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Peter L Pontoppidan et al.
International immunopharmacology, 25(1), 180-188 (2015-01-24)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a procedure with a high risk of treatment related mortality. The primary aim of the present study was to examine associations between markers of gastrointestinal toxicity, markers of systemic inflammation, and plasma levels
Matthias Erber et al.
International journal of pharmaceutics, 495(2), 692-700 (2015-09-24)
A cryopellet formulation of the diagnostic protein ecarin has been developed that is suitable for use to monitor blood coagulation via in vitro thromboelastometry. The coagulation activity of the ecarin was measured by thromelastometry using whole blood. In aqueous solution
Kimberly J Hassett et al.
Journal of pharmaceutical sciences, 104(2), 627-639 (2015-01-13)
During transport and storage, vaccines may be exposed to temperatures outside of the range recommended for storage, potentially causing efficacy losses. To better understand and prevent such losses, dominant negative inhibitor (DNI), a recombinant protein antigen for a candidate vaccine
Qian Wang et al.
Biomaterials, 35(29), 8385-8393 (2014-07-06)
Microparticle-based vaccine delivery systems are known to promote enhanced immune responses to protein antigens and can elicit TH1-biased responses when used in combination with Toll-like receptor (TLR) agonists. It is important to understand the kinetics of the immune responses to
J A Davis et al.
Letters in applied microbiology, 59(1), 1-8 (2014-04-16)
Antimicrobial-resistant staphylococci have been associated with wounded or ill companion animals, but little is known about the prevalence of resistant staphylococci among healthy animals. In this study, 276 healthy dogs and cats from veterinary clinics were tested for the presence
Wioleta Chajęcka-Wierzchowska et al.
Food microbiology, 46, 222-226 (2014-12-06)
The aim of this work was to study the pheno- and genotypical antimicrobial resistance profile of coagulase negative staphylococci (CoNS) isolated from 146 ready-to-eat food of animal origin (cheeses, cured meats, sausages, smoked fishes). 58 strains were isolated, they were
Zhenlong Cheng et al.
PloS one, 10(3), e0122450-e0122450 (2015-04-01)
Potato common scab is an economically important crop disease that is characterized by the formation of superficial, raised or pitted lesions on the potato tuber surface. The most widely distributed causative agent of the disease is Streptomyces scabies, which produces
Nermeen Adel ElKasabgy et al.
International journal of pharmaceutics, 472(1-2), 369-379 (2014-07-01)
Lipotomes were designed to enhance lacidipine's oral bioavailability by improving its solubility and enhancing the oral lymphatic uptake. Lipotomes were prepared using cetyl alcohol and Tween(®) 80 using a thin film hydration technique. Cetyl alcohol was chosen for imparting a
Enoch Chan et al.
Bioorganic & medicinal chemistry, 15(12), 4091-4097 (2007-04-11)
In search of new oligodeoxynucleotide (ODN) delivery agents, we evaluated novel peptides derived from core peptide H-GLRILLLKV-OH (CP). CP is a fragment designed from the T-cell antigen receptor (TCR) alpha-chain transmembrane sequence. CP was able to enter cells including T-cells
Adam H Kramer et al.
Journal of cellular biochemistry, 116(7), 1232-1240 (2015-01-08)
A mechanistic relationship exists between protein localisation, activity and cellular differentiation. Understanding the contribution of these molecular mechanisms is required for elucidation of conditions that drive development. Literature suggests non-canonical translocation of the Signal Transducer and Activator of Transcription 3
Michael K Stickland et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 107(3), 229-234 (2011-08-31)
Exercise challenge testing is the typical method for diagnosing exercise induced bronchoconstriction; however, alternate tests have been developed. The purpose of this paper was to summarize the current literature comparing eucapnic voluntary hyperpnea and mannitol with standard exercise challenge testing
Shmuel Hess et al.
Journal of medicinal chemistry, 50(24), 6201-6211 (2007-11-07)
A library of 18 hexapeptide analogs was synthesized, including sub-libraries of N- or C-methylation of the parent hexapeptide Phe-Gly-Gly-Gly-Gly-Phe, as well as backbone cyclized analogs of each linear analog with various ring sizes. N- or C-methylation as well as cyclization
Bodhisattwa Banerjee et al.
Indian journal of experimental biology, 52(7), 728-738 (2014-07-26)
Effect of environmental hypertonicity, due to exposure to 300 mM mannitol solution for 7 days, on the induction of ureogenesis and also on amino acid metabolism was studied in the air-breathing walking catfish, C. batrachus, which is already known to
Susana Rodrigues et al.
Carbohydrate polymers, 123, 369-380 (2015-04-07)
Chitosan/carrageenan/tripolyphosphate nanoparticles were previously presented as holding potential for an application in transmucosal delivery of macromolecules, with tripolyphosphate demonstrating to contribute for both size reduction and stabilisation of the nanoparticles. This work was aimed at evaluating the capacity of the
Akiko Kiyoshima et al.
Legal medicine (Tokyo, Japan), 6(2), 117-124 (2004-03-25)
Determining the time of brain death is one of the critical issues in forensic examinations. Few authors have attempted to determine the time of brain death using pharmacokinetic approaches. We investigated cerebral concentrations of mannitol of which a single dose
Sarah Kolitz et al.
