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Najate Benamer et al.
American journal of physiology. Heart and circulatory physiology, 304(9), H1231-H1239 (2013-02-26)
Cardiac metabolism remains altered for an extended period of time after myocardial infarction. Studies have shown fibroblasts from normal hearts express KATP channels in culture. It is unknown whether fibroblasts from infarcted hearts express KATP channels and whether these channels
R B Strutyns'kyĭ et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 58(1), 13-26 (2012-05-17)
In experiments on the anaesthetized dogs with modeling of experimental ischemia (90 min) and reperfusion (180 min) it was investigated the changes of biochemical processes in the different areas of heart (intact, risk and necrotic zone) during intragastric introduction of
Tian Yu et al.
Chinese medical journal, 124(24), 4205-4210 (2012-02-22)
Many studies have indicated that hyperpolarizing cardioplegia is responsible for myocardial preservation and researchers have suggested that the adenosine triphosphate-sensitive potassium channels (K(ATP)) were the end effectors of cardio-protection. But whether mitochondrial K(ATP) plays an important role in hyperpolarizing cardioplegia
Luke A Neill et al.
The Journal of surgical research, 191(2), 318-322 (2014-05-14)
Despite increasing interest in local microvascular alterations associated with inflammatory bowel disease (IBD), the potential contribution of a primary systemic vascular defect in the etiology of IBD is unknown. We compared reactivity of large diameter mesenteric arteries from segments affected
Won Sun Park et al.
American journal of physiology. Cell physiology, 303(2), C170-C178 (2012-05-11)
We investigated the impairment of ATP-sensitive K(+) (K(ATP)) channels in aortic smooth muscle cells (ASMCs) from isoproterenol-induced hypertrophied rabbits. The amplitude of K(ATP) channels induced by the K(ATP) channel opener pinacidil (10 μM) was greater in ASMCs from control than
Qunhua Bai et al.
Oncology reports, 28(4), 1376-1384 (2012-08-17)
The activation of ATP-sensitive potassium (KATP) channels in PC12 cells play a pivotal role in protection against the neurotoxic effect of rotenone. However, it remains unclear why rotenone seems to preferentially affect activation of KATP channels and if this could
R B Strutyns'kyĭ et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 11-16 (2013-05-30)
In experiments on the anaesthetized dogs the influence of a new fluorine-containing opener of ATP-sensitive potassium (K(ATP)) channels flocalin on the cardiohemodynamic of great animals in vivo was studied. Flocalin introduced intravenously in doses 0.01 - 1.5 mgs/kg. It is
Anthony M Pettinato et al.
Cell reports, 35(5), 109088-109088 (2021-05-06)
Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac troponin T.
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels
Bodiga S, et al.
Journal of Molecular and Cellular Cardiology, 46(6), 978-988 (2009)
Ioannis Eleftherianos et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(29), 12024-12029 (2011-07-02)
The effects of the cellular environment on innate immunity remain poorly characterized. Here, we show that in Drosophila ATP-sensitive potassium channels (K(ATP)) mediate resistance to a cardiotropic RNA virus, Flock House virus (FHV). FHV viral load in the heart rapidly
Ming-Ying Ling et al.
Atherosclerosis, 226(2), 348-355 (2012-12-12)
Ion channels expressed in monocytes/macrophages have been tightly attached to atherosclerosis by coupling cellular function with electrical activity. However, the function of ATP-sensitive potassium channels (K(ATP)) in atherosclerosis has not been investigated directly. This study was performed to explore its role
R B Strutyns'kyĭ et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(3), 3-9 (2013-08-21)
The influence of the new cardioprotector flocalin was investigated on the culture of rat's neonatal cardiomyocytes during anoxia-reoxygenation modelling. The mechanisms of apoptosis and necrosis were investigated under influence of ATP-sensitive potassium (K(ATP)) channels activation and in conditions of blocking
Kensuke Kataoka et al.
Frontiers in cell and developmental biology, 8, 307-307 (2020-07-17)
Tendons and ligaments are pivotal connective tissues that tightly connect muscle and bone. In this study, we developed a novel approach to generate tendon/ligament-like tissues with a hierarchical structure, by introducing the tendon/ligament-specific transcription factor Mohawk (MKX) into the mesenchymal
Li Nie et al.
Biochemical and biophysical research communications, 418(1), 74-80 (2012-01-19)
Prevailing data suggest that ATP-sensitive potassium channels (K(ATP)) contribute to a surprising resistance to hypoxia in mammalian embryos, thus we aimed to characterize the developmental changes of K(ATP) channels in murine fetal ventricular cardiomyocytes. Patch clamp was applied to investigate
Jun-Yih Chen et al.
Shock (Augusta, Ga.), 38(2), 203-212 (2012-05-12)
Alterations in the activity of vascular K channels are commonly associated with abnormalities in cerebral vascular function after subarachnoid hemorrhage (SAH). Subarachnoid hemorrhage-induced vasospasm remains incompletely understood; nevertheless, activation of K channels may be of benefit in relieving spastic constriction.
