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Lei Tao et al.
Organic & biomolecular chemistry, 7(17), 3481-3485 (2009-08-14)
A novel thiazolidine-2-thione functionalized chain transfer agent (CTA) was synthesized and used as a reversible addition-fragmentation chain transfer (RAFT) polymerization agent to prepare well-defined poly-N-(2-hydroxypropyl) methacrylamide (PHPMA). The polymer chains had pre-designed molecular weights, narrow polydispersities and were chain-end functionalized.
Eva Koziolová et al.
Nanoscale, 9(30), 10906-10918 (2017-07-22)
Here, we describe a novel polymer platform suitable for efficient diagnostics and potential theranostics based on
Chem. Abstr., 108, 37417r-37417r (1988)
Henryk T Flakus et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 58(2), 225-237 (2002-01-26)
This paper deals with experimental studies on the polarization IR spectra of hydrogen bonds in 2-mercaptothiazoline and 2-mercapto-1-methylimidazole crystals. The crystal structure of 2-mercaptothiazoline was determined by X-ray diffraction. The polarization spectra of the two compounds were measured in the
J C Thomes et al.
Japanese journal of pharmacology, 58(3), 201-207 (1992-03-01)
2-Thiazoline-2-thiol is an antithyroid agent that strongly reduces thyroid hormone levels. Synthesis of these hormones is catalyzed in vivo by thyroid peroxidase. The interaction of this drug with molecular iodine and its effect on peroxidase activity were investigated. Iodine and
Vladimír Subr et al.
Biomacromolecules, 7(1), 122-130 (2006-01-10)
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) containing 4-nitrophenyl ester (ONp) or thiazolidine-2-thione (TT) reactive groups in side chains and telechelic/semitelechelic pHPMA with TT groups were designed as highly hydrophilic biocompatible polymers suitable for chemical coating of polyelectrolyte-based DNA-containing nanoparticles bearing amino groups
R B Greenwald et al.
Bioconjugate chemistry, 7(6), 638-641 (1996-11-01)
A novel PEG linker that employs a thiazolidine-2-thione group has been synthesized. Kinetic studies done on this compound demonstrate a relatively long half-life compared to those of traditional succinimidyl linkers. This new PEG derivative reacts with proteins under mild conditions
Richard Laga et al.
Journal of biomaterials science. Polymer edition, 21(12), 1669-1685 (2010-06-12)
N-(2-Hydroxypropyl)methacrylamide (HPMA) co-polymers containing disulfide and carbonyl thiazolidine-2-thione (TT) reactive groups in their side-chains (pHPMA-TT) were used as reductively removable chemical modification of the surface of cowpea mosaic viruses (CPMV). CPMV was used in this study as a model particle
Arash Nanbakhsh et al.
Blood, 123(23), 3585-3595 (2014-03-29)
Cytarabine (cytosine arabinoside) is one of the most effective drugs for the treatment of patients diagnosed with acute myeloid leukemia (AML). Despite its efficiency against AML cells, the emergence of drug resistance due to prolonged chemotherapy in most patients is
Denis L Guerra et al.
Journal of hazardous materials, 183(1-3), 81-86 (2010-08-03)
The synthetic imogolite sample was used for organofunctionalization process with 2-mercaptothiazoline (MTZ). The compound 2-mercaptothiazoline was anchored onto imogolite surface by heterogeneous route. Due to the increment of basic centers attached to the pendant chains the dye adsorption capability of
Reactive polymers for modification of biologically active molecules and gene delivery vectors.
K Ulbrich et al.
Journal of controlled release : official journal of the Controlled Release Society, 116(2), e3-e5 (2007-08-28)
Yan Zhou et al.
Biomaterials, 33(6), 1863-1872 (2011-12-06)
Improved treatments for prostate cancer are in great need to overcome lethal recurrence and metastasis. Targeting the tumorigenic cancer stem cells (CSCs) with self-renewal and differentiation capacity appears to be a promising strategy. Blockade of the hedgehog (Hh) signaling pathway
Cestmír Konák et al.
Langmuir : the ACS journal of surfaces and colloids, 24(14), 7092-7098 (2008-06-12)
Vesicles bearing either cationic (amino) groups or zwitterionic (amino acid) groups on the surface were coated with a reactive multivalent hydrophilic N-(2-hydroxypropyl)methacrylamide polymer (PHPMA) and its positively charged analogue (3 mol % quaternary ammonium groups), both having reactive thiazolidine-2-thione (TT)
Homan Kang et al.
Scientific reports, 5, 10144-10144 (2015-05-29)
Recently, preparation and screening of compound libraries remain one of the most challenging tasks in drug discovery, biomarker detection, and biomolecular profiling processes. So far, several distinct encoding/decoding methods such as chemical encoding, graphical encoding, and optical encoding have been
P Bojarová et al.
