CN
Search Within
p8765
应用筛选条件
关键词:'p8765'
显示 1-30 共 108 条结果 关于 "p8765" 范围 论文
Zhenhong Hu et al.
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 15(5), 277-280 (2012-05-23)
The growth of tumor often faced up with lackness of blood and oxygen, and it has been reported that Annexin A1 may be involved in tumor. The aim of this investigation is to explore the characteristics of expression of Annexin
Haiming Xiao et al.
Pharmacological research, 151, 104559-104559 (2019-11-24)
Our previous studies indicated that the G-protein-coupled bile acid receptor, Gpbar1 (TGR5), inhibits inflammation by inhibiting the NF-κB signalling pathway, eventually attenuating diabetic nephropathy (DN). Gentiopicroside (GPS), the main active secoiridoid glycoside of Gentiana manshurica Kitagawa, has been demonstrated to
Min Qiu et al.
Journal of virology, 87(15), 8675-8686 (2013-06-07)
Pyrrolidine dithiocarbamate (PDTC) is widely used as an antioxidant or an NF-κB inhibitor. It has been reported to inhibit the replication of human rhinoviruses, poliovirus, coxsackievirus, and influenza virus. In this paper, we report that PDTC could inhibit the replication
Jiubo Liang et al.
Insect biochemistry and molecular biology, 58, 76-88 (2014-12-03)
Bombyx mori, a lepidopteran insect, is one of the earliest models for pattern recognition of Gram-negative bacteria, which may induce the IMD pathway for production of antibacterial peptides. So far, several recognition proteins have been reported in B. mori. However
Dan Xu et al.
Scandinavian journal of immunology, 92(2), e12896-e12896 (2020-06-20)
Sciatic nerve injury affects quality of life. Many immune cells and inflammatory cytokines have been reported to be involved in sciatic nerve injury, but little is known about the ligands and receptors that trigger inflammatory responses. By using a modified
Giovanni Cimmino et al.
European journal of pharmacology, 885, 173422-173422 (2020-08-07)
Epidemiologic studies have clearly demonstrated the correlation existing between Vitamin D (Vit. D) deficiency and increased risk of developing cardiovascular disease, suggesting that it might have a protective role in this clinical setting. Although many experimental studies have investigated the
Tong Yuan et al.
The Journal of surgical research, 192(1), 150-162 (2014-06-24)
Lidocaine has been used as a local anesthetic with anti-inflammatory properties, but its effects on neuroinflammation have not been well defined. In the present study, we investigated the prophylactic effects of lidocaine on lipopolysaccharide (LPS)-activated microglia and explored the underlying
Parisa Yazdizadeh Shotorbani et al.
American journal of physiology. Renal physiology, 318(3), F673-F682 (2020-01-28)
Overproduction of extracellular matrix proteins, including fibronectin by mesangial cells (MCs), contributes to diabetic nephropathy. Inhibitor of myogenic differentiation family isoform a (I-mfa) is a multifunctional cytosolic protein functioning as a transcriptional modulator or plasma channel protein regulator. However, its
J Zhang et al.
European review for medical and pharmacological sciences, 17(17), 2372-2382 (2013-09-26)
We previously showed that the calcium-binding protein S100A4 is overexpressed and related to metastasis in hepatocellular carcinoma (HCC). However, whether S100A4 participates in the regulation of metastasis and its mechanisms in HCC is mostly unknown. Given the associations of S100A4
Yi-Jie Guo et al.
Journal of neuroscience research, 96(12), 1847-1861 (2018-09-15)
We previously reported that interleukin-1β (IL-1β) in the red nucleus (RN) is involved in pain modulation and exerts a facilitatory effect in the development of neuropathic pain. Here, we explored the actions of signaling pathways, including the Janus kinase/signal transducer
Jian Guo Cui et al.
The Journal of biological chemistry, 285(50), 38951-38960 (2010-10-13)
Specific microRNAs (miRNAs), small non-coding RNAs that support homeostatic gene expression, are significantly altered in abundance in human neurological disorders. In monocytes, increased expression of an NF-κB-regulated miRNA-146a down-regulates expression of the interleukin-1 receptor-associated kinase-1 (IRAK-1), an essential component of
J S Kim et al.
Molecular oral microbiology, 27(3), 149-159 (2012-04-24)
Streptococcus mutans, a major etiological agent of dental caries, frequently causes systemic disease, such as subacute bacterial endocarditis, if it enters the bloodstream. In this study, the production pathways of the proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)
Quan Zhou et al.
Oncogene, 39(7), 1414-1428 (2019-10-30)
Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signaling cascades mediated by tumor-stroma interactions. However, the mechanisms by which
Xinghua Guo et al.
International journal of rheumatic diseases, 15(3), 322-329 (2012-06-20)
After the onset of rheumatoid arthritis (RA), fibroblast-like synoviocytes (RA-FLS) which are specialized types of fibroblasts, become tumor-like, keeping their ability to increase proliferation and invasion. The mechanism of their tumor-like growth is unclear. Fractalkine (FKN), also called CX3CL1, plays
C Raspé et al.
Cytokine, 61(1), 97-103 (2012-10-03)
Fractalkine is a unique member of the CX3C chemokine family by unfolding its potential through the chemokine (C-X3-C motif) receptor 1 (CX3CR1) with dual function acting both as an adhesion molecule and a soluble chemokine. The regulation of this chemokine
Xiong Zhang et al.
