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Mohamad Abduljalil et al.
Photobiomodulation, photomedicine, and laser surgery, 38(2), 84-90 (2019-07-25)
Objective: This study was designed to evaluate the effects of an Erbium, Chromium:Yttrium-Scandium-Gallium-Garnet (Er,Cr:YSGG) laser on removing the filling
Ana Filipa Chasqueira et al.
The journal of adhesive dentistry, 22(3), 255-264 (2020-05-22)
To evaluate the influence of application protocol on the shear bond strength (SBS) and nanoleakage of simplified adhesives over 18 months. 810 dentin slices were obtained from 405 caries-free human molars. They were randomly assigned to 54 experimental groups resulting
Nafsika Poulia et al.
The European journal of neuroscience, 52(1), 2681-2693 (2019-10-19)
Cannabinoid administration during adolescence affects various physiological processes, such as motor and affective response, cognitive-related functions and modulates neurotransmitter activity. Literature remains scant concerning the parallel examination of the effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol (Δ9 -THC) on the
Uddin Md Nazim et al.
International journal of oncology, 56(5), 1152-1161 (2020-04-23)
Prostate cancer (PCa) is a common type of cancer among males, with a relatively high mortality rate. Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL), a member of the tumor necrosis factor (TNF) family, initiates the apoptosis of certain cancer cells. Neferine
Hongdan Ma et al.
Molecules (Basel, Switzerland), 23(7) (2018-07-19)
Paeonol exhibits a wide range of pharmacological activities, such as anti-inflammatory, antidiabetic as well as pain-relieving activities. However, its intrinsic properties, such as low water solubility, poor stability and low oral bioavailability, restrict its clinical application. The current study aimed
Hiroki Mano et al.
The Journal of steroid biochemistry and molecular biology, 167, 61-66 (2016-11-20)
Hereditary vitamin D-resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR) gene. Arg274 located in the ligand binding domain (LBD) of VDR is responsible for anchoring 1α,25-dihydroxyvitamin D3 (1α,25(OH)
K M A Zinnah et al.
Anticancer research, 39(12), 6621-6633 (2019-12-08)
The antidepressant duloxetine is known as a serotonin-norepinephrine reuptake inhibitor, used for treating depression and anxiety. TRAIL selectively induces cell death in a variety of tumor cells by binding to its membrane death receptor (DR). The aim of the study
Li Li et al.
The Journal of clinical investigation, 128(10), 4525-4542 (2018-09-18)
The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote breast cancer risk. Here, we
Tomomi Sanagi et al.
Frontiers in cellular neuroscience, 13, 344-344 (2019-08-17)
Autism spectrum disorder (ASD) is one of the most widespread neurodevelopmental disorders, characterized by impairment in social interactions, and restricted stereotyped behaviors. Using immunohistochemistry and positron emission tomography (PET), several studies have provided evidence of the existence of activated microglia
Ryan du Preez et al.
Nutrients, 12(4) (2020-04-02)
Saskatoon berry (Amelanchier alnifolia) is a potential functional food containing anthocyanins and flavonols, as well as ellagitannins and phenolic acids. We have determined the potential therapeutic effects of Saskatoon berry in diet-induced metabolic syndrome. Nine- to ten-week-old male Wistar rats
María Elena Quintanilla et al.
Frontiers in behavioral neuroscience, 14, 122-122 (2020-08-28)
Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in the inhibition of: (i) oxidative stress; (ii) neuroinflammation; and
S Alex Marshall et al.
Frontiers in neuroanatomy, 14, 52-52 (2020-09-10)
Microglia are dynamic cells that have roles in neuronal plasticity as well as in recovery responses following neuronal injury. Although many hypothesize that hyperactivation of microglia contributes to alcohol-induced neuropathology, in other neurodegenerative conditions disruption of normal microglial processes also
Jinhui Li et al.
Materials (Basel, Switzerland), 11(5) (2018-05-05)
Thin BaTiO₃ (BT) coating layers are required in various multilayer ceramic technologies, and fine nanosized BT particles with good dispersion in solution are essential for this coating process. In this work, cubic and tetragonal phase monodispersed BT nanoparticles—which were referred
Xin Ding et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(1), 297-305 (2016-10-05)
Au@Ag nanoparticles (NPs) were recently found to display giant two-photon photoluminescence (2PPL) enhancement, with an enhancement factor up to 815 fold upon aggregate formation. Based on this finding, two-photon imaging of bacteria by Au@Ag NPs under near-infrared (NIR) femtosecond laser
Fatma Trabelsi et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 69(6), 349-358 (2017-03-07)
This study investigates the cytotoxicity and the genotoxicity induced by arsenic trioxide As
Adrien Pasquier et al.
Nature communications, 10(1), 3312-3312 (2019-07-28)
Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress markedly enhances macroautophagy-independent lysosomal degradation
Saurabh Bhattacharya et al.
