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关键词:'M3128'
显示 1-30 共 141 条结果 关于 "M3128" 范围 论文
Yuxin Fang et al.
European journal of medicinal chemistry, 83, 36-44 (2014-06-20)
Tryptophan and arginine rich antimicrobial peptides (AMPs) possess high potencies against both gram positive and gram negative bacteria, while lipopeptides represent another family of promising antimicrobial agents to combat invading pathogens. In the present study, we have synthesized a series
Elisabeth M Storck et al.
Biochemical Society transactions, 41(1), 56-61 (2013-01-30)
The study of post-translational modifications such as protein lipidation is a non-trivial challenge of the post-genomic era. In recent years the field of chemical proteomics has greatly advanced our ability to identify and quantify protein lipidation. In the present review
Amal Hasan et al.
International journal of molecular sciences, 20(17) (2019-08-25)
Elevated levels of IL-8 (CXCL8) in obesity have been linked with insulin resistance and type 2 diabetes (T2D). The mechanisms that lead to the profound production of IL-8 in obesity remains to be understood. TNF-α and saturated free fatty acids
Wim Reybroeck et al.
PloS one, 9(5), e98266-e98266 (2014-05-24)
Two Pseudomonas strains, identified as closely related to Pseudomonas tolaasii, were isolated from milk of a farm with frequent false-positive Delvotest results for screening putative antibiotic residues in raw milk executed as part of the regulatory quality programme. Growth at
Woosuk Lee et al.
Nanomaterials (Basel, Switzerland), 10(11) (2020-11-05)
The development of blue-emissive InP quantum dots (QDs) still lags behind that of the red and green QDs because of the difficulty in controlling the reactivity of the small InP core. In this study, the reaction kinetics of the ZnS
Anthony Tomlinson et al.
Molecular pharmaceutics, 12(11), 3805-3815 (2015-10-01)
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months) storage of two monoclonal antibody (mAb, mAb-A, and mAb-B) drug products at 2-8 °C. The PS20 degradation resulted in the accumulation of free fatty acids
Eduardo Caballero et al.
PloS one, 9(9), e107749-e107749 (2014-09-24)
Structured Lipids are generally constituents of functional foods. Growing demands for SL are based on a fuller understanding of nutritional requirements, lipid metabolism, and improved methods to produce them. Specifically, this work was aimed to add value to avocado oil
Ju-Ying Zou et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(4), 578-581 (2012-10-02)
To analyze the chemical constituents of volatile oil from the rhizomes and leaves of Pileostegia viburnoides var. glabrescens by GC-MS. The volatile oil was extracted from the rhizomes and leaves of Pileostegia viburnoides var. glabrescens by steam distillation. The constituents
J Hadrévi et al.
Scientific reports, 5, 15925-15925 (2015-11-03)
Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal
Keisuke Kaneko et al.
Journal of biochemistry, 156(1), 51-61 (2014-03-25)
Multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs) have been extensively studied in mammals, whereas fungus CaMKs still remain largely uncharacterized. We previously obtained CaMK homolog in Coprinopsis cinerea, designated CoPK12, and revealed its unique catalytic properties in comparison with the mammalian CaMKs.
Ayuko Kimura et al.
Biochemistry, 51(44), 8856-8866 (2012-10-30)
The 26S proteasome is a large, complex multisubunit protease involved in protein quality control and other critical processes in eukaryotes. More than 110 post-translational modification (PTM) sites have been identified by a mass spectrometry of the 26S proteasome of Saccharomyces
Jian Chen et al.
Journal of pharmaceutical and biomedical analysis, 167, 83-89 (2019-02-14)
The incidence of laryngeal cancer (LYC) is second only to lung cancer, which is also the second most common cancer in head and neck cancer. Risk assessment metabolomics biomarkers to diagnose LYC have not been found by now. To profile
Marcin Broniatowski et al.
Biochimica et biophysica acta, 1859(2), 155-166 (2016-11-23)
Anionic phospholipids cardiolipins (CL) and phosphatidylglycerols (PG) dominate in the biomembranes of the majority of soil bacteria. CL to PG ratio differs between the species and is also dependent on the external conditions. CL/PG ratio is different in polluted than
Milagro Mottola et al.
Journal of colloid and interface science, 457, 232-242 (2015-07-21)
L-ascorbic acid alkyl esters (ASCn) are molecules of pharmaceutical interest for their amphiphilic nature and proposed antioxidant power. In contrast to L-ascorbic acid, ASC(n) with different acyl chain lengths behaved stably upon oxidation and a tautomeric isomerization was observed. In
Dalit Shental-Bechor et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(44), 17839-17844 (2012-08-01)
We present an integrated experimental and computational study of the molecular mechanisms by which myristoylation affects protein folding and function, which has been little characterized to date. Myristoylation, the covalent linkage of a hydrophobic C14 fatty acyl chain to the
Sarah Brice Russo et al.
