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Tetyana Kobets et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 115, 228-243 (2018-03-20)
Genotoxicity of flavor and fragrance materials was assessed in Turkey Egg Genotoxicity Assay (TEGA) using 32P-nucleotide postlabeling (NPL) and comet assays to detect hepatic DNA adducts and strand breaks. Twenty materials having results in GADD45a-Gluc 'BlueScreen HC' genotoxicity assay, and
Irina Vetter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(42), 16627-16641 (2013-10-18)
Topically applied camphor elicits a sensation of cool, but nothing is known about how it affects cold temperature sensing. We found that camphor sensitizes a subpopulation of menthol-sensitive native cutaneous nociceptors in the mouse to cold, but desensitizes and partially
Spontaneous rapid odor source localization behavior requires interhemispheric communication
Rabell JE, et al.
Current Biology, 27(10), 1542-1548 (2017)
María Ll Valero et al.
PloS one, 7(12), e51825-e51825 (2012-12-20)
Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666
TRP channel mediated neuronal activation and ablation in freely behaving zebrafish
Chen S, et al.
Nature Methods, 13(2), 147-147 (2015)
Zongde Wang et al.
Bioorganic & medicinal chemistry letters, 18(9), 2854-2859 (2008-04-22)
A new class of low-toxicity mosquito repellents is synthesized from alpha- and beta-pinene in terpenoid compounds and preliminary biological tests show promising mosquito repellency. Statistical modeling is built using Codessa in order to reveal the quantitative relationship between the structure
Hiroki Kawasaki et al.
Life sciences, 92(6-7), 359-367 (2013-01-29)
Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrations inhibit action potential conduction in the neurons and thus have a local anesthetic effect. The
Sureewan Duangjit et al.
Biological & pharmaceutical bulletin, 35(10), 1720-1728 (2012-10-06)
Menthosomes, novel deformable carriers for the enhancement of transdermal delivery are introduced in this study. Meloxicam (MX)-loaded menthosomes were formulated, and their physicochemical characteristics and skin permeability were evaluated. A two-factor spherical and second-order composite experimental design was used to
Dirk W Lachenmeier et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 173-178 (2012-10-09)
Mouthwash ingestion has been observed in settings of restricted availability to alcoholic beverages such as in hospitals, prisons or military establishments. The literature offers limited evidence that ingredients of mouthwash may have health effects above the effects of ethanol. This
Ghassan Zuhair Abdullah et al.
Pakistan journal of pharmaceutical sciences, 26(1), 75-83 (2012-12-25)
Micro-emulsions and sometimes nano-emulsions are well known candidates to deliver drugs locally. However, the poor rheological properties are marginally affecting their acceptance pharmaceutically. This work aimed to modify the poor flow properties of a nano-scaled emulsion comprising palm olein esters
Mohamadi Sarkar et al.
Drug metabolism letters, 6(3), 198-206 (2012-11-13)
Menthol in cigarettes has been suggested to inhibit metabolism of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The objective of this study was to investigate the glucuronide metabolite ratios (MR) for nicotine (NICGLUC/NIC), cotinine (COTGLUC/COT), trans 3'-hydroxy cotinine (3OHCOTGLUC/3OHCOT). 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (NNAL - NNALGLUC/NNAL);
Xi Hu et al.
Chemosphere, 113, 30-35 (2014-07-30)
The effects of d-menthol on the growth of Microcystis aeruginosa FACHB-905 and microcystin (MCY) concentration were evaluated by batch culture experiments. The algal biomass and the intracellular and extracellular MCY concentrations were evaluated during 5d incubation. After the d-menthol exposure
A L Rozza et al.
Chemico-biological interactions, 206(2), 272-278 (2013-10-15)
Based on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from species of the genus Mentha.
Alec R Nickolls et al.
Cell reports, 30(3), 932-946 (2020-01-23)
Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by overexpressing NGN2 and BRN3A, human pluripotent stem cells can be transcriptionally
Ebrahim Alipanahpour Dil et al.
Talanta, 221, 121547-121547 (2020-10-21)
Present work is the preparation of novel magnetic nanofluids based on deep eutectic solvent and used for the rapid microextraction of methylparaben (MP), propylparaben (PP), and butylparaben (BP) from cosmetics samples using syringe-to-syringe dispersive magnetic nanofluid microextraction procedure (SS-DMNF-ME). The
Ayaka Tanabe et al.
