CN
Search Within
P7626
应用筛选条件
关键词:'P7626'
显示 1-30 共 3149 条结果 关于 "P7626" 范围 论文
Letteria Minutoli et al.
The Journal of pharmacology and experimental therapeutics, 355(3), 370-380 (2015-09-27)
We investigated the role of the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome during testis ischemia and reperfusion injury (TI/R) in wild-type (WT) and NLRP3 knock-out (KO) mice. WT and KO mice underwent 1 hour
Tijana Ivanovic et al.
The EMBO journal, 27(8), 1289-1298 (2008-03-29)
Nonenveloped animal viruses must disrupt or perforate a cell membrane during entry. Recent work with reovirus has shown formation of size-selective pores in RBC membranes in concert with structural changes in capsid protein mu1. Here, we demonstrate that mu1 fragments
Nina Graffmann et al.
Stem cells and development, 24(17), 2018-2031 (2015-05-12)
Human hematopoietic stem and progenitor cells (HSPCs) from umbilical cord blood exhibit higher differentiation potential and repopulation capacity compared to adult HSPCs. The molecular basis for these functional differences is currently unknown. Upon screening for epigenetic effector genes being differentially
Dina B AbuSamra et al.
The Journal of biological chemistry, 290(35), 21213-21230 (2015-07-01)
Selectins (E-, P-, and L-selectins) interact with glycoprotein ligands to mediate the essential tethering/rolling step in cell transport and delivery that captures migrating cells from the circulating flow. In this work, we developed a real time immunoprecipitation assay on a
Yong-Bin Wang et al.
Experimental and therapeutic medicine, 9(2), 451-455 (2015-01-13)
Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes in the myocardial structure and function. The aim of the present study was to investigate the protective effect of rutin on DCM in
Woo Jin Choi et al.
Foot & ankle international, 35(10), 1045-1056 (2014-06-25)
Tendinopathy is a clinical problem for which treatment shows mixed results and treatment options are limited. Gene expression signatures early in the mechanotransduction pathway can accurately predict risk and correlate with different clinical outcomes. Studies aimed at elucidating the molecular
Ethika Tyagi et al.
Neurobiology of disease, 73, 307-318 (2014-10-07)
Quality nutrition during the period of brain formation is a predictor of brain functional capacity and plasticity during adulthood; however it is not clear how this conferred plasticity imparts long-term neural resilience. Here we report that early exposure to dietary
Yuichi Sekine et al.
The Journal of biological chemistry, 290(28), 17462-17473 (2015-05-30)
Melanoma is the most serious type of skin cancer, with a highly metastatic phenotype. In this report, we show that signal transducing adaptor protein 2 (STAP-2) is involved in cell migration, proliferation, and melanogenesis as well as chemokine receptor expression
Jingli Cai et al.
Molecular medicine reports, 12(1), 1549-1555 (2015-03-12)
Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. The study of potential treatments for GBC has recently focused on microRNAs, a class of small non-coding RNAs, which post-transcriptionally regulate gene expression during various crucial
Francisco Clemente-Vicario et al.
PloS one, 10(11), e0142007-e0142007 (2015-11-13)
It has been an open question how similar human and canine lung cancers are. This has major implications in availability of human treatments for dogs and in establishing translational models to test new therapies in pet dogs. The prognosis for
Meng He et al.
Endocrinology, 155(12), 4895-4904 (2014-09-30)
Weight gain and its related metabolic disorders are major side effects associated with second generation antipsychotic drug treatment. The dorsal vagal complex (DVC) and AMP-activated protein kinase (AMPK) are implicated in the regulation of food intake and body weight. Blocking
Thorsten Langner et al.
Eukaryotic cell, 14(9), 846-857 (2015-05-03)
Chitin is an essential component of the fungal cell wall, providing rigidity and stability. Its degradation is mediated by chitinases and supposedly ensures the dynamic plasticity of the cell wall during growth and morphogenesis. Hence, chitinases should be particularly important
Yongjun Xu et al.
Behavioural brain research, 288, 71-78 (2015-04-25)
Estrogen deficiency is involved in the development of depression. However, the mechanism underlying estrogen modulates depression-like behavior remains largely unknown. Inflammation and indoleamine-2,3-dioxygenase (IDO) have been shown to play pivotal roles in various depression models. The objective of the present
Kunal Sikder et al.
Food & function, 5(6), 1294-1303 (2014-04-20)
The present study demonstrates for the first time the protective role of two common flavonoids, quercetin and its glycone rutin, against high cholesterol diet (2%) induced hepatotoxicity and inflammation. Swiss albino mice were given either a standard laboratory diet (control)
Charmaine J Green et al.
Human reproduction (Oxford, England), 30(2), 284-298 (2014-11-30)
Does insulin-like growth factor 1 (IGF1) increase adhesion competency of blastocysts to increase attachment to uterine epithelial cells in vitro? IGF1 increases apical fibronectin on blastocysts to increase attachment and invasion in an in vitro model of implantation. Fibronectin integrin
Lucy K Shewell et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5312-E5320 (2014-11-26)
The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae. Membrane cholesterol is required for the cytolytic activity of this toxin, but it is not clear whether cholesterol is the only cellular receptor. Analysis of Ply
Yeonju Lee et al.
