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Yu Matsuoka et al.
Journal of biotechnology, 168(2), 155-173 (2013-07-16)
It is quite important to understand the basic principle embedded in the main metabolism for the interpretation of the fermentation data. For this, it may be useful to understand the regulation mechanism based on systems biology approach. In the present
Xiaobing Zhu et al.
The Journal of biological chemistry, 296, 100369-100369 (2021-02-06)
Previous studies have identified GAPDH as a promising target for treating cancer and modulating immunity because its inhibition reduces glycolysis in cells (cancer cells and immune cells) with the Warburg effect, a modified form of cellular metabolism found in cancer
The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.
Nan Chen et al.
Cell research, 21(6), 983-986 (2011-04-13)
Hematologically important mutations: red cell pyruvate kinase (2nd update).
L Baronciani et al.
Blood cells, molecules & diseases, 24(3), 273-279 (1998-08-28)
Pauline Duminil et al.
The Plant journal : for cell and molecular biology, 107(5), 1478-1489 (2021-06-27)
Phosphoglycerate mutases (PGAMs) catalyse the reversible isomerisation of 3-phosphoglycerate and 2-phosphoglycerate, a step of glycolysis. PGAMs can be sub-divided into 2,3-bisphosphoglycerate-dependent (dPGAM) and -independent (iPGAM) enzymes. In plants, phosphoglycerate isomerisation is carried out by cytosolic iPGAM. Despite its crucial role
Nancy N Fang et al.
Nature cell biology, 16(12), 1227-1237 (2014-10-27)
The heat-shock response is a complex cellular program that induces major changes in protein translation, folding and degradation to alleviate toxicity caused by protein misfolding. Although heat shock has been widely used to study proteostasis, it remained unclear how misfolded
Jesper V Olsen et al.
Science signaling, 3(104), ra3-ra3 (2010-01-14)
Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are tightly regulated at defined stages of the cell division cycle. Progression through this cycle involves a large number of dedicated protein complexes and signaling pathways, and deregulation
Patrícia Machado et al.
PloS one, 7(10), e47071-e47071 (2012-10-20)
Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some
Thomas R Burkard et al.
BMC systems biology, 5, 17-17 (2011-01-29)
On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties
Lei Lv et al.
Molecular cell, 42(6), 719-730 (2011-06-28)
Most tumor cells take up more glucose than normal cells but metabolize glucose via glycolysis even in the presence of normal levels of oxygen, a phenomenon known as the Warburg effect. Tumor cells commonly express the embryonic M2 isoform of
Giovanna Valentini et al.
The Journal of biological chemistry, 277(26), 23807-23814 (2002-04-19)
Deficiency of human erythrocyte isozyme (RPK) is, together with glucose-6-phosphate dehydrogenase deficiency, the most common cause of the nonspherocytic hemolytic anemia. To provide a molecular framework to the disease, we have solved the 2.7 A resolution crystal structure of human
Richard van Wijk et al.
Human mutation, 30(3), 446-453 (2008-12-17)
Pyruvate kinase (PK) deficiency is a rare disease but an important cause of hereditary nonspherocytic hemolytic anemia. The disease is caused by mutations in the PKLR gene and shows a marked variability in clinical expression. We report on the molecular
Sandrine Caron et al.
Molecular and cellular biology, 33(11), 2202-2211 (2013-03-27)
The glucose-activated transcription factor carbohydrate response element binding protein (ChREBP) induces the expression of hepatic glycolytic and lipogenic genes. The farnesoid X receptor (FXR) is a nuclear bile acid receptor controlling bile acid, lipid, and glucose homeostasis. FXR negatively regulates
G-->T transition at cDNA nt 110 (K37Q) in the PKLR (pyruvate kinase) gene is the molecular basis of a case of hereditary increase of red blood cell ATP.
E Beutler et al.
Human mutation, 9(3), 282-285 (1997-01-01)
Mary-Rus Martínez-Cuenca et al.
Tree physiology, 33(3), 320-329 (2013-03-07)
The effects of iron (Fe) deficiency on the low-molecular-weight organic acid (LMWOA) metabolism have been investigated in Carrizo citrange (CC) [Citrus sinensis (L.) Osb. × Poncirus trifoliata (L.) Raf.] roots. Major LMWOAs found in roots, xylem sap and root exudates were citrate
Karl Kochanowski et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(3), 1130-1135 (2013-01-02)
Regulation of metabolic operation in response to extracellular cues is crucial for cells' survival. Next to the canonical nutrient sensors, which measure the concentration of nutrients, recently intracellular "metabolic flux" was proposed as a novel impetus for metabolic regulation. According
H Kanno et al.
