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Nancy Presse et al.
The Journal of nutrition, 142(10), 1910-1916 (2012-08-24)
Assessment of long-term phylloquinone exposure is challenging in studies investigating vitamin K in health. Data are equivocal as to whether a single measurement of circulating phylloquinone would be adequate. The primary purpose of the present study was to validate the
Thilo Krüger et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(11), 2618-2624 (2013-08-31)
Vascular calcification is an independent risk factor for cardiovascular disease. Once thought to be a passive process, vascular calcification is now known to be actively prevented by proteins acting systemically (fetuin-A) or locally (matrix Gla protein). Warfarin is a vitamin
Joline W J Beulens et al.
The British journal of nutrition, 110(8), 1357-1368 (2013-04-18)
Recent reports have attributed the potential health benefits of vitamin K beyond its function to activate hepatic coagulation factors. Moreover, several studies have suggested that menaquinones, also known as vitamin K2, may be more effective in activating extra-hepatic vitamin K-dependent
Nathalie Ginovart et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(11), 2355-2367 (2012-06-14)
Δ⁹-tetrahydrocannabinol (THC), through its action on cannabinoid type-1 receptor (CB₁R), is known to activate dopamine (DA) neurotransmission. Functional evidence of a direct antagonistic interaction between CB₁R and DA D₂-receptors (D₂R) suggests that D₂R may be an important target for the
Martin J Shearer et al.
Advances in nutrition (Bethesda, Md.), 3(2), 182-195 (2012-04-21)
In 2001, the US Food and Nutrition Board concluded that there were insufficient data with which to establish a RDA for vitamin K, in large part because of a lack of robust endpoints that reflected adequacy of intake. Knowledge of
Kengo Noguchi et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 26(2), 117-122 (2014-06-10)
Edoxaban is an oral direct factor Xa (FXa) inhibitor and its efficacy as an oral anticoagulant is less subject to drug-food and drug-drug interaction than existing vitamin K antagonists. Although this profile of edoxaban suggests it is well suited for
Veena L Venkat et al.
Journal of pediatric gastroenterology and nutrition, 59(6), 702-707 (2014-11-25)
Fat-soluble vitamin (FSV) deficiency is a well-recognized consequence of cholestatic liver disease and reduced intestinal intraluminal bile acid. We hypothesized that serum bile acid (SBA) would predict biochemical FSV deficiency better than serum total bilirubin (TB) level in infants with
Wei Du et al.
World journal of surgical oncology, 10, 60-60 (2012-04-24)
The combined effects of anticancer drugs with nutritional factors against tumor cells have been reported previously. This study characterized the efficacy and possible mechanisms of the combination of sorafenib and vitamin K1 (VK1) on glioma cell lines. We examined the
Nadine Kaesler et al.
Kidney international, 86(2), 286-293 (2014-01-17)
In chronic kidney disease, vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein, are largely uncarboxylated indicating that functional vitamin K deficiency may contribute to uremic vascular calcification. Since the effects of uremia on the vitamin K cycle are
Carmela T M Mascio et al.
Antimicrobial agents and chemotherapy, 58(7), 3976-3982 (2014-05-07)
Surotomycin (CB-183,315) is an orally administered, minimally absorbed, selective bactericidal cyclic lipopeptide in phase 3 development for the treatment of Clostridium difficile-associated diarrhea. The aim of this study was to evaluate the emergence of resistance in C. difficile (ATCC 700057
Geertje W Dalmeijer et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1587-1590 (2014-05-24)
To investigate the association of plasma phylloquinone concentrations with coronary artery calcification (CAC) and vascular calcification. In a prospective cohort of 508 postmenopausal women, plasma phylloquinone concentrations were measured by high-pressure liquid chromatography. Calcification was measured in the coronary arteries
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats.
Kazuyuki D Tanaka et al.
The Journal of veterinary medical science, 75(2), 135-139 (2012-09-29)
Warfarin is a rodenticide commonly used worldwide. It inhibits coagulation of blood by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity. An inadequate supply of vitamin K blocks the production of prothrombin and causes hemorrhage. Recently, warfarin-resistant brown rats (Rattus norvegicus)
Rogier Caluwé et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(7), 1385-1390 (2013-11-29)
Haemodialysis patients suffer from accelerated vascular calcification. The vitamin K-dependent matrix Gla protein (MGP) is one of the most powerful inhibitors of vascular calcification. Haemodialysis patients have high levels of the inactive form of MGP (desphosphorylated-uncarboxylated-MGP, dp-uc-MGP) and may benefit
Waralak Yamasmit et al.
The Journal of reproductive medicine, 51(6), 463-466 (2006-07-19)
To summarize current knowledge on whether prenatal prophylactic vitamin K1 administration to epileptic women receiving enzyme-inducing antiepileptic drugs (AEDs) to prevent neonatal hemorrhage is effective. A computerized MEDLINE search was conducted using the terms antiepileptic drug, hemorrhagic disease of the
Douglas L Riegert-Johnson et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 89(4), 400-406 (2002-10-24)
Phytonadione (vitamin K1) administered intravenously (i.v.) has been associated with anaphylaxis, although the incidence is not known. The anaphylaxis is thought to be attributable to the solubilizing vehicle, polyethoxylated castor oil (Cremophor EL, BASF AG, Ludwingshafen, Germany). To estimate the
Hassan S Dashti et al.
