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显示 1-30 共 187 条结果 关于 "P4252" 范围 论文
Tomohide Saio et al.
Science (New York, N.Y.), 344(6184), 1250494-1250494 (2014-05-09)
Molecular chaperones prevent aggregation and misfolding of proteins, but scarcity of structural data has impeded an understanding of the recognition and antiaggregation mechanisms. We report the solution structure, dynamics, and energetics of three trigger factor (TF) chaperone molecules in complex
Mukul Shah et al.
British journal of hospital medicine (London, England : 2005), 76(1), 25-30 (2015-01-15)
Paget's disease was first described more than 150 years ago, but the exact cause is still unknown--genes and the environment are both important. This article explores the basic science and clinical aspects of this intriguing condition.
Clement Riedel et al.
Nature, 517(7533), 227-230 (2014-12-10)
Recent studies have shown that the diffusivity of enzymes increases in a substrate-dependent manner during catalysis. Although this observation has been reported and characterized for several different systems, the precise origin of this phenomenon is unknown. Calorimetric methods are often
Charles C Clark et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(7), 894-903 (2014-03-20)
The objective of the described experiments was to determine the electrical parameters that lead to optimal expression of a number of bone-related genes in cultured human bone cells exposed to a capacitively coupled electric field. Human calvarial osteoblasts were grown
Lionel M Igaz et al.
The American journal of pathology, 173(1), 182-194 (2008-06-07)
TAR DNA-binding protein (TDP-43) has been recently described as a major pathological protein in both frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis. However, little is known about the relative abundance and distribution of different pathological TDP-43 species
Maryam Doroudi et al.
The Journal of steroid biochemistry and molecular biology, 145, 65-74 (2014-09-30)
1α,25(OH)2D3 regulates osteoblasts and chondrocytes via its membrane-associated receptor, protein disulfide isomerase A3 (Pdia3) in caveolae. 1α,25(OH)2D3 binding to Pdia3 leads to phospholipase-A2 (PLA2)-activating protein (PLAA) activation, stimulating cytosolic PLA2 and resulting in prostaglandin E2 (PGE2) release and PKCα activation
Sami Akbulut et al.
The Journal of surgical research, 193(2), 658-666 (2014-10-05)
To investigate the potential protective antioxidant role of ursodeoxycholic acid (UDCA), melatonin, and allopurinol treatment in cyclosporine (CsA)-induced hepatotoxicity. Hepatotoxicity was established in Sprague-Dawley rats by daily administration of CsA. Treatment groups were additionally administered UDCA, melatonin, or allopurinol treatments.
K P Sharma et al.
Indian journal of experimental biology, 50(12), 897-903 (2013-08-31)
Protective role of diet supplements (Spirulina, tamarind fruit pulp and their combination) on a freshwater fish G. affinis exposed at sublethal concentration of fluoride (F-) (10 ppm), Al(+3) (3 ppm) and aluminum fluoride (AlF3) (35.4 ppm) in the microcosms (15
Yoko Okubo et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 69(6), 1205-1211 (2014-03-22)
We investigated the availability of different forms of particulate soil phosphorus (P) to Microcystis aeruginosa by sequential extraction and bioassay. We cultured M. aeruginosa in media containing, as the sole source of P, soils sequentially extracted with 1 M NH4Cl
Studies on human placental alkaline phosphatase. II. Kinetic properties and studies on the apoenzyme.
D R Harkness
Archives of biochemistry and biophysics, 126(2), 513-523 (1968-08-01)
Anna M Grudniak et al.
Mutation research, 745-746, 1-5 (2013-04-27)
Mutation of the heat shock gene, htpG, causes severe defects of several cellular functions in Escherichia coli. A null htpG mutant constructed by gene replacement was impaired in the biosynthesis and secretion of several enzymes, and in biofilm formation and
Lars Hansen et al.
American journal of human genetics, 92(4), 575-583 (2013-04-09)
PGAP2 encodes a protein involved in remodeling the glycosylphosphatidylinositol (GPI) anchor in the Golgi apparatus. After synthesis in the endoplasmic reticulum (ER), GPI anchors are transferred to the proteins and are remodeled while transported through the Golgi to the cell
Yixing Cheng et al.
Journal of biomedical nanotechnology, 10(2), 287-298 (2014-04-18)
Scaffold architecture, surface topography, biochemical and mechanical cues have been shown to significantly improve cellular events and in vivo tissue regeneration. Specifically electrospun nanofiber matrices have gained tremendous interest due to their intrinsic structural resemblance to native tissue extracellular matrix
H M Kuznietsova et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(3), 74-84 (2013-08-14)
No liver and colon alterations in rats, caused by cytostatic compounds 5-amino-4-(1,3-benzothyazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one (D1) and 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) when administered over a long time were found, as evidenced by the histopathological data and the data of activity of transaminases, alkaline phosphatase and
Yufang Xu et al.
