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显示 1-30 共 139 条结果 关于 "MAB1398Z" 范围 论文
Andrew Kuo et al.
The Journal of biological chemistry, 293(3), 973-983 (2017-12-06)
Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in almost all eukaryotic cells, and LD-associated proteins tightly regulate their dynamics. One LD coat protein is caveolin-1 (Cav-1), an essential component for caveola assembly in highly differentiated cells
Yang Zhang et al.
Development (Cambridge, England), 145(3) (2018-01-24)
Maintenance of blood vessel integrity is crucial for vascular homeostasis and is mainly controlled at the level of endothelial cell (EC) junctions. Regulation of endothelial integrity has largely been investigated in the mature quiescent vasculature. Less is known about how
Nhat Minh Nguyen et al.
The world journal of men's health, 39(1), 131-138 (2019-09-10)
Proper functional and structural integrity of nervous and vascular system in urinary bladder plays an important role in normal bladder function and the disruption of these structures is known to be related to lower urinary tract symptoms. Here, we present
Mi-Hye Kwon et al.
Andrology, 12(2), 447-458 (2023-06-09)
The odds of erectile dysfunction are three times more prevalent in diabetes. Severe peripheral vascular and neural damage in diabetic patients responds poorly to phosphodiesterase-5 (PDE5) inhibitors. However, bone morphogenetic protein 2 is known to be involved in angiogenesis. To
Seung-Hwan Jeong et al.
Nature communications, 12(1), 4405-4405 (2021-07-22)
Stimulator of interferon genes (STING) promotes anti-tumour immunity by linking innate and adaptive immunity, but it remains unclear how intratumoural treatment with STING agonists yields anti-tumour effects. Here we demonstrate that intratumoural injection of the STING agonist cGAMP induces strong
Hoon-Ki Sung et al.
American journal of physiology. Endocrinology and metabolism, 297(2), E402-E409 (2009-06-06)
To test whether chronic enhanced blood flow alters insulin-stimulated glucose uptake, we measured skeletal muscle glucose uptake in chow-fed and high-fat-fed mice injected with adenovirus containing modified angiopoietin-1, COMP-Ang1, via euglycemic-hyperinsulinemic clamp. Blood flow rates and platelet endothelial cell adhesion
Tetsuichiro Inai et al.
The American journal of pathology, 165(1), 35-52 (2004-06-25)
Angiogenesis inhibitors are receiving increased attention as cancer therapeutics, but little is known of the cellular effects of these inhibitors on tumor vessels. We sought to determine whether two agents, AG013736 and VEGF-Trap, that inhibit vascular endothelial growth factor (VEGF)
Siqi Liu et al.
Cell, 186(10), 2127-2143 (2023-04-26)
Pathogen infection and tissue injury are universal insults that disrupt homeostasis. Innate immunity senses microbial infections and induces cytokines/chemokines to activate resistance mechanisms. Here, we show that, in contrast to most pathogen-induced cytokines, interleukin-24 (IL-24) is predominately induced by barrier
Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPAR? agonist-induced adipogenesis.
Ryu, MJ; Kim, SJ; Choi, MJ; Kim, YK; Lee, MH; Lee, SE; Chung, HK; Jung, SB; Kim, HJ; Kim et al.
Molecules and Cells null
Sylvaine Guérit et al.
Developmental neurobiology, 74(11), 1110-1122 (2014-05-02)
Although it has been documented that the nervous and the vascular systems share numerous analogies and are closely intermingled during development and pathological processes, interactions between the two systems are still poorly described. In this study, we investigated whether vascular
Jiyeon Ock et al.
International journal of biological sciences, 19(9), 2663-2677 (2023-06-16)
As a peripheral nerve injury disease, cavernous nerve injury (CNI) caused by prostate cancer surgery and other pelvic surgery causes organic damage to cavernous blood vessels and nerves, thereby significantly attenuating the response to phosphodiesterase-5 inhibitors. Here, we investigated the
Sang Heon Suh et al.
EMBO reports, 20(4) (2019-02-21)
A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly
Kyung Eun Kim et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(3), 564-570 (2006-12-30)
We investigated and compared the in vivo effects of all four angiopoietins (COMP-Ang1, Ang2, Ang3, and Ang4) on blood and lymphatic vascular remodeling in adult mice. We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature
Rachel E Niec et al.
Cell stem cell, 29(7), 1067-1082 (2022-06-22)
Barrier epithelia depend upon resident stem cells for homeostasis, defense, and repair. Epithelial stem cells of small and large intestines (ISCs) respond to their local microenvironments (niches) to fulfill a continuous demand for tissue turnover. The complexity of these niches
Bong Ihn Koh et al.
