitor of alcohol dehydrogenase, has replaced ethanol as antidote for methanol and ethylene glycol intoxications because of a longer duration of action and fewer adverse effects. Prior human studies have indicated that single doses of fomepizole are
Cost of hemodialysis versus fomepizole-only for treatment of ethylene glycol intoxication.
Michael A Darracq et al.
Clinical toxicology (Philadelphia, Pa.), 51(3), 188-188 (2013-01-30)
Michael Levine et al.
Annals of emergency medicine, 59(6), 527-531 (2012-01-10)
Ethylene glycol remains an important toxic cause of metabolic acidosis and acute renal failure. Traditionally, inhibition of alcohol dehydrogenase along with hemodialysis has been used for treatment. Because of reported long elimination half-life of ethylene glycol during alcohol dehydrogenase inhibition
Chloe C McAlister et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 10(2), 315-319 (2004-02-06)
The mechanism by which a liver transplantation might protect a simultaneous kidney transplant in a crossmatch-positive recipient is unknown. Flow cytometry crossmatch (FCXM) has increased the sensitivity of donor-specific antibody (DSA) detection compared with complement-dependant cytotoxicity (CDC). Here we compare
Lauren M Besenhofer et al.
Toxicological sciences : an official journal of the Society of Toxicology, 123(2), 374-383 (2011-08-02)
Misuse of diethylene glycol (DEG) has led to numerous epidemic poisonings worldwide. DEG produces toxicity because of its metabolism, although the mechanism of its toxicity has not been further defined. The purpose of this study was to investigate the accumulation
Daniel Lenz et al.
Naunyn-Schmiedeberg's archives of pharmacology, 383(6), 647-654 (2011-05-03)
The conversion of 1,4-butanediol (1,4-BD) to gamma-hydroxybutyric acid (GHB), a drug of abuse, is most probably catalyzed by alcohol dehydrogenase, and potentially by aldehyde dehydrogenase. The purpose of this study was to investigate the degradation of 1,4-BD in cytosolic supernatant
Catarina Dias et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(7), 1177-1180 (2012-07-07)
The purpose of this work was to develop and optimize a simple and suitable method to detect the potential inhibitory effect of drugs and medicines on alcohol dehydrogenase (ADH) activity in order to evaluate the possible interactions between medicines and
Karina Sommerfeld et al.
Pharmacological reports : PR, 64(6), 1547-1553 (2013-02-15)
The aim of the conducted studies was to evaluate the effect of 4-methylpyrazole, increasingly used in detoxifying treatments after ethylene glycol poisoning, on the activity of some antioxidant enzymes and lipid peroxidation formation in the liver of rats after experimental
Jephte Y Akakpo et al.
Toxicological sciences : an official journal of the Society of Toxicology, 170(1), 57-68 (2019-03-25)
Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the United States and many western countries. However, the only clinically approved antidote, N-acetylcysteine, has a limited therapeutic window. 4-Methylpyrazole (4MP) is an antidote for
Christopher O Hoyte et al.
Clinical toxicology (Philadelphia, Pa.), 50(6), 525-527 (2012-06-15)
Diethylene glycol is a toxic alcohol used as an industrial solvent in various products. Human exposure to diethylene glycol has resulted in multisystem organ dysfunction and death in cases of acute intentional ingestions as well as epidemics of mass poisoning.
Dino Luethi et al.
Biochemical pharmacology, 164, 129-138 (2019-04-15)
In recent years, experimental research on lysergic acid diethylamide (LSD) in humans has gained new momentum. In humans, LSD is metabolized rapidly into several metabolites but knowledge of the involved metabolizing enzymes is limited. The aim of the current study
Alparslan Sahin et al.
Cutaneous and ocular toxicology, 32(4), 263-267 (2013-03-07)
We aimed to test caffeic acid phenethyl ester (CAPE) as an antidote for acute methanol (MeOH) toxicity and to compare it with ethanol. This study included five groups, each containing eight rats. The groups were control, methotrexate (MTX), MeOH, ethanol
Detectable serum ethylene glycol levels after subcutaneous injection of antifreeze.
Christine M Murphy et al.
Clinical toxicology (Philadelphia, Pa.), 51(9), 908-909 (2013-09-17)
Katherine J Lepik et al.
Clinical toxicology (Philadelphia, Pa.), 49(5), 391-401 (2011-07-12)
Little is known about medication errors which occur with the antidotes ethanol and fomepizole, used for treatment of methanol and ethylene glycol poisoning. Study objectives were to describe and compare the frequency, type, outcome and underlying causes of medication errors
Kavitha Swaminathan et al.
Life sciences, 92(6-7), 325-336 (2013-01-29)
Ethanol metabolism leads to the formation of acetaldehyde and malondialdehyde. Acetaldehyde and malondialdehyde can together form malondialdehyde-acetaldehyde (MAA) adducts. The role of alcohol dehydrogenase (ADH) and cytochrome P4502E1 (CYP2E1) in the formation of MAA-adducts in liver cells has been investigated.
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