Nature communications, 11(1), 5441-5441 (2020-10-30)
With global warming and climate change, breeding crop plants tolerant to high-temperature stress is of immense significance. tRNA 2-thiolation is a highly conserved form of tRNA modification among living organisms. Here, we report the identification of SLG1 (Slender Guy 1)
M D Aisha et al.
Experimental cell research, 326(1), 46-56 (2014-06-15)
Exposure of Normal Human Osteoblast cells (NHOst) to a period of hypothermia may interrupt their cellular functions, lead to changes in bone matrix and disrupt the balance between bone formation and resorption, resulting in bone loss or delayed fracture healing.
Masaaki Inaba
Clinical calcium, 24(3), 379-384 (2014-03-01)
The importance of measurement of bone metabolic markers has been increasingly recognized in the treatment of osteoporosis. Bone is a dynamic organ in which bone formation and resorption continuously occurs. Biochemical marker for bone metabolism is an non-invasive measure to
Suk-Hyun Hong et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(47), 18820-18825 (2013-11-06)
Molecular targeting of the two receptor interaction domains of the epigenetic repressor silencing mediator of retinoid and thyroid hormone receptors (SMRT(mRID)) produced a transplantable skeletal syndrome that reduced radial bone growth, increased numbers of bone-resorbing periosteal osteoclasts, and increased bone
Christina Zachos et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(10), 1264-1270 (2014-06-26)
Impaired bone healing can occur with numerous pathologic conditions like trauma, osteoporosis, and infection. Therefore tissue-engineering strategies that aim to enhance osteogenic differentiation of stem cells in order to accelerate bone healing are a major goal of contemporary regenerative research.
Grace Y Y Teng et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(1), 19-29 (2013-12-18)
Although it has been revealed clinically that double-jaw orthognathic surgery induces a systemic increase in the baseline bone turnover and subsequently accelerates postoperative orthodontic tooth alignment, it is not clear whether less extensive osteotomy, such as interdental osteotomy, would be
Joan Chang et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1789-1799 (2014-02-28)
To investigate the role of hypoxia in the pathology of osteoarthritic (OA) bone by exploring its effect on the phenotype of isolated primary osteoblasts from patients with knee OA. OA bone samples were collected at the time of elective joint
J A Otegbayo et al.
African journal of medicine and medical sciences, 41(4), 417-422 (2013-05-16)
HAART associated hepatoxicity is an important cause of poor adherence to therapy in HIV infected persons. An initial manifestation is elevation in the level ofAlanine Transaminase (ALT) in blood. We sought to evaluate the protective effects of Livolin, a phosphatidylcholine
K A A Torres et al.
Poultry science, 92(6), 1564-1571 (2013-05-21)
The effect of replacing corn with low-tannin sorghum on broiler performance, carcass yield, integrity of mucosa of small intestine segments, and activity of membrane enzymes of the jejunum is investigated. A total of 594 male Cobb-500 broiler chicks were randomly
Cyrille B Confavreux et al.
European journal of endocrinology, 171(2), 275-283 (2014-05-21)
Bone has emerged as an endocrine organ regulating energy metabolism through secretion of osteocalcin. In epidemiological studies, presence of metabolic syndrome (MetS) was associated with lower osteocalcin level. We evaluated whether osteocalcin level was associated with MetS severity in men
Olivier Finet et al.
Molecular cell, 82(2), 404-419 (2021-11-20)
The epitranscriptome has emerged as a new fundamental layer of control of gene expression. Nevertheless, the determination of the transcriptome-wide occupancy and function of RNA modifications remains challenging. Here we have developed Rho-seq, an integrated pipeline detecting a range of
Sze Ting Cecilia Kwan et al.
Nutrients, 10(4) (2018-03-31)
The placental epigenome regulates processes that affect placental and fetal development, and could be mediating some of the reported effects of maternal choline supplementation (MCS) on placental vascular development and nutrient delivery. As an extension of work previously conducted in
Jia-Feng Chang et al.
Medicine, 93(18), e106-e106 (2014-10-17)
Hyperphosphatemia-induced vascular calcification and higher alkaline phosphatase (ALP) levels-related high-turnover bone diseases are linked to mortality among patients with chronic kidney disease (CKD). Nonetheless, no large epidemiological study in patients with CKD has been conducted to investigate the interaction and
Willem J Lammers et al.
Gastroenterology, 147(6), 1338-1349 (2014-08-28)
Noninvasive surrogate end points of long-term outcomes of patients with primary biliary cirrhosis (PBC) are needed to monitor disease progression and evaluate potential treatments. We performed a meta-analysis of individual patient data from cohort studies to evaluate whether patients' levels
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA
Basma El Yacoubi, Benjamin Lyons, et al.
RNA, 37, 2894-2909 (2009)
B R Coyac et al.
Journal of dental research, 92(7), 648-654 (2013-05-02)
While advances in biomineralization have been made in recent years, unanswered questions persist on bone- and tooth-cell differentiation, on outside-in signaling from the extracellular matrix, and on the link between protein expression and mineral deposition. In the present study, we
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