Journal of neuroinflammation, 17(1), 50-50 (2020-02-07)
Astrocytes are the most abundant glial cells in a brain that mediate inflammatory responses and provide trophic support for neurons. We have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates LPS-induced microglia activation. However, it remains elusive
Miao Shen et al.
Journal of biochemical and molecular toxicology, 36(6), e23025-e23025 (2022-05-24)
Previous studies have highlighted the involvement of nuclear factor kappa B (NF-κB) in the development of nonalcoholic fatty liver disease (NAFLD). The purpose of our investigation is to explore the interaction among NF-κB, microRNA-155-5p (miR-155-5p), and Stanniocalcin 1 (STC1), and
Shaoqing Xu et al.
Journal of neurochemistry, 145(4), 312-322 (2018-01-10)
Loss of function mutations of DJ-1 (PARK7) have been linked to the pathogenesis of Parkinson's disease. Antioxidative stress is one of the multi-protective functions of DJ-1, and oxidation of cysteine 106 has been proposed to regulate the protective activity of
Marlina O Córdoba-Moreno et al.
Journal of pineal research, 76(1), e12923-e12923 (2023-11-22)
Immune-pineal axis activation is part of the assembly of immune responses. Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in macrophages by mechanisms dependent on nuclear factor-κB (NF-κB) activation. Cytokines activating the Janus kinase/signal transducer and activator
Jamshed Ali et al.
Environmental science and pollution research international, 22(23), 19251-19263 (2015-08-10)
In present study, the ground water at different aquifers was evaluated for physicochemical parameters, iron, total arsenic, total inorganic arsenic and arsenic species (arsenite and arsenate). The samples of groundwater were collected at different depths, first aquifer (AQ1) 50-60 m
Zhi Wang et al.
Experimental neurology, 249, 74-82 (2013-09-03)
Brain injury due to birth asphyxia is the major cause of death and long-term disabilities in newborns. We determined whether intranasal pyrrolidine dithiocarbamate (PDTC) could provide neuroprotection in neonatal rats after brain hypoxia-ischemia (HI). Seven-day old male and female Sprague-Dawley
Upayan Patra et al.
Oxidative medicine and cellular longevity, 2020, 7289120-7289120 (2020-04-24)
Eukaryotic cells adopt highly tuned stress response physiology under threats of exogenous stressors including viruses to maintain cellular homeostasis. Not surprisingly, avoidance of cellular stress response pathways is an essential facet of virus-induced obligatory host reprogramming to invoke a cellular
M Kittaka et al.
Journal of periodontal research, 48(2), 228-234 (2012-09-05)
LL37, originally found in the innate immune system, is a robust antimicrobial peptide. LL37 exhibits multiple bio-functions in various cell types, such as migration, cytokine production, apoptosis, and angiogenesis besides its antimicrobial activity Periodontal ligament (PL) cells play a pivotal
Wendy Chi et al.
PloS one, 9(5), e97675-e97675 (2014-05-16)
Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to inflammation, but nutrient intake and obesity are also associated with altered bacterial load in metabolic tissues (i.e. metabolic endotoxemia).
Caiqi Ma et al.
International journal of oncology, 54(2), 572-584 (2018-11-30)
Gastric cancer is one of the most malignant tumor types, and its metastasis is a notable cause of mortality. Among the methods of tumor metastasis, lymphatic metastasis is the predominant one in gastric cancer. A previous study reported that the
Shuhua Yuan et al.
Journal of cellular and molecular medicine, 24(2), 1541-1552 (2019-12-04)
Both PNPLA3 I148M and hepatic inflammation are associated with nonalcoholic fatty liver disease (NAFLD) progression. This study aimed to elucidate whether PNPLA3 I148M is involved in NF-kB-related inflammation regulation in NAFLD. HepG2 cells homozygous for the PNPLA3 I148M mutation were
Robert J Anderberg et al.
Laboratory investigation; a journal of technical methods and pathology, 95(3), 250-262 (2014-12-23)
Inflammatory pathways are central mechanisms in diabetic kidney disease (DKD). Serum amyloid A (SAA) is increased by chronic inflammation, but SAA has not been previously evaluated as a potential DKD mediator. The aims of this study were to determine whether
Bin Zhou et al.
mBio, 10(4) (2019-08-01)
Endogenous retroviruses (ERVs) are transposable elements that cause host genome instability and usually play deleterious roles in disease such as tumorigenesis. Recent advances also suggest that this "enemy within" may encode a viral mimic to induce antiviral immune responses through
Qingxiu Wang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(7), 1183-1189 (2014-06-08)
Sevoflurane, one of the most commonly used anesthetics in clinic, induced neuroinflammation and caused cognitive impairment. 2-deoxy-d-glucose (2-DG) is a synthetic analogue of glucose and is clinically used in medical imaging safely. We examined the effect of 2-DG on sevoflurane-induced
Sergio M Borghi et al.
Frontiers in immunology, 11, 539086-539086 (2021-02-13)
The neglected tropical infirmity Chagas disease (CD) presents high mortality. Its etiological agent T. cruzi is transmitted by infected hematophagous insects. Symptoms of the acute phase of the infection include fever, fatigue, body aches, and headache, making diagnosis difficult as
1/4