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M1750000
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Antoni Torres et al.
JAMA, 313(7), 677-686 (2015-02-18)
In patients with severe community-acquired pneumonia, treatment failure is associated with excessive inflammatory response and worse outcomes. Corticosteroids may modulate cytokine release in these patients, but the benefit of this adjunctive therapy remains controversial. To assess the effect of corticosteroids
Yan-xia Lu et al.
Acta pharmacologica Sinica, 36(2), 281-288 (2014-12-17)
To develop a population pharmacokinetic (PopPK) model of tacrolimus in healthy Chinese volunteers and liver transplant recipients for investigating the difference between the populations, and for potential individualized medication. A set of 1100 sparse trough concentration data points from 112
H J Choi et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(3), 628-641 (2015-02-14)
The porcine cornea may be a good solution for the shortage of human donor corneas because its size and refractive properties are comparable to those of the human cornea. However, antigenic differences need to be overcome to apply xenocorneal transplantation
Christiaan Fokke et al.
Brain : a journal of neurology, 137(Pt 1), 33-43 (2013-10-29)
Guillain-Barré syndrome is an acute polyradiculoneuropathy with a variable clinical presentation. Accurate diagnostic criteria are essential for patient care and research, including clinical trials and vaccine safety studies. Several diagnostic criteria for Guillain-Barré syndrome have been proposed, including the recent
Fungal infections associated with contaminated methylprednisolone injections.
Carol A Kauffman et al.
The New England journal of medicine, 368(26), 2495-2500 (2012-10-23)
Rosanna de Carmen Zambrano-Infantino et al.
Investigacion clinica, 54(2), 180-185 (2013-08-21)
Optic neuritis is an acute inflammation of the optic nerve and, in its atypical form, is caused by inflammation of the optic nerve as part of infectious, immune, granulomatous, or contiguity processes. Hymenoptera stings (bees, wasps and ants) have been
Eliza A Hawkes et al.
Annals of hematology, 93(5), 827-834 (2013-10-26)
Hodgkin lymphoma (HL) is a relatively chemosensitive malignancy. However, for those who relapse, high-dose chemotherapy with autologous stem cell transplant is the treatment of choice which relies on adequate disease control with salvage chemotherapy. Regimens commonly used often require inpatient
Liza Johannesson et al.
Fertility and sterility, 103(1), 199-204 (2014-12-03)
To report the 12-month outcome of seven patients with viable uteri after uterus transplantation (UTx). Prospective observational study. University hospital. Seven patients with absolute uterine infertility and viable uteri for 12 months after live-donor UTx. Predetermined immunosuppression was with tacrolimus
Arie Reijerkerk et al.
Investigative ophthalmology & visual science, 55(4), 2788-2794 (2014-04-03)
Ocular inflammation is associated with the loss of visual acuity and subsequent blindness. Since their development, glucocorticoids have been the mainstay of therapy for ocular inflammatory diseases. However, the clinical benefit is limited by side effects due to the chronic
Are corticosteroids effective in all patients with cancer-related pain?
James F Cleary
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(29), 3210-3211 (2014-09-17)
K Tselios et al.
Scandinavian journal of rheumatology, 44(1), 29-35 (2014-09-11)
Regulatory T cells (Tregs) are inversely correlated to disease activity in systemic lupus erythematosus (SLE). However, little is known concerning the influence of immunosuppressive agents on Tregs, which was the objective of this study. Thirty-five patients with SLE (29 females
Comparison of intratympanic methylprednisolone and gentamicin for Meniere's disease may be misleading.
Benjamin T Crane
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 149(1), 175-175 (2013-07-03)
Ingjerd Sæves et al.
Therapeutic drug monitoring, 36(1), 46-53 (2013-10-02)
Mycophenolic acid (MPA) and tacrolimus play important roles in immunosuppressive therapy after solid organ transplantation (Tx) and show large intra- and interindividual pharmacokinetic (PK) variabilities. The purpose of this study was to describe the intra- and interindividual variabilities of MPA
Tanja Kersnik Levart
Croatian medical journal, 54(6), 569-573 (2014-01-03)
We describe a case of a post vaccine immune complex-mediated glomerulonephritis in an infant with compound heterozygous mutations of C2 complement component gene, which is the first such case in the literature. The three and a half months old boy
Absolute lymphocyte count and risk of short-term infection in patients with immune thrombocytopenia.
Ming-Hung Hu et al.
Annals of hematology, 93(6), 1023-1029 (2014-01-21)
Patients with immune thrombocytopenia (ITP) may be at increased risk of infection because of the steroids and other immunosuppressive agents used in its treatment. This study aimed to identify events that are associated with infection within 6 months of diagnosis and
Kaljit S Bhuller et al.
