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关键词:'M1629'
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Markus A Lill et al.
Journal of medicinal chemistry, 48(18), 5666-5674 (2005-09-02)
We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis, we simulated the
Christopher S Morello et al.
Vaccine, 30(46), 6541-6550 (2012-09-06)
Herpes Simplex Virus Type 2 (HSV-2) infection can result in life-long recurrent genital disease, asymptomatic virus shedding, and transmission. No vaccine to date has shown significant protection clinically. Here, we used a mouse model of genital HSV-2 infection to test
Jeong-Yeol Park et al.
Obstetrics and gynecology, 121(1), 136-142 (2012-12-25)
To analyze pregnancy outcomes in young women with stage IA, grade 1 endometrioid adenocarcinoma of the uterus after successful fertility-sparing management using progestin. We reviewed the medical records of 141 women with stage IA, grade 1 endometrioid adenocarcinoma of the
Annu A Söderholm et al.
Journal of medicinal chemistry, 49(14), 4261-4268 (2006-07-11)
We report a docking and comparative molecular similarity indices analysis (CoMSIA) study of progesterone receptor (PR) ligands with an emphasis on nonsteroids including tanaproget. The ligand alignment generation, a critical part of model building, comprised two stages. First, thorough conformational
Highlights from the 21st CROI.
Rebecca Cooney et al.
The Lancet. Infectious diseases, 14(4), 276-277 (2014-05-07)
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
Mitsuhiro Nakamura et al.
Cancer letters, 336(1), 68-75 (2013-04-23)
Progestin inhibits the growth of normal and cancerous endometria via the progesterone receptor (PR), but the distinct functions and signalings of PR subtypes have not been fully understood. The aim of the present study was to dissect the key pathways
Smoking, postmenopausal hormone therapy and the risk of venous thrombosis: a population-based, case-control study.
Marc Blondon et al.
British journal of haematology, 163(3), 418-420 (2013-08-10)
Medard M Lech
Wiadomosci lekarskie (Warsaw, Poland : 1960), 56(7-8), 362-368 (2004-02-19)
As it is known from demographical prognosis for Poland, in the nearest years significant increase of the number of women in the childbearing age is expected (reflecting high, postwar, demographical wave). In spite of that, the prognosis of the number
Next steps for research on hormonal contraception and HIV.
Lauren J Ralph et al.
Lancet (London, England), 382(9903), 1467-1469 (2013-07-03)
Cardiovascular effects of medroxyprogesterone acetate and progesterone: a case of mistaken identity?
R Kent Hermsmeyer et al.
Nature clinical practice. Cardiovascular medicine, 5(7), 387-395 (2008-06-04)
Heart disease presentation can differ between the sexes because nonobstructive coronary disease and angina unrelated to exercise are considerably more prevalent in women than in men. When the outcomes of large, randomized, controlled trials failed to demonstrate cardiac risk protection
Zhaolu Xie et al.
Biomaterials, 35(27), 7896-7908 (2014-06-16)
Mucus layer coating the vaginal epithelium represents a barrier for intravaginally delivered recombined adenoviral (rAd) vectors, but it could be overcome by proper polyethylene glycol (PEG) modification. Here we synthesized two cationic PEG derivatives, amino-(EO)n/(AGE)m-Cyss (APCs). The polymers contained neutral
Ezegwui Hu et al.
Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria, 21(3), 266-271 (2013-01-12)
Contraception with Depot Medroxyprogesterone Acetate (Depo provera) is quite effective though not without side effects that may cause discontinuation amongst acceptors. To evaluate client characteristics, their experiences and acceptability of Depo provera in Enugu and compare these with previous experiences
Jessica L Schwartz-Roberts et al.
Cancer research, 75(6), 1046-1055 (2015-01-13)
Interferon regulatory factor-1 (IRF1) is a tumor suppressor that regulates cell fate in several cell types. Here, we report an inverse correlation in expression of nuclear IRF1 and the autophagy regulator ATG7 in human breast cancer cells that directly affects
Andrew M Kaunitz et al.
Contraception, 77(2), 67-76 (2008-01-30)
While depot medroxyprogesterone acetate (DMPA) is a highly effective contraceptive used by millions of women, its use is associated with bone mineral density (BMD) loss, raising concerns about long-term risk of osteoporosis and/or fractures. We conducted a systematic review of
T C Unfer et al.
