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显示 1-30 共 194 条结果 关于 "P5931" 范围 论文
Juan Ignacio Felice et al.
Metabolism: clinical and experimental, 63(2), 296-305 (2013-12-21)
The aims of this study were: first, to evaluate the possible effects of a fructose rich diet (FRD)-induced metabolic syndrome (MS) on different aspects of long bone histomorphometry in young male rats; second, to investigate the effects of this diet
V O Kryliuk
Klinichna khirurhiia, (2)(2), 67-70 (2013-05-28)
The peculiarities of course of endogenous intoxication (EI) in severe combined abdominal trauma were studied up in experiment. There was established, that in the laboratory animals, to whom the blood loss compensation was done, using colloid-hyperosmolar solution, the El severity
Ante Muljacić et al.
Collegium antropologicum, 37(4), 1275-1283 (2014-03-13)
Alkaline phosphatase (ALP) and bone-specific alkaline phosphatase (S-bone ALP) activities may serve as markers of the course and rate of bone healing after sustained fractures. The aim of this study was to examine whether the assessment of S-bone ALP as
Carbon nanotube based biomimetic membranes: mimicking protein channels regulated by phosphorylation.
Journal of Materials Chemistry, 17, 1755-1757 (2007)
Yuanpei Li et al.
Nature communications, 13(1), 6350-6350 (2022-10-27)
The methyltransferase like 3 (METTL3) has been generally recognized as a nuclear protein bearing oncogenic properties. We find predominantly cytoplasmic METTL3 expression inversely correlates with node metastasis in human cancers. It remains unclear if nuclear METTL3 is functionally distinct from
Jian Zhou et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(11), 1783-1788 (2013-09-10)
To compare the effect of icariin and genistein in the osteogenic differentiation of rat bone marrow stromal cells (rBMSC). Rat marrow stromal cells were seperated in vitro, and the optimal concentration of genisten and icriin were screened. Genistein and icariin
Rogerio B Kato et al.
Journal of cellular physiology, 229(11), 1690-1696 (2014-03-13)
The aim of this study was to investigate if chemically produced nanotopography on titanium (Ti) surface induces osteoblast differentiation of cultured human bone marrow mesenchymal stem cells (hMSCs) by regulating the expression of microRNAs (miRs). It was demonstrated that Ti
Pallab Datta et al.
Journal of biomedical nanotechnology, 9(5), 870-879 (2013-06-28)
Most polymeric nanofibers used for bone tissue engineering lack adequate functional groups for bioactivity. This study explores the potential of nanofibers of phosphate functionalized derivative of chitosan-N-methylene phosphonic chitosan (NMPC) for bone tissue engineering. Nanofibers were fabricated by electrospinning of
Tadayuki Iida et al.
Hiroshima journal of medical sciences, 62(3), 49-53 (2013-11-28)
The relationship of bone mineral density (BMD) and bone metabolic markers in women is an interesting field of research. In this study, we aimed to clarify the relationship of body weight, bone metabolic markers and BMD. The subjects were 72
Primo N Lara et al.
Journal of the National Cancer Institute, 106(4), dju013-dju013 (2014-02-26)
Prior studies suggest that elevated markers of bone turnover are prognostic for poor survival in castration-resistant prostate cancer (CRPC). The predictive role of these markers relative to bone-targeted therapy is unknown. We prospectively evaluated the prognostic and predictive value of
Soumojit Pal et al.
Journal of the American Heart Association, 10(15), e021768-e021768 (2021-07-30)
Background Sarcomere gene mutations lead to cardiomyocyte hypertrophy and pathological myocardial remodeling. However, there is considerable phenotypic heterogeneity at both the cellular and the organ level, suggesting modifiers regulate the effects of these mutations. We hypothesized that sarcomere dysfunction leads
Kohji Miura et al.
Clinical calcium, 23(12), 1789-1794 (2013-12-03)
Skeletal dysplasia is the term which represents disorders including growth and differentiation of bone, cartilage and ligament. A lot of diseases are included, and new disorders have been added. However, the therapy of most bone diseases is less well-established. Achondroplasia
J W Kim et al.
Journal of dental research, 93(5), 483-489 (2014-02-27)
ATF6 is an endoplasmic reticulum (ER) membrane-bound transcription factor that regulates various cellular functions. The purpose of this study was to investigate the role of ATF6 in odontoblast differentiation. Rat tooth germs were isolated, changes in gene expression were evaluated
Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway.
An J, Wang X, Guo P, et al.
Toxicology Letters, 229(1), 265-272 (2014)
Marta Starczak et al.
Methods in molecular biology (Clifton, N.J.), 2198, 91-108 (2020-08-22)
Our hereby presented methodology is suitable for reliable assessment of the most common DNA modifications which arise as a product of fundamental metabolic processes. 8-oxoguanine, one of the oxidatively modified DNA bases is a typical biomarker of oxidative stress. A
T Guo et al.
