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显示 1-30 共 350 条结果 关于 "M8046" 范围 论文
Laura C D Pomatto et al.
Aging, 9(4), 1153-1185 (2017-04-05)
Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins in
Ping Wu et al.
Psychopharmacology, 231(24), 4659-4668 (2014-05-16)
The persistence of physical dependence and craving in addicts is considered to contribute to relapse. Increasing evidence indicates that neuropeptide systems are associated with several phases of drug addiction, but little is known about whether the neuropeptide trefoil factor affects
Sherin Al-Safadi et al.
PloS one, 10(6), e0130085-e0130085 (2015-06-16)
The secretion of glucocorticoids in mammals is under circadian control, but glucocorticoids themselves are also implicated in modulating circadian clock gene expression. We have shown that the expression of the circadian clock protein PER1 in the forebrain is modulated by
Lisa Wessel et al.
Cellular and molecular life sciences : CMLS, 71(9), 1723-1740 (2013-08-29)
Cerebellar Purkinje cells (PC) physiologically reveal an age-dependent expression of progesterone with high endogenous concentrations during the neonatal period. Even if progesterone has been previously shown to induce spinogenesis, dendritogenesis and synaptogenesis in immature PC, data about the effects of
Elizabeth Carroll Driver et al.
Developmental biology, 376(1), 86-98 (2013-01-16)
The organ of Corti, located within the mammalian cochlea, contains a precise mosaic of hair cells (HC) and supporting cells (SC), the patterning of which is critical for auditory function. Progenitors of HCs and SCs are found in the same
Li Zhang et al.
Cell and tissue research, 338(3), 413-421 (2009-10-21)
In mouse, decidualization is characterized by the proliferation of stromal cells and their differentiation into specialized type of cells (decidual cells) with polyploidy, surrounding the implanting blastocyst. However, the mechanisms involved in these processes remain poorly understood. Using multiple approaches
Chloé Boitard et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 4092-4103 (2015-03-06)
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence during adolescence is particularly alarming since recent evidence indicates that obesity can affect hippocampal function during this developmental period. Adolescence is
Adam J Dobson et al.
PLoS genetics, 15(7), e1008212-e1008212 (2019-07-30)
Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TFs) can ameliorate deleterious effects of age. Here we explore how a circuit of TFs coordinates
Jerome H Check et al.
Anticancer research, 34(5), 2413-2416 (2014-04-30)
Mifepristone has been demonstrated to cause palliation from murine and human cancer, even in cancers not known to be positive for expression of progesterone receptors. The aim of the present study was to determine if rapidly advancing chronic lymphocytic leukemia
Muhammad T K Zia et al.
Experimental neurology, 263, 200-213 (2014-09-30)
Postnatal glucocorticoids (GCs) are widely used in the prevention of chronic lung disease in premature infants. Their pharmacologic use is associated with neurodevelopmental delay and cerebral palsy. However, the effect of GC dose and preparation (dexamethasone versus betamethasone) on short
Baichun Yang et al.
BMC pharmacology, 8, 7-7 (2008-05-14)
Glucocorticoids down-regulate cytokine synthesis and suppress inflammatory responses. The glucocorticoid receptor (GR) antagonist RU486 may exacerbate the inflammatory response, and concerns over this exacerbation have limited the development and clinical use of GR antagonists in the treatment of diabetes and
Na Wei et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(5), 760-767 (2013-01-03)
Glucocorticoids (GCs) potentially regulate the proliferation, differentiation, and premature senescence of bone marrow mesenchymal stem/stromal cells (MSCs). In the present study we investigated the effects mediated by endogenous GCs and the effects of an antagonist of the glucocorticoid receptor, RU486
Xiaoqing Yang et al.
Fertility and sterility, 96(4), 1029-1036 (2011-08-02)
To investigate the effect of mesenchymal stem cells isolated from Wharton jelly of umbilical cord (WJ-MSCs) on ameliorating damaged human endometrial stromal cells (ESCs). Experimental study. University-affiliated hospital. Sixteen endometrial tissues were obtained from women undergoing hysterectomy. Eight umbilical cords
Sarah K Sasse et al.
Molecular and cellular biology, 33(11), 2104-2115 (2013-03-20)
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyzed the transcriptional consequences of GR activation
Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line.
Andiara E Freitas et al.
Molecular neurobiology, 51(3), 1504-1519 (2014-08-03)
Hyperactivation of the hypothalamic-pituitary-adrenal axis is a common finding in major depression; this may lead to increased levels of cortisol, which are known to cause oxidative stress imbalance and apoptotic neuronal cell death, particularly in the hippocampus, a key region
Laura C D Pomatto et al.
