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Daniel Zewge et al.
Bioconjugate chemistry, 25(12), 2222-2232 (2014-11-15)
Chemical modification of siRNA is achieved in a high-throughput manner (96-well plate format) by copper catalyzed azide-alkyne cycloadditions. This transformation can be performed in one synthetic operation at up to four positions with complete specificity, good yield, and acceptable purity.
Nathalie Ségaud et al.
Inorganic chemistry, 52(2), 691-700 (2013-01-11)
We report the synthesis, characterization, and solution chemistry of a series of new Fe(II) complexes based on the tetradentate ligand N-methyl-N,N'-bis(2-pyridyl-methyl)-1,2-diaminoethane or the pentadentate ones N,N',N'-tris(2-pyridyl-methyl)-1,2-diaminoethane and N,N',N'-tris(2-pyridyl-methyl)-1,3-diaminopropane, modified by propynyl or methoxyphenyltriazolyl groups on the amino functions. Six of
Robert Gruber et al.
The American journal of pathology, 185(4), 1012-1021 (2015-02-11)
Although keratosis pilaris (KP) is common, its etiopathogenesis remains unknown. KP is associated clinically with ichthyosis vulgaris and atopic dermatitis and molecular genetically with filaggrin-null mutations. In 20 KP patients and 20 matched controls, we assessed the filaggrin and claudin
Fernando Montañés et al.
Journal of chromatography. A, 1418, 218-223 (2015-09-29)
Preparative scale supercritical fluid chromatography was used to separate derivatized anomeric monosaccharides. Methyl 2,3,4,6-tetra-O-benzoyl-α-d-glucopyranoside and methyl 2,3,4,6-tetra-O-benzoyl-β-d-glucopyranoside were synthesized by benzoyl derivatization of the parent anomerically pure monosaccharides. The elution profiles of each anomer were studied, suggesting that separation was
David G Belair et al.
Biomacromolecules, 15(6), 2038-2048 (2014-04-30)
Vascular endothelial growth factor (VEGF) activity is highly regulated via sequestering within the ECM and cell-demanded proteolysis to release the sequestered VEGF. Numerous studies have demonstrated that VEGF activity mediates cellular events leading to angiogenesis and capillary formation in vivo.
Jin Wang et al.
Journal of nanoscience and nanotechnology, 13(1), 523-528 (2013-05-08)
The low bandgap 3-hexylthiophene/pyridine copolymers (P3HT/PY) were synthesized and the composites of P3HT/PY and CdSe QDs were prepared. The characterization are performed with 1H NMR, UV-vis, PL, TEM, XPS and cyclic voltammetry (CV). The results show that the P3HT/PY copolymers
Md Mujahid et al.
Journal of proteome research, 14(2), 711-727 (2014-11-13)
Aromatic amines are widely distributed in the environment and are major environmental pollutants. Although degradation of aromatic amines is well studied in bacteria, physiological adaptations and stress response to these toxic compounds is not yet fully understood. In the present
Alberto Sánchez-Guijo et al.
Journal of lipid research, 56(2), 403-412 (2014-12-17)
Steroid sulfatase (STS) deficiency is the underlying cause of the skin condition known as recessive X-linked ichthyosis (RXLI). RXLI patients show scales on their skin caused by high concentrations of cholesterol sulfate (CS), as they are not capable of releasing
Lu Ren et al.
Carbohydrate research, 406, 19-26 (2015-02-07)
A purified water-soluble fraction (ICP5) of a polysaccharide, isolated from a local Maori mushroom Iliodiction cibarium in New Zealand, was investigated for its structural properties. Size exclusion chromatography and dynamic light scattering showed that ICP5 had a large MW of
Panagiota Nikolaou et al.
Journal of pharmaceutical and biomedical analysis, 102, 25-32 (2014-09-23)
A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extraction (SPE) procedure using HF Bond Elut C18 columns followed by derivatization using N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide (MTBSTFA)
Greg M Kowalski et al.
Biochimica et biophysica acta, 1851(2), 210-219 (2014-12-10)
Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide. There is evidence that enzymes involved in ceramide or sphingolipid
Hani Nasser Abdelhamid et al.
Analytica chimica acta, 767, 104-111 (2013-03-05)
Application of two new series of ionic liquid matrices (ILMs) based on the two most predominantly used conventional organic matrices (Sinapinic acid and 2,5-DHB) in conjugation with various bases (aniline (ANI), dimethyl aniline (DMANI), diethylamine (DEA), dicyclohexylamine (DCHA), pyridine (Pyr)
Andrew W Owen et al.
Analytica chimica acta, 849, 12-18 (2014-10-11)
A specially designed thermal vaporiser was used with a process mass spectrometer designed for gas analysis to monitor the esterification of butan-1-ol and acetic anhydride. The reaction was conducted at two scales: in a 150 mL flask and a 1L
A H Wu et al.
Clinical chemistry, 45(7), 1051-1057 (1999-07-01)
In vitro adulterants are used to invalidate assays for urine drugs of abuse. The present study examined the effect of pyridinium chlorochromate (PCC) found in the product "Urine Luck". PCC was prepared and added to positive urine controls at concentrations
Mohammed J Farooqi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 153, 124-131 (2015-08-25)
Perylene diimide derivatives have attracted initial interest as industrial dyes. Recently, much attention has been focused on their strong π-π stacks resulting from the large PDI aromatic core. These PDI stacks have distinct optical properties, and provide informative models that
Daniel T Bowers et al.
