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Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey.
Medalla, M; Luebke, JI
The Journal of Neuroscience null
Nikolaj R Christensen et al.
EMBO molecular medicine, 12(6), e11248-e11248 (2020-05-01)
Maladaptive plasticity involving increased expression of AMPA-type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we developed a cell-permeable, high-affinity (~2 nM) peptide inhibitor, Tat-P4 -(C5)2
Anish K Simhal et al.
Frontiers in neuroanatomy, 12, 51-51 (2018-08-02)
Application-specific validation of antibodies is a critical prerequisite for their successful use. Here we introduce an automated framework for characterization and screening of antibodies against synaptic molecules for high-resolution immunofluorescence array tomography (AT). The proposed Synaptic Antibody Characterization Tool (SACT)
Wolfgang Wagner et al.
Cell reports, 28(1), 11-20 (2019-07-04)
Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We find that myosin VI localizes at cerebellar parallel fiber to
Daniel Radzicki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(9), 2292-2304 (2017-02-01)
In chronic pain, the medial prefrontal cortex (mPFC) is deactivated and mPFC-dependent tasks such as attention and working memory are impaired. We investigated the mechanisms of mPFC deactivation in the rat spared nerve injury (SNI) model of neuropathic pain. Patch-clamp
Jing-Yi Jeng et al.
Molecular therapy. Methods & clinical development, 26, 355-370 (2022-08-30)
The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively. Eps8 knockout mice (Eps8 -/- )
Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites.
Hayashi, T; Rumbaugh, G; Huganir, RL
Neuron null
Rui Cai et al.
Neurobiology of aging, 62, 53-63 (2017-11-07)
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells. We examined
Elsa Ghirardini et al.
PLoS pathogens, 16(7), e1008654-e1008654 (2020-07-17)
Prion protein (PrP) mutations are linked to genetic prion diseases, a class of phenotypically heterogeneous neurodegenerative disorders with invariably fatal outcome. How mutant PrP triggers neurodegeneration is not known. Synaptic dysfunction precedes neuronal loss but it is not clear whether
Marie-Eve Laramée et al.
PloS one, 11(7), e0159320-e0159320 (2016-07-15)
In blind individuals, visually deprived occipital areas are activated by non-visual stimuli. The extent of this cross-modal activation depends on the age at onset of blindness. Cross-modal inputs have access to several anatomical pathways to reactivate deprived visual areas. Ectopic
Supriya Swarnkar et al.
Cell reports, 36(2), 109369-109369 (2021-07-15)
Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive. Here, we explore the roles of KIF5C and KIF3A, two
M Kondo et al.
The European journal of neuroscience, 12(8), 2812-2822 (2000-09-06)
alpha-Amino-3-hydroxy-5-methyl-4-isoxazle propionic acid (AMPA) receptors are ubiquitously expressed; however, their subtypes and abundance vary from region to region. We classified the neurons in various forebrain regions (hippocampus, striatum, amygdala, piriform cortex and somatosensory cortex) into six types: [R1+/R2+], [R1-/R2+], [R1+/R2-]
Jason Aoto et al.
Nature neuroscience, 18(7), 997-1007 (2015-06-02)
α- and β-neurexins are presynaptic cell-adhesion molecules whose general importance for synaptic transmission is well documented. The specific functions of neurexins, however, remain largely unknown because no conditional neurexin knockouts are available and targeting all α- and β-neurexins produced by
Hong-Bo Zhao et al.
Communications biology, 4(1), 24-24 (2021-01-06)
Inner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy
Fanny Jaudon et al.
Molecular therapy. Nucleic acids, 29, 462-480 (2022-08-30)
Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3, the gene encoding the extracellular matrix receptor β3 integrin, was associated with ASD. Accordingly, Itgb3
Xike Qin et al.
The Journal of biological chemistry, 290(49), 29603-29616 (2015-10-18)
The N-methyl-d-aspartate receptor (NMDAR) controls synaptic plasticity and memory function and is one of the major inducers of transcription factor Egr-1 in the hippocampus. However, how Egr-1 mediates the NMDAR signal in neurons has remained unclear. Here, we show that
Y Pen et al.
