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Olumuyiwa N Adedeji et al.
Antimicrobial agents and chemotherapy, 59(9), 5114-5122 (2015-04-22)
Artemisinin-based combination therapies (ACTs) have been adopted by most African countries, including Nigeria, as first-line treatments for uncomplicated falciparum malaria. Fixed-dose combinations of these ACTs, amodiaquine-artesunate (FDC AQAS) and artemether-lumefantrine (AL), were introduced in Nigeria to improve compliance and achieve
Juliana Bidone et al.
BioMed research international, 2015, 238010-238010 (2015-06-24)
This study investigated the inhibitory effects of Achyrocline satureioides extract (ASE) incorporated into a topical nanoemulsion on Herpes Simplex Virus type 1 (HSV-1/KOS strain) replication, as well as the distribution of the main ASE flavonoids (quercetin, luteolin, and 3-O-methylquercetin) in
Ashani Samaratunga et al.
Applied biochemistry and biotechnology, 176(4), 1114-1130 (2015-05-04)
Production costs of cellulosic biofuels can be lowered if cellulases are recovered and reused using particulate carriers that can be extracted after biomass hydrolysis. Such enzyme recovery was recently demonstrated using enzymogel nanoparticles with grafted polymer brushes loaded with cellulases.
Sruthi Purushothaman et al.
Journal of proteomics, 112, 113-124 (2014-09-03)
The extensive arm regeneration of brittle stars following amputation is becoming increasingly recognized as a model system for understanding cellular differentiation and regeneration in a whole animal context. In this study we have used the emerging brittle star model Amphiura
Shuichi Suzuki et al.
Journal of medical virology, 87(11), 1853-1859 (2015-05-12)
Vaccine modified measles (VMM) affects individuals with attenuated vaccine induced immunity. An outbreak of measles occurred in a junior high school, starting from an unvaccinated eighth-grade student who developed natural measles and affected a majority of students who were immunized
Byul G Kim et al.
Biochemistry, 54(22), 3420-3430 (2015-05-20)
In an atmosphere of potassium ions, a modified c-MYC NHE III1 sequence with two G-to-T mutations (MYC22-G14T/G23T) forms a highly stable parallel-stranded G-quadruplex. The G-quadruplex exhibits a steady increase in its melting temperature, T(M), with an increase in the concentration
Mahmoud N Taha et al.
Journal of chromatography. A, 1394, 137-147 (2015-04-08)
Extraction parameters, chemical fingerprint, and the single compounds' activity levels were considered for the selection of active botanicals. For an initial survey, the total bioactivity (i.e., total reducing capacity, total flavonoids contents and free radical scavenging capacity) of 21 aqueous
Chih-Hung Chiang et al.
Cell transplantation, 24(3), 541-559 (2015-02-11)
Acute hepatic failure (AHF) is a severe liver injury leading to sustained damage and complications. Induced pluripotent stem cells (iPSCs) may be an alternative option for the treatment of AHF. In this study, we reprogrammed human dental pulp-derived fibroblasts into
Meera Gujjar et al.
International journal of pharmaceutics, 472(1-2), 362-368 (2014-07-01)
The purpose of this study was to compare the transdermal permeation of a model compound, diclofenac diethylamine, from a hydrophilic and lipophilic vehicle across in vitro models simulating compromised skin. Mineral oil served as a lipophilic vehicle while 10mM phosphate
Juan Liu et al.
Bio-medical materials and engineering, 26 Suppl 1, S2123-S2132 (2015-09-26)
The Yinzhihuang injection, a traditional Chinese medicine, has been the recent target of increasing interest due to its anti-inflammatory properties. The molecular basis by which Yinzhihuang injection could cure Riemerella anatipestifer (RA) serositis in ducks is unclear. This study evaluated
J Brent Friesen et al.
Journal of chromatography. A, 1377, 55-63 (2014-12-30)
Rational solvent system selection for countercurrent chromatography and centrifugal partition chromatography technology (collectively known as countercurrent separation) studies continues to be a scientific challenge as the fundamental questions of comparing polarity range and selectivity within a solvent system family and
Harshavardhan V Pawar et al.
Journal of pharmaceutical sciences, 103(6), 1720-1733 (2014-04-05)
Wafers combining weight ratios of Polyox with carrageenan (75/25) or sodium alginate (50/50) containing streptomycin and diclofenac were prepared to improve chronic wound healing. Gels were freeze-dried using a lyophilisation cycle incorporating an annealing step. Wafers were characterised for morphology
Eleonora Dellera et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 643-650 (2014-08-17)
In the treatment of chronic wounds, topical application of anti-infective drugs such as silver sulfadiazine (AgSD) is of primary importance to avoid infections and accelerate wound repair. AgSD is used in burns and chronic wounds for its wide antibacterial spectrum
Rushd Khalaf et al.
Journal of chromatography. A, 1407, 169-175 (2015-07-08)
Reversed-phase (RP) chromatography is one of the main tools for the preparative purification of therapeutic peptides. In previous works [1,2], a new type of RP chromatography, doped reversed-phase chromatography (DRP) was presented. By adding small amounts (up to 15% of
Masato Kobayashi et al.
