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关键词:'M4125'
显示 1-30 共 659 条结果 关于 "M4125" 范围 论文
Soumyaditya Mula et al.
Bioorganic & medicinal chemistry, 16(6), 2932-2938 (2008-01-22)
The Piper betel phenolics, allylpyrocatechol (APC) and chavibetol (CHV), were found to protect photosensitization-mediated lipid peroxidation (LPO) of rat liver mitochondria effectively, APC being significantly more potent. The better activity of APC vis-à-vis CHV could be attributed to its higher
Yong Ye et al.
BMC veterinary research, 11, 214-214 (2015-08-19)
Escherichia coli and Staphylococcus aureus are the main pathogens infectious to poultry, and their resistances against antibiotics have become troublesome currently. Biofilm formation is an important reason for drug resistance. Our previous research has found that the extract of Camellia
T Narender et al.
Bioorganic & medicinal chemistry letters, 21(21), 6393-6397 (2011-09-21)
In continuation of our drug discovery program on metabolic diseases, we identified an alkaloidal amide, that is, Aegeline (V) from the plant Aegle marmelos leaves as a dual acting agent (antihyperlipidemic and antihyperglycemic). We therefore synthesized a series of alkaloidal
Hjalte Trnka et al.
Pharmaceutical development and technology, 20(1), 65-73 (2014-01-15)
Freeze-drying in presence of excipients is a common practice to stabilize biomacromolecular formulations. The composition of this formulation is known to affect the quality of the final product. The aim of this study was to evaluate freeze-drying in well-plates as
María Virumbrales-Muñoz et al.
ACS biomaterials science & engineering, 7(1), 242-253 (2020-12-19)
Microencapsulation of cells in hydrogel-based porous matrices is an approach that has demonstrated great success in regenerative cell therapy. These microcapsules work by concealing the exogenous cells and materials in a robust biomaterial that prevents their recognition by the immune
Wioleta Chajęcka-Wierzchowska et al.
Food microbiology, 46, 222-226 (2014-12-06)
The aim of this work was to study the pheno- and genotypical antimicrobial resistance profile of coagulase negative staphylococci (CoNS) isolated from 146 ready-to-eat food of animal origin (cheeses, cured meats, sausages, smoked fishes). 58 strains were isolated, they were
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
Norisuke Shibuya et al.
Oncology, 88(5), 309-319 (2015-01-17)
Glycolysis and the pentose phosphate pathway (PPP) are preferentially activated in cancer cells. Accumulating evidence indicated the significance of the altered glucose metabolism in cancer, but the implication for oncotherapy remains unclear. Here we report that the synthesis of glycolytic
A F Brito et al.
Journal of dairy science, 98(1), 443-457 (2014-12-04)
We investigated the interactions of corn meal or molasses [nonstructural carbohydrate (NSC) supplements] with a soybean-sunflower meal mix or flaxseed meal [rumen-degradable protein (RDP) supplements] on animal production, milk fatty acids profile, and nutrient utilization in dairy cows fed grass
Marta Maycas et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(7), 1231-1244 (2014-12-23)
Osteocytes have a major role in the control of bone remodeling. Mechanical stimulation decreases osteocyte apoptosis and promotes bone accrual, whereas skeletal unloading is deleterious in both respects. PTH1R ablation or overexpression in osteocytes in mice produces trabecular bone loss
C Quoilin et al.
Biochimica et biophysica acta, 1837(10), 1790-1800 (2014-07-16)
To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal tubular epithelial cells exposed to a bacterial endotoxin (lipopolysaccharide, LPS). This
Isabel Silva et al.
The Journal of urology, 194(4), 1146-1154 (2015-05-26)
Deregulation of purinergic bladder signaling may contribute to persistent detrusor overactivity in patients with bladder outlet obstruction. Activation of uridine diphosphate sensitive P2Y6 receptors increases voiding frequency in rats indirectly by releasing adenosine triphosphate from the urothelium. To our knowledge
Traumatic intracranial hypertension.
Nino Stocchetti et al.
The New England journal of medicine, 370(22), 2121-2130 (2014-05-30)
Mie Kristensen et al.
The AAPS journal, 17(5), 1200-1209 (2015-05-21)
Penetratin is a widely used carrier peptide showing promising potential for mucosal delivery of therapeutic proteins. In the present study, the importance of specific penetratin residues and pH was investigated with respect to complexation with insulin and subsequent transepithelial insulin
Christiane Iserman et al.
Cell, 181(4), 818-831 (2020-05-04)
Cells sense elevated temperatures and mount an adaptive heat shock response that involves changes in gene expression, but the underlying mechanisms, particularly on the level of translation, remain unknown. Here we report that, in budding yeast, the essential translation initiation
Oded Skaliter et al.
Bio-protocol, 8(13), e2912-e2912 (2018-07-05)
Plant vacuoles are the largest compartment in plant cells, occupying more than 80% of the cell volume. A variety of proteins, sugars, pigments and other metabolites are stored in these organelles ( Paris et al., 1996 ; Olbrich et al.
