MAB1576

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关键词:'MAB1576'

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Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment.

Eleanor D Muise et al.

Data in brief, 10, 482-486 (2017-01-06)

The data presented in this article are related to the research article entitled "Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine" (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1]. We recently demonstrated that

Macaques Exhibit Implicit Gaze Bias Anticipating Others' False-Belief-Driven Actions via Medial Prefrontal Cortex.

Taketsugu Hayashi et al.

Cell reports, 30(13), 4433-4444 (2020-04-03)

The ability to infer others' mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and to accompany the activation of a

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.

Lorenza A D'Alessandro et al.

PLoS computational biology, 11(4), e1004192-e1004192 (2015-04-24)

Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations is crucial to predict the impact of targeted perturbations. However, a major challenge in identifying cell-context

Lack of specificity of commercially available antisera: better specifications needed.

Pradidarcheep, W; Labruyere, WT; Dabhoiwala, NF; Lamers, WH

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society null

Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.

Sinead M Clancy et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(24), 6388-6399 (2007-06-15)

Many inhibitory neurotransmitters in the brain activate Kir3 channels by stimulating pertussis toxin (PTX)-sensitive G-protein-coupled receptors. Here, we investigated the regulation of native muscarinic receptors and Kir3 channels expressed in NGF-differentiated PC12 cells, which are similar to sympathetic neurons. Quantitative

Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus.

Kristi A Kohlmeier et al.

Journal of neurophysiology, 108(10), 2751-2766 (2012-09-08)

Cholinergic neurons in the laterodorsal tegmental (LDT) and peduncolopontine tegmental (PPT) nuclei regulate reward, arousal, and sensory gating via major projections to midbrain dopamine regions, the thalamus, and pontine targets. Muscarinic acetylcholine receptors (mAChRs) on LDT neurons produce a membrane

Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.

Javier Milara et al.

Respiratory research, 17(1), 145-145 (2016-11-09)

Inhaled corticosteroid (ICS) with long-acting beta-2 agonists is a well-documented combination therapy for chronic obstructive pulmonary disease (COPD) based on its additive anti-inflammatory properties. By contrast, the recommendation of ICS in combination with long-acting muscarinic antagonist (LAMA) is not evidence-based.

Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.

Franziska Richter et al.

PloS one, 14(12), e0226080-e0226080 (2019-12-06)

In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1 knock-in (KI) mice. Ex

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