Scientific reports, 5, 10191-10191 (2015-05-23)
Glatiramer Acetate (GA) has provided safe and effective treatment for multiple sclerosis (MS) patients for two decades. It acts as an antigen, yet the precise mechanism of action remains to be fully elucidated, and no validated pharmacokinetic or pharmacodynamic biomarkers
Isabel Silva et al.
The Journal of urology, 194(4), 1146-1154 (2015-05-26)
Deregulation of purinergic bladder signaling may contribute to persistent detrusor overactivity in patients with bladder outlet obstruction. Activation of uridine diphosphate sensitive P2Y6 receptors increases voiding frequency in rats indirectly by releasing adenosine triphosphate from the urothelium. To our knowledge
Prateek Kakar et al.
Journal of controlled release : official journal of the Controlled Release Society, 319, 428-437 (2020-01-11)
Traditional patches are most successful in transdermal delivery of low-dose hydrophobic drugs. Week-long transdermal delivery of high-dose hydrophilic drugs remains a big challenge. This study explored ablative fractional laser (AFL) to assist 3-day to week-long sustained transdermal delivery of powder
Mie Kristensen et al.
The AAPS journal, 17(5), 1200-1209 (2015-05-21)
Penetratin is a widely used carrier peptide showing promising potential for mucosal delivery of therapeutic proteins. In the present study, the importance of specific penetratin residues and pH was investigated with respect to complexation with insulin and subsequent transepithelial insulin
Roberto Rangel et al.
Nature protocols, 8(10), 1916-1939 (2013-09-14)
Techniques that are largely used for protein interaction studies and the discovery of intracellular receptors, such as affinity-capture complex purification and the yeast two-hybrid system, may produce inaccurate data sets owing to protein insolubility, transient or weak protein interactions or
Hjalte Trnka et al.
Journal of pharmaceutical sciences, 103(9), 2839-2846 (2014-03-26)
Evaluation of freeze-dried biopharmaceutical formulations requires careful analysis of multiple quality attributes. The aim of this study was to evaluate the use of near-infrared (NIR) imaging for fast analysis of water content and related physical properties in freeze-dried formulations. Model
Intestinal permeability in subjects from two different race groups with diverse stone-risk profiles.
Takalani Theka et al.
Urolithiasis, 41(2), 111-117 (2013-03-19)
It is well established that calcium oxalate stones may be caused by colonic or ileum oxalate (Ox) hyperabsorption (secondary to intestinal dysfunction). Studies have reported that increased intestinal permeability (IP) can cause hyperabsorption of nutrients culminating in passive diffusion of
Juerg Barben et al.
Pediatric pulmonology, 36(6), 490-494 (2003-11-18)
Our objective was to determine the repeatability of bronchial responsiveness to mannitol dry powder (MDP) as an objective marker of asthma in children. MDP challenge was performed in children with stable asthma at the same time of the day on
Simonetta Visintin et al.
International journal of food microbiology, 216, 69-78 (2015-10-02)
Yeast, lactic acid bacteria (LAB) and acetic acid bacteria (AAB) populations, isolated from cocoa bean heap and box fermentations in West Africa, have been investigated. The fermentation dynamicswere determined by viable counts, and 106 yeasts, 105 LAB and 82 AAB
Beth D Kirkpatrick et al.
The American journal of tropical medicine and hygiene, 92(4), 744-751 (2015-02-26)
Oral vaccines appear less effective in children in the developing world. Proposed biologic reasons include concurrent enteric infections, malnutrition, breast milk interference, and environmental enteropathy (EE). Rigorous study design and careful data management are essential to begin to understand this
T Narender et al.
Bioorganic & medicinal chemistry letters, 21(21), 6393-6397 (2011-09-21)
In continuation of our drug discovery program on metabolic diseases, we identified an alkaloidal amide, that is, Aegeline (V) from the plant Aegle marmelos leaves as a dual acting agent (antihyperlipidemic and antihyperglycemic). We therefore synthesized a series of alkaloidal
Kim Tardif et al.
Cardiovascular diabetology, 13, 119-119 (2014-08-21)
Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following
Carey D Schlett et al.
Antimicrobial agents and chemotherapy, 58(8), 4404-4410 (2014-05-21)
Chlorhexidine has been increasingly utilized in outpatient settings to control methicillin-resistant Staphylococcus aureus (MRSA) outbreaks and as a component of programs for MRSA decolonization and prevention of skin and soft-tissue infections (SSTIs). The objective of this study was to determine
Hermine V Mkrtchyan et al.
BMC microbiology, 15, 120-120 (2015-06-14)
Staphylococci are commonly associated with antibiotic resistance in healthcare settings including resistance to methicillin and other beta lactam antibiotics primarily associated with the carriage of SCCmec mobile genetic elements. We investigated oxacillin susceptibility in 11 different species of environmental staphylococci
Li-Xia Qin et al.
Plant molecular biology, 86(6), 609-625 (2014-09-15)
Di19 (drought-induced protein19) family is a novel type of Cys2/His2 zinc-finger proteins. In this study, Arabidopsis Di19-3 was functionally characterized. The experimental results revealed that AtDi19-3 is a transcriptional activator, and could bind to the TACA(A/G)T sequence. AtDi19-3 expression in
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