A 51 year old male was admitted to our hospital with sudden consciousness disturbance, global aphagia and right hemiparesis. Magnetic resonance imaging (MRI) revealed fresh infarctions in the territory of the left middle cerebral artery, and MR angiography (MRA) showed
Environmental science and pollution research international, 27(2), 1941-1955 (2019-11-27)
In the present study, the occurrence of 40 pharmaceuticals belonging to several therapeutic groups was investigated for the first time in hospital effluent, wastewater treatment plant influent and effluent, and seawater in Mahdia, Tunisia. Forty-six samples were collected within a
[Antipyrine test in evaluating the detoxifying function of the liver in chronic diseases].
Journal of chromatography. A, 1624, 461239-461239 (2020-06-17)
Effect-directed analysis (EDA) is increasingly used in environmental monitoring to detect and identify key toxicants. High-performance thin-layer chromatography (HPTLC) has proven to be a very suitable fractionation technique for this purpose. However, HPTLC is limited in its separation efficiency. Thus
[The use of antipyrine for assessing the enzymatic activity of the liver monooxygenase system (a review of the literature)].
Toxicology and applied pharmacology, 276(1), 63-72 (2014-02-15)
Drinking water can be contaminated with pharmaceuticals. However, it is uncertain whether this contamination can be harmful for the liver, especially during obesity. Hence, the goal of our study was to determine whether chronic exposure to low doses of pharmaceuticals
The Science of the total environment, 631-632, 1360-1370 (2018-05-08)
The occurrence of pharmaceutical and steroid compounds in groundwater due to wastewater reuse has been reported and is of concern in tropical islands which primarily rely on groundwater. The objective of this study was to investigate the occurrence and removal
The aim of the present work was to develop a tool for the study of the enzyme activities relevant for the biotransformation of foreign compounds, their elimination and/or activation to toxic substances. The activity of an enzyme may be assessed
Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite
[Phenazone and its value as an indicator of metabolic efficiency of the liver].
A Wiela et al.
Postepy higieny i medycyny doswiadczalnej, 41(2), 136-151 (1987-03-01)
Analytical and bioanalytical chemistry, 409(26), 6141-6148 (2017-08-27)
A first of its kind, simple, rapid, and sensitive liquid chromatography mass spectrometry (LC-MS/MS) method was developed and validated for quantification of perindopril and perindoprilat in both human plasma and breast milk. The analytes and internal standards (phenazone and acetyl
Dynamic interactions among host factors that influence antipyrine metabolism: implications for the design and interpretation of studies on ethnic pharmacokinetic variations.
E S Vesell
Progress in clinical and biological research, 214, 425-451 (1986-01-01)
Factors influencing antipyrine elimination.
I H Stevenson
British journal of clinical pharmacology, 4(3), 261-265 (1977-06-01)
Pharmacokinetic studies indicate the diurnal rhythmicity of metabolism of many drugs. Partially it is a result of circadian variations of mixed function oxidase system, which metabolizes some drugs. The aim of the experiment was to evaluate the elimination rate phenacetin
The disposition of phenazone (antipyrine), a low extraction compound with low protein binding, is known to be altered in the presence of various types of hepatic dysfunction. As such, its pharmacokinetics may be useful in the objective characterisation of altered
Drug testing and analysis, 9(1), 96-105 (2016-02-26)
Amphetamine-type-stimulants (ATS) are the second most commonly used group of illicit drugs worldwide. However, in the last few years, new psychoactive substances (NPS) with stimulant effects have appeared on the illegal market, which are not detected with traditional analytical methods.
Farmakologiia i toksikologiia, 52(3), 95-101 (1989-05-01)
The presented findings indicate that the determination in the blood or saliva of antipyrine concentration kinetics as well as the profile and the ratio of the products of its hydroxylation in the urine makes it possible to evaluate under clinical
Application of high performance thin layer chromatography with densitometry for determination of active ingredients and preservatives in various pharmaceutical marketed formulations.
Kostik V, et al.
IOSR Journal of Pharmacy, 5(4), 7-15 (2015)
Measurement of blood flow with freely diffusible indicators as inert gases, antipyrine, labelled water and rubidium.
Neurosciences (Riyadh, Saudi Arabia), 19(2), 106-110 (2014-04-18)
To explore the effects of edaravone on the expression of matrix metalloproteinase-9 (MMP-9) posterior to cerebral hemorrhage, and to analyze the relationship between this expression and neurological deficit. A total of 160 basal ganglia hemorrhage patients enrolled in Dongfeng Hospital
[The antipyrine test: its 35-year history and prospects].
Farmakologiia i toksikologiia, 53(1), 74-77 (1990-01-01)
The data about the use of "antipyrine test" in clinical practice for studying the drug oxidation peculiarities are presented. The data characterize the main pharmacokinetic properties of antipyrine as a "metabolic marker" for quantitative estimation of the effects of inductors
Antipyrine as a model drug to study hepatic drug-metabolizing capacity.
Trypanosoma evansi is mechanically transmitted by biting flies and affects camels, equines, and other domestic and wild animals in which it causes a disease called surra. At least two types of Trypanosoma evansi circulate in Ethiopia: type A, which is
Riverbank filtration (RBF) is a reliable water purification technique that has proven to be suitable for the removal of organic micropollutants. Its removal efficiency and dependency on a variety of factors such as redox conditions, temperatures, geology, travel times, level
[Pharmacokinetics of antipyrine. Comparison between total, free and salivary concentrations].
D Vital Durand et al.
Therapie, 43(4), 263-266 (1988-06-01)
[Antipyrine elimination in acute toxic hepatitis in rats].