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M B Youdim et al.
Biochemical pharmacology, 41(2), 155-162 (1991-01-15)
Identification, cellular localization, and cDNA cloning of MAO subtypes A and B have increased the insight into the pharmacology of these enzymes, whose primary functions are intra- and extraneuronal inactivation of neurotransmitter (dopamine, noradrenaline and serotonin) and other biogenic amines.
Karamkolly R Rekha et al.
Biochemical and biophysical research communications, 440(4), 664-670 (2013-10-10)
Parkinson's disease (PD) is characterized by progressive loss of dopamine (DA) neurons in the nigrostriatal system and by the presence of Lewy bodies (LB), proteinaceous inclusions mainly composed of filamentous α-synuclein (α-Syn) aggregates. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was adopted to generate PD
Pavan Kare et al.
Molecular diversity, 17(1), 111-122 (2013-01-18)
Parkinson's disease (PD) is a degenerative disorder of the CNS, characterized by cerebral depletion of dopamine (DA), hence one of the approaches to delay the depletion of DA is to inhibit its oxidative deamination. Monoamine oxidases (MAO) carry out the
Gabor Faludi et al.
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 14(4), 221-229 (2012-12-28)
Anxiety disorders (ADs) are among the most frequent psychiatric disorders. In addition, key features of ADs include that they are among the earliest mental disorders to manifest and that their first specific treatment frequently occurs several years after the onset
Ji Zeng et al.
Journal of bacteriology, 195(22), 5141-5150 (2013-09-10)
FeaR is an AraC family regulator that activates transcription of the tynA and feaB genes in Escherichia coli. TynA is a periplasmic topaquinone- and copper-containing amine oxidase, and FeaB is a cytosolic NAD-linked aldehyde dehydrogenase. Phenylethylamine, tyramine, and dopamine are
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
R M Denney et al.
Journal of neurochemistry, 63(3), 843-856 (1994-09-01)
Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Recent evidence that MAO A-deficient males in a large Dutch kindred suffer from mild mental retardation and occasional episodes of impulsive aggressive
M Bellani et al.
Epidemiology and psychiatric sciences, 21(4), 347-351 (2012-11-24)
In a short series of articles, we will review the evidence for genotype by environment interaction (G × E) in developmental psychopathology. We will focus specifically on the characteristics of types of exposure assessed with respect to both their methods and findings.
Claudia Binda et al.
Journal of medicinal chemistry, 47(7), 1767-1774 (2004-03-19)
Monoamine oxidase B (MAO B) is an outer mitochondrial membrane enzyme that catalyzes the oxidation of arylalkylamine neurotransmitters. The crystal structures of MAO B in complex with four of the N-propargylaminoindan class of MAO covalent inhibitors (rasagiline, N-propargyl-1(S)-aminoindan, 6-hydroxy-N-propargyl-1(R)-aminoindan, and
Toshio Ota et al.
Nature genetics, 36(1), 40-45 (2004-01-01)
As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to
Vittorio Canale et al.
European journal of medicinal chemistry, 208, 112765-112765 (2020-09-20)
The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT6 receptor (5-HT6R) antagonists/MAO-B inhibitors using pharmacophore hybridization strategy. Our approach involved
H Thomas Lee et al.
Journal of the American Society of Nephrology : JASN, 24(3), 445-455 (2013-02-09)
Elevated levels of plasma catecholamines accompany ischemic AKI, possibly contributing the inflammatory response. Renalase, an amine oxidase secreted by the proximal tubule, degrades circulating catecholamines and reduces myocardial necrosis, suggesting that it may protect against renal ischemia reperfusion injury. Here
M S Benedetti
Fundamental & clinical pharmacology, 15(2), 75-84 (2001-07-27)
Although the cytochrome P450 (CYP) system ranks first in terms of catalytic versatility and the wide range of xenobiotics it detoxifies or activates to reactive intermediates, the contribution of amine oxidases and in particular of monoamine oxidases (MAOs) to the
Natalia Sacilotto et al.
ACS pharmacology & translational science, 4(6), 1818-1834 (2021-12-21)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymatic activity, LSD1 plays
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
Nibha Mishra et al.