Amit Kumar et al.
Environmental microbiology, 17(11), 4459-4468 (2015-05-01)
Although Staphylococcus aureus and Pseudomonas aeruginosa can individually colonize and infect their hosts, the commensalistic effect of the two is more tenacious and lethal. In this study, it was shown that in co-culture with P. aeruginosa, a sub-population of S. aureus exhibited
M Rezaei et al.
The Journal of hospital infection, 89(3), 186-191 (2015-01-27)
Meticillin-resistant Staphylococcus aureus (MRSA) has become widespread in the hospital and in the community. Nasal colonization with MRSA has been identified as a risk factor for MRSA infection. To determine the prevalence of nasal colonization with MRSA among adult patients
D J Naisbitt et al.
AIDS research and human retroviruses, 16(18), 1929-1938 (2001-01-12)
The aim of these studies was to determine whether HIV-infected patients have a plasma thiol deficiency and whether this is associated with decreased detoxification of the toxic metabolites of sulfamethoxazole. Reduced, oxidized, protein-bound, and total thiol levels were measured in
Bing Zhu et al.
Journal of pharmaceutical sciences, 104(7), 2169-2176 (2015-05-02)
The current study presents a new approach to tackle high-dose lung delivery using a prototype multibreath Orbital® dry powder inhaler (DPI). One of the key device components is the "puck" (aerosol sample chamber) with precision-engineered outlet orifice(s) that control the
Shmuel Hess et al.
Journal of medicinal chemistry, 50(24), 6201-6211 (2007-11-07)
A library of 18 hexapeptide analogs was synthesized, including sub-libraries of N- or C-methylation of the parent hexapeptide Phe-Gly-Gly-Gly-Gly-Phe, as well as backbone cyclized analogs of each linear analog with various ring sizes. N- or C-methylation as well as cyclization
Adam H Kramer et al.
Journal of cellular biochemistry, 116(7), 1232-1240 (2015-01-08)
A mechanistic relationship exists between protein localisation, activity and cellular differentiation. Understanding the contribution of these molecular mechanisms is required for elucidation of conditions that drive development. Literature suggests non-canonical translocation of the Signal Transducer and Activator of Transcription 3
Michael K Stickland et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 107(3), 229-234 (2011-08-31)
Exercise challenge testing is the typical method for diagnosing exercise induced bronchoconstriction; however, alternate tests have been developed. The purpose of this paper was to summarize the current literature comparing eucapnic voluntary hyperpnea and mannitol with standard exercise challenge testing
Sarah Kolitz et al.
Scientific reports, 5, 10191-10191 (2015-05-23)
Glatiramer Acetate (GA) has provided safe and effective treatment for multiple sclerosis (MS) patients for two decades. It acts as an antigen, yet the precise mechanism of action remains to be fully elucidated, and no validated pharmacokinetic or pharmacodynamic biomarkers
Inaccuracy of fluid container volume markings.
R W A Nowicki
Anaesthesia, 68(6), 651-651 (2013-05-15)
Susana Rodrigues et al.
Carbohydrate polymers, 123, 369-380 (2015-04-07)
Chitosan/carrageenan/tripolyphosphate nanoparticles were previously presented as holding potential for an application in transmucosal delivery of macromolecules, with tripolyphosphate demonstrating to contribute for both size reduction and stabilisation of the nanoparticles. This work was aimed at evaluating the capacity of the
Prateek Kakar et al.
Journal of controlled release : official journal of the Controlled Release Society, 319, 428-437 (2020-01-11)
Traditional patches are most successful in transdermal delivery of low-dose hydrophobic drugs. Week-long transdermal delivery of high-dose hydrophilic drugs remains a big challenge. This study explored ablative fractional laser (AFL) to assist 3-day to week-long sustained transdermal delivery of powder
Nagahiko Yumita et al.
Anticancer research, 34(11), 6481-6487 (2014-11-05)
Sonodynamic cancer therapy is based on the preferential uptake and/or retention of a sonosensitizing drug (sonosensitizer) in tumor tissues and subsequent activation of the drug by ultrasound irradiation. In the present study, we investigated the participation of lipid peroxidation in
Amber L Jolly et al.
mBio, 6(2), e02533-e02533 (2015-02-26)
The opportunistic pathogen Pseudomonas aeruginosa can infect almost any site in the body but most often targets epithelial cell-lined tissues such as the airways, skin, and the cornea of the eye. A common predisposing factor is cystic fibrosis (CF), caused
M T van der Wal et al.
Perfusion, 30(8), 643-649 (2015-02-26)
A common effect of autologous blood withdrawal before cardiopulmonary bypass (CPB) is a decrease in haematocrit (Hct) and haemoglobin (Hb) content. A refinement of this technique is autologous blood withdrawal with the sequestration of platelet rich plasma (PRP) and red
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