N7505

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Perturbation of phosphoglycerate kinase 1 (PGK1) only marginally affects glycolysis in cancer cells.

Chengmeng Jin et al.

The Journal of biological chemistry, 295(19), 6425-6446 (2020-03-29)

Phosphoglycerate kinase 1 (PGK1) plays important roles in glycolysis, yet its forward reaction kinetics are unknown, and its role especially in regulating cancer cell glycolysis is unclear. Here, we developed an enzyme assay to measure the kinetic parameters of the

Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity.

David E Wright et al.

Antioxidants & redox signaling, 29(4), 377-388 (2017-11-10)

Thioredoxin reductase 1 (TrxR1) is a cancer target and essential selenoprotein that defends the cell against reactive oxygen species and regulates cellular signaling and redox pathways. Previous cell-based studies correlated TrxR1 acetylation with modulated cellular reduction activity, yet the function

Biomarker responses and accumulation of polycyclic aromatic hydrocarbons in Mytilus trossulus and Gammarus oceanicus during exposure to crude oil.

Raisa Turja et al.

Environmental science and pollution research international, 27(13), 15498-15514 (2020-02-23)

In the brackish water Baltic Sea, oil pollution is an ever-present and significant environmental threat mainly due to the continuously increasing volume of oil transport in the area. In this study, effects of exposure to crude oil on two common

Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.

Yukiko Ohara et al.

Scientific reports, 11(1), 3191-3191 (2021-02-06)

The Kif26a protein-coding gene has been identified as a negative regulator of the GDNF-Ret signaling pathway in enteric neurons. The aim of this study was to investigate the influence of genetic background on the phenotype of Kif26a-deficient (KO, -/-) mice.

Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways.

Isabelle Hernandez et al.

Antioxidants (Basel, Switzerland), 10(2) (2021-03-07)

Preeclampsia, a hypertensive disorder occurring during pregnancy, is characterized by excessive oxidative stress and trophoblast dysfunction with dysregulation of soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) production. Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase (Nox) is the

Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments.

Jeffrey M Stolwijk et al.

Redox biology, 32, 101518-101518 (2020-04-12)

Selenium is a metalloid trace element essential for maintaining the optimal redox environment in cells and tissues. It is structurally incorporated into over 25 selenoproteins and enzymes. The glutathione peroxidase (GPx) family of enzymes has a critical role in human

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.

Grant R Drummond et al.

Nature reviews. Drug discovery, 10(6), 453-471 (2011-06-02)

NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery wall in conditions such as hypertension, hypercholesterolaemia, diabetes and ageing

TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure.

B R Mattos et al.

Biochemical pharmacology, 180, 114121-114121 (2020-06-28)

Systemic arterial hypertension is a public health problem associated with an increased risk of cardiovascular disease. Matrix metalloproteinases (MMP) are endopeptidases that participate in hypertension-induced cardiovascular remodeling, which may be activated by oxidative stress. Angiotensin II (Ang II), a potent

Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.

Xue-Mei Zhang et al.

The European journal of neuroscience, 30(12), 2271-2283 (2010-01-23)

The presence of neuritic plaques is a pathological hallmark of Alzheimer's disease (AD). However, the origin of extracellular beta-amyloid peptide (Abeta) deposits and the process of plaque development remain poorly understood. The present study attempted to explore plaque pathogenesis by

Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury.

Jian-Ming Li et al.

Neurotoxicity research, 24(1), 1-14 (2012-10-12)

The spinal cord is composed of distinct neuronal groups with well-defined anatomic connections. In some transgenic (Tg) models of Alzheimer's disease (AD), amyloid plaques develop in this structure, although the underlying cellular mechanism remains elusive. We attempted to explore the

The role of free radical generation in increasing cerebrovascular permeability.

Paul A Fraser

Free radical biology & medicine, 51(5), 967-977 (2011-06-30)

The brain endothelium constitutes a barrier to the passive movement of substances from the blood into the cerebral microenvironment, and disruption of this barrier after a stroke or trauma has potentially fatal consequences. Reactive oxygen species (ROS), which are formed

Estrogen signaling and neuroprotection in cerebral ischemia.

