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Antonio Rodríguez-Núñez et al.
Brain & development, 25(2), 102-106 (2003-02-13)
To determine the effects of meningitis on cerebral energy metabolism, cerebrospinal fluid concentrations of adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine and urate were determined by high-performance liquid chromatography, and neuron-specific enolase by an enzyme immunoassay
Guozan Yuan et al.
Dalton transactions (Cambridge, England : 2003), 42(8), 2921-2929 (2012-12-18)
We reported here the self-assembly of two supramolecular structures based on similar trimeric Zn(II) units that are built from novel 2-substituted 8-hydroxyquinoline ligands and coordination Zn(II) ions. The aggregation behavior of zinc salt and ligand in solution was investigated by
Yiquan Chen et al.
Neurotoxicity research, 18(2), 132-142 (2009-11-19)
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease of unknown pathogenesis. The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS. The KP is the major route for tryptophan (TRP)
Han Zhou et al.
Acta oto-laryngologica, 132(9), 938-943 (2012-05-10)
Elevated levels of hypoxia-inducible factor 1α (HIF-1α) in middle ear effusion may play an important role in the pathogenesis of bone conduction impairment associated with otitis media with effusion (OME). The mechanism may be related to the up-regulation of nitric
Raffaela Silvestre Ignarro et al.
Journal of chemical neuroanatomy, 48-49, 14-22 (2013-02-14)
Quinolinic acid (QA) striatal lesion in rodents induces neuronal death, astrogliosis and migration of neuroblasts from subventricular zone to damaged striatum. These phenomena occur in some human neurodegenerative illnesses, but the underlying mechanisms are unknown. We investigated the effect of
Miki Terakata et al.
The Journal of nutrition, 142(12), 2148-2153 (2012-10-26)
Pyridine nucleotide coenzymes are involved in >500 enzyme reactions and are biosynthesized from the amino acid L-tryptophan (L-Trp) as well as the vitamin niacin. Hence, "true" niacin-deficient animals cannot be "created" using nutritional techniques. We wanted to establish a truly
Fernando Dobrachinski et al.
Neurochemical research, 37(9), 1993-2003 (2012-06-08)
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-induced toxicity. Thus, here we investigate if the use of diphenyl diselenide (PhSe)(2), guanosine (GUO) and MK-801, alone
M Castro-Gago et al.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 5(6), 361-363 (1989-12-01)
The xanthine, hypoxanthine, and total oxypurine levels were determined in the CSF of 28 hydrocephalic patients (age from newborn to 2 years) and 8 healthy controls using HPLC. The Evans' index, the mean weekly increase in cranial circumference, and the
Sawsan M S Haggag et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 150-158 (2012-12-12)
Nano Al(III)-8-hydroxy-5-nitrosoquinolate [Al(III)-(HNOQ)(3)] thin films were synthesized by the rapid, direct, simple and efficient successive ion layer adsorption and reaction (SILAR) technique. Thin film formation optimized factors were evaluated. Stoichiometry and structure were confirmed by elemental analysis and FT-IR. The
M P Heyes et al.
The Biochemical journal, 320 ( Pt 2), 595-597 (1996-12-01)
Immune activation leads to accumulations of the neurotoxin and kynurenine pathway metabolite quinolinic acid within the central nervous system of human patients. Whereas macrophages can convert L-tryptophan to quinolinic acid, it is not known whether human brain microglia can synthesize
Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
Laszlo Vecsei et al.
Expert review of clinical pharmacology, 5(4), 351-353 (2012-09-05)
Ethel Antunes Wilhelm et al.
European journal of pharmacology, 701(1-3), 65-72 (2013-01-24)
The present study was designed to examine the correlations between behavioural and oxidative parameters in a quinolinic acid model of Huntington's disease in rats. The protective effect of melatonin against the excitotoxicity induced by quinolinic acid was investigated. Rats were
Ned Sacktor et al.
Journal of neurovirology, 20(6), 620-626 (2014-11-08)
Elevated cerebrospinal fluid (CSF) levels of markers of oxidative stress, neuronal injury, and inflammation and decreased neurotransmitter levels have been reported in HIV-associated neurocognitive disorders (HAND). Minocycline may have a neuroprotective effect by inhibiting inducible nitric oxide synthase, which produces
Isabelle M Medana et al.
The Journal of infectious diseases, 185(5), 650-656 (2002-02-28)
A retrospective study of 261 Vietnamese adults with severe malaria was conducted to determine the relationship between cerebrospinal fluid (CSF) levels of metabolites of the kynurenine pathway, the incidence of neurologic complications, and the disease outcome. Three metabolites were measured:
Hulya Bayir et al.