Autonomic neuroscience : basic & clinical, 171(1-2), 36-40 (2012-11-16)
Corticotropin-releasing factor (CRF) is a neuropeptide that mediates neuroendocrine, autonomic, and behavioral processes associated with the stress response. CRF-containing fibers and receptors are found in various regions of the central nervous system including the spinal cord. Here, we report excitatory
FDA might consider restrictions on menthol cigarettes.
Mike Mitka
JAMA, 310(8), 784-784 (2013-08-29)
Bin Yang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(9), 1421-1425 (2013-08-16)
To determine the concentration of menthol in rat plasma by GC. Rats were administered with single dose of Zhike Chuanbei Pipa dropping pills (ZCPDP) and different doses of menthol herbs. DAS 3. 1.6 software was used to calculate pharmacokinetic parameters
Shengyi Lu et al.
European journal of oral sciences, 121(1), 29-35 (2013-01-22)
This study was designed to investigate the effect of surrogate orofacial pain models on the quantitative sensory testing (QST) profile in healthy participants. Capsaicin, menthol, or saline (control) were applied topically onto the gingiva of 15 healthy subjects for 15 min.
Julia Fabbri et al.
Acta tropica, 205, 105411-105411 (2020-02-27)
Alveolar echinococcosis is one of the most dangerous parasitic zoonoses. This disease, widely distributed in the northern hemisphere, is caused by the metacestode stage of the tapeworm Echinococcus multilocularis. All surgical and non-surgical patients should perform chemotherapy with benzimidazoles, mainly
Joanne D'Silva et al.
American journal of preventive medicine, 43(5 Suppl 3), S242-S248 (2012-10-25)
Menthol cigarettes account for 25% of the market in the U.S. The Food and Drug Administration currently is considering regulatory action on tobacco products, including a ban on menthol cigarettes. With 39% of menthol smokers reporting that they would quit
Efficacy of Benzocaine, Eugenol, and Menthol as Anesthetics for Freshwater Angelfish
Romaneli RD et al.
Journal of Aquatic Animal Health, 30(3), 210-216 (2018)
M Carmen Acosta et al.
Investigative ophthalmology & visual science, 55(6), 3403-3412 (2014-05-03)
To produce in guinea pigs a UV-induced keratitis, to analyze the effects of this pathology on corneal nerve activity. In anesthetized animals, one eye was exposed to 254 nm UV-C radiation (500-1000 mJ/cm(2)), excised 24 to 48 hours later and
A Gillissen et al.
Drug research, 63(1), 19-27 (2013-03-01)
GeloMyrtol® forte (Myrtol®) is a phytomedicine obtained by distillation from essential oils. The trial was conducted to confirm the efficacy of Myrtol® in the treatment of acute bronchitis. Patients with acute bronchitis and without confounding co-morbidity or co-medication were randomly
Kohta Kurohane et al.
Toxicology letters, 217(3), 192-196 (2013-01-09)
We studied the involvement of sensory neurons in skin sensitization to allergens using a mouse model in which the T-helper type 2 response is essential. Skin sensitization to fluorescein isothiocyanate (FITC) has been shown to be enhanced by several phthalate
Lene Vase et al.
Neuroscience letters, 534, 52-57 (2012-12-26)
The mechanisms underlying phantom limb pain are not fully known, but hypersensitivity appears to be a central element. Menthol has previously been suggested as a model for hypersensitivity, but it has not yet been investigated if different levels of neuropathic
Bibi F Choonara et al.
AAPS PharmSciTech, 16(4), 771-786 (2015-01-01)
A menthol-based solid dispersion was designed to improve the intrinsic solubility of the poorly soluble sulfamethoxazole- a class II drug molecule of Biopharmaceutics Classification System (BCS) displaying widespread antibacterial activity. Solid dispersions of menthol and sulfamethoxazole were compressed with hydroxypropyl
Joshua E Muscat et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18(1), 35-41 (2009-01-07)
Menthol is a controversial cigarette additive because its physiologic or pharmacologic effects may possibly increase the risk for cancer and its targeted market is the Black community. In a community-based cross-sectional study on 525 Black and White volunteers, we compared
Andrea C Villanti et al.
American journal of preventive medicine, 44(4), 388-391 (2013-03-19)
Passage of the U.S. Family Smoking Prevention and Tobacco Control Act in 2009 led to a ban on the sale of flavored cigarettes, largely because of studies showing targeting of these products to youth and young adults. There are no
Eva Millqvist et al.
Respiratory medicine, 107(3), 433-438 (2012-12-26)
Chronic cough is a common clinical problem and there is a shortage of effective treatments for it. Within the group of transient receptor potential ion channels a receptor for the cooling substance menthol has been identified. This study aimed to
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