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Daniel Hernandez-Patlan et al.
Animals : an open access journal from MDPI, 9(4) (2019-04-25)
Two experiments were conducted to evaluate the effect of the prophylactic or therapeutic administration of a 0.1% mixture containing ascorbic acid and a solid dispersion of curcumin with polyvinylpyrrolidone and boric acid (AA-CUR/PVP-BA) against Salmonella Enteritidis (S. Enteritidis) in broiler
Giovanni Appendino et al.
Journal of medicinal chemistry, 49(7), 2333-2338 (2006-03-31)
The three amide oxyhomologues of the endolipids N-arachidonoylethanolamine (anandamide, AEA, 1a), N-oleoylethanolamine (OEA, 2a), and N-palmitoylethanolamine (PEA, 3a) have been prepared in a chemoselective way, capitalizing on the easy availability of O-[2-(triisopropylsilyoxy)ethyl]hydroxylamine (6) and the surprising complementary selectivity observed in
Laëtitia Merle et al.
Psychoneuroendocrinology, 104, 249-258 (2019-03-25)
The influence of maternal diet on progeny's metabolic health has been thoroughly investigated, but the impact on sensory systems remains unexplored. Neurons of the olfactory system start to develop during the embryonic life and carry on their maturation after birth.
Myrna Déciga-Campos et al.
Drug development research, 76(5), 228-234 (2015-07-29)
Preclinical Research The objective of this study was to evaluate the pharmacological antihyperalgesic interaction between N-palmitoylethanolamide (PEA) and acetaminophen in diabetic rats using the formalin paw test. Streptozotocin (STZ)-induced diabetic rats received subcutaneous injections in the paw of PEA alone
Alistair Mallard et al.
Nutrients, 12(3) (2020-02-29)
The aim of this study was to evaluate the effect of palmitoylethanolamide (PEA), a cannabimimetic compound and lipid messenger, on recovery from muscle damaging exercise. Twenty-eight healthy young male participants attended the laboratory four times on subsequent days. In the
Alessandra Misto et al.
Cell metabolism, 29(1), 91-102 (2018-10-16)
The conversion of lipolysis-derived fatty acids into ketone bodies (ketogenesis) is a crucial metabolic adaptation to prolonged periods of food scarcity. The process occurs primarily in liver mitochondria and is initiated by fatty-acid-mediated stimulation of the ligand-operated transcription factor, peroxisome
C Cremon et al.
Alimentary pharmacology & therapeutics, 45(7), 909-922 (2017-02-07)
Intestinal immune activation is involved in irritable bowel syndrome (IBS) pathophysiology. While most dietary approaches in IBS involve food avoidance, there are fewer indications on food supplementation. Palmithoylethanolamide, structurally related to the endocannabinoid anandamide, and polydatin are dietary compounds which
D Luque-Córdoba et al.
Talanta, 185, 602-610 (2018-05-16)
Endocannabinoids are lipids with a key role in physiological processes such as the immune response or the metabolism. This involvement explains their association to pathologies such as cancer, obesity or multiple sclerosis. The determination of endocannabinoids constitutes a challenge for
Bright N Okine et al.
British journal of pharmacology, 167(3), 627-640 (2012-05-19)
Elevating levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is a major focus of pain research, purported to be a safer approach devoid of cannabinoid receptor-mediated side effects. Here, we have determined the effects of sustained pharmacological
Daniel G Couch et al.
Clinical science (London, England : 1979), 131(21), 2611-2626 (2017-09-29)
We sought to quantify the anti-inflammatory effects of two cannabinoid drugs, cannabidiol (CBD) and palmitoylethanolamide (PEA), in cultured cell lines and compared this effect with experimentally inflamed explant human colonic tissue. These effects were explored in acutely and chronically inflamed
Shigemi Yoshihara et al.
International archives of allergy and immunology, 138(1), 80-87 (2005-08-17)
Although neurogenic inflammation via the activation of C fibers in the airway must have an important role in the pathogenesis of asthma, their regulatory mechanism remains uncertain. The pharmacological profiles of endogenous cannabinoid receptor agonists on the activation of C
Whitney H Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14966-14971 (2012-08-23)
Fatty acid amide hydrolase (FAAH) knockout mice are prone to excess energy storage and adiposity, whereas mutations in FAAH are associated with obesity in humans. However, the molecular mechanism by which FAAH affects energy expenditure (EE) remains unknown. Here we
Rachel E Exler et al.
Experimental cell research, 340(2), 283-294 (2015-12-01)
Biomechanical insult contributes to many chronic pathological processes, yet the resulting influences on signal transduction mechanisms are poorly understood. The retina presents an excellent mechanotransduction model, as mechanical strain on sensitive astrocytes of the optic nerve head (ONH) is intimately
Kenneth J Broadley et al.
European journal of pharmacology, 818, 198-205 (2017-10-28)
Sympathomimetic and trace amines, including β-phenylethylamine (PEA) and amphetamine, increase blood pressure and constrict isolated blood vessels. By convention this is regarded as a sympathomimetic response, however, recent studies suggest trace amine-associated receptor (TAAR) involvement. There is also uncertainty whether
Ernesto Strobbe et al.