Hippocampus, 26(9), 1149-1167 (2016-04-14)
The serine/threonine kinase AKT/PKB plays a fundamental role in a wide variety of neuronal functions, including neuronal cell development, axonal growth, and synaptic plasticity. Multiple evidence link AKT signaling pathways to regulation of late phase long-term synaptic plasticity, synaptogenesis, and
Jithin D Nair et al.
iScience, 24(9), 103029-103029 (2021-09-24)
It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) endocytosis and induces LTD of AMPARs
Tong-Yao Hou et al.
Journal of neurochemistry, 154(4), 441-457 (2020-01-18)
MicroRNAs have been implicated in diverse physiological and pathological processes. We previously reported that aberrant microRNA-124 (miR-124)/non-receptor-type protein phosphatase 1 (PTPN1) signaling plays an important role in the synaptic disorders associated with Alzheimer's disease (AD). In this study, we further
Angela M Getz et al.
Science advances, 8(30), eabm5298-eabm5298 (2022-07-28)
Regulation of synaptic neurotransmitter receptor content is a fundamental mechanism for tuning synaptic efficacy during experience-dependent plasticity and behavioral adaptation. However, experimental approaches to track and modify receptor movements in integrated experimental systems are limited. Exploiting AMPA-type glutamate receptors (AMPARs)
Susana R Louros et al.
Cell reports, 7(5), 1614-1625 (2014-06-03)
During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) accumulation at synapses. Here, we report a critical role for
Matylda Roszkowska et al.
Cellular and molecular life sciences : CMLS, 79(5), 278-278 (2022-05-04)
Alterations in social behavior are core symptoms of major developmental neuropsychiatric diseases such as autism spectrum disorders or schizophrenia. Hence, understanding their molecular and cellular underpinnings constitutes the major research task. Dysregulation of the global gene expression program in the developing
Pankaj Bhatia et al.
Frontiers in cellular neuroscience, 18, 1408208-1408208 (2024-08-06)
Exposure to heavy metal lead can cause serious health effects such as developmental neurotoxicity in infants, cognitive impairment in children, and cardiovascular and nephrotoxic effects in adults. Hearing loss is one of the toxic effects induced by exposure to lead.
Jun Suzuki et al.
Scientific reports, 6, 24907-24907 (2016-04-26)
In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves. Because the cell
Nicholas C Weiler et al.
Scientific data, 1, 140046-140046 (2014-01-01)
A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute
Wenhui Qiao et al.
Molecular neurodegeneration, 18(1), 8-8 (2023-02-02)
The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer's disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expression of TREM2-H157Y in HEK293 cells
Sho Wakayama et al.
Nature communications, 8, 14850-14850 (2017-04-08)
The location and number of neurotransmitter receptors are dynamically regulated at postsynaptic sites. However, currently available methods for visualizing receptor trafficking require the introduction of genetically engineered receptors into neurons, which can disrupt the normal functioning and processing of the
Jing-Jing Zheng et al.
Nature neuroscience, 17(3), 391-399 (2014-01-28)
Sensory experience is critical to development and plasticity of neural circuits. Here we report a new form of plasticity in neonatal mice, where early sensory experience cross-modally regulates development of all sensory cortices via oxytocin signaling. Unimodal sensory deprivation from
Jessica A Loweth et al.
The European journal of neuroscience, 50(3), 2590-2601 (2018-09-18)
In several brain regions, ongoing metabotropic glutamate receptor 1 (mGlu1) transmission has been shown to tonically suppress synaptic levels of Ca2+ -permeable AMPA receptors (CP-AMPARs) while pharmacological activation of mGlu1 removes CP-AMPARs from these synapses. Consistent with this, we previously
Paolo Bigini et al.
Journal of neuroscience research, 90(6), 1148-1158 (2012-02-04)
Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene
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