ACS nano, 8(12), 12080-12091 (2014-11-27)
Oxygenation in tissue scaffolds continues to be a limiting factor in regenerative medicine despite efforts to induce neovascularization or to use oxygen-generating materials. Unfortunately, many established methods to measure oxygen concentration, such as using electrodes, require mechanical disturbance of the
Andrés Castellanos-Martín et al.
Genome biology, 16, 40-40 (2015-04-09)
An essential question in cancer is why individuals with the same disease have different clinical outcomes. Progress toward a more personalized medicine in cancer patients requires taking into account the underlying heterogeneity at different molecular levels. Here, we present a
Teresa Mairinger et al.
Analytical chemistry, 87(23), 11792-11802 (2015-10-30)
For the first time an analytical work flow based on accurate mass gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOFMS) with chemical ionization for analysis providing a comprehensive picture of (13)C distribution along the primary metabolism is elaborated. The method provides a
Vaibhav Khare et al.
International journal of pharmaceutics, 470(1-2), 51-62 (2014-05-09)
Gemcitabine, a nucleoside analogue, is used in the treatment of various solid tumors, however, its efficacy is limited by rapid metabolism by cytidine deaminase and fast kidney excretion. In this study, a polymeric conjugate of gemcitabine was prepared by covalent
Zoran Rankovic
Journal of medicinal chemistry, 58(6), 2584-2608 (2014-12-17)
The human brain is a uniquely complex organ, which has evolved a sophisticated protection system to prevent injury from external insults and toxins. Designing molecules that can overcome this protection system and achieve optimal concentration at the desired therapeutic target
Sylvie Mavel et al.
Bioorganic & medicinal chemistry, 20(4), 1388-1395 (2012-02-04)
The dopamine transporter (DAT) plays a pivotal role in the regulation of dopamine neurotransmission, and is involved in a number of physiological functions and brain disorders. Furthermore the DAT analysis by molecular imaging techniques is a useful tool for the
Si Chen et al.
Molecular bioSystems, 10(12), 3310-3321 (2014-10-16)
As a classical formula, Sini decoction (SND) has been fully proved to be clinically effective in treating doxorubicin (DOX)-induced cardiomyopathy. Current chemomics and pharmacology proved that the total alkaloids (TA), total gingerols (TG), total flavones and total saponins (TFS) are
V Divya et al.
Dalton transactions (Cambridge, England : 2003), 42(34), 12317-12323 (2013-07-16)
Our recently developed Eu(3+) coordination compound, Eu(pfppd)3(tpy) [where Hpfppd = 4,4,5,5,5-pentafluoro-3-hydroxy-1-(phenanthren-3-yl)pentanedione and tpy = 2,2':6,6''-terpyridine] exhibits significant quantum yield (Φoverall = 41%) and long (5)D0 lifetime (880 μs) values under biologically relevant pH conditions (pH = 7.4) when excited with
Jipan Yu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(13), 4271-4277 (2013-02-13)
Efficient copper-catalyzed aerobic oxidative C-H and C-C functionalization of 1-[2-(arylamino)aryl]ethanones leading to acridones has been developed. The procedure involves cleavage of aromatic C-H and acetyl C-C bonds with intramolecular formation of a diarylketone bond. The protocol uses inexpensive Cu(O2CCF3)2 as
Fei Tian et al.
Journal of environmental sciences (China), 25(11), 2299-2305 (2014-02-21)
A series of precious metals catalysts (M/TiO2, M = Ru, Rh, Pd, Ag, Ir, Pt or Au) were prepared by a light deposition method and the synergistic photocatalytic degradations of pyridine (20 mg/L) under UV irradiation (365 nm) using M/TiO2
E Mázl Chánová et al.
Physiological research, 64 Suppl 1, S61-S73 (2015-10-09)
In this study, we investigate the preparation of surface pattern of functional groups on poly(lactide) (PLA) surfaces through the controlled deposition of core-shell self-assemblies based on functionalized PLA-b-PEO amphiphilic block copolymers from selective solvents. Through grafting RGDS peptide onto the
Rebeca Y Cabrera-Padilla et al.
Bioprocess and biosystems engineering, 38(5), 805-814 (2014-11-14)
Candida rugosa lipase (CRL) was immobilized on an eco-friendly support poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV), by physical adsorption, using different ionic liquids (ILs) as immobilization additives. This was to investigate the influence of cationic core ([C4mpy]Cl, [C4min]Cl), of anions ([C4min]Cl, [C4min]N(CN)2, [C4min]Tf2N), and
V Subbaramaiah et al.
Journal of hazardous materials, 248-249, 355-363 (2013-02-19)
Cerium supported SBA-15 (Ce/SBA-15) was synthesized by two-step synthesis method in acidic medium. It was further characterized by various characterization techniques such as X-ray diffraction, field-emission scanning electron microscopy, Fourier transform infrared spectroscopy and N2 adsorption-desorption pore size distribution analysis.
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage
Ogbole Omonike Oluyemisi et al.
Pharmaceutical biology, 53(6), 882-887 (2014-11-29)
Plants of the Zephyranthes genus are globally used in folk medicine. In a previous study, Zephyranthes candida Linn. (Amaryllidaceae) was identified as having antiviral properties; this led to anti-poliovirus assay-guided isolation of compounds from crude methanol extract of the plant.
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