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Karine Meisser Redeuil et al.
Journal of chromatography. A, 1422, 89-98 (2015-11-03)
This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol enriched with stable isotope labelled internal
Maryam Mehrabi et al.
In vitro cellular & developmental biology. Animal, 51(6), 595-603 (2015-01-30)
Advances in cell-replacement strategies for diabetes have focused on renewable sources of glucose-responsive, insulin-producing cells (IPCs). One of the most proper alternatives is multipotent skin-derived precursors cells (SKPs), which can be differentiated into IPCs. In this study, we reported the
Jessica Walter et al.
Journal of clinical research in pediatric endocrinology, 6(2), 93-99 (2014-06-17)
The vision of potential autologous cell therapy for the cure of diabetes encourages ongoing research. According to a previously published protocol for the generation of insulin-producing cells from human monocytes, we analyzed whether the addition of growth factors could increase
Yoshinao Soma et al.
International journal of dermatology, 44(3), 197-202 (2005-04-06)
Certain moisturizers can improve skin barrier function in atopic dermatitis. The effect of topical nicotinamide on atopic dry skin is unknown. We examined the effect of topical nicotinamide on atopic dry skin and compared the results with the effect of
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Philippe Bahadoran et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e324-e326 (2013-05-30)
Elisa De Crignis et al.
eLife, 10 (2021-07-31)
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for modeling
Sang Woo Lee et al.
Biochemical and biophysical research communications, 464(4), 1178-1184 (2015-07-26)
Activin A, which is a signaling molecule similar to Nodal, rapidly promotes endoderm induction of both embryonic stem (ES) cells and MSCs. Protocols for hepatic induction exhibit differences in efficiency and reproducibility depending on the specific methods or sources of
Meihua Zheng et al.
Molecular and cellular biochemistry, 393(1-2), 59-67 (2014-04-15)
The present study was designed to investigate the effect of hydrogen sulfide on cellular senescence of human umbilical vascular endothelial cells (HUVECs CC-2517) and its underlying mechanism. The premature senescence-like phenotype HUVECs (the fourth passage) was induced by treatment with
Lei Zhong et al.
International journal of cancer, 135(12), 2972-2983 (2014-05-03)
Hepatocellular carcinoma (HCC) is a serious life-threatening malignant disease of liver. Molecular targeted therapies are considered a promising strategy for the treatment of HCC. Sorafenib is the first, and so far the only targeted drug approved by the US Food
Christian W Johnson et al.
Cell reports, 28(6), 1538-1550 (2019-08-08)
Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or
O B Christiansen et al.
BJOG : an international journal of obstetrics and gynaecology, 122(4), 500-508 (2014-11-22)
To determine whether infusions with intravenous immunoglobulin (IVIg) during early pregnancy increase live birth rate in women with secondary recurrent miscarriage compared with placebo. A single-centre, randomised, double-blind, placebo-controlled trial. A tertiary centre for recurrent miscarriage in Copenhagen, Denmark. A
Ping Xu et al.
Mechanisms of ageing and development, 131(4), 287-298 (2010-03-24)
Organism aging is a process of time and maturation culminating in senescence and death. The molecular details that define and determine aging have been intensely investigated. It has become appreciated that the process is partly an accumulation of random yet
Christoph Koentges et al.
Basic research in cardiology, 110(4), 37-37 (2015-05-20)
Hypoadiponectinemia is an independent predictor of cardiovascular disease, impairs mitochondrial function in skeletal muscle, and has been linked to the pathogenesis of Type 2 diabetes. In models of Type 2 diabetes, myocardial mitochondrial function is impaired, which is improved by
Dong-Hyun Kim et al.
The EMBO journal, 34(2), 184-199 (2014-11-27)
Acetylation of transcriptional regulators is normally dynamically regulated by nutrient status but is often persistently elevated in nutrient-excessive obesity conditions. We investigated the functional consequences of such aberrantly elevated acetylation of the nuclear receptor FXR as a model. Proteomic studies
Taekmin Kwon et al.
Journal of surgical oncology, 110(2), 145-150 (2014-04-08)
To evaluate the impact of surgery on the prognosis of metastatic renal cell carcinoma (mRCC) with inferior vena cava (IVC) thrombus. In this retrospective study, the medical records of 45 patients who presented with synchronous mRCC with IVC thrombus, between
Géraldine Carlier et al.
