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M7441
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Andreas Brunschweiger et al.
ChemMedChem, 9(8), 1704-1724 (2014-05-13)
8-Benzyl-substituted tetrahydropyrazino[2,1-f]purinediones were designed as tricyclic xanthine derivatives containing a basic nitrogen atom in the tetrahydropyrazine ring to improve water solubility. A library of 69 derivatives was prepared and evaluated in radioligand binding studies at adenosine receptor (AR) subtypes and
Total Synthesis and Monoamine Oxidase Inhibitory Activities of (A?)-Entonalactam A and Its Derivatives.
Kamauchi, et al.
ACS Omega, 7, 41804-41814 (2022)
Helena M Gaweska et al.
Biochemistry, 52(15), 2620-2626 (2013-03-26)
The flavoprotein tryptophan 2-monooxygenase catalyzes the oxidative decarboxylation of tryptophan to yield indole-3-acetamide. This is the initial step in the biosynthesis of the plant growth hormone indole-acetic acid by bacterial pathogens that cause crown gall and related diseases. The structure
Frantisek Hubálek et al.
The Journal of biological chemistry, 280(16), 15761-15766 (2005-02-16)
Several reversible inhibitors selective for human monoamine oxidase B (MAO B) that do not inhibit MAO A have been described in the literature. The following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to inhibit competitively human, horse, rat, and mouse
Brett A Beaupre et al.
Biochemistry, 52(49), 8929-8937 (2013-11-26)
Renalase is a recently discovered flavoprotein that has been reported to be a hormone produced by the kidney to down-modulate blood pressure and heart rate. The consensus belief has been that renalase oxidizes circulating catecholamine neurotransmitters thereby attenuating vascular tone.
W Weyler
The Biochemical journal, 260(3), 725-729 (1989-06-15)
I present the first clear evidence that the protein: FAD ratio in human monoamine oxidase A and bovine monoamine oxidase B has an upper limit of 65 kDa and 57 kDa per FAD, respectively. To now it had been assumed
Jordi Juárez-Jiménez et al.
Biochimica et biophysica acta, 1844(2), 389-397 (2013-11-20)
Since cyanide potentiates the inhibitory activity of several monoamine oxidase (MAO) inhibitors, a series of carbonitrile-containing aminoheterocycles was examined to explore the role of nitriles in determining the inhibitory activity against MAO. Dicarbonitrile aminofurans were found to be potent, selective
Yang Sun et al.
Bioorganic & medicinal chemistry, 21(23), 7406-7417 (2013-10-17)
A series of Tacrine-Homoisoflavonoid hybrids were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and human monoamine oxidases (MAOs). Most of the compounds were found to be potent against both ChEs and MAO-B. Among these hybrids, compound 8b, with
Omaima M Abdelhafez et al.
Neurochemistry international, 62(2), 198-209 (2012-11-28)
New series of bioactive 7-oxycoumarin derivatives were synthesized and tested for their in vitro and in vivo monoamine oxidase (MAO) A and B inhibitory effect. In vitro studies revealed exceptionally potent and selective MAO-A inhibitors with K(i) values on a
Jens Hagenow et al.
Drug design, development and therapy, 14, 371-393 (2020-02-27)
Ligands consisting of two aryl moieties connected via a short spacer were shown to be potent inhibitors of monoamine oxidases (MAO) A and B, which are known as suitable targets in treatment of neurological diseases. Based on this general blueprint
Yangyang Liu et al.
Twin research and human genetics : the official journal of the International Society for Twin Studies, 16(6), 1103-1106 (2013-11-16)
In a sample of 569 Chinese high school students, the present findings indicated that students with the 4-repeat genotype showed a higher level of test anxiety. Furthermore, the prediction of academic performance on test anxiety was stronger among students with
Chiharu Sakane et al.
Journal of clinical biochemistry and nutrition, 56(2), 123-131 (2015-03-12)
Lysine-specific demethylase 1 (LSD1/KDM1A), a histone-modifying enzyme, is upregulated in many cancers, especially in neuroblastoma, breast cancer and hepatoma. We have established a simple method to measure LSD1 activity using a synthetic N-terminal 21-mer peptide of histone H3, which is
Kalpana Nagpal et al.
Drug delivery, 19(8), 378-391 (2012-11-24)
Gallic acid had been reported to possess antidepressant like activity, which may be attributed to its CNS effects like increase in reduced glutathione levels, increased catalase activity and decreased malonaldehyde levels in brain. This study was designed to enhance the
Leonardo Pisani et al.
Journal of medicinal chemistry, 56(6), 2651-2664 (2013-02-27)
The use of selective inhibitors of monoamine oxidase A (MAO-A) and B (MAO-B) holds a therapeutic relevance in the treatment of depressive disorders and Parkinson's disease (PD), respectively. Here, the discovery of a new class of compounds acting as monoamine
Pierre Koch et al.