Pediatric blood & cancer, 61(12), 2321-2323 (2014-07-24)
Acute graft versus host disease (GVHD) is a significant complication of bone marrow transplantation with approximately half of patients being refractory to steroids. There are numerous second-line systemic immunosuppressive treatments but the overall prognosis is poor and these therapies are
Sarah Tatencloux et al.
Developmental medicine and child neurology, 57(1), 95-99 (2014-07-22)
Anti-NDMA receptor (NMDAR) encephalitis is an auto-immune condition. There is no uniformly agreed treatment strategy for the disorder in children. We report the use of intrathecal treatment with methotrexate and methylprednisolone in three children (one male, two females, age 10y
Marije J Hoornweg et al.
European journal of ophthalmology, 24(6), 940-947 (2014-04-15)
To compare intralesional corticosteroid (IC) injections with oral propranolol in children with periorbital infantile hemangioma (IH). Children were diagnosed with IH and treated with IC (n = 29) or propranolol (n = 14). In cases in which no further improvement
Drug combination improves outcomes after in hospital cardiac arrest.
BMJ (Clinical research ed.), 347, f4683-f4683 (2013-07-25)
Jennifer A Su et al.
Pediatric transplantation, 19(1), 68-75 (2014-10-28)
Mechanical circulatory support has been used for more than 30 yr to allow the heart to recover from ischemia and injury. There are limited pediatric data, however, on the efficacy of ECMO in the setting of post-transplantation support for primary graft
Koji Takeda et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 34(1), 89-99 (2014-12-03)
This study assessed the early and late outcomes after cardiac transplantation in patients receiving long-term continuous-flow left ventricular assist device (CF-LVAD) support. Between April 2004 and September 2013, 192 patients underwent HeartMate II (Thoratec, Pleasanton, CA) CF-LVAD placement as a
A O Ferreiro et al.
Transplantation proceedings, 46(10), 3496-3501 (2014-12-17)
Liver transplantation offers the most effective treatment in patients with hepatocellular carcinoma (HCC). However, transplant patients outside the Milan criteria have a high risk of tumor recurrence, which has been linked to standard immunosuppression regimens. Everolimus is a mammalian target
Pawel Tabakow et al.
Cell transplantation, 23(12), 1631-1655 (2014-10-24)
Treatment of patients sustaining a complete spinal cord injury remains an unsolved clinical problem because of the lack of spontaneous regeneration of injured central axons. A 38-year-old man sustained traumatic transection of the thoracic spinal cord at upper vertebral level
U Blume-Peytavi et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 25(5), 508-515 (2011-04-16)
Atopic dermatitis (AD) is a chronic, recurring, pruritic, inflammatory skin condition which has its onset in early childhood in most cases. A stepped approach to therapy, starting with emollients and adding first mild and then more potent topical medications is
Ryan A Crane et al.
The Laryngoscope, 125(1), 209-217 (2014-07-22)
To systematically review the available evidence regarding steroid treatment for sudden sensorineural hearing loss (SSHL) and to update prior analyses when possible. OVID Medline. An electronic database search (OVID Medline) was performed with the objective of identifying all randomized controlled
H Hassanian-Moghaddam et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 1235-1236 (2013-10-09)
A young rural man referred to us with profound icterus and dyspnea after he had eaten three grapes almost 10 days earlier. He had referred to a local hospital 30 min after ingestion with nausea, vomiting and abdominal pain and
Kristen Breslin et al.
Pediatric emergency care, 28(11), 1238-1245 (2012-11-07)
The use of methylprednisolone after acute spinal cord injury has been under discussion for more than 20 years. There is ongoing debate about the efficacy and clinical impact of methylprednisolone in recovery from spinal cord injury, and studies show considerable
Anurag N Malani et al.
JAMA, 309(23), 2465-2472 (2013-06-20)
Injection of contaminated methylprednisolone has resulted in an unprecedented nationwide outbreak of Exserohilum rostratum fungal infections, manifested initially as meningitis and/or basilar stroke. Insidious onset of spinal or paraspinal infection at the injection site has been increasingly reported and is
Tom M Chiller et al.
The New England journal of medicine, 369(17), 1610-1619 (2013-10-25)
Since September 18, 2012, public health officials have been investigating a large outbreak of fungal meningitis and other infections in patients who received epidural, paraspinal, or joint injections with contaminated lots of methylprednisolone acetate. Little is known about infections caused
R Lukáš et al.
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 78(4), 305-313 (2011-09-06)
High doses of methylprednisolone (MPSS) came into use as part of a therapeutic protocol for acute spinal cord injuries following the published results from the NASCIS II study in 1992; they soon became a standard of care around the world.
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