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关键词:'N1909'
显示 1-30 共 39 条结果 关于 "N1909" 范围 论文
One-pot transition-metal-free synthesis of Weinreb amides directly from carboxylic acids
Niu T, et al.
Synthesis, 46, 320-330 (2014)
Dustyn A Barnette et al.
Biochemical pharmacology, 170, 113661-113661 (2019-10-13)
Terbinafine N-dealkylation pathways result in formation of 6,6-dimethyl-2-hepten-4-ynal (TBF-A), a reactive allylic aldehyde, that may initiate idiosyncratic drug-induced liver toxicity. Previously, we reported on the importance of CYP2C19 and 3A4 as major contributors to TBF-A formation. In this study, we
Debajyoti Ghosal et al.
FEMS microbiology letters, 313(2), 103-110 (2010-10-23)
The present study describes the assimilation of phenanthrene by an aerobic bacterium, Ochrobactrum sp. strain PWTJD, isolated from municipal waste-contaminated soil sample utilizing phenanthrene as a sole source of carbon and energy. The isolate was identified as Ochrobactrum sp. based
Xiao Luo et al.
Nature communications, 11(1), 28-28 (2020-01-09)
The mechanisms of triplet energy transfer across the inorganic nanocrystal/organic molecule interface remain poorly understood. Many seemingly contradictory results have been reported, mainly because of the complicated trap states characteristic of inorganic semiconductors and the ill-defined relative energetics between semiconductors
Kristyn Greco et al.
Pharmaceutical development and technology, 16(1), 75-87 (2010-01-29)
A flow-through dissolution apparatus was designed and evaluated to screen small quantities of pharmaceutical drug compounds early in development. The apparatus was designed to mount on a microscope slide such that a compacted solid drug was positioned flush along one
Regioselective synthesis of isocoumarins by ruthenium-catalyzed aerobic oxidative cyclization of aromatic acids with alkynes
Kirana CR, et al.
Chemical Communications (Cambridge, England), 48, 2030-2032 (2012)
The Metal-Ammonia Reduction of 1-Naphthoic Acid
Rabideau PW, et al.
Synthetic Communications, 10, 627-632 (1980)
Yating Cheng et al.
Toxicological sciences : an official journal of the Society of Toxicology, 155(2), 458-473 (2016-11-12)
1,4-Dihydroxy-2-naphthoic acid (1,4-DHNA) is a bacterial-derived metabolite that binds the aryl hydrocarbon receptor (AhR) and exhibits anti-inflammatory activity in the gut. The structure-dependent AhR activity of hydroxyl/carboxy-substituted naphthoic acids (NAs) was determined in young adult mouse colonic (YAMC) cells and
Susanna Monti et al.
Physical chemistry chemical physics : PCCP, 13(48), 21471-21478 (2011-11-05)
The conformational and photophysical properties in toluene solution of a naphthoic acid derivative, namely 4-naphthoyloxy-1-methoxy-2,2,6,6-tetramethylpiperidine, which can simulate a pendant active group grafted on apolar polymer structures, were studied by means of calculations based on the density functional theory (DFT)
K Hanna et al.
Environmental science & technology, 44(23), 8863-8869 (2010-11-10)
While the transport of low molecular weight organic acids was widely investigated, little is known about the mobility of the carboxylated aromatic compounds containing double rings in natural porous media. This study combines macroscopic (batch and column), microscopic (vibration spectroscopy)
Regadia Aissaoui et al.
The Journal of organic chemistry, 77(1), 718-724 (2011-11-24)
Substitution of an ortho-fluoro or methoxy group in 1- and 2-naphthoic acids furnishing substituted naphthoic acids occurs in good to excellent yields upon reaction with alkyl/vinyl/aryl organolithium and Grignard reagents, in the absence of a metal catalyst without the need
Carolina Berdugo-Clavijo et al.
FEMS microbiology ecology, 81(1), 124-133 (2012-02-14)
Polycyclic aromatic hydrocarbons (PAH) are widespread in methane-rich subsurface environments, such as oil reservoirs and fuel-contaminated aquifers; however, little is known about the biodegradation of these compounds under methanogenic conditions. To assess the metabolism of PAH in the absence of
Somnath Mallick
Chemosphere, 219, 748-755 (2018-12-18)
A gram-negative bacterium designated as RTSB was isolated from a petroleum-contaminated soil competent of utilizing acenaphthene as the solitary source of carbon and energy. The strain RTSB was identified as a Sphingobacterium species based on the morphological, nutritional and biochemical
Anand S Nayak et al.
FEMS microbiology letters, 320(2), 128-134 (2011-05-07)
The chrysene-degrading bacterium Pseudoxanthomonas sp. PNK-04 was isolated from a coal sample. Three novel metabolites, hydroxyphenanthroic acid, 1-hydroxy-2-naphthoic acid and salicylic acid, were identified by TLC, HPLC and MS. Key enzyme activities, namely 1-hydroxy-2-naphthoate hydroxylase, 1,2-dihydroxynaphthalene dioxygenase, salicylaldehyde dehydrogenase and
Josef B G Gluyas et al.
Organic & biomolecular chemistry, 10(34), 6914-6929 (2012-07-21)
Silicon chemistry offers the potential to tune the effects of biologically active organic molecules. Subtle changes in the molecular backbone caused by the exchange of a carbon atom for a silicon atom (sila-substitution) can significantly alter the biological properties. In
Takashi Hashimoto et al.