Nature communications, 11(1), 3866-3866 (2020-08-02)
Upon severe head injury (HI), blood vessels of the meninges and brain parenchyma are inevitably damaged. While limited vascular regeneration of the injured brain has been studied extensively, our understanding of meningeal vascular regeneration following head injury is quite limited.
Jae-Ho Jeong et al.
Scientific reports, 7, 39848-39848 (2017-01-04)
Inflammaging is defined as low-grade, chronic, systemic inflammation in aging, in the absence of overt infection. Age-associated deterioration of gastrointestinal function could be ascribed to the inflammaging, although evidence is yet to emerge. Here we show that microvessels in aging
Silvia Villahoz et al.
Nature communications, 9(1), 4795-4795 (2018-11-18)
Aortic intramural hematoma (IMH) can evolve toward reabsorption, dissection or aneurysm. Hypertension is the most common predisposing factor in IMH and aneurysm patients, and the hypertensive mediator angiotensin-II induces both in mice. We have previously shown that constitutive deletion of
Alicia L Connor et al.
Laboratory investigation; a journal of technical methods and pathology, 96(3), 270-282 (2015-12-15)
Postnatal inflammatory lymphangiogenesis presumably requires precise regulatory processes to properly assemble proliferating lymphatic endothelial cells (LECs). The specific mechanisms that regulate the assembly of LECs during new lymphatic vessel synthesis are unclear. Dynamic endothelial shuffling and rearrangement has been proposed
Ana J Chucair-Elliott et al.
The American journal of pathology, 186(10), 2665-2678 (2016-08-09)
Herpes simplex virus type 1 (HSV-1) is a leading cause of neurotrophic keratitis characterized by decreased corneal sensation because of damage to the corneal sensory fibers. We and others have reported regression of corneal nerves during acute HSV-1 infection. To
Honsou Kim et al.
Yonsei medical journal, 62(7), 622-630 (2021-06-25)
Expression of organic anion transporting polypeptides (OATPs) 1B1/1B3 in hepatocellular carcinoma (HCC) induces a paradoxical enhancement of gadoxetic acid on liver magnetic resonance imaging (MRI). We examined the expression profile of OATPs with regard to tumor differentiation in a genetically
Marjorie J Lindhurst et al.
Human molecular genetics, 29(20), 3350-3360 (2020-10-09)
Proteus syndrome is a progressive overgrowth disorder with vascular malformations caused by mosaic expression of the AKT1 c.49G > A, p.(E17K) activating variant which was predicted to cause lethality if expressed ubiquitously. To test that hypothesis, we used the ACTB-Cre gene to
Yu-Kai Su et al.
Pharmaceuticals (Basel, Switzerland), 14(9) (2021-09-29)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median duration of survival of approximately 14 months after diagnosis. High resistance to chemotherapy remains a major problem. Previously, BTK has been shown to be involved
Vasileios Askoxylakis et al.
Journal of the National Cancer Institute, 108(2) (2015-11-10)
Central nervous system (CNS) metastases represent a major problem in the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer because of the disappointing efficacy of HER2-targeted therapies against brain lesions. The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) has
Duk Ki Kim et al.
Nature communications, 13(1), 6292-6292 (2022-10-23)
Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients with PDAC display limited benefits after undergoing chemotherapy or immunotherapy modalities. Herein, we reveal that chemotherapy upregulates placental growth factor (PlGF), which directly activates cancer-associated fibroblasts (CAFs) to
Sandro Da Mesquita et al.
Nature, 560(7717), 185-191 (2018-07-27)
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks lymphatic vasculature and waste products are removed partly through a paravascular route. (Re)discovery
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations.
Krasniewski, et al.
eLife, 11 (2022)
Tomoko Matsubara et al.
The Journal of experimental medicine, 219(4) (2022-03-24)
The skeletal system consists of bones and teeth, both of which are hardened via mineralization to support daily physical activity and mastication. The precise mechanism for this process, especially how blood vessels contribute to tissue mineralization, remains incompletely understood. Here
Iacovos P Michael et al.
EMBO molecular medicine, 6(5), 604-623 (2014-04-08)
Current therapeutic antiangiogenic biologics used for the treatment of pathological ocular angiogenesis could have serious side effects due to their interference with normal blood vessel physiology. Here, we report the generation of novel antivascular endothelial growth factor-A (VEGF) biologics, termed
Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
Yang, et al.
Experimental & Molecular Medicine, 55, 1013-1022 (2023)
Ren-Yuan Bai et al.
Neuro-oncology, 17(4), 545-554 (2014-09-26)
Medulloblastoma is the most common malignant brain tumor in children. Current standard treatments cure 40%-60% of patients, while the majority of survivors suffer long-term neurological sequelae. The identification of 4 molecular groups of medulloblastoma improved the clinical management with the
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