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关键词:'P6782'
显示 1-30 共 152 条结果 关于 "P6782" 范围 论文
Yaiza Montes-Cebrián et al.
Sensors (Basel, Switzerland), 19(24) (2019-12-11)
Considerable efforts are made to develop Point-of-Care (POC) diagnostic tests. POC devices have the potential to match or surpass conventional systems regarding time, accuracy, and cost, and they are significantly easier to operate by or close to the patient. This
Edwin van Bloois et al.
Applied microbiology and biotechnology, 83(4), 679-687 (2009-02-19)
Streptomyces coelicolor A3(2) alditol oxidase (AldO) is a soluble monomeric flavoprotein in which the flavin cofactor is covalently linked to the polypeptide chain. AldO displays high reactivity towards different polyols such as xylitol and sorbitol. These characteristics make AldO industrially
Nicole M Sayles et al.
Cell reports, 38(10), 110475-110475 (2022-03-10)
Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of heart mitochondrial function activate the mitochondrial integrated stress response (ISRmt), a transcriptional program affecting cell metabolism, mitochondrial biogenesis, and proteostasis. In humans, mutations in CHCHD10, a mitochondrial protein with
D Saha et al.
Journal of environmental biology, 33(5), 861-866 (2013-06-06)
Tea [Camellia sinensis L. (O.) Kuntze] is an economically important plantation crop of India but is prone to attack by several fungal pathogens. Copper based fungicides are being used for decades to control fungal diseases in tea which may lead
G S Murzagulov et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 49(1), 24-29 (2013-05-15)
The work deals with effect of density of population on functional activity of components pf protective system of adult individuals and nymphs of the marble cockroach. The resistance of individuals has been noted to decrease both at individual maintenance and
Matthias Karer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 71(4), 497-511 (2022-03-19)
To evaluate the contribution of endogenous diamine oxidase (DAO) in the inactivation of exogenous histamine, to find a mouse strain with increased histamine sensitivity and to test the efficacy of rhDAO in a histamine challenge model. Diamine oxidase knockout (KO)
Andrew D Pucker et al.
Investigative ophthalmology & visual science, 51(6), 2949-2954 (2010-01-22)
The purpose of this work was to develop an enzymatic method of quantification of cholesterol and cholesterol esters derived from contact lenses, both in vitro and ex vivo. Lotrafilcon B (O2 Optix; CIBA Vision, Inc., Duluth, GA) and galyfilcon A
Myeloperoxidase-mediated dysfunctional high-density lipoprotein.
Godfrey S Getz et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(4), 695-696 (2014-03-26)
[NETs in pathogenesis of vasculitis].
Daigo Nakazawa et al.
Nihon Jinzo Gakkai shi, 56(2), 117-123 (2014-04-16)
Zhimin Song et al.
Biochemical pharmacology, 178, 114088-114088 (2020-06-13)
Phagocytes, especially neutrophils, can produce reactive oxygen species (ROS), through the activation of the NADPH oxidase (NOX2). Although this enzyme is crucial for host-pathogen defense, ROS production by neutrophils can be harmful in several pathologies such as cardiovascular diseases or
R Sorrentino et al.
British journal of pharmacology, 154(4), 864-871 (2008-06-10)
Lung epithelial cells express pattern recognition receptors, which react to bacteria. We have evaluated the effect of Gram-positive and Gram-negative bacteria on interleukin-8 (CXCL8) release from epithelial cells and the integrity of the epithelial barrier. Primary cultures of human airway
Katarzyna Grychowska et al.
European journal of medicinal chemistry, 236, 114329-114329 (2022-04-10)
The incorporation of the fluorine motif is a strategy widely applied in drug design for modulating the activity, physicochemical parameters, and metabolic stability of chemical compounds. In this study, we attempted to reduce the affinity for ether-à-go-go-related gene (hERG) channel
Juliette Azimzadeh et al.
The Plant cell, 20(8), 2146-2159 (2008-09-02)
Plant cells have specific microtubule structures involved in cell division and elongation. The tonneau1 (ton1) mutant of Arabidopsis thaliana displays drastic defects in morphogenesis, positioning of division planes, and cellular organization. These are primarily caused by dysfunction of the cortical
R Adam Shane et al.
Chemical research in toxicology, 15(10), 1324-1329 (2002-10-22)
Two supercoiled (SC), double-stranded DNAs, pBR 322 and pUC 19, have been subjected to oxidative stress using horseradish peroxidase (HRP) and HRP + tert-butyl hydroperoxide (BOOH). HRP alone causes single-strand cleavage of these SC DNAs. Strand cleavage is enhanced substantially
Aitken et al.
Biotechnology progress, 14(3), 487-492 (1998-06-17)
Coprinus cinereus peroxidase (CIP) and other peroxidases are susceptible to mechanism-based inactivation during the oxidation of phenolic substrates. The turnover capacity (defined as the molar or mass concentration of substrate oxidized per unit concentration of enzyme inactivated) of CIP was
The isolation and purification of lactoperoxidase by ion exchange chromatography.
