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M8046
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Shinrye Lee et al.
Autophagy, 16(8), 1396-1412 (2019-11-07)
TARDBP/TDP-43 (TAR DNA binding protein) proteinopathies are a common feature in a variety of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and Alzheimer disease (AD). However, the molecular mechanisms underlying TARDBP-induced neurotoxicity are largely unknown. In
Rupture of uterus in the first trimester during medical termination of pregnancy for exomphalos using mifepristone/misoprostol.
F J Willmott et al.
BJOG : an international journal of obstetrics and gynaecology, 115(12), 1575-1577 (2008-11-28)
Ghassem Attarzadeh-Yazdi et al.
Behavioural brain research, 252, 339-346 (2013-06-27)
Addiction is a common chronic psychiatric disease which represents a global problem and stress has an important role to increase drug addiction and relapse. In the present study, we investigated the effects of physical stress and exogenous corticosterone on the
Zhenyu Ma et al.
PloS one, 9(8), e105528-e105528 (2014-08-16)
Glucocorticoids are the only therapy that has been demonstrated to alter the progress of Duchenne muscular dystrophy (DMD), the most common muscular dystrophy in children. However, glucocorticoids disturb skeletal muscle metabolism and hamper myogenesis and muscle regeneration. The mechanisms involved
Shu-Ping Hou et al.
Contraception, 84(3), 214-223 (2011-08-17)
Mifepristone combined with misoprostol for second-trimester abortion (MM) and intra-amniotic injection of ethacridine lactate (EL; Rivanol®) are the common methods for termination of second-trimester pregnancy in China. The systematic review of relevant literature was conducted to evaluate the effectiveness and
Medical abortion in Canada: behind the times.
Sheila Dunn et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 186(1), 13-14 (2013-11-28)
Ovarian steroids regulate prostaglandin secretion in the feline endometrium
Siemieniuch MJ, et al.
Animal Reproduction Science, 120(1-4), 142-150 (2010)
Chromewell Agustin R Mojica et al.
Endocrinology, 161(7) (2020-05-21)
Glucocorticoids (GCs; eg, hydrocortisone [CORT]) are routinely used as chemotherapeutic, anti-emetic, and palliative agents in breast cancer (BCa) therapy. The effects of GC signaling on BCa progression, however, remain a contentious topic as GC treatment seems to be beneficial for
Darja Gramec Skledar et al.
Chemosphere, 220, 706-713 (2019-01-06)
Urolithins are metabolites produced in the gut following consumption of ellagitannins and ellagic-acid-rich food, such as pomegranates, berries, and nuts. Compelling biological activities of urolithins together with variabilities between individuals in the metabolic capacity of the resident gut microbiota to
Yohan Choi et al.
Asian-Australasian journal of animal sciences, 25(1), 44-51 (2012-01-01)
Calcium ions play an important role in the establishment and maintenance of pregnancy, but molecular and cellular regulatory mechanisms of calcium ion action in the uterine endometrium are not fully understood in pigs. Previously, we have shown that calcium regulatory
Jaclyn I Wamsteeker Cusulin et al.
Nature neuroscience, 16(5), 596-604 (2013-04-09)
Stressful experience initiates a neuroendocrine response culminating in the release of glucocorticoid hormones into the blood. Glucocorticoids feed back to the brain, causing adaptations that prevent excessive hormone responses to subsequent challenges. How these changes occur remains unknown. We found
Corrigendum.
American journal of physiology. Endocrinology and metabolism, 319(6), E1121-E1121 (2020-12-16)
Gabriel Gasque et al.
Scientific reports, 3, srep02120-srep02120 (2013-07-03)
Dysregulation of eating behavior can lead to obesity, which affects 10% of the adult population worldwide and accounts for nearly 3 million deaths every year. Despite this burden on society, we currently lack effective pharmacological treatment options to regulate appetite.
Aiping Lu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21378-e21378 (2021-02-11)
The decline of muscle regenerative potential with age has been attributed to a diminished responsiveness of muscle progenitor cells (MPCs). Heterochronic parabiosis has been used as a model to study the effects of aging on stem cells and their niches.
Irving M Spitz
Contraception, 82(5), 442-452 (2010-10-12)
Administration of mifepristone followed by the prostaglandin, misoprostol, has been used successfully in the medical termination of pregnancy for over 25 years, and the method is registered in 35 countries. Single doses of mifepristone are also effective as an emergency
Po-Kai Wang et al.