Nuclear medicine and biology, 42(6), 536-540 (2015-03-07)
A specific diagnosis for melanoma is strongly desired because malignant melanoma has poor prognosis. In a previous study, although radioiodine-125-labeled 4-hydroxyphenyl-L-cysteine ((125)I-L-PC) was found to have good substrate affinity for tyrosinase enzyme in the melanin metabolic pathway, (123/131)I-L-PC had insufficient
R Meier et al.
International journal of pharmaceutics, 496(1), 12-23 (2015-05-31)
As different batches of the same excipients will be intermixed during continuous processes, the traceability of batches is complicated. Simplified formulations may help to reduce problems related to batch intermixing and traceability. Twin-screw granulation with subsequent tableting was used to
Daniela Remane et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 998-999, 40-44 (2015-07-08)
During the last decades exposure sciences and epidemiological studies attracts more attention to unravel the mechanisms for the development of chronic diseases. According to this an existing HPLC-DAD method for determination of creatinine in urine samples was expended for seven
Jesús Torres et al.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 200, 126-133 (2015-05-02)
The aim of this study was to test bone tissue response to monetite granules in comparison with intramembranous autologous bone graft in a rabbit calvaria critical size defect model. Novel monetite granules were synthesized by thermal conversion of set brushite
Yu He et al.
Drug and chemical toxicology, 38(2), 145-151 (2014-05-23)
Tripterygium wilfordii Hook. f. (TW) is a traditional herbal medicine which has been widely used for the treatment of rheumatoid arthritis and other autoimmune diseases. However, adverse reactions of TW such as hepatotoxicity and nephrotoxicity have been frequently reported in
Jenna L Terebetski et al.
AAPS PharmSciTech, 15(5), 1334-1344 (2014-06-13)
To maximize the pharmacological effect of a pain reliever such as ibuprofen, early onset of action is critical. Unfortunately, the acidic nature of ibuprofen minimizes the amount of drug that can be solubilized under gastric conditions and would be available
Carolina Santezi et al.
The journal of contemporary dental practice, 13(5), 735-739 (2012-12-20)
It is becoming more common for patients to look for cosmetic procedures in dental offices. The search for lost or desired esthetics by patients is increasingly frequent and the professional must be able to meet this demand. To do this
Bo Chen et al.
The Analyst, 140(13), 4676-4686 (2015-05-23)
Peptides from scorpion venom represent one of the most promising drug sources for drug discovery for some specific diseases. Current challenges in their separation include high complexity, high homologies and the huge range of peptides. In this paper, a modified
Ondrej Cerny et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4901-4913 (2015-04-17)
The adenylate cyclase toxin-hemolysin (CyaA) plays a key role in the virulence of Bordetella pertussis. CyaA penetrates complement receptor 3-expressing phagocytes and catalyzes uncontrolled conversion of cytosolic ATP to the key second messenger molecule cAMP. This paralyzes the capacity of
Kristina Nelson et al.
Food chemistry, 194, 495-502 (2015-10-17)
Metabolic dysfunction in obesity may be attenuated by whole-grain intake, which has been attributed to synergistic actions of bioactive compounds. Germination/malting may increase grain bioactives, including polyphenols, however biological effects compared with non-germinated grains are unclear. Polyphenols and biological effects
Wenfa Lu et al.
Journal of parasitology research, 2011, 316067-316067 (2011-05-18)
Wild-type (WT) C57BL/6 mice infected intraperitoneally with 5 × 10(6) Trypanosoma congolense survive for more than 30 days. C57BL/6 mice deficient in inducible nitric oxide synthase (iNOS(-/-)) and infected with 10(3) or 5 × 10(6) parasites do not control the
Fan-Zhi Kong et al.
Journal of chromatography. A, 1422, 318-324 (2015-10-27)
The traditional recycling free-flow isoelectric focusing (RFFIEF) suffered from complex structure, tedious operations and poor extensibility as well as high cost. To address these issues, a novel reciprocating free-flow isoelectric focusing device (ReFFIEF) was developed for proteins or peptides pre-fractionation.
Dentin matrix component solubilization by solutions of pH relevant to self-etching dental adhesives.
Jack L Ferracane et al.
The journal of adhesive dentistry, 15(5), 407-412 (2013-04-06)
To evaluate the potential for phosphoric acid solutions - common constituents of dental adhesive systems - of varying pH to solubilize dentin matrix components (DMCs) from human dentin. Human dentin chips were ground under liquid nitrogen to a powder (ca
Kun Peng et al.
The AAPS journal, 16(4), 625-633 (2014-04-23)
Data generated using various immunoassay methods are an integral part of the development of protein therapeutics. These assays are used in clinical and preclinical studies to establish the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics as well as to assess the
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
Laura Mews et al.
The Angle orthodontist, 85(4), 645-650 (2014-08-27)
To examine differences in the shear bond strength of orthodontic brackets on differently mineralized enamel surfaces after applying a caries infiltrant or conventional adhesive. A total of 320 bovine incisors were assigned to eight pretreated groups, and the shear force
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