Pediatric research, 51(5), 571-578 (2002-04-30)
Studies in experimental traumatic brain injury (TBI) support a key role for oxidative stress. The degree of oxidative injury in clinical TBI, however, remains to be defined. We assessed antioxidant defenses and oxidative stress in pediatric TBI by applying a
C Blázquez et al.
Cell death and differentiation, 22(10), 1618-1629 (2015-02-24)
The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the CB1 receptor is highly expressed in the basal ganglia, mostly on terminals
George A Smythe et al.
Advances in experimental medicine and biology, 527, 705-712 (2004-06-23)
To study the complex inter-relationships between inflammatory and apoptotic responses and the kynurenine pathway, we have utilized electron-capture negative ion mass spectrometry to develop trace analyses to concurrently quantify nicotinic acid (NIC), picolinic acid (PIC) and quinolinic acid (QUIN) in
Yan Li et al.
International journal of molecular sciences, 16(7), 15150-15171 (2015-07-08)
Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestations of SLE. Among the potential pathophysiological mechanisms responsible for NP-SLE
G M Megson et al.
Journal of clinical microbiology, 34(1), 218-221 (1996-01-01)
Cryptococcal meningitis (CM) is associated with raised intracranial pressure which is linked with serious neurological sequelae. Cryptococcus neoformans produces D-mannitol in vitro and in experimental meningitis in rabbits. Mannitol present in the cerebrospinal fluid (CSF) of CM patients could exacerbate
Kynurenine pathway enzymes in brain. Properties of enzymes and regulation of quinolinic acid synthesis.
K Saito et al.
Advances in experimental medicine and biology, 398, 485-492 (1996-01-01)
M Ellaurie et al.
The Pediatric infectious disease journal, 11(4), 286-289 (1992-04-01)
Neopterin concentrations in 50 children with human immunodeficiency virus infection were correlated with disease course. The neopterin concentrations ranged from 4 to 70 nM with a mean of 34.7 +/- 25.1 (SD) nM compared with a mean of 6.1 +/-
D W Ellison et al.
Brain : a journal of neurology, 110 ( Pt 6), 1657-1673 (1987-12-01)
Concentrations of gamma-aminobutyric acid (GABA), glutamate, aspartate, and taurine were measured in postmortem tissue from the brains of patients with Huntington's disease (HD) and in the quinolinic acid (QA) lesioned rat striatum. The aim of the study was to assess
A S Basile et al.
Gastroenterology, 108(3), 818-823 (1995-03-01)
Quinolinic acid is an endogenous neuroexcitant derived from tryptophan. Brain quinolinic acid concentrations are reportedly elevated in chronic liver failure. The aim of this study was to determine if brain quinolinic acid levels correlate with the severity of hepatic encephalopathy.
A L Colín-González et al.
Neuroscience, 231, 91-101 (2012-12-04)
Quinolinic acid (QA)-induced overactivation of N-methyl-d-aspartate receptors yields excitotoxicity, oxidative stress and mitochondrial dysfunction, which altogether contribute to trigger a wide variety of toxic pathways with biochemical, behavioral and neuropathological alterations similar to those observed in Huntington's disease. Noteworthy, in
Miki Terakata et al.
The Journal of nutrition, 143(7), 1046-1051 (2013-05-24)
In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (tdo(-/-)) mice fed a diet without preformed niacin
Apsara Kandanearatchi et al.
The FEBS journal, 279(8), 1366-1374 (2012-01-21)
This brief review will first consider HIV associated neurocognitive disorder followed by the current understanding of its neuropathogenesis. Against this background the role of the kynurenine pathway will be detailed. Evidence both direct and indirect will be discussed for involvement
Koenraad F van der Sluijs et al.
Thorax, 68(12), 1122-1130 (2013-07-25)
Patients with allergic asthma have exacerbations which are frequently caused by rhinovirus infection. The antiviral tryptophan-catabolising enzyme indoleamine 2,3-dioxygenase (IDO) is induced by interferon-γ and suppressed by Th2 mediators interleukin (IL)-4 and IL-13. We hypothesised that local IDO activity after
K Saito et al.
Neuroscience, 51(1), 25-39 (1992-11-01)
Accumulation of quinolinic acid and neuroactive kynurenines derived from tryptophan are of potential significance in human neuropathologic diseases because of their neurotoxic and convulsant properties. Clinical studies have established that sustained elevations of quinolinic acid, L-kynurenine and kynurenic acid within
Nathan R Rose et al.
Journal of medicinal chemistry, 51(22), 7053-7056 (2008-10-24)
The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Gelareh Mazarei et al.
Journal of neurochemistry, 127(6), 852-867 (2013-06-22)
Indoleamine 2,3 dioxygenase (Ido1), the first and rate-limiting enzyme of the kynurenine pathway (KP), is a striatally enriched gene with increased expression levels in the YAC128 mouse model of Huntington disease (HD). Our objective in this study was to delineate
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