The journal of pain : official journal of the American Pain Society, 16(11), 1186-1199 (2015-09-08)
Chronic sleep disturbance-induced stress is known to increase basal pain sensitivity. However, most surgical patients frequently report short-term sleep disturbance/deprivation during the pre- and postoperation periods and have normal pain perception presurgery. Whether this short-term sleep disturbance affects postsurgical pain
Fumitake Ito et al.
The Journal of clinical endocrinology and metabolism, 99(6), 2188-2197 (2014-03-13)
Monocyte adhesion to endothelial cells is an important initial event in atherosclerosis and is partially mediated by adhesion molecule expression on the cell surface. Although estrogens inhibit atherosclerosis development, effects of coadministered progestogen remain controversial. We examined the effects of
Pauline Sallin et al.
Open biology, 6(3) (2016-04-01)
Psychological stress is one of the factors associated with human cardiovascular disease. Here, we demonstrate that acute perceived stress impairs the natural capacity of heart regeneration in zebrafish. Beside physical and chemical disturbances, intermittent crowding triggered an increase in cortisol
Elizabeth G Raymond et al.
Contraception, 87(1), 26-37 (2012-08-18)
The dose of mifepristone approved by most government agencies for medical abortion is 600 mg. Our aim was to summarize extant data on the effectiveness and safety of regimens using the widely recommended lower mifepristone dose, 200 mg, followed by
It may take more than a shot: alternatives to immunotherapy for Alzheimer's disease.
Michael K O'Banion
Biological psychiatry, 74(5), 316-317 (2013-08-13)
Yohan Choi et al.
Biology of reproduction, 81(6), 1122-1130 (2009-07-31)
Calcium ions have been implicated in the establishment and maintenance of pregnancy, but the regulatory mechanisms of calcium ions in the uterine endometrium and conceptus are not well understood in pigs. Recently, we showed that TRPV6, a calcium ion channel
Miriam Bolz et al.
PLoS neglected tropical diseases, 9(8), e0004011-e0004011 (2015-08-15)
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a necrotizing disease of the skin and subcutaneous tissue, which is most prevalent in rural regions of West African countries. The majority of clinical presentations seen in patients are ulcers on
Robin M Skory et al.
Human reproduction (Oxford, England), 30(6), 1386-1395 (2015-03-19)
Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation? Under gonadotrophin stimulation, murine follicles grown in an encapsulated three-dimensional system ovulate in vitro and murine and human follicle hormone synthesis mimics follicular and
D P Macfarlane et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(7), G760-G768 (2014-08-12)
To investigate the potential of therapies which reduce glucocorticoid action in patients with Type 2 diabetes we performed a randomized, double-blinded, placebo-controlled crossover study of acute glucocorticoid blockade, using the glucocorticoid receptor antagonist RU38486 (mifepristone) and cortisol biosynthesis inhibitor (metyrapone)
Kushal Kr Banerjee et al.
Aging, 4(3), 206-223 (2012-03-14)
Sir2 is an evolutionarily conserved NAD+ dependent protein. Although, SIRT1 has been implicated to be a key regulator of fat and glucose metabolism in mammals, the role of Sir2 in regulating organismal physiology, in invertebrates, is unclear. Drosophila has been
Simona Boncompagni et al.
The Journal of physiology, 593(12), 2679-2692 (2015-04-08)
Many studies have previously suggested the existence of stress hormone receptors on the cell membrane of many cell types, including skeletal muscle fibres; however, the exact localisation of these receptors and how they signal to the rest of the cell
Brenda C Timmons et al.
Endocrinology, 155(1), 287-298 (2013-11-06)
Globally, an estimated 13 million preterm babies are born each year. These babies are at increased risk of infant mortality and life-long health complications. Interventions to prevent preterm birth (PTB) require an understanding of processes driving parturition. Prostaglandins (PGs) have
Martina Ott et al.
Glia, 63(1), 78-90 (2014-08-19)
Tryptophan catabolism is increasingly recognized as a key and druggable molecular mechanism active in cancer, immune, and glioneural cells and involved in the modulation of antitumor immunity, autoimmunity and glioneural function. In addition to the pivotal rate limiting enzyme indoleamine-2,3-dioxygenase
Ann-Sofie Thorsen et al.
Disease models & mechanisms, 14(1) (2020-10-24)
Somatic models of tissue pathology commonly use induction of gene-specific mutations in mice mediated by spatiotemporal regulation of Cre recombinase. Subsequent investigation of the onset and development of disease can be limited by the inability to track changing cellular behaviours
Mifepristone
Autry BM and Wadhwa R
StatPearls [Internet] (2020)
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