The American journal of clinical nutrition, 100(6), 1462-1469 (2014-11-21)
Poor vitamin K status is linked to greater risk of several chronic diseases. Age, sex, and diet are determinants of circulating vitamin K; however, there is still large unexplained interindividual variability in vitamin K status. Although a strong genetic component
Huyen A Tran et al.
The Medical journal of Australia, 198(4), 198-199 (2013-03-05)
• Despite the associated bleeding risk, warfarin is the most commonly prescribed anticoagulant in Australia and New Zealand. Warfarin use will likely continue for anticoagulation indications for which novel agents have not been evaluated and among patients who are already
Aurélie Goncalves et al.
The Journal of biological chemistry, 289(44), 30743-30752 (2014-09-18)
Vitamin K1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K1 was examined using Caco-2 TC-7 cell monolayers as a model of human intestinal epithelium and
Tobias Piroth et al.
Cell transplantation, 23(8), 995-1007 (2013-05-03)
Restorative cell therapy concepts in neurodegenerative diseases are aimed at replacing lost neurons. Despite advances in research on pluripotent stem cells, fetal tissue from routine elective abortions is still regarded as the only safe cell source. Progenitor cells isolated from
B K Pang et al.
The Australasian journal of dermatology, 37(1), 44-47 (1996-02-01)
Cutaneous reactions to vitamin K1 (phytomenadione) are uncommon. They can present as acute eczematous reactions or late reactions that resemble localized scleroderma after vitamin K1 injections. A case is reported here of a patient who developed bilateral sclerodermoid plaques in
Studies on the absorption and metabolism of phylloquinone (vitamin K1) in man.
M J Shearer et al.
Vitamins and hormones, 32, 513-542 (1974-01-01)
Bernard Laubscher et al.
European journal of pediatrics, 172(3), 357-360 (2012-11-30)
In 2003, the Swiss guidelines to prevent vitamin K deficiency bleeding (VKDB) were adapted. As two oral doses (2 mg, hour/day 4) of mixed micellar VK preparation had failed to abolish late VKDB, a third dose (week 4) was introduced.
Ellen C M Cranenburg et al.
Kidney international, 82(5), 605-610 (2012-06-01)
Vitamin K is essential for the activity of γ-carboxyglutamate (Gla)-proteins including matrix Gla28 protein and osteocalcin; an inhibitor of vascular calcification and a bone matrix protein, respectively. Insufficient vitamin K intake leads to the production of non-carboxylated, inactive proteins and
Maria T Chao et al.
Alternative therapies in health and medicine, 20(1), 49-56 (2014-01-22)
Dysmenorrhea, the occurrence of painful menstrual cramping of the uterus, is a major cause of activity restriction and absences from school and work among young women. Standard pharmaceuticals used to treat dysmenorrhea are not effective for all women and have
Hironobu Hashimoto et al.
Japanese journal of clinical oncology, 43(1), 92-94 (2012-11-09)
A double-blind, placebo-controlled study evaluating the efficacy and safety of vitamin K1 ointment for the treatment of patients with cetuximab-induced acneiform eruption has started. Vitamin K1 ointment and placebo are applied twice daily for 8 consecutive weeks after the development
Ana Luiza M da Silva et al.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 19(1), e223-e230 (2012-06-08)
The incorporation of substances in nanocarriers can modulate and/or manage their delivery profiles (immediate or sustained) and permeation through skin. Consequently, drug nanencapsulation intended for topical treatment can reduce the systemic absorption of the substance. To obtain and characterize vitamin
Alison Busfield et al.
Archives of disease in childhood, 98(1), 41-47 (2012-11-14)
To survey vitamin K deficiency bleeding (VKDB) and document vitamin K (VK) prophylaxis practice, and compare with findings predating withdrawal of Konakion Neonatal and guidance from the National Institute of Health and Clinical Excellence (NICE), both occurring in 2006. Two-year
Yoshihisa Hirota et al.
The Journal of biological chemistry, 288(46), 33071-33080 (2013-10-03)
Mice have the ability to convert dietary phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) and store the latter in tissues. A prenyltransferase enzyme, UbiA prenyltransferase domain-containing 1 (UBIAD1), is involved in this conversion. There is evidence that UBIAD1 has a
R von Kries
Drug safety, 21(1), 1-6 (1999-08-05)
Oral and intramuscular phytomenadione (vitamin K1) prophylaxis became an issue following the report of a potential carcinogenic effect of intramuscular but not oral phytomenadione prophylaxis. There is increasing evidence, however, that oral phytomenadione prophylaxis is less effective for the prevention
[Biosynthesis of alpha-tocopherol (vitamin E), phylloquinone (2-methyl-3-phytylnaphtoquinone, vitamin K1) and other prenylquinones in plants. On the problem of inability of the biosynthesis in animals--a survey (author's transl)].
G Schultz et al.
DTW. Deutsche tierarztliche Wochenschrift, 87(11), 410-412 (1980-11-05)
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