Brann D, Raz L, Wang R, et al.

Journal of Neuroendocrinology, 24(1), 34-47 (2011)

William B. Wood

Biochemistry: A Problems Approach, 195-195 null

Structurally distributed surface sites tune allosteric regulation.

James W McCormick et al.

eLife, 10 (2021-06-17)

Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed? To examine this, we conducted saturation mutagenesis of a synthetic allosteric switch

Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development.

Filomena Caccavale et al.

eLife, 10 (2021-08-26)

During animal ontogenesis, body axis patterning is finely regulated by complex interactions among several signaling pathways. Nitric oxide (NO) and retinoic acid (RA) are potent morphogens that play a pivotal role in vertebrate development. Their involvement in axial patterning of

Alzheimer's disease and cholesterol: the fat connection.

Laura Canevari et al.

Neurochemical research, 32(4-5), 739-750 (2006-12-28)

Since the discovery of the significance of the cholesterol-carrying apolipoprotein E and cholesterolaemia as major risk factors for Alzheimer's Disease (AD) there has been a mounting interest in the role of this lipid as a possible pathogenic agent. In this

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.

Lisa Mayr et al.

Nature communications, 11(1), 1775-1775 (2020-04-15)

The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic

L-Cysteine-mediated modulation of copper trafficking in prostate cancer cells: an in vitro and in vivo investigation with 64Cu and 64Cu-PET.

Joanna J Bartnicka et al.

Metallomics : integrated biometal science, 12(10), 1508-1520 (2020-09-23)

Copper imbalance is implicated in many diseases, including cancer. Copper in blood is mainly transported by carrier proteins but a small fraction is bound to low molecular weight species, possibly amino acids. Their roles in cellular copper delivery are unknown.

Berg, J.M., et al.

Biochemistry (5th Edition) (2002)

Doublecortin-expressing cells are present in layer II across the adult guinea pig cerebral cortex: partial colocalization with mature interneuron markers.

Kun Xiong et al.

Experimental neurology, 211(1), 271-282 (2008-04-02)

Doublecortin-immunoreactive (DCX+) cells were detected across the allo- and neo-cortical regions in the adult guinea pig cerebrum, localized to layer II specifically at its border with layer I. The density of labeled cells declined with age, whereas no apparent apoptotic

Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.

Sofi Eriksson et al.

Nature communications, 6, 6479-6479 (2015-03-21)

Across phyla, reduced nicotinamide adenine dinucleotide phosphate (NADPH) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting fundamental housekeeping and antioxidant pathways. Here we show that a third, NADPH-independent pathway can bypass the need for

Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups.

Yan Cai et al.

Experimental neurology, 216(2), 342-356 (2009-01-27)

DCX-immunoreactive (DCX+) cells occur in the piriform cortex in adult mice and rats, but also in the neocortex in adult guinea pigs and rabbits. Here we describe these cells in adult domestic cats and primates. In cats and rhesus monkeys

Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions.

Minfeng Ying et al.

Redox biology, 46, 102065-102065 (2021-07-23)

Although glucose, through pentose phosphate pathway (PPP), is the main source to generate NADPH, solid tumors are often deprived of glucose, hence alternative metabolic pathways to maintain NADPH homeostasis in cancer cells are required. Here, we report that lactate and

Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.

Allen T Hopper et al.

Journal of medicinal chemistry, 62(3), 1562-1576 (2019-01-10)

A safer treatment for toxoplasmosis would be achieved by improving the selectivity and potency of dihydrofolate reductase (DHFR) inhibitors, such as pyrimethamine (1), for Toxoplasma gondii DHFR ( TgDHFR) relative to human DHFR ( hDHFR). We previously reported on the

Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors.

Joshua E Lewis et al.

Cell systems, 12(1), 68-81 (2021-01-22)

Redox cofactor production is integral toward antioxidant generation, clearance of reactive oxygen species, and overall tumor response to ionizing radiation treatment. To identify systems-level alterations in redox metabolism that confer resistance to radiation therapy, we developed a bioinformatics pipeline for

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