CN
Search Within
M4910
应用筛选条件
关键词:'M4910'
显示 1-29 共 29 条结果 关于 "M4910" 范围 论文
Suppressed weight gain following chronic I-histidine loading--involvement of neuronal histaminergic system?
S Lensu et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S35-S36 (2003-05-21)
Inability to replicate cerebrospinal fluid histamine deficits in the primary hypersomnias: a back to the drawing board moment.
David B Rye
Sleep, 35(10), 1315-1317 (2012-10-02)
M Motawaj et al.
The Journal of pharmacology and experimental therapeutics, 336(2), 479-487 (2010-11-09)
We previously reported that some N-methyl-D-aspartate (NMDA)-receptor antagonists enhanced histamine neuron activity in rodents. Here, we have investigated the effects of memantine, an NMDA-receptor antagonist used for the treatment of Alzheimer's disease, on histaminergic neurotransmission. In vitro, memantine antagonized native
Yasuhisa Miyamoto et al.
Analytical biochemistry, 334(1), 89-96 (2004-10-07)
An improved high-performance liquid chromatography (HPLC) method was developed for simultaneous analysis of histamine (HA) and tele-methylhistamine (tele-MHA) levels in mouse and rat brain. The method consists of a solid-phase extraction (SPE) and subsequent HPLC with postcolumn derivatization of the
Violina Lozeva et al.
Journal of hepatology, 39(4), 522-527 (2003-09-16)
Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of chronic liver disease. To determine whether changes in the central histaminergic system are a feature of human HE, we studied histamine, tele-methylhistamine, and presynaptic autoregulatory H(3) receptors in cerebral cortex and
Lakshminarayanan Gowtham et al.
Molecular vision, 27, 564-573 (2021-09-18)
Neurotransmitters (NTs) are the key mediators of essential ocular functions, such as processing the visual functions of the retina, maintaining homeostasis of aqueous humor, and regulating ocular blood flow. This study aims to determine variations in the levels of L-glutamate
Yanhua Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(22), 2023-2033 (2011-06-21)
A UPLC-MS/MS assay was developed and validated for simultaneous quantification of acetylcholine (ACh), histamine (HA), tele-methylhistamine (t-mHA), and tele-methylimidazolacetic acid (t-MIAA) in rat cerebrospinal fluid (CSF). The biological stability of ACh in rat CSF was investigated. Following fit-for-purpose validation, the
Brain histamine turnover and seizure behaviour in two mouse strains: preliminary findings.
L Tuomisto et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S27-S28 (2003-05-21)
Seiichi Chiba et al.
Brain research bulletin, 79(1), 37-40 (2009-01-20)
Histamine suppresses feeding behavior via histamine H1 receptors in the hypothalamus. This study was performed to examine whether the acute reduction of histamine release in the hypothalamus caused by immepip, a histamine H3 agonist, modulates the feeding behavior of rats.
Peter C Konturek et al.
Medical science monitor : international medical journal of experimental and clinical research, 14(9), CR452-CR458 (2008-09-02)
There is some evidence that Helicobacter pylori (Hp) infection may protect against asthma and allergy. The aim of the present study was to analyse the prevalence of Hp infection in adults with proven food allergy and to compare it with
Mikaël Croyal et al.
Analytical biochemistry, 409(1), 28-36 (2010-10-12)
An ultra-performance liquid chromatography tandem mass spectrometry (UPLC™-MS/MS) assay was developed for the simultaneous analysis of histamine, its major metabolite tele-methylhistamine, and an internal standard (N-tele-(R)-α-dimethylhistamine) from human cerebrospinal fluid (CSF) samples. The method involves derivatization of primary amines with
Emi Itateyama et al.
Experimental biology and medicine (Maywood, N.J.), 228(10), 1132-1137 (2003-11-12)
Leptin regulates feeding behavior and energy metabolism by affecting hypothalamic neuromodulators. The present study was designed to examine hypothalamic neuronal histamine, a recently identified mediator of leptin signaling in the brain, in genetic obese animals. Concentrations of hypothalamic histamine and
Zhaopin Wang et al.
Analytica chimica acta, 774, 1-10 (2013-04-10)
Histamine, a neurotransmitter crucially involved in a number of basic physiological functions, undergoes changes in neuropsychiatric disorders. Detection of histamine in biological samples such as cerebrospinal fluid (CSF) is thus of clinical importance. The most commonly used method for measuring
Confirmation of biological effects of high dilutions. Effects of submolecular concentrations of histamine and 1-, 3- and 4-methylhistamines on human basophil activation.
J Sainte-Laudy et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 57 Suppl 1, S27-S28 (2008-03-18)
Alcoholics show altered histaminergic neurotransmission in several cortical areas--preliminary report.
