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Ray M Kaplan et al.
Journal of the American Veterinary Medical Association, 225(6), 903-910 (2004-10-16)
To determine prevalence of anthelmintic resistance in cyathostome nematodes of horses in the southern United States. Cross-sectional study. 786 horses on 44 farms and stables in Georgia, South Carolina, Florida, Kentucky, and Louisiana. Fecal egg count (FEC) reduction tests were
C Gokbulut et al.
Research in veterinary science, 72(1), 11-15 (2002-05-11)
Oxibendazole (OBZ) was administered to eight horses at an oral dose of 10 mg kg(-1) bodyweight each. Parent OBZ could only be detected in plasma at the 0.5 and 1.0 hours post administration sampling times and the mean maximum plasma
Patricia E Pensel et al.
Acta tropica, 152, 185-194 (2015-09-28)
Therapeutic failures attributed to medical management of cystic echinococcosis (CE) with albendazole (ABZ) have been primarily linked to the poor drug absorption rate resulting in low drug level in plasma and hydatid cysts. Lipid nanocapsules (LNCs) represent nanocarriers designed to
Ceballos Laura et al.
Acta tropica, 148, 89-96 (2015-04-29)
The current chemotherapy of cystic echinococcosis (CE) is mainly based on the use of albendazole, and the results have been shown to be highly variable. Thus, new and more efficient treatment options are urgently needed. The goals of the current
E T Lyons et al.
Veterinary parasitology, 52(3-4), 271-277 (1994-04-01)
Studies in a band of ponies harboring Population S benzimidazole-resistant small strongyles were initiated in 1974 and have continued for 18 years. Treatment (bimonthly) was with cambendazole for the first 4 years and with oxibendazole (OBZ) for the next 14
R P Herd et al.
Veterinary parasitology, 48(1-4), 229-240 (1993-06-01)
Environmental consequences of treating horses with recommended dosages of ivermectin paste were studied in two controlled experiments with 29 horses in Ohio. In 1988, dung dispersal rates were measured by changes in dry weight over time of 48 copromes (300
F F Franssen et al.
Antimicrobial agents and chemotherapy, 39(6), 1265-1268 (1995-06-01)
In the light of the increased incidence of human Encephalitozoon infections and the absence of an established treatment protocol, a simple in vitro testing method to compare activities of drugs against Encephalitozoon cuniculi was developed. With this in vitro method
M R Chapman et al.
The Journal of parasitology, 88(4), 678-683 (2002-08-29)
The development of acquired resistance to cyathostome challenge after 1 season's exposure to a cyathostome-contaminated pasture was investigated using 17 parasite-naive ponies, which were 2-3 yr of age. These were divided into 3 groups: 1 to graze a cyathostome-contaminated pasture
C R Reinemeyer et al.
Journal of the American Veterinary Medical Association, 206(11), 1710-1715 (1995-06-01)
Forty 11- to 12-week-old helminth-naive Beagles were categorized by sex and weight and randomly assigned to 4 treatment groups (group 1, ivermectin/pyrantel pamoate; group 2, milbemycin oxime; group 3, untreated control; group 4, diethylcarbamazine/oxibendazole). Each pup was inoculated PO with
Eugene T Lyons et al.
Parasitology research, 109(4), 1193-1197 (2011-04-19)
The activity of three anthelmintics (fenbendazole-FBZ; oxibendazole-OBZ; and pyrantel pamoate-PRT) was ascertained against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010) in field tests. A total of 316 foals were treated, and 168 (53.2%)
Eugene Lyons
Parasitology research, 91(5), 407-411 (2003-10-08)
Population-S small strongyles have been studied since 1974 in central Kentucky in a closed Shetland pony breeding herd. The ponies were treated approximately every 8 weeks with cambendazole (1974-1978), oxibendazole (OBZ) (1978-1992), or pyrantel pamoate (PRT) (1992-1999). Small strongyles in
E T Lyons et al.
American journal of veterinary research, 54(3), 406-410 (1993-03-01)
Antiparasitic activity of several compounds was evaluated over a long period (about 25 years) in the same flock of sheep. Haemonchus contortus was of special interest, including its relation to drug resistance, especially to thiabendazole and other benzimidazoles, in addition
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
S E Bunch
The Veterinary clinics of North America. Small animal practice, 23(3), 659-670 (1993-05-01)
Historical aspects, mechanisms, and treatment of hepatotoxicity associated with pharmacologic agents in dogs and cats are discussed. All agents that cause clinically relevant drug-induced hepatotoxicity have been reviewed within the last 5 years; therefore, only selected drugs that more recently
Donato Traversa et al.
Experimental parasitology, 121(1), 92-95 (2008-10-28)
Cyathostome populations in horses on two farms located in central Italy with a history of fenbendazole (FBZ) resistance were investigated with the Faecal Egg Count Reduction Test to evaluate the susceptibility to oxibendazole and moxidectin. Faecal eggs were collected pre-
R P Herd et al.