PloS one, 9(9), e108202-e108202 (2014-09-27)
Regulation of cell cycle in beta cells is poorly understood, especially in humans. We exploited here the recently described human pancreatic beta cell line EndoC-βH2 to set up experimental systems for cell cycle studies. We derived 2 populations from EndoC-βH2
L Claret et al.
Clinical pharmacology and therapeutics, 95(4), 446-451 (2014-01-21)
The motesanib phase III MONET1 study failed to show improvement in overall survival (OS) in non-small cell lung cancer, but a subpopulation of Asian patients had a favorable outcome. We performed exploratory modeling and simulations based on MONET1 data to
Ning Jia et al.
Anticancer research, 33(6), 2797-2800 (2013-06-12)
Post-transplant hepatocellular carcinoma recurrence has been reported to be between 15-18% and is higher among patients with high-risk features (bilobar tumor, macrovascular invasion, or multifocality). There are no known treatments which reduce risk of recurrence post-transplant. Sorafenib is currently approved
Federica Gaudino et al.
Antioxidants & redox signaling, 31(15), 1150-1165 (2019-08-29)
Aim: Nicotinamide adenine dinucleotide (NAD+) plays central roles in a wide array of normal and pathological conditions. Inhibition of
Federico Pereyra-Bonnet et al.
PloS one, 9(6), e100369-e100369 (2014-06-26)
The conversion of differentiated cells into insulin-producing cells is a promising approach for the autologous replacement of pancreatic cells in patients with type 1 diabetes (T1D). At present, cellular reprogramming strategies encompass ethical problems, epigenetic failure or teratoma formation, which
Marie-Hélène Massicotte et al.
European journal of endocrinology, 170(4), 575-582 (2014-01-16)
Tyrosine kinase inhibitors (TKIs) are used to treat patients with advanced thyroid cancers. We retrospectively investigated the efficacy of TKIs administered outside of clinical trials in metastatic sites or locally advanced thyroid cancer patients from five French oncology centers. THERE
Jinmi Lee et al.
Cell stress & chaperones, 19(5), 649-656 (2014-01-22)
Accumulation of excess hepatic lipids contributes to insulin resistance and liver disease associated with endoplasmic reticulum (ER) stress. Exendin-4 is an agonist of the glucagon-like peptide 1 receptor and plays a role in improving insulin resistance and liver disease by
Hye Young Kim et al.
Cancer letters, 355(1), 61-69 (2014-09-15)
Previous studies have revealed that HBx expression has anti-apoptotic effects, resulting in increased drug resistance in HCC cells. Thus, we examined if sorafenib efficiently induces apoptosis in HBx-overexpressing HCC cells. Noticeably, sorafenib efficiently induced apoptosis, even in HBx-expressing HepG2 cells
Martin Mraz et al.
Urolithiasis, 43(1), 61-67 (2014-11-06)
Hereditary xanthinuria (HX) is a rare inherited disorder caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO). Missing XDH/XO activity leads to undetectable levels of uric acid excessively replaced by xanthine in serum/urine. The allopurinol loading test has been traditionally used
Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Andrew X Zhu et al.
JAMA, 312(1), 57-67 (2014-07-25)
Aside from the multikinase inhibitor sorafenib, there are no effective systemic therapies for the treatment of advanced hepatocellular carcinoma. To assess the efficacy of everolimus in patients with advanced hepatocellular carcinoma for whom sorafenib treatment failed. EVOLVE-1 was a randomized
Alessio Ciulli et al.
Journal of medicinal chemistry, 49(16), 4992-5000 (2006-08-04)
Mapping interactions at protein-ligand binding sites is an important aspect of understanding many biological reactions and a key part of drug design. In this paper, we have used a fragment-based approach to probe "hot spots" at the cofactor-binding site of
Firat Bayraktar et al.
Endocrine journal, 51(6), 601-608 (2005-01-13)
The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS
Yusuke Kobayashi et al.
Kekkaku : [Tuberculosis], 88(9), 671-675 (2013-12-05)
A 66-year-old man with hepatocellular carcinoma (HCC) and suspicion of lung metastasis consulted us because of an abnormal chest shadow as seen on a radiograph. He had been treated with sorafenib for 2 months. A chest CT scan showed cavitating
Luigi Bartalena et al.
BioFactors (Oxford, England), 19(3-4), 155-163 (2004-02-06)
Graves' ophthalmopathy (GO) is a disorder of autoimmune origin caused by a complex interplay of endogenous and environmental factors. After recognition of one or more antigens shared by thyroid and orbit, activated T lymphocytes infiltrating the orbit trigger a cascade
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