Free radical biology & medicine, 160, 67-77 (2020-08-08)
Our studies center on the physiological phenomenon of adaptive homeostasis in which very low, signaling levels of an oxidant can induce transient expansion of the baseline homeostatic range of protective mechanisms, resulting in transient stress protection. The 20S proteasome is
Bigang Liu et al.
Cancer cell, 14(3), 212-225 (2008-09-06)
It has long been known that excessive mitotic activity due to H-Ras can block keratinocyte differentiation and cause skin cancer. It is not clear whether there are any innate surveillants that are able to ensure that keratinocytes undergo terminal differentiation
Young-Hoon Kim et al.
Nature communications, 6, 7451-7451 (2015-06-17)
Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion
Susan E Clare et al.
BMC cancer, 16, 326-326 (2016-05-25)
The synthesis of specific, potent progesterone antagonists adds potential agents to the breast cancer prevention and treatment armamentarium. The identification of individuals who will benefit from these agents will be a critical factor for their clinical success. We utilized telapristone
Jun Young Hong et al.
Cell, 180(5), 847-861 (2020-03-07)
Early life environmental exposure, particularly during perinatal period, can have a life-long impact on organismal development and physiology. The biological rationale for this phenomenon is to promote physiological adaptations to the anticipated environment based on early life experience. However, perinatal
Haili Bao et al.
PLoS genetics, 17(8), e1009786-e1009786 (2021-08-31)
The maternal recognition of pregnancy is a necessary prerequisite for gestation maintenance through prolonging the corpus luteum lifespan and ensuring progesterone production. In addition to pituitary prolactin and placental lactogens, decidual derived prolactin family members have been presumed to possess
R G Krug et al.
Genes, brain, and behavior, 13(5), 478-487 (2014-04-01)
Gene regulation resulting from glucocorticoid receptor and glucocorticoid response element interactions is a hallmark feature of stress response signaling. Imbalanced glucocorticoid production and glucocorticoid receptor activity have been linked to socioeconomically crippling neuropsychiatric disorders, and accordingly there is a need
Caroline H Diep et al.
Cell cycle (Georgetown, Tex.), 12(9), 1433-1449 (2013-04-12)
Loss of nuclear progesterone receptors (PR) and low circulating progesterone levels are associated with increased ovarian cancer (OC) risk. However, PR are abundantly expressed in a significant percentage of serous and endometrioid ovarian tumors; patients with PR+ tumors typically experience
Sang Yoon Lee et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 131-138 (2014-08-26)
1. The herb-drug interaction potential of Hwang-Ryun-Hae-Dok-Tang (HR) extracts mediated by cytochrome P450 (CYP) inhibition was determined using human liver microsomes. 2. HR strongly inhibited CYP1A2 and moderately inhibited CYP2C19, CYP2D6, and CYP3A4 (testosterone) but not CYP2A6, CYP2B6, CYP2C8, CYP2C9, and CYP3A4
Pia Kiilerich et al.
The Journal of endocrinology, 194(2), 417-427 (2007-07-21)
Based on real-time RT-PCR, analysis of transcripts of selected ion-regulatory proteins (Na(+), K(+)-ATPase alpha1a and alpha1b subunit, Na(+), K(+), 2Cl(-) cotransporter, cystic fibrosis transmembrane conductance regulator (CFTR), and H(+)-ATPase B-subunit), the regulatory role of cortisol and the associated receptor signaling
Geum Joon Cho et al.
Journal of perinatal medicine, 43(5), 537-543 (2014-12-17)
To investigate the use of magnesium sulfate (MgSO4) as a neuroprotective agent in a mouse model of inflammation-associated and noninflammation-associated preterm birth. On embryonic day 15 of gestation, lipopolysaccharide (LPS) and mifepristone (RU486) were used, respectively, to create mouse models
Menglong Rui et al.
EMBO reports, 21(5), e48843-e48843 (2020-03-19)
Pruning that selectively eliminates inappropriate projections is crucial for sculpting neural circuits during development. During Drosophila metamorphosis, ddaC sensory neurons undergo dendrite-specific pruning in response to the steroid hormone ecdysone. However, the understanding of the molecular mechanisms underlying dendrite pruning
Katra Kolšek et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(1), 8-15 (2014-09-07)
A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune diseases, infertility, cancer. Fifteen widely used industrial chemicals that disrupt endocrine activity were
Chen-Min Yeh
Frontiers in neuroscience, 9, 436-436 (2015-12-24)
The circadian activity of the hypothalamo-pituitary-adrenal/interrenal (HPA/I) axis is crucial for maintaining vertebrate homeostasis. In mammals, both the principle regulator, corticotropin-releasing hormone (crh) in the hypothalamic paraventricular nucleus (PVN) and the final effector, the glucocorticoids show daily rhythmic patterns. While
Chenyang Huang et al.
Cell death discovery, 4, 23-23 (2018-08-16)
Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endometria of women with RIF is involved in impaired endometrial receptivity
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