The Journal of clinical investigation, 122(11), 3919-3930 (2012-10-02)
Diabetic cardiomyopathy (DbCM), which consists of cardiac hypertrophy and failure in the absence of traditional risk factors, is a major contributor to increased heart failure risk in type 2 diabetes patients. In rodent models of DbCM, cardiac hypertrophy and dysfunction
Michael Englert et al.
Analytical and bioanalytical chemistry, 407(18), 5503-5511 (2015-05-07)
Purification of individual fatty acids from vegetable oils by preparative liquid chromatography techniques such as countercurrent chromatography (CCC) is a challenging task due to the equivalent-chain-length (ECL) rule. It implies that one double bond equals two carbon atoms in the
Jieyan V Chen et al.
The Journal of cell biology, 211(2), 435-453 (2015-10-21)
Cilia are essential for cell signaling and sensory perception. In many cell types, a cytoskeletal structure called the ciliary rootlet links the cilium to the cell body. Previous studies indicated that rootlets support the long-term stability of some cilia. Here
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Frank Heinrich et al.
The Journal of biological chemistry, 289(14), 9683-9691 (2014-02-08)
The mammalian Golgi reassembly stacking protein (GRASP) proteins are Golgi-localized homotypic membrane tethers that organize Golgi stacks into a long, contiguous ribbon-like structure. It is unknown how GRASPs undergo trans pairing given that cis interactions between the proteins in the
Xiaobing Yang et al.
Bioresource technology, 193, 557-562 (2015-07-15)
Microbial lipids produced by oleaginous yeasts serve as promising alternatives to traditional oils and fats for the production of biodiesel and oleochemicals. To improve its techno-economics, it is pivotal to use wastes and produce high quality lipids of special fatty
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Henry Dabadie et al.
The Journal of nutritional biochemistry, 16(6), 375-382 (2005-06-07)
Among the saturated fatty acids (SFA), myristic acid is known to be one of the most atherogenic when consumed at high levels. Our purpose was to compare the effects of two moderate intakes of myristic acid on plasma lipids in
María Isabel Giacopini de Z et al.
Investigacion clinica, 54(2), 171-179 (2013-08-21)
We analyzed in 31 subjects, regular guests of the University food service of the Central University of Venezuela (UCVFS), in Caracas, the effects of replacing sunflower oil, commonly used in the preparation of meals, by a mix of sunflower oil
Giovanna Fragneto et al.
Colloids and surfaces. B, Biointerfaces, 103, 416-421 (2012-12-25)
Competitive adsorption is a general problem both in polymer and in biological systems. The equilibrium composition at a surface in contact either with polymer solutions or biological fluids depends on the competition between all the surface active material present in
Ivan Juric et al.
PLoS computational biology, 15(4), e1006982-e1006982 (2019-04-16)
Hi-C and chromatin immunoprecipitation (ChIP) have been combined to identify long-range chromatin interactions genome-wide at reduced cost and enhanced resolution, but extracting information from the resulting datasets has been challenging. Here we describe a computational method, MAPS, Model-based Analysis of
Marie W Pettit et al.
International journal of pharmaceutics, 468(1-2), 264-271 (2014-04-01)
An increasing human population requires a secure food supply and a cost effective, oral vaccine delivery system for livestock would help facilitate this end. Recombinant antigen adsorbed onto silica beads and coated with myristic acid, was released (∼15% (w/v)) over
Shoghag Panjarian et al.
The Journal of biological chemistry, 288(9), 6116-6129 (2013-01-11)
Multidomain kinases such as c-Src and c-Abl are regulated by complex allosteric interactions involving their noncatalytic SH3 and SH2 domains. Here we show that enhancing natural allosteric control of kinase activity by SH3/linker engagement has long-range suppressive effects on the
Anja Meier et al.
Hepatology (Baltimore, Md.), 58(1), 31-42 (2012-12-06)
Chronic infection with the human hepatitis B virus (HBV) is a global health problem and a main cause of progressive liver diseases. HBV exhibits a narrow host range, replicating primarily in hepatocytes. Both host and hepatocyte specificity presumably involve specific
A N Hristov et al.
Journal of animal science, 90(12), 4449-4457 (2012-09-07)
The objective of this experiment, part of a larger study, was to investigate changes in rumen bacterial, archaeal, and fungal diversity in cows fed medium-chain saturated fatty acids. In the main study, 6 lactating dairy cows were dosed intraruminally with
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