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Conall M O'Seaghdha et al.
American journal of nephrology, 36(1), 68-77 (2012-06-23)
Cardiovascular risk factors are associated with the development of chronic kidney disease (CKD), and CKD and vascular disease are etiologically linked. Evidence suggests deficiencies of vitamins D and K may adversely affect the cardiovascular system, but data from longitudinal studies
L G Israels et al.
Seminars in perinatology, 21(1), 90-96 (1997-02-01)
Vitamin K in the fetus and newborn is maintained at levels less than that necessary to achieve full gamma-carboxylation of the K-dependent proteins, including those required for hemostasis. As the infant matures and even into adulthood, there is no significant
Núria Ibarrola-Jurado et al.
The American journal of clinical nutrition, 96(5), 1113-1118 (2012-10-05)
Limited evidence from human and animal studies has suggested that vitamin K has a potentially beneficial role in glucose metabolism and insulin resistance. We analyzed the cross-sectional and longitudinal associations between dietary phylloquinone intake and type 2 diabetes in elderly
D Bates et al.
Pharmacotherapy, 20(10), 1208-1215 (2000-10-18)
We cared for a patient who ingested an unknown amount of acetaminophen with zopiclone and warfarin. The only liver function test that was abnormal was an increased international normalized ratio (INR), which remained elevated despite treatment with subcutaneous phytonadione and
P M Loughnan et al.
Journal of paediatrics and child health, 32(3), 251-254 (1996-06-01)
To propose a hypothesis that the long duration of effect of intramuscular (i.m.) vitamin K1 in preventing late onset haemorrhagic disease results from a depot effect after i.m. injection. Review of scientific literature relating to the pharmacology of vitamin K
Gary Hastings
Biochimica et biophysica acta, 1847(1), 55-68 (2014-08-03)
Fourier transform infrared difference spectroscopy (FTIR DS) has been widely used to study the structural details of electron transfer cofactors (and their binding sites) in many types of photosynthetic protein complexes. This review focuses in particular on work that has
Interaction between vitamin K1 and fat absorption.
Nutrition reviews, 34(10), 314-315 (1976-10-01)
M Kyla Shea et al.
The American journal of clinical nutrition, 98(1), 197-208 (2013-05-31)
Animal studies have shown that vitamin K treatment reduced vascular calcification, but human data are limited. We determined the association between vitamin K status and coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis by using a case-cohort
Gabriel S Krigsfeld et al.
International journal of radiation biology, 89(10), 823-831 (2013-05-09)
To determine the mechanism of proton radiation- induced coagulopathy. Ferrets were exposed to either solar particle event (SPE)-like proton radiation at a predetermined dose rate of 0.5 Gray (Gy) per hour (h) for a total dose of 0 or 1
Zhen Hui Lim et al.
The journal of physical chemistry. B, 117(8), 2396-2402 (2013-02-13)
When the quinone, vitamin K1 (VK1), is electrochemically reduced in aqueous-acetonitrile solutions (CH3CN with 7.22 M H2O), it undergoes a two-electron reduction to form the dianion that is hydrogen-bonded with water [VK1(H2O)y(2–)]. EPR and voltammetry experiments have shown that the
Clinical Pharmacology, (11) (2012)
Sherry M Farley et al.
Molecular nutrition & food research, 56(6), 912-922 (2012-06-19)
The mechanism for increased bleeding and decreased vitamin K status accompanying vitamin E supplementation is unknown. We hypothesized that elevated hepatic α-tocopherol (α-T) concentrations may stimulate vitamin K metabolism and excretion. Furthermore, α-T may interfere with the side chain removal
Martí Juanola-Falgarona et al.
The Journal of nutrition, 144(5), 743-750 (2014-03-22)
Vitamin K has been related to cardiovascular disease and cancer risk. However, data on total mortality are scarce. The aim of the present study was to assess the association between the dietary intake of different types of vitamin K and
Ji-Hoi Moon et al.
BMC microbiology, 14, 218-218 (2014-08-26)
Polyphosphate (polyP) has bactericidal activity against a gram-negative periodontopathogen Porphyromonas gingivalis, a black-pigmented gram-negative anaerobic rod. However, current knowledge about the mode of action of polyP against P. gingivalis is incomplete. To elucidate the mechanisms of antibacterial action of polyP
Pierluigi Delmonte et al.
Journal of AOAC International, 96(1), 91-101 (2013-03-22)
Vitamin K1 (phylloquinone) occurs in foods in relatively low concentrations. It is synthesized for addition to formulated nutritional products (infant formulas, medical foods, and adult nutritional products). In recent years, nutritional products formulated with free amino acids and partially hydrolyzed
Eibhlís M O'Connor et al.