Olivier Bardou et al.
Biochimica et biophysica acta, 1818(7), 1682-1690 (2012-03-13)
Active Na+ absorption by alveolar ENaC is the main driving force of liquid clearance at birth and lung edema resorption in adulthood. We have demonstrated previously that long-term modulation of KvLQT1 and KATP K+ channel activities exerts sustained control in
Yi-Hsien Fang et al.
International journal of molecular sciences, 21(7) (2020-04-03)
Mature mammalian hearts possess very limited regenerative potential. The irreversible cardiomyocyte loss after heart injury can lead to heart failure and death. Pluripotent stem cells (PSCs) can differentiate into cardiomyocytes for cardiac repair, but there are obstacles to their clinical
L Gojković-Bukarica et al.
Fundamental & clinical pharmacology, 13(5), 527-534 (1999-10-16)
The present study was undertaken to examine the antivasoconstrictor effects of pinacidil and levcromakalim, two potassium channel openers (PCOs), on the isolated rabbit portal vein and to define the role for different subtypes of pre- and/or post-synaptic K+ channels in
Milla Mikkola et al.
Stem cells and development, 22(5), 707-716 (2012-10-31)
Lectins are carbohydrate-binding proteins, which occur ubiquitously in nature and are abundant in all living organisms from bacteria to mammals. They have several biological functions among which cell adhesion is well known and characterized. Based on the characterization of the
Asami Mori et al.
European journal of pharmacology, 669(1-3), 94-99 (2011-08-30)
The large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels modulate the retinal vascular tone, but question of whether the impairment of the channel function contributes to abnormalities of retinal circulation has not yet been completely elucidated. The purpose of this study was to
Dispersion of repolarization and arrhythmogenesis
Coronel R, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 6(4), 537-543 (2009)
Effects of pinacidil and calcium on isolated rat heart mitochondria.
S M Korotkov et al.
Doklady. Biochemistry and biophysics, 443, 113-117 (2012-05-09)
Jorge P López-Alonso et al.
Biochemistry, 51(45), 9211-9222 (2012-10-20)
ATP sensitive potassium (K(ATP)) channels are composed of four copies of a pore-forming inward rectifying potassium channel (Kir6.1 or Kir6.2) and four copies of a sulfonylurea receptor (SUR1, SUR2A, or SUR2B) that surround the pore. SUR proteins are members of
Adebowale Adebiyi et al.
American journal of physiology. Heart and circulatory physiology, 301(4), H1360-H1368 (2011-07-26)
Physiological functions of arterial smooth muscle cell ATP-sensitive K(+) (K(ATP)) channels, which are composed of inwardly rectifying K(+) channel 6.1 and sulfonylurea receptor (SUR)-2 subunits, during metabolic inhibition are unresolved. In the present study, we used a genetic model to
Wengeng Zhang et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 797-806 (2015-07-30)
Previous studies indicate that ion channels are mediators of bioelectricity promoting wound closure/regeneration in nonmammalian, lower vertebrate systems. The role of ion channels however in regeneration of wounds in mammalian systems that do not regenerate as adults is not yet
Jing Xu et al.
Journal of cardiovascular pharmacology, 59(6), 514-522 (2012-02-22)
We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine. Using hemorrhagic shock rats, the protective effects of
Charlotte Boydens et al.
The journal of sexual medicine, 14(4), 502-509 (2017-03-05)
Intracellular cyclic guanosine monophosphate (cGMP) concentrations are regulated by degradation enzymes (phosphodiesterases) and by active transport across the plasma membrane by multidrug resistance proteins (MRPs) 4 and 5. To evaluate the functional effect of MRP-4 inhibition and the role of MRP-4-mediated
Ivana Barbaric et al.
Cryobiology, 63(3), 298-305 (2011-10-27)
Human embryonic stem cells (hESCs) can be maintained as undifferentiated cells in vitro and induced to differentiate into a variety of somatic cell types. Thus, hESCs provide a source of differentiated cell types that could be used to replace diseased
Luciano Amarelle et al.
American journal of physiology. Lung cellular and molecular physiology, 316(6), L1094-L1106 (2019-03-21)
Cardiac glycosides (CGs) are used primarily for cardiac failure and have been reported to have other effects, including inhibition of viral replication. Here we set out to study mechanisms by which CGs as inhibitors of the Na-K-ATPase decrease influenza A
Yung-Kuo Lin et al.
Clinical science (London, England : 1979), 122(3), 121-132 (2011-09-02)
Ischaemia and reperfusion contribute to the genesis of AF (atrial fibrillation). PVs (pulmonary veins) and the atria are important foci for AF initiation and maintenance. However, the effect of ischaemia and reperfusion on PVs and the atria has not yet
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