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显示 31-60 共 715 条结果 关于 "N6876" 范围 论文
Yang Yi et al.
Fish & shellfish immunology, 45(2), 757-770 (2015-06-09)
Cyprinid herpesvirus 3 (CyHV3) is a large double-stranded DNA virus of Alloherpesviridae family in the order Herpesvirales. It causes significant morbidity and mortality in common carp and its ornamental koi variety, and threatens the aquaculture industries worldwide. Mimicry of cytokines
Makoto Yamagishi et al.
Scientific reports, 5, 17868-17868 (2015-12-08)
Biological robustness is exposed to stochastic perturbations, which should be controlled by intrinsic mechanisms; the promiscuous signaling network without appropriate alleviation is the true nature of cancer cells. B cell receptor (BCR) signaling is a major source of gene expression
Magdalena Kakareko et al.
Clinical laboratory, 61(3-4), 345-351 (2015-05-16)
IL-17, classified as an inflammatory cytokine, plays a key role in the activation of inflammatory processes involving neutrophils. Twenty healthy voluntary blood donors were controlled in the study. The granulocyte suspensions were stimulated with rhIL-17 and fMLP. Expression of Bcl-xl
Kaidi D Zhang et al.
PloS one, 10(7), e0132796-e0132796 (2015-07-16)
The miR-183 family consists of 3 related microRNAs (miR-183, miR-96, miR-182) that are required to complete maturation of primary sensory cells in the mammalian inner ear. Because the level of these microRNAs is not uniform across hair cell subtypes in
Qingxia Yuan et al.
Carbohydrate polymers, 128, 52-62 (2015-05-26)
Extraction optimization, characterization and antioxidant activity in vitro of polysaccharides from mulberry leaves (MLP) were investigated in the present study. The optimal extraction conditions with an extraction yield of 10.0 ± 0.5% for MLP were determined as follows: extraction temperature
Chihiro Yamada et al.
Psychoneuroendocrinology, 55, 81-93 (2015-03-04)
The combination of depression and anorexia may influence morbidity and progressive physical disability in the elderly. Gender differences exist in hypothalamic-pituitary-adrenal axis activation following stress exposure. The objective of this study was to investigate gender differences in feeding behavior under
Emanuela Romano et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6140-6145 (2015-04-29)
Enhancing immune responses with immune-modulatory monoclonal antibodies directed to inhibitory immune receptors is a promising modality in cancer therapy. Clinical efficacy has been demonstrated with antibodies blocking inhibitory immune checkpoints such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) or PD-1/PD-L1.
Sheng Su et al.
Investigative ophthalmology & visual science, 55(12), 7848-7861 (2014-11-20)
To identify differential changes in proteins and metabolites underlying "fast" type 1 (T1DC) and "slow" type 2 (T2DC) diabetic cataract (DC) formation in rat. Rat models of types 1 and 2 diabetes consisted of streptozotocin injection without and with high-fat
Regina Hoo et al.
PloS one, 9(12), e115243-e115243 (2014-12-17)
Polysaccharide (PS) capsules are important virulence determinants for many bacterial pathogens. Bordetella pertussis, the agent of whooping cough, produces a surface associated microcapsule but its role in pertussis pathogenesis remained unknown. Here we showed that the B. pertussis capsule locus
Germana Zaccagnini et al.
Antioxidants & redox signaling, 21(8), 1177-1188 (2013-08-13)
Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to
L H Pugholm et al.
Scandinavian journal of immunology, 82(6), 498-505 (2015-09-04)
Targeting of antigen to dendritic cells (DCs) increase the efficiency of immunization procedures and may facilitate the development of more effective vaccines. Several surface molecules on DCs have shown to be useful for antigen targeting, but many more deserves investigation
Alka Singh et al.
Scientific reports, 10(1), 14722-14722 (2020-09-09)
Objectives of the current work were to investigate the role of photoperiod and melatonin in the alteration of immune responses in a reptilian species. Animals were kept on a regimen of short or long days. Blood was obtained and leucocytes
Shaolei Zang et al.
BMC cancer, 14, 886-886 (2014-11-28)
We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In this study we investigated whether Wnt signaling pathways played roles in
Sanne Grundvad Boelt et al.
Analytical biochemistry, 481, 33-42 (2015-04-25)
Here we present an agarose gel shift assay that, in contrast to other electrophoresis approaches, is loaded in the center of the gel. This allows proteins to migrate in either direction according to their isoelectric points. Therefore, the presented assay
Shukai Yuan et al.
PLoS genetics, 11(5), e1005253-e1005253 (2015-05-29)
Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest. The transitions from anagen (growth), to catagen (regression), to telogen (rest) involve a physiological involution of the HF. This process is likely coordinated by a variety of
An in vitro model of antibody-enhanced killing of the intracellular parasite Leishmania amazonensis.
Katherine N Gibson-Corley et al.
