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Sara N Mitchell et al.
PloS one, 9(3), e92662-e92662 (2014-03-29)
The development of resistance to insecticides has become a classic exemplar of evolution occurring within human time scales. In this study we demonstrate how resistance to DDT in the major African malaria vector Anopheles gambiae is a result of both
Bob Glaudemans et al.
The Journal of clinical investigation, 119(4), 936-942 (2009-03-25)
Primary hypomagnesemia is a heterogeneous group of disorders characterized by renal or intestinal magnesium (Mg2+) wasting, resulting in tetany, cardiac arrhythmias, and seizures. The kidney plays an essential role in maintaining blood Mg2+ levels, with a prominent function for the
Santosh Gupta et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(5), 1346-1357 (2016-09-08)
Purpose: Beyond enumeration, circulating tumor cells (CTCs) can provide genetic information from metastatic cancer that may facilitate a greater understanding of tumor biology and enable a precision medicine approach.Experimental Design: CTCs and paired leukocytes from men with metastatic castration-resistant prostate
Ewa Monika Waszkiewicz et al.
Animals : an open access journal from MDPI, 10(5) (2020-05-30)
Porcine myometrium possesses steroidogenic activity but its regulation is not well understood. It was hypothesized that the regulators of myometrial steroidogenesis are insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF), which were found to modulate the steroidogenic activity
Gopalakrishnan Mohan Valiathan et al.
Asian Pacific journal of cancer prevention : APJCP, 13(12), 6155-6157 (2012-01-01)
Mutations in the MAPK (Mitogen Activated Protein Kinase) signaling pathway - EGFR/Ras/ RAF/MEK have been associated with the development of several carcinomas. ERK2, a downstream target of the MAPK pathway and a founding member of the MAPK family is activated
Yan Xing et al.
Biology open, 9(4) (2020-03-07)
Infants with intrauterine growth retardation (IUGR) have a high risk of developing bronchial asthma in childhood, but the underlying mechanisms remain unclear. This study aimed to disclose the role of vascular non-inflammatory molecule 1 (vannin-1, encoded by the Vnn1 gene)
Lihong Chen et al.
Immunology and cell biology, 97(8), 714-725 (2019-04-13)
Acute rejection is the major determinant for the long-term survival of donor liver after liver transplantation (LT). The aim of this study was to examine the therapeutic potential of interleukin (IL)-10-FasL-overexpressing immature dendritic cells (imDCs) to induce local immunosuppression in
Diana Guallar et al.
Cell stem cell, 27(2), 300-314 (2020-05-13)
RNA editing of adenosine to inosine (A to I) is catalyzed by ADAR1 and dramatically alters the cellular transcriptome, although its functional roles in somatic cell reprogramming are largely unexplored. Here, we show that loss of ADAR1-mediated A-to-I editing disrupts
Deepak Chandrasekharan et al.
European journal of dentistry, 8(4), 528-532 (2014-12-17)
Mutations in exon 1 of ARHGAP29, a RhoA specific GTPase have been identified in North American and Filipino subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate. Since the genetic status of ARHGAP29 in Indian subjects
Célia Deville et al.
Cell reports, 27(12), 3433-3446 (2019-06-20)
AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops. Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism.
A Katrin Helfer-Hungerbuehler et al.
Molecular biology international, 2013, 587680-587680 (2013-06-06)
Quantitative real-time PCR (qPCR) is broadly used to detect and quantify nucleic acid targets. In order to determine cell copy number and genome equivalents, a suitable reference gene that is present in a defined number in the genome is needed
Thirupambaram Natarajasundaram Uma Maheswari et al.
Brazilian oral research, 34, e002-e002 (2020-02-13)
Oral potentially malignant disorders (OPMD) possess significant chances of malignancy conversion. In order to develop an early diagnostic tool, the present study evaluated the expression of miRNA-21 and 31 as salivary markers. The case-control study was carried out in 36
Sheliang Wang et al.
Bio-protocol, 8(5), e2755-e2755 (2018-03-05)
Boron (B) is essential for plant growth and taken up by plant roots as boric acid. Under B limitation, B uptake and translocation in plants are dependent on the boric acid channels located in the plasma membrane. Xenopus leavis oocyte
Anil Melath et al.
Asian Pacific journal of cancer prevention : APJCP, 14(11), 6803-6806 (2014-01-01)
Interferon regulatory factor 6 (IRF6) is a transcription factor with distinct and conserved DNA and protein binding domains. Mutations within the protein binding domain have been significantly observed in subjects with orofacial cleft relative to healthy controls. In addition, recent
Heterozygous Ile453Val codon mutation in exon 7, homozygous single nucleotide polymorphisms in intron 2 and 5 of cathepsin C are associated with Haim-Munk syndrome.
Aswath N
European journal of dentistry, 8(1), 79-84 (2014)
Daniel Pérez-Mendoza et al.
Journal of bacteriology, 188(21), 7488-7499 (2006-08-19)
Genetic and biochemical characterization of TraA, the relaxase of symbiotic plasmid pRetCFN42d from Rhizobium etli, is described. After purifying the relaxase domain (N265TraA), we demonstrated nic binding and cleavage activity in vitro and thus characterized for the first time the
Anjanirina Rahantamalala et al.
