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显示 1-30 共 187 条结果 关于 "P6556" 范围 论文
Bruce Reed et al.
Methods in molecular biology (Clifton, N.J.), 1652, 229-256 (2017-08-10)
For several decades, genetic analysis in Drosophila has made important contributions to the understanding of signaling by Egfr. Egfr has been well characterized with regard to its oncogenic potential but is also being studied for its roles in organismal development.
Susann Burow et al.
General and comparative endocrinology, 272, 93-108 (2018-12-24)
The two gonadotropins follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh) are of particular importance within the hypothalamic-pituitary-gonadal (HPG) axis of vertebrates. In the current study, we demonstrate the production and validation of Japanese medaka (Oryzias latipes) recombinant (md) gonadotropins Fshβ
Antonio Dominguez-Meijide et al.
Scientific reports, 10(1), 12827-12827 (2020-08-01)
Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect a growing number of patients worldwide. Both diseases share, as a common hallmark, the accumulation of characteristic protein aggregates, known as Lewy bodies
Marco Gargaro et al.
Immunity, 55(6), 1032-1050 (2022-06-16)
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis
Julie F Jameson et al.
Frontiers in bioengineering and biotechnology, 9, 664306-664306 (2021-07-24)
Sponge-like biomaterials formed from silk fibroin are promising as degradable materials in clinical applications due to their controllable breakdown into simple amino acids or small peptides in vivo. Silk fibroin, isolated from Bombyx mori silkworm cocoons, can be used to
Mary H Young et al.
PloS one, 8(1), e53789-e53789 (2013-01-24)
Mucosal-associated invariant T cells are a unique population of T cells that express a semi-invariant αβ TCR and are restricted by the MHC class I-related molecule MR1. MAIT cells recognize uncharacterized ligand(s) presented by MR1 through the cognate interaction between
Lily Agranat-Tamir et al.
Cell, 181(5), 1146-1157 (2020-05-30)
We report genome-wide DNA data for 73 individuals from five archaeological sites across the Bronze and Iron Ages Southern Levant. These individuals, who share the "Canaanite" material culture, can be modeled as descending from two sources: (1) earlier local Neolithic
Maria Angela de Mello Marques et al.
Journal of microbiological methods, 91(3), 487-489 (2012-10-02)
Six commercially available DNA extraction kits, as well as thermal lysis and proteinase K DNA extraction were evaluated regarding bacterial inactivation, DNA yield and purity, and their use in a Burkholderia pseudomallei real-time PCR. While all methods successfully inactivated the
Thomas Kroneis et al.
Methods in molecular biology (Clifton, N.J.), 1347, 245-261 (2015-09-17)
Multiple analyses such as DNA profiling, sequencing, or comparative genome hybridization (CGH) done on the single-cell level long for pre-amplification due to the diploid human genome. Isothermal whole genome amplification allows amplification of long DNA templates from single cells. When
Bruno Marçal Repolês et al.
Mitochondrion, 61, 179-187 (2021-11-04)
The integrity of mitochondrial DNA (mtDNA) isolated from solid tissues is critical for analyses such as long-range PCR, but is typically assessed under conditions that fail to provide information on the individual mtDNA strands. Using denaturing gel electrophoresis, we show
TRPV4 regulates I?1 integrin-mediated cell-matrix adhesions and collagen remodeling.
Ji, et al.
Faseb Journal, 37, e22946-e22946 (2023)
Haruka Chino et al.
Molecular cell, 74(5), 909-921 (2019-04-23)
Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that bind to autophagosomal LC3 and GABARAP family proteins. Here, we performed a differential interactome screen using wild-type LC3B
Yue Xie et al.
Genomics, proteomics & bioinformatics, 20(2), 366-381 (2021-09-07)
Baylisascaris schroederi, a roundworm (ascaridoid) parasite specific to the bamboo-feeding giant panda (Ailuropoda melanoleuca), represents a leading cause of mortality in wild giant panda populations. Here, we present a 293-megabase chromosome-level genome assembly of B. schroederi to infer its biology
Paulina H Wanrooij et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(25), 14306-14313 (2020-06-10)
Ribonucleotides (rNMPs) incorporated in the nuclear genome are a well-established threat to genome stability and can result in DNA strand breaks when not removed in a timely manner. However, the presence of a certain level of rNMPs is tolerated in
Johnathan R Whetstine et al.
STAR protocols, 3(1), 101209-101209 (2022-03-05)
Traditional replication timing (RT) experiments divide S phase into two phases: early and late. However, there is an increasing awareness that variation in RT can occur during the course of S phase and impact our understanding of RT patterns and
Laura Maringele et al.