The British journal of nutrition, 112(7), 1163-1174 (2014-09-03)
Although epidemiological findings support a role for vitamin K status in the improvement of bone indices in adult patients with Crohn's disease (CD), this needs to be confirmed in double-blind, randomised controlled trials (RCT) with phylloquinone (vitamin K1). By conducting
C C Harrell et al.
The Annals of pharmacotherapy, 29(12), 1228-1232 (1995-12-01)
To report 6 patients taking oral vitamin K1 (phytonadione) to reduce warfarin's activity. Six patient cases are summarized in which oral vitamin K1 was used to reduce the international normalized ratio (INR) in patients at risk of bleeding. The use
Hrisi Bahar Tokman et al.
Clinical laboratory, 60(11), 1879-1886 (2015-02-05)
Anaerobic bacteria play an important role in eye infections; however, there is limited epidemiologic data based on the the role of these bacteria in the etiology of keratitis and endophthalmitis. The aim of this re- search is to determine the
S Lembo et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 147(2), 203-205 (2012-04-07)
Vitamin K1 (phytomenadione or phytonadione) is a fat soluble vitamin used to treat certain coagulation disorders. Intra muscular injection of vitamin K1 can occasionally be complicated by different types of skin reactions: erythematous plaques, urticarial rashes or scleroderma-like lesions at
Milka Marinova et al.
European journal of clinical pharmacology, 69(3), 467-475 (2012-08-07)
The pharmacokinetics of phylloquinone (vitamin K1) were evaluated in healthy human adult volunteers (15 male and 15 female) following oral and intravenous administration of a mixed micelles formulation (Konakion MM 2 mg) in an open label study design. The subjects
Jeffrey M Hegarty et al.
Development (Cambridge, England), 140(8), 1713-1719 (2013-03-28)
Multi-organ animals, such as vertebrates, require the development of a closed vascular system to ensure the delivery of nutrients to, and the transport of waste from, their organs. As a result, an organized vascular network that is optimal for tissue
Development and validation of spectrophotometric methods for determination of phytomenadione in injection
Patel AS and Parikh KP
Current Research in Pharmaceutical Sciences, 26-30 (2012)
Ilona Olędzka et al.
Journal of pharmaceutical and biomedical analysis, 102, 45-53 (2014-09-23)
The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully
Prescrire international, 7(36), 125-127 (1999-05-26)
(1) Haemorrhagic disease of the newborn is due to vitamin K deficiency. Although rare, it is life-threatening and can have neurological sequelae. Prevention is based on routine vitamin K1 administration at birth. (2) The oral route is suitable for healthy
Niina M Suni et al.
Journal of mass spectrometry : JMS, 47(5), 611-619 (2012-05-12)
In this article, the effect of spray solvent on the analysis of selected lipids including fatty acids, fat-soluble vitamins, triacylglycerols, steroids, phospholipids, and sphingolipids has been studied by two different ambient mass spectrometry (MS) methods, desorption electrospray ionization-MS (DESI-MS) and
Thomas C Wehler et al.
Journal of cancer research and clinical oncology, 139(10), 1667-1672 (2013-08-07)
Treatment with cetuximab is accompanied by the development of an acneiform follicular skin exanthema in more than 80 % of patients. Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or
Fumiaki Hanzawa et al.
The Journal of nutrition, 143(7), 1067-1073 (2013-05-24)
We have shown that intake of sesame seed and its lignan increases vitamin E concentrations and decreases urinary excretion levels of vitamin E metabolites in male Wistar rats, suggesting inhibition of vitamin E catabolism by sesame lignan. The aim of
S L Booth et al.
Thrombosis and haemostasis, 77(3), 504-509 (1997-03-01)
Case reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the
M Kyla Shea et al.
The Journal of nutrition, 142(6), 1060-1066 (2012-04-13)
Differences in micronutrient status are reported to contribute to racial and ethnic differences in chronic diseases. Diseases related to vitamin K are reported to differ by race and ethnicity, but it is unclear if circulating vitamin K concentrations similarly differ.
J Alonso-Llamazares et al.
Journal of the American Academy of Dermatology, 38(2 Pt 2), 322-324 (1998-03-05)
We describe a 45-year-old white man in whom distinctive clinical and histologic features of localized scleroderma developed at sites of injection of vitamin K1 (phytonadione). A direct immunofluorescence test demonstrated prominent linear deposition of IgA along the basement membrane zone.
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