CN
Search Within
P4957
应用筛选条件
关键词:'P4957'
显示 1-30 共 135 条结果 关于 "P4957" 范围 论文
Yueyu Tang et al.
Neuroscience letters, 735, 135208-135208 (2020-07-03)
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and the underlying molecular mechanisms of this neurodegenerative disorder are still unclear. γ-Aminobutyric acid (GABA) neurons play an essential role in the excitatory/inhibitory (E/I) balance in the
Wenhao Zhang et al.
Stem cell reports, 15(1), 185-197 (2020-06-06)
Phenotypes of haploid embryonic stem cells (haESCs) are dominant for recessive traits in mice. However, one major obstacle to their use is self-diploidization in daily culture. Although haESCs maintain haploidy well by deleting p53, whether they can sustain haploidy in
Ocular Neuroprotection (2003)
Y Wang et al.
Colloids and surfaces. B, Biointerfaces, 87(2), 505-509 (2011-06-21)
Electrophoretic deposition (EPD) method has been developed for the deposition of thin films of chiral polymers. EPD of poly-L-lysine (PLL) and poly-L-ornithine (PLO) films was performed for the first time on conductive substrates from aqueous and ethanol-water solutions. The deposition
Sung-Won Choi et al.
The journal of international advanced otology, 17(1), 46-51 (2021-02-20)
This study aimed to investigate the feasibility of using optical coherence tomography (OCT) to provide information about cochlear microanatomy at a cellular level, specifically of cochlear hair cells in mammals. A total of 10 Sprague-Dawley rats were divided into 2
Ekin Ucuncu et al.
Nature communications, 11(1), 6087-6087 (2020-12-02)
Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. Here, we describe an early-onset neurodegenerative syndrome caused by loss-of-function mutations in the multiple
Kirsten Jahn et al.
Journal of neural transmission (Vienna, Austria : 1996), 124(11), 1341-1367 (2017-09-10)
SH-SY5Y neuroblastoma cells are frequently used for different neuronal cell culture models. As there is no "gold-standard", miscellaneous protocols exist to differentiate these cells into a neuronal cell type. Here, the aim was to find a differentiation condition making cells
Xinyue Yuan et al.
Nature communications, 11(1), 4854-4854 (2020-09-27)
Chronic imaging of neuronal networks in vitro has provided fundamental insights into mechanisms underlying neuronal function. Current labeling and optical imaging methods, however, cannot be used for continuous and long-term recordings of the dynamics and evolution of neuronal networks, as
Colleen A Stoyas et al.
Neuron, 105(4), 630-644 (2019-12-21)
Sirtuin 1 (Sirt1) is a NAD+-dependent deacetylase capable of countering age-related neurodegeneration, but the basis of Sirt1 neuroprotection remains elusive. Spinocerebellar ataxia type 7 (SCA7) is an inherited CAG-polyglutamine repeat disorder. Transcriptome analysis of SCA7 mice revealed downregulation of calcium
Antonietta Franco et al.
eLife, 9 (2020-10-20)
Charcot-Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2. Here, pharmacological activation of endogenous normal mitofusins overcame dominant inhibitory effects of CMT2A mutants in reprogrammed human patient
Claudia Salcedo et al.
Frontiers in aging neuroscience, 13, 736580-736580 (2021-10-05)
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are important nitrogen donors for synthesis of glutamate, the main excitatory neurotransmitter in the brain. The glutamate carbon skeleton originates from the tricarboxylic acid (TCA) cycle intermediate α-ketoglutarate, while the amino
Fadi Jacob et al.
Cell stem cell, 27(6), 937-950 (2020-10-05)
Neurological complications are common in patients with COVID-19. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect brain cells and impact their function is not
Anna M van Ziel et al.
Journal of neurochemistry, 152(2), 208-220 (2019-08-24)
The unfolded protein response (UPR) is one of the major cell-autonomous proteostatic stress responses. The UPR has been implicated in the pathogenesis of neurodegenerative diseases and is therefore actively investigated as therapeutic target. In this respect, cell non-autonomous effects of
Zhen Chen et al.
Frontiers in cell and developmental biology, 9, 728352-728352 (2021-10-09)
In the mammalian cochlea, spiral ganglion neurons (SGNs) relay the acoustic information to the central auditory circuits. Degeneration of SGNs is a major cause of sensorineural hearing loss and severely affects the effectiveness of cochlear implant therapy. Cochlear glial cells
Jonathan E Henninger et al.
Cell, 184(1), 207-225 (2020-12-18)
Regulation of biological processes typically incorporates mechanisms that initiate and terminate the process and, where understood, these mechanisms often involve feedback control. Regulation of transcription is a fundamental cellular process where the mechanisms involved in initiation have been studied extensively
C G Thanos et al.
Journal of biomedical materials research. Part A, 81(1), 1-11 (2006-11-08)
Alginate encapsulation is a form of cell-based therapy with numerous preclinical successes but recalcitrant complications related to stability and reproducibility. Understanding how alginate stability varies across different transplant sites will help identify indications that might benefit most from this approach.