Methods in molecular biology (Clifton, N.J.), 313, 65-73 (2005-08-25)
Pulsed-field gel electrophoresis (PFGE) can be used to separate the 16 budding yeast chromosomes on the basis of size. Here we describe a detailed, practical protocol that will allow a novice to perform informative PFGE experiments. We first describe the
Chiara Scaramuzzino et al.
Science advances, 8(1), eabj8812-eabj8812 (2022-01-06)
When a neurotrophin binds at the presynapse, it sends survival signals all the way to the nucleus on signaling endosomes. These endosomes fuel their own journey with on-board glycolysis—but how is that journey initiated and maintained? Using microfluidic devices and
A Manoj-Kumar et al.
Molekuliarnaia biologiia, 46(4), 598-604 (2012-11-02)
Abelmoschus esculentus (okra) is one of the polysaccharide rich crop plants. The polysaccharides interfere with nucleic acids and protein isolation thereby affecting the downstream molecular analysis. So, to understand the molecular systematics of okra, high quality DNA, RNA and proteins
Yiyi Chen et al.
International journal of molecular sciences, 23(20) (2022-10-28)
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly understood. The aim of this study was to systematically map the transcriptional changes that occur in the degenerating mouse retina at the single cell level. To this end, we employed
William A Dion et al.
Gene expression patterns : GEP, 38, 119132-119132 (2020-08-24)
To understand how novel animal body colorations emerged, one needs to ask how the development of color patterns differs among closely related species. Here we examine three species of fruit flies - Drosophila guttifera (D. guttifera), D. palustris, and D.
Mariana G Simões et al.
BMC developmental biology, 14, 49-49 (2015-01-01)
Zebrafish are able to regenerate many of its tissues and organs after damage. In amphibians this process is regulated by nerve fibres present at the site of injury, which have been proposed to release factors into the amputated limbs/fins, promoting
Noa Roitenberg et al.
EMBO reports, 19(8) (2018-06-28)
Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis), and elevates stress resistance of worms, flies, and mammals. How these functions are orchestrated across the organism is only partially understood. Here, we report that in the nematode Caenorhabditis elegans
Bo-Wen Wu et al.
IUBMB life, 72(2), 198-213 (2019-08-25)
Atherosclerotic plaque rupture is an important pathophysiologic mechanism of acute coronary syndrome. Emerging microRNAs (miRNAs) have been implicated in the atherosclerotic plaque formation and macrophage autophagy during the development of atherosclerosis (AS). Hence, this study was conducted to explore the
Meng Jiang et al.
Nature communications, 11(1), 19-19 (2020-01-09)
Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/β-catenin pathway
Minaka Ishibashi et al.
Human genetics, 134(11-12), 1163-1182 (2015-09-05)
Protein-coding mutations in the transcription factor-encoding gene ARX cause various forms of intellectual disability (ID) and epilepsy. In contrast, variations in surrounding non-coding sequences are correlated with milder forms of non-syndromic ID and autism and had suggested the importance of
Birgitt Gutbier et al.
American journal of physiology. Lung cellular and molecular physiology, 309(3), L250-L261 (2015-06-07)
In patients with chronic obstructive pulmonary disease (COPD), Moraxella catarrhalis infection of the lower airways is associated with chronic colonization and inflammation during stable disease and acute exacerbations. Chronic smoke exposure induces chronic inflammation and impairs mucociliary clearance, thus contributing
Asma Manzoor et al.
Microbial pathogenesis, 131, 22-32 (2019-03-25)
Fourteen Lactobacillus plantarum strains isolated from various food sources and two different climatic regions, Ireland and Pakistan were analyzed for their probiotic functions. RecA gene based multiplex PCR amplifications and pulsed-field gel electrophoresis (PFGE) were performed to genetically characterize these
Karine Berthelot et al.
PloS one, 7(10), e48065-e48065 (2012-11-08)
REF (Hevb1) and SRPP (Hevb3) are two major components of Hevea brasiliensis latex, well known for their allergenic properties. They are obviously taking part in the biosynthesis of natural rubber, but their exact function is still unclear. They could be
Jian Liu et al.
Applied and environmental microbiology, 79(18), 5593-5600 (2013-07-10)
Stenotrophomonas maltophilia is an important global opportunistic pathogen for which limited therapeutics are available because of the emergence of multidrug-resistant strains. A novel bacteriocin, maltocin P28, which is produced by S. maltophilia strain P28, may be the first identified phage
E Kraus et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 357(7), 937-947 (1976-07-01)
1) The specificity of proteinase K towards amino acid and oligopeptide nitroanilide substrates is investigated. 2) The active center of the enzyme contains an extended binding region consisting of several subsites. An integral part of the S1-subsite are hydrophobic areas
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