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Kristy K Michael Miller et al.
Steroids, 78(1), 15-25 (2012-11-06)
Dehydroepiandrosterone (DHEA) levels were reported to associate with increased breast cancer risk in postmenopausal women, but some carcinogen-induced rat mammary tumor studies question this claim. The purpose of this study was to determine how DHEA and its metabolites affect estrogen
Ali Reza Khosravi et al.
Foodborne pathogens and disease, 9(7), 674-679 (2012-06-14)
The purpose of the present study was to evaluate and assess the capability of Zataria multiflora, Geranium herbarium, and Eucalyptus camaldolensis essential oils in treating Saprolegnia parasitica-infected rainbow (Oncorhynchus mykiss) trout eggs. A total of 150 infected eggs were collected
V M Litvinov et al.
Molecular pharmaceutics, 9(10), 2924-2932 (2012-08-22)
The use of hot-melt extrusion for preparing homogeneous API-excipient mixtures is studied for miconazole-PEG-g-PVA [poly(ethylene glycol)-poly(vinyl alcohol) graft copolymer] solid dispersions with a 5 cm(3) table-top, twin-screw corotating microcompounder (DSM Xplore). Phase behavior of PEG-g-PVA, miscibility of miconazole in PEG-g-PVA
Charlotte Nirma et al.
Journal of natural products, 76(5), 988-991 (2013-05-01)
Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound
J Scott Weese et al.
Veterinary dermatology, 23(5), 400-e74-400-e74 (2012-07-27)
The emergence and dissemination of meticillin-resistant staphylococci has created significant treatment challenges in veterinary medicine and increased interest in topical therapy for superficial infections. Concern has been expressed regarding the use of some topical antimicrobials in animals because of the
Stefano Veraldi
Mycoses, 56 Suppl 1, 41-43 (2013-04-19)
A 43-year-old male, with intertrigo due to Candida albicans located at the inguinal folds and accompanied by severe pruritus, was treated with topical 1% isoconazole nitrate and 0.1% diflucortolone valerate (2 applications/day for 7 days). An improvement of pruritus was
Ana Maria Carmona-Ribeiro
Methods in molecular biology (Clifton, N.J.), 906, 283-294 (2012-07-14)
Biomimetic nanoparticles are hybrid nanostructures in which the uppermost layer is similar to a cell membrane. This report provides instructions for the preparation and physical characterization of three different types of biomimetic nanoparticles: (1) polystyrene sulfate nanoparticles covered with one
Ahmet Uysal et al.
Archives of gynecology and obstetrics, 286(4), 959-963 (2012-05-25)
Our aim was to investigate whether posthysterectomy infectious morbidity could be reduced by intravaginal therapy before operations. Women expected to undergo elective total abdominal hysterectomy were included. Vaginal flora was evaluated by preoperative Gram-stained vaginal smears up to Nugent's criteria.
Byong Hoon Yoo et al.
Journal of biomolecular screening, 17(9), 1211-1220 (2012-07-04)
Breast cancers expressing hormone receptors for estrogen (ER) and progesterone (PR) represent ~70% of all cases and are treated with both ER-targeted and chemotherapies, with near 40% becoming resistant. We have previously described that in some ER(+) tumors, the resistant
Husein Husein El Ahmed et al.
Biomedica : revista del Instituto Nacional de Salud, 32(2), 170-173 (2012-12-18)
Cutaneous candidiasis is a disease that affects children as well as adults. The presentation may be localized or systemic, and with multiple etiological agents. The most prevalent infecting species in children differs from that of the adult. A case is
Viktor A Czaika et al.
Mycoses, 56 Suppl 1, 16-22 (2013-04-19)
Bacterial superinfections often occur in dermatomycoses, resulting in greatly inflamed or eczematous skin. The objective of this study was to evaluate the antibacterial efficacy of isoconazole nitrate (ISN), a broad-spectrum antimicrobial imidazole, commonly used to treat dermatomycoses. Several gram-positive bacteria
André Luiz Rossetto et al.
Revista do Instituto de Medicina Tropical de Sao Paulo, 55(2), 125-128 (2013-04-09)
The authors report a case of bilateral Tinea nigra plantaris treated through a double-blind study with the topical antifungal agents Isoconazole and Terbinafine. The objective of the study was to clinically compare the efficacy of these two topical antifungal agents
Stefano Veraldi
Mycoses, 56 Suppl 1, 3-15 (2013-04-19)
Fungal skin infections, or dermatomycoses, are associated with a broad range of pathogens. Involvement of gram-positive bacteria is often suspected in dermatomycoses. Inflammation plays an important role in dermatomycoses, displaying a close association between frequent inflammation and reduced skin-related quality
Sónia P M Ventura et al.
Ecotoxicology and environmental safety, 83, 55-62 (2012-06-30)
A wide range of ionic liquids (ILs), containing a diverse set of cations, anions and alkyl chain lengths, was screened for their antimicrobial activity toward four microorganisms, Escherichia coli CCT-0355, Staphylococcus aureus ATCC-6533, Fusarium sp. LM03 and Candida albicans ATCC-76645.