Journal of ginseng research, 39(3), 250-256 (2015-07-23)
It has been known that ginseng can be applied as a potential nutraceutical for memory impairment; however, experiments with animals of old age are few. To determine the memory enhancing effect of red ginseng, C57BL/6 mice (21 mo old) were
Atsuko Nakayama et al.
PloS one, 10(9), e0137106-e0137106 (2015-09-04)
Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Luteolin (3',4',5,7-tetrahydroxyflavone), a widely distributed flavonoid found in many
Kazime Gonca Akbulut et al.
Biogerontology, 16(1), 99-108 (2014-11-29)
The protein family of sirtuins and FoXO1 transcription factor have been shown to play significant roles in the aging process. In this study we aimed to investigate the changes in the levels of SIRT2, NFκB and FoXO1 and oxidative parameters
Xin-xin Xiong et al.
Acta pharmacologica Sinica, 36(3), 362-374 (2015-01-27)
To investigate the effects of piperlongumine (PL), an anticancer alkaloid from long pepper plants, on the primary myeloid leukemia cells from patients and the mechanisms of action. Human BM samples were obtained from 9 patients with acute or chronic myeloid
Shujun Wang et al.
Oxidative medicine and cellular longevity, 2015, 903782-903782 (2015-08-15)
Multidrug resistance-associated protein 1 (MRP1) plays a protective role in the etiology and progression of chronic obstructive pulmonary disease (COPD) which results from oxidative stress and inflammation of lung injury. The lower functional MRP1 activity is related to COPD development.
Maizom Hassan et al.
Bioscience, biotechnology, and biochemistry, 76(8), 1463-1470 (2012-08-11)
NADP(+)-dependent geraniol dehydrogenase (EC 1.1.1.183) is an enzyme that catalyzes the oxidation of geraniol to geranial. Stable, highly active cell-free extract was obtained from Polygonum minus leaves using polyvinylpolypyrrolidone, Amberlite XAD-4, glycerol, 2-mercaptoethanol, thiourea, and phenylmethylsulfonylfluoride in tricine-NaOH buffer (pH
Hye-Youn Cho et al.
Antioxidants & redox signaling, 22(4), 325-338 (2014-10-01)
Nrf2 is a master transcription factor for antioxidant response element (ARE)-mediated cytoprotective gene induction. A protective role for pulmonary Nrf2 was determined in model oxidative disorders, including hyperoxia-induced acute lung injury (ALI). To obtain additional insights into the function and
Mohamed Aittaleb et al.
Journal of cell science, 128(20), 3744-3756 (2015-09-04)
Rapsyn, a scaffold protein, is required for the clustering of acetylcholine receptors (AChRs) at contacts between motor neurons and differentiating muscle cells. Rapsyn is also expressed in cells that do not express AChRs. However, its function in these cells remains
Mariana Labarca et al.
American journal of physiology. Renal physiology, 308(11), F1306-F1315 (2015-03-27)
The aldosterone-sensitive distal nephron (ASDN) exhibits axial heterogeneity in structure and function from the distal convoluted tubule to the medullary collecting duct. Ion and water transport is primarily divided between the cortex and medulla of the ASDN, respectively. Transcellular transport
Akira Takaguri et al.
Cell biology international, 39(9), 1053-1060 (2015-04-11)
Doxorubicin is an anthracycline antibiotic widely used in cancer treatment. Although its antitumor efficacy appears to be dose dependent, its clinical use is greatly restricted by the development of cardiotoxicity associated with apoptosis. Although caveolin-1, the major structural protein in
Rwei-Fen S Huang et al.
International journal of nanomedicine, 10, 2823-2846 (2015-04-29)
Lycopene (LP), an important functional compound in tomatoes, and gold nanoparticles (AN), have received considerable attention as potential candidates for cancer therapy. However, the extreme instability and poor bioavailability of LP limits its in vivo application. This study intends to
Guiting Lin et al.
The Journal of urology, 193(6), 2131-2137 (2014-12-24)
We investigated the effect and mechanism of estrogen on elastogenesis in urethral smooth muscle cells in vitro. Urethral smooth muscle cells were isolated from normal adult female rats. For elastogenesis assay cells were treated with TGF-β1, the potent TGF-β1 receptor
Jing Wang et al.
Proteomics, 14(11), 1393-1402 (2014-03-13)
The rhesus macaque is similar to humans both anatomically and physiologically as a primate, and has therefore been used extensively in medical and biological research, including reproductive physiology. Despite sequencing of the macaque genome, limited postgenomic studies have been performed
Yong Zhang et al.
Journal of ethnopharmacology, 172, 124-132 (2015-06-28)
Acupuncture attenuates neuronal damages following ischemia. The purpose of the present study was to investigate the beneficial effects of acupuncture on hypoxia-ischemia induced brain damages in neonatal rats. Male postnatal 7 days rats were randomly divided into 3 groups: sham
1/105