M MORRISON et al.
The Journal of biological chemistry, 228(2), 767-776 (1957-10-01)
Bin Ye et al.
Biochemical and biophysical research communications, 434(3), 547-551 (2013-04-16)
Stress ulcers are a common complication in critically ill patients, but the underlying mechanism is little known. This study characterized the function of the p50 subunit of NF-κB in an experimental model of cold immobilization stress-induced gastric ulcers. Stress-induced gastric
Z S Farhangrazi et al.
Biochemistry, 33(18), 5647-5652 (1994-05-10)
At neutral pH, compound I of Arthromyces ramosus peroxidase (ARP) was stable and was reduced to ferric ARP without apparent formation of compound II upon titration with ascorbate or hydroquinone. In the titration experiments, compound II was seen as an
Jalal Soubhye et al.
Journal of medicinal chemistry, 56(10), 3943-3958 (2013-04-16)
Due to its production of potent antimicrobial oxidants including hypochlorous acid, human myeloperoxidase (MPO) plays a critical role in innate immunity and inflammatory diseases. Thus MPO is an attractive target in drug design. (Aminoalkyl)fluoroindole derivatives were detected to be very
Diana Humer et al.
International journal of molecular sciences, 20(4) (2019-02-23)
Horseradish peroxidase (HRP) is an intensely studied enzyme with a wide range of commercial applications. Traditionally, HRP is extracted from plant; however, recombinant HRP (rHRP) production is a promising alternative. Here, non-glycosylated rHRP was produced in Escherichia coli as a
Bahareh Ebrahimi et al.
Iranian journal of medical sciences, 45(3), 188-198 (2020-06-18)
Sperm cryopreservation-thawing process has damaging effects on the structure and function of sperm, namely cryoinjury. Calcium overload has been reported as a postulated mechanism for sperm damage during the first steps after thawing. This study was designed to assess the
Diana Humer et al.
Monatshefte fur chemie, 152(11), 1389-1397 (2021-11-12)
Targeted cancer treatment is a promising, less invasive alternative to chemotherapy as it is precisely directed against tumor cells whilst leaving healthy tissue unaffected. The plant-derived enzyme horseradish peroxidase (HRP) can be used for enzyme prodrug cancer therapy with indole-3-acetic
Irene Granlund et al.
Plant & cell physiology, 50(11), 1898-1910 (2009-10-16)
The TL29 protein is one of the more abundant proteins in the thylakoid lumen of plant chloroplasts. Based on its sequence homology to ascorbate peroxidases, but without any supporting biochemical evidence, TL29 was suggested to be involved in the plant
Guojin Wu et al.
The Journal of experimental biology, 212(Pt 14), 2176-2182 (2009-06-30)
It has been speculated that free amino acids digested from proteins in bird eggs are transported to the circulation for the nourishment of the embryo. In the present study, we found that early chicken embryo protein in the serum might
Fernando Navarrete et al.
PLoS pathogens, 17(6), e1009641-e1009641 (2021-06-25)
Biotrophic plant pathogens secrete effector proteins to manipulate the host physiology. Effectors suppress defenses and induce an environment favorable to disease development. Sequence-based prediction of effector function is impeded by their rapid evolution rate. In the maize pathogen Ustilago maydis
A V Razygraev
Biomeditsinskaia khimiia, 59(6), 636-643 (2014-02-12)
Recently it was shown that the presence of rat blood plasma (as well as of erythrocyte hemolysate) in the reaction mixture containing 43 mM Tris-HCl-buffer (pH 8.5), 0.29 mM EDTA, 19.2 mM sodium azide, 1 mM DL-homocysteine (Hcy), and 198
Veronika Binder et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1020-1027 (2013-03-16)
Elevated levels of advanced oxidation protein products have been described in several chronic inflammatory diseases, like chronic renal insufficiency, rheumatoid arthritis, and atherosclerosis. Recent findings revealed that advanced oxidation protein products are inhibitors of the major high-density lipoprotein receptor, scavenger
Erica S Schwartz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5603-5611 (2013-03-29)
Visceral afferents expressing transient receptor potential (TRP) channels TRPV1 and TRPA1 are thought to be required for neurogenic inflammation and development of inflammatory hyperalgesia. Using a mouse model of chronic pancreatitis (CP) produced by repeated episodes (twice weekly) of caerulein-induced
Emiko Miyahara et al.
Toxicology, 317, 50-57 (2014-02-18)
While it is known that benzene induces myeloid leukemia in humans, the mechanism has yet to be clarified. Previously, we suggested that myeloperoxidase (MPO) was the key enzyme because it promotes generation of powerful oxidant hypochlorous acid (HOCl) which, reacting
Sara Keshtgar et al.
Cell and tissue banking, 21(4), 675-684 (2020-07-02)
Sperm cryopreservation leads to various structural and functional damages, some of which induce by oxidative stress. The reactive oxygen species (ROS) generates by mitochondria and membrane NADPH oxidases (NOXs). Among the NOXs, only NOX5 has been identified in the cell
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