K Alakärppä et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S37-S38 (2003-05-21)
R M Eglen et al.
British journal of pharmacology, 99(4), 637-642 (1990-04-01)
1. The antagonistic actions of parafluorohexahydrosiladiphenidol (pFHHSiD) at muscarinic receptors has been studied in cardiac muscle, smooth muscle and cell culture preparations. In this paper, the classification scheme of Doods et al. (1987) is employed. This scheme is based upon
F Gbahou et al.
The Journal of pharmacology and experimental therapeutics, 334(3), 945-954 (2010-06-10)
We previously suggested that therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). However, H(3)Rs exhibit constitutive activity, and most H(3)R antagonists act as inverse agonists. Here, we have investigated the effects
X Ligneau et al.
The Journal of pharmacology and experimental therapeutics, 320(1), 365-375 (2006-09-29)
Histamine H3 receptor inverse agonists are known to enhance the activity of histaminergic neurons in brain and thereby promote vigilance and cognition. 1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride (BF2.649) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor.
A Burban et al.
The Journal of pharmacology and experimental therapeutics, 332(3), 912-921 (2009-12-17)
Histamine potentiates activation of native and recombinant N-methyl-d-aspartate receptors (NMDARs), but its mechanisms of action and physiological functions in the brain remain controversial. Using four different models, we have further investigated the histamine-induced potentiation of various NMDAR-mediated responses. In single
Y Hashimoto et al.
Acta anaesthesiologica Scandinavica, 42(7), 858-863 (1998-08-12)
Histamine is most densely distributed in the hypothalamus and has an important effect on consciousness or wakefulness. It has been little considered whether general anesthetics could exert their effects on hypothalamic histamine metabolism. The present study was conducted to investigate
Standardised evaluation of urinary excretion of N-tele-methylhistamine in different periods of age in a healthy population.
S Winterkamp et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52 Suppl 1, S57-S58 (2003-05-21)
Raphaël Faucard et al.
Journal of neurochemistry, 98(5), 1487-1496 (2006-08-23)
The modulation of histamine neuron activity by various non-competitive NMDA-receptor antagonists was evaluated by changes in tele-methylhistamine (t-MeHA) levels and histidine decarboxylase (hdc) mRNA expression induced in rodent brain. The NMDA open-channel blockers phencyclidine (PCP) and MK-801 enhanced t-MeHA levels
Yves Dauvilliers et al.
Sleep, 35(10), 1359-1366 (2012-10-02)
To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. sensitive liquid
Hiroki Kawanishi et al.
Clinica chimica acta; international journal of clinical chemistry, 378(1-2), 122-127 (2007-01-02)
According to a previous study, the concentration of HA in the hair of SD rats was similar in each rat and the variation in HA concentration was not so great. However, the concentration in human hair was fairly different in
J Sainte-Laudy et al.
Homeopathy : the journal of the Faculty of Homeopathy, 98(4), 186-197 (2009-12-01)
At the beginning of this series of experiments we were looking for a model based on the use of purified commercially available compounds based on a fully described and accepted pharmacological model to study of the biological effect of high
Mouhammad Motawaj et al.
Journal of Alzheimer's disease : JAD, 22(3), 861-871 (2010-09-23)
Neuropathological studies have reported a strong neurofibrillary degeneration of the tuberomamillary nucleus, the region of origin of histamine neurons, in Alzheimer's disease (AD). Histaminergic neurons enhance cognition and memory, suggesting that their degeneration may contribute to the cognitive decline of
Nadia Pelloux-Léon et al.
Journal of medicinal chemistry, 47(12), 3264-3274 (2004-05-28)
4-(3-Aryloxypropyl)-1H-imidazoles, which possess a meta-positioned substituent in the aryl ring, have been synthesized and tested for activity at histamine H(3) receptors. The compounds having a CN, Me, or Br substituent were found to be antagonists, whereas CF(3), Et, i-Pr, t-Bu
Koro Gotoh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(9), 1131-1133 (2005-05-17)
Glucagon-like peptide-1 (GLP-1), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine suppress food intake, a target of leptin action in the brain. This study examined the interactions of GLP-1, CRH, and histamine downstream from the leptin-signaling pathway in regulating feeding behavior.
C L Toftegaard et al.
Neuroimmunomodulation, 10(6), 344-350 (2003-08-09)
Circulating cytokines such as interleukin-1 (IL-1), and tumor necrosis factor-alpha as well as lipopolysaccharide (LPS) are potent ACTH secretagogues, acting via stimulation of corticotropin-releasing hormone (CRH) and vasopressinergic neurons in the paraventricular nucleus of the hypothalamus (PVN). Histamine (HA) has
1/1