Oral chronic hyperplastic candidiasis associated with juvenile dermatomyositis.
Dennis de Carvalho Ferreira et al.
Revista da Sociedade Brasileira de Medicina Tropical, 45(4), 540-540 (2012-08-30)
Hala M Heneedak et al.
Journal of chromatographic science, 50(10), 855-861 (2012-08-11)
High-performance liquid chromatography (HPLC) and chemometric methods were applied to the simultaneous determination of the two nonsteroidal antifungal drugs, miconazole (MIC) and nystatin (NYS). The applied chemometric techniques are multivariate methods including classical least squares, principal component regression and partial
Malagoli Piergiorgio
Mycoses, 56 Suppl 1, 38-40 (2013-04-19)
A warm and moist environment is a common risk factor for erythrasma, a condition characterized by pruritic, scaly and erythematous tan patches on the skin. Here we report on a 13-year-old athletic student presenting with pruritus and mild burning on
Tomonori Takami et al.
PloS one, 7(11), e49004-e49004 (2012-11-13)
Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on
Nicola Austin et al.
The Cochrane database of systematic reviews, 3(3), CD003478-CD003478 (2013-04-02)
Invasive fungal infection is an important cause of mortality and morbidity in very preterm or very low birth weight infants. Uncertainty exists about the effect of prophylactic oral/topical non-absorbed antifungals to reduce mucocutaneous colonisation and so limit the risk of
S Gebremedhin et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(4), 593-600 (2014-09-03)
Oral candidiasis in the form of Candida-associated denture stomatitis (CaDS) is associated with Candida adhesion and biofilm formation on the fitting surface of poly (methyl methacrylate) (PMMA) dentures. Candida biofilms show considerable resistance to most conventional antifungal agents, a phenomenon
The benefits of combination therapy in dermatomycoses.
Stefano Veraldi
Mycoses, 56 Suppl 1, 1-2 (2013-04-19)
Reginaldo G Lima-Neto et al.
Molecules (Basel, Switzerland), 17(5), 5882-5892 (2012-05-18)
1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1H-1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or click chemistry). Next the in vitro antifungal activity of these ten
Viktor A Czaika
Mycoses, 56 Suppl 1, 26-29 (2013-04-19)
There have been few published reports on the human transmission of Trichophyton mentagrophytes, a zoophilic fungus frequently occurring in pets. Here we report on 2 girls, living with a pet dwarf rabbit, who presented with inflammatory skin lesions positive for
Tarek A Ahmed et al.
AAPS PharmSciTech, 13(3), 760-771 (2012-05-16)
The interest in and need for formulating miconazole nitrate (MN), a broad-spectrum antifungal, as an oral disintegrating tablet for treatment of some forms of candidiasis have increased. Formulation of MN in this dosage form will be more advantageous, producing dual
Dong-Jun Sung et al.
Biological & pharmaceutical bulletin, 35(9), 1469-1475 (2012-09-15)
Some azole antifungal agents induce long QT syndrome and arrhythmias. Although composite functions of ion channels in cardiomyocytes contribute to the shaping of action potentials, information on the effects of azole antifungal agents on ion currents, except human-ether-a-go-go-related gene (HERG)
Naomi T Jessurun et al.
Nederlands tijdschrift voor geneeskunde, 157(4), A5317-A5317 (2013-01-25)
The imidazole derivative miconazole is often used to treat fungal infections of the skin, mouth and gastrointestinal tract. Used concomitantly with coumarin derivatives, it may enhance their anticoagulant effects by inhibiting the CYP2C9 isoenzyme; an interaction which has been well
Viktor Alexander Czaika et al.
Mycoses, 56 Suppl 1, 33-37 (2013-04-19)
Trichophytia infection, paraphrased cuddly toy mycosis, occurs primarily in prepubertal children, occasionally in infants and adults. The presented case shows the highly contagious infection of four family members with Trichophyton mentagrophytes. Effective treatment requires detailed diagnostic: identifying the dermatophyte, finding
Jelena Obad et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 71, 93-98 (2015-02-25)
Pharmaceutical industry has been encountering antimicrobial activity of non-antibiotics during suitability tests carried out prior to routine pharmacopoeial microbiological purity analysis of finished dosage forms. These properties are usually ignored or perceived as a nuisance during pharmaceutical analysis. The aim
Jae Yong Choi et al.
Synapse (New York, N.Y.), 66(12), 1015-1023 (2012-08-29)
[(18) F]MeFWAY has been developed for imaging the serotonin 1A receptors in the brain. The purpose of this study were to verify the metabolic stability of [(18) F]MeFWAY, to measure the degree of defluorination of [(18) F]MeFWAY in vivo, to
Bart Pauwels et al.
The journal of sexual medicine, 11(7), 1664-1674 (2014-05-21)
Erectile dysfunction (ED), as well as many cardiovascular diseases, is associated with impaired nitric oxide (NO) bioavailability. Recently, oxime derivatives have emerged as vasodilators due to their NO-donating capacities. However, whether these oximes offer therapeutic perspectives as an alternative NO
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