Maria Masnata et al.
Acta neuropathologica, 137(6), 981-1001 (2019-02-23)
In recent years, evidence has accumulated to suggest that mutant huntingtin protein (mHTT) can spread into healthy tissue in a prion-like fashion. This theory, however, remains controversial. To fully address this concept and to understand the possible consequences of mHTT spreading
Ling-Yan Su et al.
Autophagy, 13(9), 1496-1511 (2017-07-20)
The molecular basis of chronic morphine exposure remains unknown. In this study, we hypothesized that macroautophagy/autophagy of dopaminergic neurons would mediate the alterations of neuronal dendritic morphology and behavioral responses induced by morphine. Chronic morphine exposure caused Atg5 (autophagy-related 5)-
Geoffroy Laumet et al.
Pain, 161(10), 2344-2352 (2020-05-20)
Understanding the mechanisms that drive transition from acute to chronic pain is essential to identify new therapeutic targets. The importance of endogenous resolution pathways acting as a "brake" to prevent development of chronic pain has been largely ignored. We examined
Jae Young Kim et al.
Experimental neurobiology, 28(1), 85-103 (2019-03-12)
Cell replacement therapy using neural progenitor cells (NPCs) following ischemic stroke is a promising potential therapeutic strategy, but lacks efficacy for human central nervous system (CNS) therapeutics. In a previous in vitro study, we reported that the overexpression of human
Beatriz Fernández-Muñoz et al.
Stem cells translational medicine, 9(9), 1085-1101 (2020-06-01)
Intraventricular hemorrhage is a common cause of morbidity and mortality in premature infants. The rupture of the germinal zone into the ventricles entails loss of neural stem cells and disturbs the normal cytoarchitecture of the region, compromising late neurogliogenesis. Here
Andy Leung et al.
Journal of microencapsulation, 25(6), 387-398 (2008-05-10)
Alginate/poly-L-ornithine/alginate (APA) coherent microencapsulation, which provides an immunoselective and highly biocompatible membrane, creates a viable option for cellular or tissue transplantation. This study explored the potential of incorporating immunosuppressive drugs onto the capsule surface to provide local immunosuppression in addition
Anita Mann et al.
Biophysical chemistry, 129(2-3), 126-136 (2007-07-03)
Atomic force microscopy (AFM) has been used to visualize the process of condensation of plasmid DNA by poly-L-ornithine on mica surface. AFM images reveal that the transition of negatively charged DNA to condensed nanoparticles on addition of increasing amounts of
Eduardo H Sanchez-Mendoza et al.
Molecular neurobiology, 57(7), 3171-3182 (2020-06-07)
Disrupted neuronal plasticity due to subtle inflammation is considered to play a fundamental role in the pathogenesis of major depressive disorder. Interferon-α (IFN-α) potentiates immune responses against viral pathogens that induce toll-like receptor-3 (TLR3) activation but evokes severe major depressive
Jie Ren et al.
Cells, 10(11) (2021-11-28)
Limited access to human neurons, especially motor neurons (MNs), was a major challenge for studying neurobiology and neurological diseases. Human pluripotent stem cells (hPSCs) could be induced as neural progenitor cells (NPCs) and further multiple neural subtypes, which provide excellent
Patrick C Hoffmann et al.
eLife, 10 (2021-10-27)
During brain development, axons must extend over great distances in a relatively short amount of time. How the subcellular architecture of the growing axon sustains the requirements for such rapid build-up of cellular constituents has remained elusive. Human axons have
Tingting Zhang et al.
Cell reports, 35(10), 109208-109208 (2021-06-10)
Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory neurons derive from separate, spatially segregated progenitors. Whether bi-potential progenitors
Tatsuya Okuda et al.
Journal of controlled release : official journal of the Controlled Release Society, 114(1), 69-77 (2006-07-04)
In this study, we synthesized dendritic poly(L-lysine)s (DPKs), dendritic poly(L-ornithine)s (DPOs), which are constructed as novel amino acid dendrimers, and PEGylated KG6 (the sixth generation of DPKs), and evaluated the physicochemical properties and biodistribution characteristics of these dendrimers. The particle
Lin Zhang et al.
Stem cells and development, 29(22), 1444-1456 (2020-09-30)
The cell-type-specific response of neural cells to oxidative stress, a crucial mechanism for accelerating aging and cognitive dysfunction in Alzheimer's disease (AD), is still far from understood. Here, we employed human-induced pluripotent stem cells (hiPSCs)-derived neural stem cells (hiPSC-NSCs), neurons
Sara Ponce et al.
Biomaterials, 27(28), 4831-4839 (2006-06-13)
Implantation of microencapsulated cells has been proposed as a therapy for a wide variety of diseases. An absolute requirement is that the applied microcapsules have an optimal biocompatibility. The alginate-poly-L-lysine system is the most commonly applied system but is still
1/5