Veterinary parasitology, 55(1-2), 93-104 (1994-10-01)
Studies on a Thoroughbred breeding farm in Ohio were done to: (1) compare the effects of daily administration of pyrantel tartrate feed pellets with monthly administration of a pyrantel pamoate paste to yearling horses (21 January-3 September); (2) assess the
Raquel Gonzalo-Lumbreras et al.
Journal of separation science, 38(14), 2394-2402 (2015-05-07)
The behavior of 15 benzimidazoles, including their main metabolites, using several C18 columns with standard or narrow-bore diameters and different particle size and type were evaluated. These commercial columns were selected because their differences could affect separation of benzimidazoles, and
G Virkel et al.
European journal of drug metabolism and pharmacokinetics, 24(1), 31-37 (1999-07-21)
The in vitro biotransformation of the anthelmintic compounds, netobimin (NTB) pro-drug and albendazole sulphoxide (ABZSO), by ruminal fluid obtained from sheep fed either hay or concentrate-based diets was investigated. No metabolic activity was observed in boiled samples of ruminal fluid
M R Chapman et al.
Veterinary parasitology, 66(3-4), 205-212 (1996-11-15)
Three fecal egg count reduction assays (FECR) and one critical trial were performed to determine the efficacy of pyrantel pamoate (PP) at 6.6 mg base kg-1 on a well managed stud farm in Louisiana where a loss of efficacy was
D W Gottschall et al.
Veterinary parasitology, 64(1-2), 83-93 (1996-08-01)
Groups of male swine were administered a single oral dose of 14C-oxibendazole in a gelatin capsule at a level of 15 mg kg-1 bodyweight and killed after 10 h, 24 h, and 7 days withdrawal. Combustion analysis indicated that liver
P A Overgaauw et al.
The Veterinary quarterly, 20(2), 69-72 (1998-05-01)
The anthelmintic efficacy and safety of the oxibendazole component in a combination oxibendazole-niclosamide paste were investigated in dogs and cats and in litters of pups with naturally acquired nematode infections. A single dose of 15 mg oxibendazole/kg body weight given
P F Rolfe et al.
Australian veterinary journal, 76(5), 332-334 (1998-06-19)
To compare the efficacy of moxidectin to ivermectin, oxibendazole and morantel against some gastrointestinal nematodes in horses. Faecal egg count reduction after treatment. A farm was selected where the population of small strongyles in horses was known to be resistant
S C Tolliver et al.
American journal of veterinary research, 54(6), 908-913 (1993-06-01)
Critical tests were conducted in horses (n = 11) with naturally acquired infections of benzimidazole (BZ)-resistant population-B small strongyles in 1989 and 1990. Anthelmintics administered were thiabendazole (44 mg/kg of body weight, n = 4), oxibendazole (10 mg/kg, n =
G W Lubega et al.
Biochemical pharmacology, 47(9), 1705-1715 (1994-04-29)
The role of beta-tubulin genes in benzimidazole (BZ) resistance was investigated using one susceptible (S) and two resistant (Rt and Rc) strains of Haemonchus contortus. The Rt strain was isolated from the field on the basis of thiabendazole resistance. The
Fabien Vincent et al.
Bioorganic & medicinal chemistry letters, 19(23), 6793-6796 (2009-10-24)
The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described
G W Lubega et al.
Biochemical pharmacology, 41(1), 93-101 (1991-01-01)
The low- and high-affinity binding of tritiated benzimidazole anthelmintics (mebendazole and oxibendazole) to tubulin-containing supernatants derived from unembryonated eggs, third stage larvae or adult worms of thiabendazole-susceptible and -resistant strains of Haemonchus contortus were examined and compared. The displacement of
A field evaluation of three methods of administration of anthelminthics to horses.
C Uhlinger et al.
Equine veterinary journal, 24(6), 487-488 (1992-11-01)
J A DiPietro et al.
Veterinary parasitology, 48(1-4), 241-246 (1993-06-01)
A study was carried out to assess the feasibility of determining the grazing patterns of horses bimonthly via aerial survey and standard cartographic techniques. The grazing patterns in pastures with equivalent stocking rates of horses treated bimonthly with 200 micrograms
E T Lyons et al.
Parasitology research, 103(2), 287-291 (2008-05-13)
Horse foals on five farms in Central Kentucky were used in field studies in 2007 evaluating activity of paste formulations of four compounds (fenbendazole-FBZ, ivermectin-IVM, oxibendazole-OBZ, and pyrantel pamoate-PRT) against internal parasites with emphasis on ascarids (Parascaris equorum). It has
Sean Ekins et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(12), 2302-2308 (2010-09-17)
Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify compounds
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