Bioscience, biotechnology, and biochemistry, 73(10), 2299-2302 (2009-10-08)
Basidifferquinones, isolated from Streptomyces sp., are potent inducers of fruiting-body formation in the basidiomycete, Polyporus arcularius. The first synthesis of (+/-)-basidifferquinone C was accomplished by starting from 3,5-dihydroxy-2-naphthoic acid.
Jacques Yves Gauthier et al.
Bioorganic & medicinal chemistry letters, 21(10), 2836-2839 (2011-04-22)
A weak, UDP-competitive antagonist of the pyrimidinergic receptor P2RY(14) with a naphthoic acid core was identified through high-throughput screening. Optimization provided compounds with improved potency but poor pharmacokinetics. Acylglucuronidation was determined to be the major route of metabolism. Increasing the
Dong-Hui Wang et al.
Science (New York, N.Y.), 327(5963), 315-319 (2009-12-08)
The Mizoroki-Heck reaction, which couples aryl halides with olefins, has been widely used to stitch together the carbogenic cores of numerous complex organic molecules. Given that the position-selective introduction of a halide onto an arene is not always straightforward, direct
K Hanna et al.
Water research, 46(14), 4457-4467 (2012-06-19)
In contrast to the parent compounds, the mechanisms responsible for the transport of natural metabolites of polycyclic aromatic hydrocarbons (PAH) in contaminated soils have been scarcely investigated. In this study, the sorption of three aromatic acids (1-naphthoic acid (NA), 1-hydroxy-2-naphthoic
Gabriel S Suarez et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(5), 1989-1998 (2008-09-23)
Mid-, far-infrared and Raman vibrational spectra of 2-acetylphenyl-2-naphthoate have been measured at room and low temperatures. The molecule was also analyzed by means of ab initio calculations. The conformational space has been scanned using molecular dynamics and complemented with functional
Jean-Baptiste Arlin et al.
Acta crystallographica. Section C, Crystal structure communications, 68(Pt 8), m213-m218 (2012-08-02)
The structures of the Mg, Ca, Sr and Ba salts of 1-naphthoic acid are examined and compared with analogous structures of salts of benzoate derivatives. It is shown that catena-poly[[[diaquabis(1-naphthoato-κO)magnesium(II)]-μ-aqua] dihydrate], {[Mg(C(11)H(7)O(2))(2)(H(2)O)(3)]·2H(2)O}(n), exists as a one-dimensional coordination polymer that propagates
Mohamed El Amine Benmalti et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1), 58-66 (2009-06-16)
A full quantum theoretical model is proposed to study the nu(O-H) experimental IR line shapes of polarized crystalline glutaric and 1-naphthoic acid dimer crystals at room and liquid nitrogen temperatures. This work is an application of a previous model [M.
Yu-mei Song et al.
Chemical communications (Cambridge, England), 48(7), 1006-1008 (2011-12-14)
Reversible single-crystal-to-single-crystal transformation (SCSC) was for the first time observed between 4f-based molecular magnets.
Dustyn A Barnette et al.
Biochemical pharmacology, 156, 10-21 (2018-08-05)
Lamisil (terbinafine) may cause idiosyncratic liver toxicity through a proposed toxicological mechanism involving the reactive metabolite 6,6-dimethyl-2-hepten-4-ynal (TBF-A). TBF-A toxicological relevance remains unclear due to a lack of identification of pathways leading to and competing with TBF-A formation. We resolved
Björn Walse et al.
Biochemistry, 47(34), 8929-8936 (2008-08-05)
Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium, and bacterial and fungal infections. Here we present the structures of N-terminally truncated (residues Met30-Arg396) DHODH in complex with two inhibitors: a
S Chandra et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(3), 704-713 (2009-09-02)
The Fourier transform infrared gas phase spectrum of Naphthoic acid (NA) was recorded in the region 4000-400 cm(-1). The Fourier transform Raman spectrum and Fourier transform IR spectra of NA were recorded in solid phase. Quantum chemical calculations of energies
Vu Thi Thu Hang et al.
FEMS microbiology letters, 311(2), 119-125 (2010-08-26)
Neocarzinostatin (NCS) is an enediyne antibiotic produced by Streptomyces carzinostaticus. The NCS chromophore consists of an enediyne core, a sugar moiety, and a naphthoic acid (NA) moiety. The latter plays a key role in binding the NCS chromophore to its
Qunfei Zhao et al.
Chemistry & biology, 15(7), 693-705 (2008-07-19)
Azinomycin B is a complex natural product containing densely assembled functionalities with potent antitumor activity. Cloning and sequence analysis of the azi gene cluster revealed an iterative type I polyketide synthase (PKS) gene, five nonribosomal peptide synthetases (NRPSs) genes and
Mutual activation: Suzuki-Miyaura coupling through direct cleavage of the sp2 C-O bond of naphtholate.
Da-Gang Yu et al.
Angewandte Chemie (International ed. in English), 50(31), 7097-7100 (2011-06-29)
Rajesh Sunasee et al.
The Journal of organic chemistry, 73(20), 8016-8020 (2008-09-26)
A method is described for converting tert-butyl benzoates or tert-butyl 1-naphthoates into derivatives having an alkyl or substituted alkyl group in a 1,4-relationship to an alkyl, aryl, alkenyl, or alkynyl group. Key steps in the sequence are (i) addition of
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