Biochemical and biophysical research communications, 192(1), 46-52 (1993-04-15)
Conversion of pyruvate kinase (PK) isozymes from M2- to R-PK has been observed during erythroid cell maturation. To understand this mechanism, we analyzed the PK gene of a R-PK deficient patient, in whose erythrocytes the M2-PK was persistently expressed. A
James M Urness et al.
Biochemistry, 52(1), 1-3 (2012-12-22)
A series of substrate analogues has been used to determine which chemical moieties of the substrate phosphoenolpyruvate (PEP) contribute to the allosteric inhibition of rabbit muscle pyruvate kinase by phenylalanine. Replacing the carboxyl group of the substrate with a methyl
Cindy D Crocker et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 166(2), 141-147 (2013-08-27)
The African cichlid, Pseudocrenilabrus multicolor victoriae is a eurytopic fish that exhibits high levels of developmental plasticity in response to dissolved oxygen availability. In this study, F1 offspring from three sites in the Mpanga River drainage of Western Uganda characterized
I Mor et al.
Oncogene, 31(6), 683-693 (2011-07-05)
Death-associated protein kinase (DAPk), a multi-domain serine/threonine kinase, regulates numerous cell death mechanisms and harbors tumor suppressor functions. In this study, we report that DAPk directly binds and functionally activates pyruvate kinase M2 (PKM2), a key glycolytic enzyme, which contributes
Katherine Tech et al.
Cancer letters, 356(2 Pt A), 268-272 (2014-02-27)
Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained
Zhenhai Yu et al.
The Journal of biological chemistry, 288(49), 35406-35416 (2013-10-22)
Pyruvate kinase M2 (PKM2) is a key player in the Warburg effect of cancer cells. However, the mechanisms of regulating PKM2 are not fully elucidated. Here, we identified the protein-serine/threonine kinase PIM2, a known oncogene, as a novel binding partner
Nicolas Galazis et al.
PloS one, 8(1), e53801-e53801 (2013-02-06)
Preterm Birth (PTB) is a major cause of neonatal mortality and morbidity. Women with Polycystic Ovary Syndrome (PCOS) are at high risk of PTB. There is a need for research studies to investigate the mechanisms linking PCOS and PTB, to
Francesc R Garcia-Gonzalo et al.
FEBS letters, 539(1-3), 78-84 (2003-03-26)
HERC proteins are characterized by having one or more RCC1-like domains as well as a C-terminal HECT domain in their amino acid sequences. This has led researchers to suggest that they may act as both guanine nucleotide exchange factors and
Ian K Webb et al.
Journal of mass spectrometry : JMS, 48(9), 1059-1065 (2013-10-01)
The application of dipolar direct current (DDC) to the radio frequency-only ion guide (Q0) of a hybrid quadrupole/time-of-flight mass spectrometer for collision-induced declustering of large bio-ions is described. As a broadband technique, ion trap DDC collisional activation (CA) is employed
Weibo Luo et al.
Cell, 145(5), 732-744 (2011-05-31)
The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the PKM2 gene. PKM2, but not PKM1, alters glucose metabolism in cancer cells and contributes to tumorigenesis by mechanisms that are not explained by its known biochemical activity.
Hematologically important mutations: red cell pyruvate kinase (1st update).
L Baronciani et al.
Blood cells, molecules & diseases, 22(3), 259-264 (1996-01-01)
Takanori Kigawa et al.
Journal of structural and functional genomics, 5(1-2), 63-68 (2004-07-21)
As structural genomics and proteomics research has become popular, the importance of cell-free protein synthesis systems has been realized for high-throughput expression. Our group has established a high-throughput pipeline for protein sample preparation for structural genomics and proteomics by using
Chunyan Liu et al.
Cellular immunology, 285(1-2), 141-148 (2013-11-05)
Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure with high mortality. Our previous studies have demonstrated that both immature and activated DC1 increased in the bone marrow of SAA patients, and the balance of DC1 subsets
Toshio Ota et al.
Nature genetics, 36(1), 40-45 (2004-01-01)
As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to
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