Investigative ophthalmology & visual science, 54(2), 968-973 (2013-01-12)
We assessed the effect of palmitoylethanolamide (PEA) on systemic endothelial function in ocular hypertensive patients (OH). We enrolled in this randomized, double-blind, placebo-controlled, crossover single-center study 40 never-treated OH patients and 40 healthy age-matched controls. At baseline, each participant underwent
Iryna A Khasabova et al.
Pharmacological research, 90, 67-75 (2014-10-12)
Cisplatin has been used effectively to treat a variety of cancers but its use is limited by the development of painful peripheral neuropathy. Because the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG) is anti-hyperalgesic in several preclinical models of chronic pain, the anti-hyperalgesic effect
Reiner Jumpertz et al.
The Journal of clinical endocrinology and metabolism, 96(3), 787-791 (2010-12-24)
Peripheral and central endocannabinoids and cognate acylethanolamides (AEs) may play important but distinct roles in regulating energy balance. We hypothesized that in humans central/peripheral endocannabinoids are differently associated with adiposity and energy expenditure and differ by race. We examined associations
Qingfu Zhu et al.
Analytica chimica acta, 978, 55-60 (2017-06-10)
Capillary electrophoresis (CE) is a powerful separation technique with advantages over HPLC in terms of separation efficiency, speed, and cost. However, CE suffers in poor reproducibility in quantitative chemical analysis, which is one of major drawbacks preventing its widespread use
Gregory G Martin et al.
Archives of biochemistry and biophysics, 650, 93-102 (2018-05-16)
Dysregulation of the hepatic endocannabinoid (EC) system and high fat diet (HFD) are associated with non-alcoholic fatty liver disease. Liver cytosol contains high levels of two novel endocannabinoid binding proteins-liver fatty acid binding protein (FABP1) and sterol carrier protein-2 (SCP-2).
E Wallin et al.
Acta anaesthesiologica Scandinavica, 62(9), 1237-1245 (2018-05-26)
Using cerebral oxygen venous saturation post-cardiac arrest (CA) is limited because of a small sample size and prior to establishment of target temperature management (TTM). We aimed to describe variations in jugular bulb oxygen saturation during intensive care in relation
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Hongxiang Ou et al.
Water environment research : a research publication of the Water Environment Federation, 89(4), 348-356 (2017-04-06)
Two kinds of hollow silica materials, namely H-SiS1 and H-SiS2, were synthesized using the yeast template method and the Pickering emulsion polymerization method, respectively. The adsorbents were synthesized to adsorb amoxicillin (AMX) from an aqueous environment. Characterization results indicated that
Petra Schneiderova et al.
Oncotarget, 8(41), 69408-69421 (2016-08-12)
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored. Using highly-sensitive Proximity Extension ImmunoAssay on 92 cancer biomarkers (Proseek Multiplex, Olink), enhanced serum levels of Adrenomedullin
Ying Tang et al.
Analytica chimica acta, 1031, 161-168 (2018-08-19)
A simple and sensitive quartz crystal microbalance (QCM) immunosensing platform was designed for the high-efficient detection of aflatoxin B1 (AFB1) in foodstuff. Initially, phenoxy-derived dextran molecule was immobilized on the surface of QCM gold substrate by using thiolated β-cyclodextrin based
D De Filippis et al.
CNS & neurological disorders drug targets, 12(1), 78-83 (2013-02-12)
Since its discovery palmitoylethanolamide was considered as an endogenous compound able to negatively modulate the inflammatory process. Its effects have been extensively investigated in in vitro, in vivo and in clinical studies. Notwithstanding some discrepancy, nowadays the efficacy of palmitoylethanolamide
Marta Valenza et al.
Frontiers in pharmacology, 10, 1656-1656 (2020-02-18)
Among the diverse cell types included in the general population named glia, astrocytes emerge as being the focus of a growing body of research aimed at characterizing their heterogeneous and complex functions. Alterations of both their morphology and activities have
Myrna Déciga-Campos et al.
European journal of pharmacology, 765, 68-74 (2015-08-25)
Pharmacological synergism has been used to obtain a higher efficacy using drug concentrations at which side effects are minimal. In this study, the pharmacological antinociceptive interaction between N-palmitoylethanolamide (PEA) and tramadol was investigated. The individual concentration-response curves for PEA (0.1-56.2
Emanuela Esposito et al.
PloS one, 7(8), e41880-e41880 (2012-08-23)
The biochemical and cellular changes that occur following treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). PD is characterized by the degeneration of dopaminergic nigrostriatal neurons, which results in disabling motor disturbances. Activation
Filippo Murina et al.
Journal of lower genital tract disease, 17(2), 111-116 (2013-01-25)
The study aimed to assess the effect of palmitoylethanolamide + transpolydatin combination in patients with vestibulodynia undergoing transcutaneous electrical nerve stimulation (TENS) therapy and to confirm the effectiveness of TENS also in a domiciliary protocol. The study is based on
Jun Mo et al.
Redox biology, 20, 75-86 (2018-10-09)
Oxidative stress and neuronal apoptosis have been demonstrated to be key features in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have indicated that Mas receptor activation initiates an anti-oxidative and anti-apoptotic role in the brain. However, whether
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