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Kyoung-Jin Kim et al.
Cellular immunology, 285(1-2), 92-99 (2013-10-22)
The mechanisms of mucosal immunogenicity and adjuvanticity of bacterial exotoxins remains unknown. In this study, we investigated the role of the transcription factor nuclear factor-κB (NF-κB) in cholera toxin (CT)-induced alteration of oral tolerance. Feeding CT abrogated ovalbumin (OVA)-induced oral
Jung-Chen Su et al.
Carcinogenesis, 35(12), 2807-2814 (2014-10-18)
Regulatory factor X-1 (RFX-1) is a transcription factor that has been linked to negative regulation of tumor progression; however, its biological function and signaling cascades are unknown. Here, we performed several studies to elucidate the roles of RFX-1 in the
Michal Sibony et al.
Inflammatory bowel diseases, 21(12), 2778-2786 (2015-09-04)
Autophagy is implicated in Crohn's disease (CD) pathogenesis. Recent evidence suggests autophagy regulates the microRNA (miRNA)-induced silencing complex (miRISC). Therefore, autophagy may play a novel role in CD by regulating expression of miRISC, thereby altering miRNA silencing. As microbes associated
Masayuki Koizumi et al.
Journal of atherosclerosis and thrombosis, 21(9), 904-916 (2014-04-15)
Vascular senescence, which is accelerated in individuals with chronic kidney disease (CKD), contributes to the development of cardio-renal syndrome, and various uremic toxins may play important roles in the mechanisms underlying this phenomenon. We recently reported that indoxyl sulfate (IS)
Guohai Sun et al.
Journal of proteomics, 109, 199-211 (2014-07-20)
Protein lysine acetylation is a dynamic and reversible post-modification that is known to play diverse functions in eukaryotes. Nevertheless, the composition and function of non-histone lysine acetylation in gametes remain unknown. In humans, only capacitated sperm have the capacity to
Nicholas A Dillon et al.
Antimicrobial agents and chemotherapy, 58(12), 7258-7263 (2014-09-24)
Pyrazinamide (PZA) is a first-line tuberculosis drug that inhibits the growth of Mycobacterium tuberculosis via an as yet undefined mechanism. An M. tuberculosis laboratory strain that was auxotrophic for pantothenate was found to be insensitive to PZA and to the
Xiu-feng Hua et al.
PloS one, 9(7), e102198-e102198 (2014-07-11)
Human pancreatic islet transplantation is a prospective curative treatment for diabetes. However, the lack of donor pancreases greatly limits this approach. One approach to overcome the limited supply of donor pancreases is to generate functional islets from human embryonic stem
Moo-Young Jung et al.
Applied and environmental microbiology, 80(19), 6195-6203 (2014-08-03)
Klebsiella pneumoniae is considered a good host strain for the production of 2,3-butanediol, which is a promising platform chemical with various industrial applications. In this study, three genes, including those encoding glucosyltransferase (wabG), lactate dehydrogenase (ldhA), and pyruvate formate-lyase (pflB)
Occurrence of hepatocellular carcinoma upon advanced liver fibrosis thirteen years after achieving sustained virological response to hepatitis C: how long surveillance should be maintained?
Gino S Albines et al.
Digestive diseases and sciences, 60(2), 582-585 (2014-10-16)
Liang Guo et al.
Journal of cellular physiology, 230(10), 2390-2402 (2015-03-03)
Lung inflammation and alveolar epithelial cell death are critical events in the development and progression of acute lung injury (ALI). Although angiopoietin-like protein 4 (ANGPTL4) participates in inflammation, whether it plays important roles in ALI and alveolar epithelial cell inflammatory
Anne H-H Tseng et al.
The Biochemical journal, 464(1), 157-168 (2014-08-28)
The endothelial cells (ECs) that line the vascular lumen are exposed to a wide variety of environmental stresses, such as hypoxia. Maladaptation to stress in ECs is a key event in the development of cardiovascular disease. Sirtuin 3 (SIRT3) is
Kaoru Tsuchiya et al.
Cancer, 120(2), 229-237 (2013-10-15)
A new predictive biomarker for determining prognosis in patients with hepatocellular carcinoma (HCC) who receive sorafenib is required, because achieving a reduction in tumor size with sorafenib is rare, even in patients who have a favorable prognosis. Vascular endothelial growth
Yun H Kim et al.
Vascular pharmacology, 72, 35-42 (2015-05-15)
Silent mating type information regulation 2 homolog 1 (SIRT1) is known as a key regulator in the protection of various vascular disorders, however, no direct evidences have been reported in the progression of atherosclerosis. Considering the pivotal role of matrix
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Li Ma et al.
Cancer letters, 355(1), 96-105 (2014-09-15)
Sorafenib is the approved systemic drug of choice for advanced hepatocellular carcinoma (HCC), but has demonstrated limited benefits because of drug resistance. 2-Methoxyestradiol (2ME2) has been shown to be a promising anticancer drug against various types of cancers and acts
Li Lin et al.