Free radical research, 47(3), 219-232 (2013-01-10)
This study aimed to evaluate whether natural or synthetic steroid hormones could directly modulate the activity of the different superoxide dismutase (SOD) isoforms found in human blood fractions without changing enzyme expression. Enzyme samples of human erythrocytes, the human platelet-rich
Kazuya Kusama et al.
Reproduction (Cambridge, England), 147(6), 897-906 (2014-03-04)
The optimal decidualization of endometrial stromal cells (ESCs) following embryo implantation is one of the critical steps to establish pregnancy in rodents and humans. This step is intricately regulated by ovarian hormones. Using in vitro human ESCs model, we previously
Long-acting reversible contraception in adolescents.
Kathleen Morrell
Journal of pediatric and adolescent gynecology, 25(6), 407-409 (2013-01-11)
Yusuf Omosun et al.
Infection and immunity, 83(12), 4662-4672 (2015-09-16)
Interleukin-10 (IL-10) has been implicated in susceptibility to genital chlamydial infection and the development of tubal pathologies. IL-10 limitation also resulted in the rapid elicitation of immune responses against Chlamydia, and decreased levels of IL-10 correlated with protective anti-Chlamydia immunity.
Elizabeth P Gurney et al.
The Journal of steroid biochemistry and molecular biology, 142, 4-11 (2013-11-01)
The Women's Health Initiative (WHI) assessed the long-term effects of hormone therapy (HT) in postmenopausal women. The WHI started HT treatment on women aged 50-79 years in order to ascertain these effects. The study was ended early, due to findings
Liangzhu Li et al.
PloS one, 7(5), e37381-e37381 (2012-05-23)
Sifuvirtide is a proven effective HIV-1 entry inhibitor and its safety profile has been established for systemic administration. The present study evaluated the potential of sifuvirtide formulated in a universal gel for topical use as a microbicide candidate for preventing
Hanna Hautamäki et al.
Acta obstetricia et gynecologica Scandinavica, 92(8), 902-908 (2013-05-10)
To compare in controlled cardiovascular autonomic function tests the effects of hormone therapy (HT) on heart rate variability (HRV) responses in postmenopausal women with and without pretreatment hot flushes. A randomized placebo-controlled trial. Finland, Helsinki University Central Hospital. A total
Leslie Curry et al.
Reproductive health, 10, 39-39 (2013-08-07)
Use of depot medroxyprogesterone acetate (DMPA), often known by the brand name Depo-Provera, has increased globally, particularly in multiple low- and middle-income countries (LMICs). As a reproductive health technology that has scaled up in diverse contexts, DMPA is an exemplar
Liling Wan et al.
Cancer cell, 26(1), 92-105 (2014-07-02)
The Metadherin gene (MTDH) is prevalently amplified in breast cancer and associated with poor prognosis; however, its functional contribution to tumorigenesis is poorly understood. Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical
Research on hormonal contraception and HIV.
Erica L Gollub et al.
Lancet (London, England), 383(9914), 304-305 (2014-01-28)
John P Sundberg et al.
PloS one, 9(12), e113582-e113582 (2014-12-05)
Papillomaviruses (PVs) induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities. A laboratory mouse papillomavirus, MmuPV1 (formerly MusPV), was horizontally transmitted
Keisuke Murakami et al.
Endocrinology, 155(11), 4542-4553 (2014-08-15)
The endometrial perivascular microenvironment is rich in mesenchymal stem-like cells that express type 1 integral membrane protein Sushi domain containing 2 (SUSD2) but the role of these cells in the decidual transformation of this tissue in pregnancy is unknown. We
Lauren J Ralph et al.
The Lancet. Infectious diseases, 15(2), 181-189 (2015-01-13)
The evidence from epidemiological research into whether use of hormonal contraception increases women's risk of HIV acquisition is inconsistent. We did a robust meta-analysis of existing data to provide summary estimates by hormonal contraceptive method which can be used to
Jeong-Yeol Park et al.
Obstetrics and gynecology, 122(1), 7-14 (2013-06-08)
To estimate the oncologic and pregnancy outcomes after oral progestin treatment of women of reproductive age with stage IA endometrial adenocarcinoma with stage IA, grade 1 differentiation with superficial myometrial invasion or stage IA, grade 2-3 differentiation with or without
JoAnn E Manson et al.
JAMA, 310(13), 1353-1368 (2013-10-03)
Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention. To report a comprehensive, integrated overview of findings from the 2 Women's Health Initiative (WHI) hormone therapy trials with extended postintervention
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