Bioorganic & medicinal chemistry, 21(23), 7435-7452 (2013-10-22)
Adenosine receptors and monoamine oxidases are drug targets for neurodegenerative diseases such as Parkinson's and Alzheimer's disease. In the present study we prepared a library of 55 mostly novel tetrahydropyrimido[2,1-f]purinediones with various substituents in the 1- and 3-position (1,3-dimethyl, 1,3-diethyl
David S Goldstein et al.
The Journal of pharmacology and experimental therapeutics, 379(3), 253-259 (2021-09-11)
The endogenous catecholamines dopamine (DA), norepinephrine (NE), and epinephrine (EPI) play key roles in neurobehavioral, cardiovascular, and metabolic processes; various clinical disorders; and effects of numerous drugs. Steps in intracellular catecholamine synthesis and metabolism were delineated long ago, but there
I N Basova et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 49(2), 105-110 (2013-06-26)
The goal of the work consisted in study of substrate and inhibitor specificity of liver monoamine oxidase (MAO) of the freshwater Ladoga subspecies of the ringed seal Phoca hispida ladogensis. The studied enzyme has been established to have large substrate
Julia C Fitzgerald et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(1), 218-229 (2013-09-21)
The study examined how the mitochondrial enzyme monoamine oxidase-A (MAO-A), which produces hydrogen peroxide as a catalytic by-product, influences death and survival mechanisms. Targeted microRNA (miRNA) was used to stably knock down MAO-A mRNA, protein, and catalytic activity by 60-70%
Tuba Aydin et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 75(11-12), 459-466 (2020-07-01)
The aim of this study was to investigate the effects of extracts and pure Artemisia dracunculus L. (tarragon) metabolites on the antimonoamine oxidase and anticholinesterase activities. The compounds were characterized as stigmasterol (1), herniarin (2), (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one (3), (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide (4), 3,4-dehydroherniarin
J Grimsby et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(9), 3637-3641 (1991-05-01)
Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries
Alexandra Soliman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(48), 17120-17127 (2012-12-01)
Monoamine oxidase-A (MAO-A), a key brain enzyme which metabolizes monoamines, is implicated in the pathophysiology of stress-related illnesses, including major depressive disorder, addiction, and violent behavior. Chronic stressors and glucocorticoid-administration typically associate with elevated MAO-A levels/activity. However, the relationship of
Dorota Łażewska et al.
International journal of molecular sciences, 21(10) (2020-05-16)
Dual target ligands are a promising concept for the treatment of Parkinson's disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H3 receptor (H3R) antagonism could have positive effects on dopamine regulation. Thus, a series of
Brett A Beaupre et al.
Journal of the American Chemical Society, 135(37), 13980-13987 (2013-08-24)
Renalase is a protein hormone secreted into the blood by the kidney that is reported to lower blood pressure and slow heart rate. Since its discovery in 2005, renalase has been the subject of conjecture pertaining to its catalytic function.
Kenneth I Shulman et al.
CNS drugs, 27(10), 789-797 (2013-08-13)
This paper reviews the discovery and history of the use of irreversible monoamine oxidase (MAO) inhibitors (MAOIs) such as phenelzine, tranylcypromine and isocarboxazid, as well as the second generation selective and reversible MAOIs such as the MAO-A inhibitor, moclobemide and
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Edward E Putnins et al.
Frontiers in pharmacology, 12, 741460-741460 (2021-12-07)
Mucosal epithelial cell integrity is an important component of innate immunity and it protects the host from an environment rich in microorganisms. Virulence factors from Gram-negative bacteria [e.g. lipopolysaccharide (LPS)] induce significant pro-inflammatory cytokine expression. Monoamine oxidase (MAO) inhibitors reduce
Zaixin Li et al.
Journal of medicinal food, 15(12), 1057-1063 (2012-12-12)
Memory impairment is one of main clinical symptoms of brain senescence. To address the effects of Cordyceps militaris Link extract (CE) on memory impairment, a D-galactose (D-Gal)-induced aging mouse model was employed. Mice injected with D-Gal showed a significant learning
Natalia Sacilotto et al.
ACS pharmacology & translational science, 4(6), 1818-1834 (2021-12-21)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymatic activity, LSD1 plays
Bárbara Arias et al.
Neuropsychobiology, 67(1), 41-47 (2012-12-12)
Serotonergic genes have been widely investigated regarding antidepressant response in major depressive disorder (MDD) but results are still not univocal. 159 MDD patients treated with citalopram were genotyped and evaluated by the 21-item Hamilton Depression Rating Scale at the beginning
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