BMC plant biology, 10, 130-130 (2010-06-30)
Cinnamoyl CoA reductase (CCR) and cinnamyl alcohol dehydrogenase (CAD) catalyze the final steps in the biosynthesis of monolignols, the monomeric units of the phenolic lignin polymers which confer rigidity, imperviousness and resistance to biodegradation to cell walls. We have previously
Lakshmi Prabha Das et al.
Asian Pacific journal of cancer prevention : APJCP, 18(10), 2679-2681 (2017-10-27)
Background: The ARID2 gene, encoding a sub unit of the chromatin remodelling complex, has a possible tumour suppressor function and has been found to be frequently mutated in various tumours, including gingivo buccal oral squamous cell carcinomas. The present study
Victoria L Halperin Kuhns et al.
American journal of physiology. Renal physiology, 317(1), F172-F186 (2019-05-02)
The kidney uses specialized G protein-coupled receptors, including olfactory receptors (ORs), to act as sensors of molecules and metabolites. In the present study, we cloned and studied seven renal ORs, which we previously found to be expressed in the murine
Srinivas Gopinath Kodaganur et al.
Molecular vision, 19, 1694-1706 (2013-08-08)
Congenital hereditary endothelial dystrophy 2 (CHED2) is an autosomal recessive disorder caused by mutations in the solute carrier family 4, sodium borate transporter, member 11 (SLC4A11) gene. The purpose of this study was to identify the genetic cause of CHED2
Riluwan Siddique et al.
BDJ open, 6, 8-8 (2020-06-19)
To compare the antibacterial effectiveness of three rotary file systems i.e., ProTaper Next, ProTaper Gold and XP-endo Shaper in root canals of teeth with asymptomatic apical periodontitis by using the real-time polymerase chain reaction. Root canals from single or multi-rooted
Wenfei Zhang et al.
Bosnian journal of basic medical sciences, 20(1), 44-55 (2019-06-20)
Major depressive disorder (MDD) is one of the most common psychiatric disorders characterized by major depressive episodes. Although great efforts have been made to develop antidepressant drugs that target the monoaminergic system, these drugs are effective in only approximately 50%
Kanchana Sukumar et al.
Photodiagnosis and photodynamic therapy, 31, 101949-101949 (2020-08-10)
The clinical efficacy of multiple applications of Photodynamic therapy (PDT) needs to be better investigated for the management of chronic periodontitis subjects. The aim of this study was to evaluate the clinical and antimicrobial efficacy of multiple application of PDT
Senthilnathan Rajendran et al.
Asian Pacific journal of cancer prevention : APJCP, 14(2), 1073-1075 (2013-04-30)
In normal cells, activated epidermal growth factor receptor (EGFR) molecules are subjected to ubiquitination-mediated proteasome degradation pathway by c-Cbl, an ubiquitin ligase that checks uncontrolled proliferation. Hence expression of wild type c-Cbl molecule is essential to keep this degradation machinery
Luqman Shah et al.
RSC advances, 9(8), 4258-4267 (2019-02-01)
Glutaminase (GLS) is an enzyme essential for amino acid metabolism; in particular, it acts as a catalyst in glutaminolysis, a reaction exploited by the malignant cells to meet the nutrient requirements for their accelerated growth and proliferation. Via regulating the
Attempts to Construct an Enlarged pUC19 via Insertion of HindIII-digested Coliphage ? DNA
Muhamed Amirie
Journal of Experimental Microbiology and Immunology, 18, 96-101 (2014)
Benoy Jacob et al.
International journal of dentistry, 2021, 5563945-5563945 (2021-09-14)
The aim of the present study was to compare the antibacterial effectiveness of chlorhexidine and PPE oral rinse on S. mutans, Lactobacilli, and Veillonella, in clinical salivary samples of patients with advanced stages of dental caries at baseline and two
K Michael Lee et al.
Yeast (Chichester, England), 22(6), 431-440 (2005-04-26)
The Saccharomyces cerevisiae ADH2 promoter (P(ADH2)) is repressed several hundred-fold in the presence of glucose; transcription is initiated once the glucose in the medium is exhausted. The promoter can thus be utilized for effective regulation of recombinant gene expression in
Nalini Aswath et al.
European journal of dentistry, 8(1), 79-84 (2014-06-27)
In the present study, we have investigated the genetic status of CTSC gene in a HMS subject, who along with her parents belonged to non-Jewish South Indian Dravidian community. Genomic deoxyribonucleic acid isolated from the peripheral blood of the subject
Puja Yadav et al.
Nucleic acids research, 44(2), 718-729 (2015-11-04)
Highly transcribed guanine-run containing sequences, in Saccharomyces cerevisiae, become unstable when topoisomerase I (Top1) is disrupted. Topological changes, such as the formation of extended RNA:DNA hybrids or R-loops or non-canonical DNA structures including G-quadruplexes has been proposed as the major
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