Cell reports, 27(2), 334-342 (2019-04-02)
We have previously described the existence of membranous nanotubes, bridging adjacent bacteria, facilitating intercellular trafficking of nutrients, cytoplasmic proteins, and even plasmids, yet components enabling their biogenesis remain elusive. Here we reveal the identity of a molecular apparatus providing a
Jeong-Min Hong et al.
The international journal of biochemistry & cell biology, 119, 105680-105680 (2019-12-24)
It is usually accepted that prion proteins induce apoptosis in nerve cells. However, the mechanisms of PrPSc-neurotoxicity are not completely clear. Calcineurin is a Ca2+/calmodulin-dependent phosphatase. It activates autophagy, and may represent a link between deregulation of Ca2+ homeostasis and
Ligen Chen et al.
International journal of biological macromolecules, 112, 1055-1061 (2018-02-10)
Sulfated polysaccharides from marine algae exhibit various bioactivities with potential benefits for human health and well-being. In this study, the in vitro digestibility and fermentability of polysaccharides from the brown seaweed Ascophyllum nodosum (AnPs) were examined, and the effects of
Irene Veneziani et al.
Cancer immunology research, 9(2), 170-183 (2020-12-12)
In this study, we explored whether Nutlin-3a, a well-known, nontoxic small-molecule compound antagonizing the inhibitory interaction of MDM2 with the tumor suppressor p53, may restore ligands for natural killer (NK) cell-activating receptors (NK-AR) on neuroblastoma cells to enhance the NK
Uddin Md Nazim et al.
International journal of molecular medicine, 43(2), 701-708 (2018-11-30)
Tumor necrosis factor (TNF)‑related apoptosis‑inducing ligand (TRAIL) is a member of the TNF superfamily and is an antitumor drug that induces apoptosis in tumor cells with minimal or no effects on normal cells. Here, it is demonstrated that 6‑shogaol (6‑sho)
Romy Mueller et al.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 76, 236-242 (2020-07-31)
Tumor-associated antigens are a promising target of immunotherapy approaches for cancer treatments but rely on sufficient expression of the target antigen. This study investigates the expression of the carcinoembryonic antigen (CEA) on the surface of irradiated lung cancer cells in
Hui Peng et al.
Alcohol (Fayetteville, N.Y.), 62, 29-40 (2017-08-02)
Microglia activation and neuroinflammation are common features of neurodegenerative conditions, including alcohol use disorders (AUDs). When activated, microglia span a continuum of diverse phenotypes ranging from classically activated, pro-inflammatory (M1) microglia/macrophages to alternatively activated, growth-promoting (M2) microglia/macrophages. Identifying microglia phenotypes
Chandrasekaran Karthikeyan et al.
Journal of colloid and interface science, 554, 9-18 (2019-07-03)
The study explores biogenic nitrogen doped carbon microspheres derived from resorcinol, formaldehyde (BNCMs), for battery application. Ureolytic bacteria were used to produce biogenic ammonia in the form of ammonium carbonate and ammonium bicarbonate. Copolymerization of resorcinol, formaldehyde and biogenic ammonia
Sunil Kumar Yadava et al.
Colloids and surfaces. B, Biointerfaces, 190, 110927-110927 (2020-03-15)
Lipid Nanocapsules (LNCs) have been used for drug delivery in cells and animal models for several years. LNCs with unique physicochemical properties for favorable biorecognition, biocompatibility and stimuli responsive (pH/temperature etc.) properties i.e., smart-LNCs, are most promising for future nanomedicine
Mariela Giacchino et al.
Journal of molecular histology, 49(3), 245-255 (2018-02-23)
The South American hystricognathe Lagostomus maximus is a fossorial rodent whose females show unique reproductive characteristics. They have a 155-day long gestation, show massive polyovulation and a selective process of embryonic resorption in the first half of gestation. In order
Qiao Jiang et al.
Current pharmaceutical biotechnology, 19(5), 428-437 (2018-06-30)
The aim of this study was to investigate anti-apoptotic effects of luteolin on angiotensin II-stimulated murine peritoneal macrophages and to explore its mechanisms. The viability and cytotoxicity of murine peritoneal macrophages were assessed using the Cell Counting Kit-8 assay and
Madlen Hubert et al.
eLife, 9 (2020-05-05)
Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids. However, the influence of lipid composition on caveolae surface stability is not well described or understood.
Gregor Žerjav et al.
Nanoscale, 9(13), 4578-4592 (2017-03-23)
The as-synthesized TiO
Vianni Chopra et al.
ACS biomaterials science & engineering, 6(12), 6710-6725 (2020-12-16)
Repair of critical size bone defects is a clinical challenge that usually necessitates the use of bone substitutes. For successful bone repair, the substitute should possess osteoconductive, osteoinductive, and vascularization potential, with the ability to control post-implantation infection serving as
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