Molecular and cellular biochemistry, 394(1-2), 199-208 (2014-06-05)
Streptococcus pneumoniae is an important pathogen of pneumonia in human. Human alveolar epithelium acts as an effective barrier and is an active participant in host defense against invasion of bacterial by production of various mediators. Sirtuin 1 (SIRT1), the prototypic
Jia-lin Wang et al.
Investigative ophthalmology & visual science, 54(13), 7983-7989 (2013-11-10)
To achieve a combination therapy of targeted PDT and anti-VEGF for choroidal neovascularization (CNV). Arg-Gly-Asp (RGD)-modified liposomes encapsulating photocyanine and sorafenib (RGD-SSL-[P]-[S]) were prepared and characterized. Drug concentration in RGD-SSL-[P]-[S] and irradiation time were optimized on ARPE-19 and HUVEC cells
Matteo Santoni et al.
International journal of cancer, 136(1), 1-10 (2014-01-15)
Fatigue is the most common symptom associated with cancer and cancer treatment. We performed an up-to-date meta-analysis to determine the incidence and relative risk (RR) of fatigue in patients (pts) with cancer treated with sorafenib (SO), sunitinib (SU) and pazopanib
Xiao Li Wang et al.
Cytotherapy, 16(11), 1519-1527 (2014-10-08)
Human umbilical cord mesenchymal stromal cells (hUC-MSCs) hold great potential as a therapeutic candidate to treat diabetes, owing to their unlimited source and ready availability. In this study, we differentiated hUC-MSCs with in vitro-synthesized pancreatic-duodenal homebox 1 (PDX1) messenger (m)RNA
Elin Hall et al.
BMC medicine, 12, 103-103 (2014-06-24)
Circulating free fatty acids are often elevated in patients with type 2 diabetes (T2D) and obese individuals. Chronic exposure to high levels of saturated fatty acids has detrimental effects on islet function and insulin secretion. Altered gene expression and epigenetics
Jennifer M Hughes-Large et al.
Atherosclerosis, 237(2), 696-704 (2014-12-03)
Niacin (nicotinic acid) as a monotherapy can reduce vascular disease risk, but its mechanism of action remains controversial, and may not be dependent on systemic lipid modifying effects. Niacin has recently been shown to improve endothelial function and vascular regeneration
Adolfo Virgen-Ortiz et al.
Nanomaterials (Basel, Switzerland), 10(10) (2020-10-16)
Different studies in experimental diabetes models suggest that zinc oxide nanoparticles (ZnONPs) are useful as antidiabetic agents. However, this evidence was performed and measured in long-term treatments and with repeated doses of ZnONPs. This work aimed to evaluate the ZnONPs
Yi-Jun Wang et al.
Biochemical pharmacology, 90(4), 367-378 (2014-06-18)
Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP binding cassette (ABC)
Ming Xu et al.
DNA and cell biology, 33(5), 275-281 (2014-03-13)
Hypoxia and hypoxia-driven angiogenesis play an important role on the recurrence of hepatocellular carcinoma after insufficient radiofrequency ablation. The hypoxia-inducible factor (HIF)-1α/vascular endothelial growth factor-A (VEGFA) pathway plays an important part in this process. Sorafenib is a multikinase inhibitor with
Eric M Brown et al.
Nature communications, 6, 7806-7806 (2015-08-05)
Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date
Kenneth Maiese
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 62(4), 218-232 (2008-03-18)
Oxidative stress is a principal pathway for the dysfunction and ultimate destruction of cells in the neuronal and vascular systems for several disease entities, not promoting the ravages of oxidative stress to any less of a degree than diabetes mellitus.
A wife asks for futile therapy for her husband, a "fighter": how to respond?
Paul R Helft
Oncology (Williston Park, N.Y.), 27(4), 348-349 (2013-06-21)
Sandeep Kumar Vishwakarma et al.
Journal of diabetes investigation, 5(5), 492-500 (2014-11-21)
Diabetes is a major health concern throughout the world because of its increasing prevalence in epidemic proportions. β-Cell deterioration in the pancreas is a crucial factor for the progression of diabetes mellitus. Therefore, the restoration of β-cell mass and its
Hiroyuki Fukuda et al.
Radiology, 272(2), 598-604 (2014-04-03)
To retrospectively compare radiofrequency ablation (RFA) combined with the multikinase inhibitor sorafenib (hereafter, sorafenib-RFA) and RFA alone in the treatment of hepatocellular carcinoma (HCC). Institutional review board approval and informed consent were obtained. Between January 2007 and December 2011, 16
Nicotinamide in Friedreich's ataxia: useful or not?
David R Lynch et al.
Lancet (London, England), 384(9942), 474-475 (2014-05-06)
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