P0547

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S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response.

Deiziane V S Costa et al.

Frontiers in cellular and infection microbiology, 11, 739874-739874 (2021-09-28)

The involvement of the enteric nervous system, which is a source of S100B, in Clostridioides difficile (C. difficile) infection (CDI) is poorly understood although intestinal motility dysfunctions are known to occur following infection. Here, we investigated the role of S100B

Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium.

Lucia Acebey et al.

Planta medica, 76(4), 365-368 (2009-10-16)

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the

Reduced Antimony Accumulation in ARM58-Overexpressing Leishmania infantum.

Schafer C, et al.

Antimicrobial Agents and Chemotherapy, 58(3), 1565-1574 (2014)

Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium

Acebey L, et al.

Planta Medica, 76(04), 365-368 (2010)

Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

Lisa Sanderson et al.

PLoS neglected tropical diseases, 15(4), e0009276-e0009276 (2021-04-16)

Human African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system stage where the

Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds

Himmel HM

Journal of Pharmacological and Toxicological Methods, 68(1), 97-111 (2013)

Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro.

I J Reynolds et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(3), 970-975 (1992-03-01)

Acquired immunodeficiency syndrome (AIDS) is frequently associated with dementia. The wide spectrum of neurological abnormalities associated with this dementia may involve a neurotoxin that activates the NMDA subtype of glutamate receptor in neurons. We have found that the antimicrobial agent

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.

Mark R Davies et al.

Cell reports. Medicine, 1(5), 100076-100076 (2020-11-19)

There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in vitro data combined with computational models

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis.

Juan D Unciti-Broceta et al.

PLoS pathogens, 11(6), e1004942-e1004942 (2015-06-26)

African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized by high drug toxicity and increasing drug resistance mainly associated with loss-of-function mutations in the transporters involved in drug import. The introduction

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