Journal of dental research, 93(12), 1290-1295 (2014-08-21)
In previous studies, fluorapatite (FA) crystal-coated surfaces have been shown to stimulate the differentiation and mineralization of human dental pulp stem cells (DPSCs) in two-dimensional cell culture. However, whether the FA surface can recapitulate these properties in three-dimensional culture is
Gulvahid Shaikh et al.
Clinical laboratory, 60(3), 491-494 (2014-04-05)
Wilson's disease presenting as fulminant hepatic failure is a rare presentation that carries a high morbidity and mortality. We report a young patient who developed fulminant hepatic failure as the initial manifestation of Wilson's disease. Virtually undetectable serum alkaline phosphatase
Johad F Khoury et al.
The Israel Medical Association journal : IMAJ, 16(1), 26-32 (2014-03-01)
In osteosarcoma the histological response, measured by the percentage of tumor necrosis, constitutes one of the most significant predictive factors, with better survival in patients whose tumor necrosis is > or = 90%. To determine if the decrease rate of
Naomi Ofer et al.
The Journal of biological chemistry, 288(16), 11287-11293 (2013-03-09)
Protein degradation via prokaryotic ubiquitin-like protein (Pup) tagging is conserved in bacteria belonging to the phyla Actinobacteria and Nitrospira. The physiological role of this novel proteolytic pathway is not yet clear, although in Mycobacterium tuberculosis, the world's most threatening bacterial
Veslemøy Rolseth et al.
Scientific reports, 7(1), 4384-4384 (2017-07-01)
Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence
Ryosuke Yamaguchi et al.
Rheumatology (Oxford, England), 53(12), 2191-2195 (2014-06-25)
The aim of this study was to compare the levels of bone and cartilage metabolism markers in the synovial fluid of the hip joint between patients with secondary OA due to osteonecrosis of the femoral head (ONFH), rapidly destructive arthrosis
Alexandra M Roch et al.
Annals of surgery, 260(4), 680-688 (2014-09-10)
As such, the natural history of MPD-involved IPMN is poorly understood. The high-risk of malignancy associated with main pancreatic duct (MPD)-involved intraductal papillary mucinous neoplasm (IPMN) has been established by surgical series. The International Consensus Guidelines recommend surgical resection of
G U Mohangi et al.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 67(7), 354-358 (2013-08-21)
Demineralised bone matrix (DBM) is an allograft material widely used as a bone filler and bone graft substitute. DBM contains bone morphogenetic proteins (BMPs), which induce and regulate bone formation during embryogenesis and in postnatal life. To investigate the osteoinductivity
Gregory R Sondag et al.
Journal of cellular physiology, 229(7), 955-966 (2013-11-23)
Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA plays a role in wound healing and its expression
Evaluation of parathyroid levels and bone densitometry after cinacalcet treatment in severe primary hyperparathyroidism.
C Ogrin
Minerva endocrinologica, 38(3), 337-338 (2013-10-16)
K T Shalumon et al.
Journal of biomedical nanotechnology, 9(3), 430-440 (2013-04-30)
A biomimetic scaffold which can very closely mimic the extracellular matrix of the bone was fabricated by incorporating nano-bioceramic particles such as nano bioglass (nBG) and nano hydroxyapatite (nHAp) within electrospun nanofibrous scaffold. A comparative study between nHAp incorporated poly(caprolactone)
Xia Kang et al.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 27(9), 1122-1127 (2013-11-28)
To investigate the role of micro RNA-451 (miRNA-451) in promoting the osteogenesis of mesenchymal stem cells (MSCs) by targeting regulatory calcium binding protein 39 (CAB39). pMIR-report and pRL-TK vectors were selected to identify the relationship between miRNA-451 and CAB39 by
Rui Su et al.
Cell, 172(1-2), 90-105 (2017-12-19)
R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here that R-2HG also exerts a broad anti-leukemic activity in vitro and in vivo by inhibiting leukemia cell proliferation/viability and by promoting
S R Pidruchna
Klinichna khirurhiia, (3)(3), 59-62 (2013-05-31)
In recent years there are intensively studied the role of hepatocytic affection in the complications progress in trauma of various genesis, including the multiple and combined. Positive correcting impact of lyophilized xenoimplants on the hepatic markers activity was demonstrated in
Yuki Matsushita et al.
The Journal of biological chemistry, 288(27), 19973-19985 (2013-05-09)
CCN3, a member of the CCN protein family, inhibits osteoblast differentiation in vitro. However, the role of CCN3 in bone regeneration has not been well elucidated. In this study, we investigated the role of CCN3 in bone regeneration. We identified
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