PloS one, 9(9), e106426-e106426 (2014-09-06)
Footpad infection of C3HeB/FeJ mice with Leishmania amazonensis leads to chronic lesions accompanied by large parasite loads. Co-infecting these animals with L. major leads to induction of an effective Th1 immune response that can resolve these lesions. This cross-protection can
Hui Tian et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(3), 157-167 (2014-10-28)
Melanoma differentiation-associated gene-7 (mda-7)/interleukin-24 (IL-24) induces caspase-3 cleavage and subsequent activation via the intrinsic or extrinsic pathway to result in cancer cell-selective apoptosis, but whether mda-7/IL-24 may directly regulate caspase-3 through the post-translational modification remains unknown. Here, we reported that
Wenwen Zheng et al.
Journal of virology, 91(7) (2017-01-27)
The virion infectivity factor (Vif) open reading frame is conserved among most lentiviruses. Vif molecules contribute to viral replication by inactivating host antiviral factors, the APOBEC3 cytidine deaminases. However, various species of lentiviral Vif proteins have evolved different strategies for
Guangcheng Luo et al.
Molecular medicine reports, 11(2), 1284-1291 (2014-11-06)
A weak T‑cell immune response to the hepatitis B virus (HBV) is hypothesized to be the primary cause of chronic HBV infection. Emerging evidence suggests that long‑term effective antiviral therapy restores the HBV‑specific T‑cell response from exhaustion. However, the extent
Bo Zhang et al.
Oxidative medicine and cellular longevity, 2012, 781516-781516 (2012-11-03)
Among various cancer cell lines, the leukemia cell line HL-60 was most sensitive to Shikonin, with evidence showing both the prooxidative activities and proapoptotic effects of micromolar concentrations of Shikonin. However, the mechanism involved in the cytotoxicity of Shikonin in
Luz Natalia Franco Montoya et al.
Fish & shellfish immunology, 83, 314-320 (2018-09-17)
This study investigated the effects of two β-glucan molecules with different purities and isolated by different biotechnological processes on the immune response of matrinxã (Brycon amazonicus) prior and after challenge with Aeromonas hydrophila. In this sense, we evaluated serum cortisol
Mayada Woriedh et al.
Journal of experimental botany, 66(17), 5205-5216 (2015-06-14)
EMBRYO SAC1-4 (ES1-4) peptides belong to the defensin subgroup of cysteine-rich peptides known to mediate pollen tube burst in Zea mays (maize). ES1-4 are reported here to also be capable of inhibiting germination and growth of the maize fungal pathogens
Ewa Wons et al.
Nucleic acids research, 43(8), 3950-3963 (2015-04-01)
DNA-dependent T7 RNA polymerase (T7 RNAP) is the most powerful tool for both gene expression and in vitro transcription. By using a Next Generation Sequencing (NGS) approach we have analyzed the polymorphism of a T7 RNAP-generated mRNA pool of the
Zoe White et al.
Skeletal muscle, 6(1), 45-45 (2016-12-15)
There is much interest in the capacity of resistance exercise to prevent the age-related loss of skeletal muscle mass and function, known as sarcopenia. This study investigates the molecular basis underlying the benefits of resistance exercise in aging C57BL/6J mice
Ji-Hye Yun et al.
Biochemical and biophysical research communications, 456(1), 116-121 (2014-12-03)
G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melanocortin-4 receptor (hMC4R) plays an important role in the control of energy homeostasis, and
J Burns et al.
Journal of clinical pathology, 41(8), 897-899 (1988-08-01)
Recently, sensitive non-isotopic in situ hybridisation (NISH) methodology for the detection of human DNA and human papilloma virus (HPV) DNA in archival paraffin blocks of cervix was described. An amended protocol, now used in this laboratory for detection of these
Farzaneh Bagheri et al.
Behavioural brain research, 287, 215-225 (2015-03-24)
Chronic alcoholism leads to elevated plasma and brain homocysteine (Hcy) levels, as demonstrated by animal experiments. This study was designed to evaluate the alterations in offspring rat cerebellum following increase of plasma Hcy level induced by maternal exposure to ethanol
Qingqing Wang et al.
General and comparative endocrinology, 216, 9-23 (2015-05-07)
Gonadotropin-inhibitory hormone (GnIH) and its receptor (GnIHR) play an important role in reproduction regulation in birds, mammals and some teleost species. In protogynous hermaphroditic orange-spotted grouper (Epinephelus coioides), the GnIH/GnIHR signaling pathway and its reproductive function have not been addressed
Claire Chevaleyre et al.
Journal of immunology (Baltimore, Md. : 1950), 195(4), 1891-1901 (2015-07-03)
Cyclin B1 (CCNB1) is considered as a potential target for a cancer vaccine, as it is overexpressed in many malignant cells, while being transiently expressed in normal cells. To evaluate the CD4 T cell response to CCNB1, we derived T
Hye-Young Wang et al.
Experimental and molecular pathology, 98(3), 510-516 (2015-04-04)
Human papillomavirus (HPV) is a major cause of cervical cancer, which is the third most common cancer in women. Human telomerase reverse transcriptase (hTERT) and Ki67 are tumor cell markers indicating cancer cell proliferation in cancer patients, and activation of
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