CN
Search Within
P8865
应用筛选条件
关键词:'P8865'
显示 1-30 共 304 条结果 关于 "P8865" 范围 论文
Bala Murugan Shanmugaraj et al.
International journal of phytoremediation, 15(3), 206-218 (2013-03-16)
Cadmium is a hazardous heavy metal; its presence in the agricultural soil constrains the crop productivity and restricts crop plants from reaching their full genetic potential. In the present study, two Brassica juncea cultivars (Pusa Bold and Pusa Jaikisan), were
[Hepatitis C update: what has changed? What can we expect in the near future?].
Andreas Geier
MMW Fortschritte der Medizin, 155(19), 59-62 (2014-01-31)
L Zhang et al.
British journal of anaesthesia, 110 Suppl 1, i82-i91 (2013-04-23)
Isoflurane can increase pro-inflammatory cytokine interleukin (IL)-6 levels. However, the up-stream mechanism remains unknown. Nuclear factor-kappa B (NF-κB) promotes the generation of pro-inflammatory cytokines. We examined the effects of isoflurane and sevoflurane on the NF-κB signalling pathway and its association
Yu Zhu et al.
Molecular pharmaceutics, 12(2), 332-341 (2014-08-26)
Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm).
Carlo Camilloni et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10203-10208 (2014-07-02)
Proline isomerization is a ubiquitous process that plays a key role in the folding of proteins and in the regulation of their functions. Different families of enzymes, known as "peptidyl-prolyl isomerases" (PPIases), catalyze this reaction, which involves the interconversion between
Mi Lan Kang et al.
Biomaterials, 35(37), 9984-9994 (2014-09-23)
We developed an intra-articular (IA) drug delivery system to treat osteoarthritis (OA) that consisted of kartogenin conjugated chitosan (CHI-KGN). Kartogenin, which promotes the selective differentiation of mesenchymal stem cells (MSCs) into chondrocytes, was conjugated with low-molecular-weight chitosan (LMWCS) and medium-molecular-weight
Airi Sekine et al.
SpringerPlus, 4, 48-48 (2015-02-13)
The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and depression.
Michael Dietachmayr et al.
Nature communications, 11(1), 1268-1268 (2020-03-11)
Regulation of mitosis secures cellular integrity and its failure critically contributes to the development, maintenance, and treatment resistance of cancer. In yeast, the dual phosphatase Cdc14 controls mitotic progression by antagonizing Cdk1-mediated protein phosphorylation. By contrast, specific mitotic functions of
Li Zhang et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(2), 136-144 (2013-05-01)
The aim of our study was to find a novel method to evaluate the strain quality of Schizochytrium sp. HX-308. An acclimatized strain and an original strain were cultivated under normal condition. Meanwhile, the same acclimatized strain was cultured under
D S Raj et al.
Blood purification, 18(2), 97-102 (2000-06-06)
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.
F Ahmed
Journal of viral hepatitis, 20(5), 367-368 (2013-04-10)
Summary. Directly acting antiviral (DAA) agents are currently revolutionizing the treatment of chronic hepatitis C infection. The first generation of these agents have significant limitations including cost issues that are of particular concern in the developing world and a lack
Heather D Hickman et al.
European journal of immunology, 43(11), 2814-2817 (2013-10-25)
MHC class I molecules bind intracellular oligopeptides and present them on the cell surface for CD8(+) T-cell activation and recognition. Strong peptide/MHC class I (pMHC) interactions typically induce the best CD8(+) T-cell responses; however, many immunotherapeutic tumor-specific peptides bind MHC
Ryushi Kawakami et al.
Applied microbiology and biotechnology, 93(1), 83-93 (2011-11-18)
Dye-linked L-proline dehydrogenase (ProDH) catalyzes the oxidation of L-proline to ∆(1)-pyrroline-5-carboxylate (P5C) in the presence of artificial electron acceptors. The enzyme is known to be widely distributed in bacteria and eukarya, together with nicotinamide adenine dinucleotide (phosphate)-dependent P5C dehydrogenase, and
Yong-Beom Park et al.
Biomedical materials (Bristol, England), 10(3), 035014-035014 (2015-06-25)
The extracellular matrix (ECM) surrounding cells contains a variety of proteins that provide structural support and regulate cellular functions. Previous studies have shown that decellularized ECM isolated from tissues or cultured cells can be used to improve cell differentiation in
[Treatment of hepatitis C infection. A revolution should not hide another].
Philippe Sogni
Presse medicale (Paris, France : 1983), 43(4 Pt 1), 339-340 (2014-03-26)
Betul Kul Babur et al.
