MBD0015

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A Comparison of Automated Perfusion- and Manual Diffusion-Based Human Regulatory T Cell Expansion and Functionality Using a Soluble Activator Complex.

Mark Jones et al.

Cell transplantation, 29, 963689720923578-963689720923578 (2020-07-15)

Absence or reduced frequency of human regulatory T cells (Tregs) can limit the control of inflammatory responses, autoimmunity, and the success of transplant engraftment. Clinical studies indicate that use of Tregs as immunotherapeutics would require billions of cells per dose.

Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development.

Ting-Ting Yu et al.

Cell & bioscience, 11(1), 47-47 (2021-03-04)

Skeletal development and maintenance are complex processes known to be coordinated by multiple genetic and epigenetic signaling pathways. However, the role of long non-coding RNAs (lncRNAs), a class of crucial epigenetic regulatory molecules, has been under explored in skeletal biology.

Endothelial Progenitor Cell-Derived Microvesicles Promote Angiogenesis in Rat Brain Microvascular Endothelial Cells In vitro.

Wen Zeng et al.

Frontiers in cellular neuroscience, 15, 638351-638351 (2021-03-09)

Brain microvascular endothelial cells (BMECs) are a major component of the blood-brain barrier that maintains brain homeostasis. Preserving and restoring the normal biological functions of BMECs can reverse or reduce brain injury. Endothelial progenitor cells (EPCs) may promote brain vascular

Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth.

Vasileios Kampanis et al.

Cells, 10(1) (2021-01-01)

The central nervous system (CNS) does not recover from traumatic axonal injury, but the peripheral nervous system (PNS) does. We hypothesize that this fundamental difference in regenerative capacity may be based upon the absence of stimulatory mechanical forces in the

Molecular signatures of the rediae, cercariae and adult stages in the complex life cycles of parasitic flatworms (Digenea: Psilostomatidae).

Maksim A Nesterenko et al.

Parasites & vectors, 13(1), 559-559 (2020-11-11)

Parasitic flatworms (Trematoda: Digenea) represent one of the most remarkable examples of drastic morphological diversity among the stages within a life cycle. Which genes are responsible for extreme differences in anatomy, physiology, behavior, and ecology among the stages? Here we report

Protective effects and molecular mechanisms of baicalein on thioacetamide-induced toxicity in zebrafish larvae.

June Zhang et al.

Chemosphere, 256, 127038-127038 (2020-05-30)

Baicalein is a flavonoid that is widely found in plants. Studies have shown that baicalein has anti-inflammatory, anti-cancer, and liver-protective effects. However, the effects of baicalein on TAA-induced toxicity and the underlying molecular mechanisms in zebrafish larvae are still unknown.

Jian Yao Ng et al.

Frontiers in bioengineering and biotechnology, 8, 564667-564667 (2020-10-13)

The global cell culture market is experiencing significant growth due to the rapid advancement in antibody-based and cell-based therapies. Both rely on the capacity of different living factories, namely prokaryotic and eukaryotic cells, plants or animals for reliable and mass

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