Bioorganic & medicinal chemistry letters, 23(3), 702-705 (2013-01-02)
MAO-B and AChE are the two validated targets for Alzheimer's disease. In pursuit of a single molecule hitting both the targets, we explored a set of previously reported extremely potent MAO-B selective inhibitors, for their additional AChE inhibitory activity. We
Moussa B H Youdim et al.
Nature reviews. Neuroscience, 7(4), 295-309 (2006-03-23)
Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such. It now seems that many of these agents might have therapeutic value in several common neurodegenerative conditions, independently of their inhibition of
P Newton-Vinson et al.
Protein expression and purification, 20(2), 334-345 (2000-10-26)
The high-level heterologous expression, purification, and characterization of the mitochondrial outer membrane enzyme human liver monoamine oxidase B (MAO B) using the methylotrophic yeast Pichia pastoris expression system are described. A 2-L culture of P. pastoris expresses approximately 1700 U
Luigi De Colibus et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(36), 12684-12689 (2005-09-01)
The three-dimensional structure of recombinant human monoamine oxidase A (hMAO A) as its clorgyline-inhibited adduct is described. Although the chain-fold of hMAO A is similar to that of rat MAO A and human MAO B (hMAO B), hMAO A is
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
K Chen et al.
Journal of neurochemistry, 61(1), 187-190 (1993-07-01)
Monoamine oxidases (MAOs) A and B play important roles in the metabolism of neuroactive, vasoactive amines. Human platelets contain only MAO B, often used as an indicator of brain MAO B. The validity of this model remained to be evaluated.
D E Edmondson et al.
Current medicinal chemistry, 11(15), 1983-1993 (2004-07-29)
Monoamine oxidases A and B (MAO A and MAO B) are mitochondrial outer membrane-bound flavoproteins that catalyze the oxidative deamination of neurotransmitters and biogenic amines. A number of mechanism-based inhibitors (MAOI's) have been developed for clinical use as antidepressants and
Edward E Putnins et al.
Frontiers in pharmacology, 12, 741460-741460 (2021-12-07)
Mucosal epithelial cell integrity is an important component of innate immunity and it protects the host from an environment rich in microorganisms. Virulence factors from Gram-negative bacteria [e.g. lipopolysaccharide (LPS)] induce significant pro-inflammatory cytokine expression. Monoamine oxidase (MAO) inhibitors reduce
Leonardo Pisani et al.
Journal of medicinal chemistry, 56(6), 2651-2664 (2013-02-27)
The use of selective inhibitors of monoamine oxidase A (MAO-A) and B (MAO-B) holds a therapeutic relevance in the treatment of depressive disorders and Parkinson's disease (PD), respectively. Here, the discovery of a new class of compounds acting as monoamine
Frantisek Hubálek et al.
The Journal of biological chemistry, 280(16), 15761-15766 (2005-02-16)
Several reversible inhibitors selective for human monoamine oxidase B (MAO B) that do not inhibit MAO A have been described in the literature. The following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to inhibit competitively human, horse, rat, and mouse
Total Synthesis and Monoamine Oxidase Inhibitory Activities of (A?)-Entonalactam A and Its Derivatives.
Kamauchi, et al.
ACS Omega, 7, 41804-41814 (2022)
Brett A Beaupre et al.
Biochemistry, 52(49), 8929-8937 (2013-11-26)
Renalase is a recently discovered flavoprotein that has been reported to be a hormone produced by the kidney to down-modulate blood pressure and heart rate. The consensus belief has been that renalase oxidizes circulating catecholamine neurotransmitters thereby attenuating vascular tone.
J Grimsby et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(9), 3637-3641 (1991-05-01)
Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries
Andreas Brunschweiger et al.
ChemMedChem, 9(8), 1704-1724 (2014-05-13)
8-Benzyl-substituted tetrahydropyrazino[2,1-f]purinediones were designed as tricyclic xanthine derivatives containing a basic nitrogen atom in the tetrahydropyrazine ring to improve water solubility. A library of 69 derivatives was prepared and evaluated in radioligand binding studies at adenosine receptor (AR) subtypes and
W Weyler
The Biochemical journal, 260(3), 725-729 (1989-06-15)
I present the first clear evidence that the protein: FAD ratio in human monoamine oxidase A and bovine monoamine oxidase B has an upper limit of 65 kDa and 57 kDa per FAD, respectively. To now it had been assumed
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