Cell and tissue research, 361(3), 755-768 (2015-05-01)
Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral
Simon Kluters et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 37-46 (2015-11-02)
Cation exchange chromatography (CEX) is an integral part of many downstream processes for monoclonal antibodies (mAbs). However, in some cases CEX methods with standard mobile phase conditions do not lead to a sufficient removal of soluble antibody aggregates. The addition
Yifeng Xue et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 12(3), 253-260 (2014-06-09)
To evaluate the immunomodulatory properties of human amniotic mesenchymal stromal cells. Human amniotic mesenchymal stromal cells were isolated, characterized by flow cytometry, cultured in vitro, and evaluated in allogeneic and xenogeneic mixed lymphocyte reactions. The proliferation of T cells and
John M Curto et al.
Organic letters, 16(7), 1948-1951 (2014-03-29)
The first asymmetric synthesis of α-allyl-α-aryl α-amino acids by means of a three-component coupling of α-iminoesters, Grignard reagents, and cinnamyl acetate is reported. Notably, the enolate from the tandem process provides a much higher level of reactivity and selectivity than
Henrique V Almeida et al.
Advanced healthcare materials, 4(7), 1043-1053 (2015-02-07)
An alternative strategy to the use of in vitro expanded cells in regenerative medicine is the use of freshly isolated stromal cells, where a bioactive scaffold is used to provide an environment conducive to proliferation and tissue-specific differentiation in vivo.
Neta Sal-Man et al.
Biochimica et biophysica acta, 1838(9), 2313-2318 (2014-05-21)
Assembly of transmembrane domains (TMDs) is a critical step in the function of membrane proteins. In recent years, the role of specific amino acids in TMD-TMD interactions has been better characterized, with more emphasis on polar and aromatic residues. Despite
James M Phang et al.
Frontiers in bioscience (Landmark edition), 17, 1835-1845 (2011-12-29)
Proline plays a special role in cancer metabolism. Proline oxidase (POX), a.k.a. proline dehydrogenase (PRODH), is among a few genes induced rapidly and robustly by P53, the tumor suppressor. Ectopic expression of POX under control of tet-off promoter initiated mitochondrial
Shankumar Mooyottu et al.
International journal of food microbiology, 192, 111-116 (2014-12-03)
Clostridium difficile is a pathogen of significant public health concern causing a life-threatening, toxin-mediated enteric disease in humans. The incidence and severity of the disease associated with C. difficile have increased in the US with the emergence of hypervirulent strains
K Kuchta et al.
Die Pharmazie, 68(7), 534-540 (2013-08-09)
Stachydrine ((2S)-1,1-dimethylpyrrolidinium-2-carboxylic acid) may be regarded as an essential active principle of the aerial parts of Leonurus japonicus Houtt. (Leonuri herba, yimucao; Chin.Ph., DAB) which are used in TCM and Kampo for the treatment of various gynaecological and cardiovascular disorders.
J M Feldman et al.
Cancer, 38(5), 2127-2131 (1976-11-01)
Plasma tryptophan (Trp) is reported to be decreased in some patients with the carcinoid syndrome. To determine if the plasma levels of other amino acids are also altered in the carcinoid syndrome, we used a fas-liquid chromatographic method to determine
W Wei et al.
European cells & materials, 30, 303-314 (2015-12-03)
Cartilage repair by bone marrow derived mesenchymal stem cells (MSCs) can be influenced by inflammation in the knee. Next to synovium, the infrapatellar fat pad (IPFP) has been described as a source for inflammatory factors. Here, we investigated whether factors
Khader Valli Rupanagudi et al.
Annals of the rheumatic diseases, 74(2), 452-463 (2013-12-05)
Major histocompatibility complex (MHC) class II-mediated priming of T and B lymphocytes is a central element of autoimmunity in systemic lupus erythematosus (SLE) and lupus nephritis. The cysteine protease cathepsin S degrades the invariant peptide chain during MHC II assembly
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Jasmin Hotzy et al.
The Journal of biological chemistry, 288(51), 36492-36501 (2013-11-12)
Excitatory amino acid transporters (EAATs) are crucial for glutamate homeostasis in the mammalian central nervous system. They are not only secondary active glutamate transporters but also function as anion channels, and different EAATs vary considerably in glutamate transport rates and
Guo-Shiang Huang et al.
Biomaterials, 65, 154-162 (2015-07-15)
Adipose-derived adult stem cells (ASCs) have gained much attention because of their multipotency and easy access. Here we describe a novel chitosan-based selection (CS) system instead of the conventional plastic adherence (PA) to obtain the primary ASCs. The minimal amount
1/11