Journal of nanobiotechnology, 16(1), 73-73 (2018-09-22)
Galectin-3 (Gal-3) is a promising target in cancer therapy with a high therapeutic potential due to its abundant localization within the tumor tissue and its involvement in tumor development and proliferation. Potential clinical application of Gal-3-targeted inhibitors is often complicated
Taro Hase et al.
Urology, 60(3), 542-547 (2002-09-28)
To investigate the expression of peroxisome proliferator activator-receptor (PPAR)-alpha, beta, and gamma in human testicular cancer (TC) and normal testicular (NT) tissues, as well as the effects of the PPAR-gamma ligand. Recent studies have demonstrated that PPAR-gamma is expressed in
Stud. Org. Chem., 28, 57-57 (1987)
Robert Pola et al.
Pharmaceutics, 12(1) (2020-01-08)
This report describes the design, synthesis and evaluation of tumor-targeted polymer probes to visualize epidermal growth factor receptor (EGFR)-positive malignant tumors for successful resection via fluorescence guided endoscopic surgery. Fluorescent polymer probes of various molecular weights enabling passive accumulation in
M Beyssen et al.
Pharmacology, 61(1), 22-30 (2000-07-15)
The influence of administration of tamoxifen (TAM) on thyroid metabolism was investigated. The potential action of TAM on iodine in the thyroid gland was evaluated by determination of the equilibrium constant of the charge transfer complex formed with molecular iodine
M T Crimmins et al.
Organic letters, 2(6), 775-777 (2001-02-07)
[formula: see text] Asymmetric aldol additions using chlorotitanium enolates of thiazolidinethione propionates proceed with high diastereoselectivity for the "Evans" or "non-Evans" syn product depending on the nature and amount of the base used. With (-)-sparteine as the base, selectivities of
Damián Pérez-Quintanilla et al.
Journal of hazardous materials, 134(1-3), 245-256 (2005-12-06)
Mesoporous silicas (SBA-15 and MCM-41) have been functionalized by two different methods. Using the heterogeneous route the silylating agent, 3-chloropropyltriethoxysilane, was initially immobilized onto the mesoporous silica surface to give the chlorinated mesoporous silica Cl-SBA-15 or Cl-MCM-41. In a second
Usama M Rabie et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 1411-1417 (2011-06-18)
Interaction of thiazolidine-2-thione (T2T) as an electron donor with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an electron π-acceptor has been studied. Electronic absorption spectra of the system T2T-DDQ in several organic solvents of different polarities have been measured. A charge transfer (CT) complexation
Usama M Rabie et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 78(1), 512-517 (2010-12-15)
Thiazolidine-2-thione (T2T) has been studied spectrophotometrically by UV-visible and IR spectra. The spectral studies have indicated that T2T has two tautomeric forms, namely thione and thiole forms, in addition to the dimeric thioamide complex existing as a hydrogen-bonded dimer of
Jing Wang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 228, 117725-117725 (2019-11-14)
We developed PIM, a pyrene-based fluorescence sensor bearing an imidazole moiety and a carbonyl group as the binding sites for Fe3+ ions. The pyrene-based control compounds 1 and 2 were synthesized to demonstrate the structure-activity relationships. Compound 1, which contained
Yahia N Mabkhot et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-01)
A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed
Eliška Böhmová et al.
Pharmaceutics, 12(1) (2020-01-16)
Cell-penetrating peptides (CPPs) are commonly used substances enhancing the cellular uptake of various cargoes that do not easily cross the cellular membrane. CPPs can be either covalently bound directly to the cargo or they can be attached to a transporting
Libin Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 103, 36-46 (2017-03-03)
The aim of this study was to develop a new class of antibody-drug conjugates (ADCs) with the potential to not only enhance treatment efficacy but also improve tolerability for patients with B-cell lymphomas. Classic ADCs consist of monoclonal antibodies (mAbs)
M L Beyssen et al.
The Journal of pharmacy and pharmacology, 51(6), 745-750 (1999-08-24)
Several compounds of pharmaceutical importance from a variety of chemical families, for example chlorpromazine and clomipramine, have been found to form charge-transfer complexes with iodine. We have investigated the influence of dietary iodine on thyroid-gland dysfunction induced by clomipramine, chlorpromazine
D Atzei et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 57A(5), 1073-1083 (2001-05-26)
Metal complexes of general formula M(ttz)2X2 (with M= Pd(II) or Pt(II); X = Cl or Br; ttz = 1,3-thiazolidine-2-thione) have been synthetized as crystalline compounds and studied by means of X-ray Photoelectron Spectroscopy (XPS). The chemical shift of core level
Petra Votavova et al.
Journal of biomedical nanotechnology, 11(9), 1662-1673 (2015-10-22)
Interleukin-2 (IL-2) possesses a strong stimulatory activity for activated T and NK cells and it is an attractive molecule for immunotherapy. Nevertheless, extremely short half-life and severe toxicities associated with high-dose IL-2 treatment are serious and limiting drawbacks. In order
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