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Michelle Grace Acoba et al.
Cell reports, 34(11), 108869-108869 (2021-03-18)
Mitochondrial carriers (MCs) mediate the passage of small molecules across the inner mitochondrial membrane (IMM), enabling regulated crosstalk between compartmentalized reactions. Despite MCs representing the largest family of solute carriers in mammals, most have not been subjected to a comprehensive
Lu Xu et al.
Journal of pharmacokinetics and pharmacodynamics, 30(3), 185-219 (2003-10-24)
A whole-body physiologically-based model was developed to describe the pharmacokinetics of the ansamycin benzoquinone antibiotic 17-(allylamino)-17-demethoxygeldanamycin (17AAG) and its active metabolite 17-(amino-)-17-demethoxygeldanamycin (17AG) in blood, normal organs (lung, brain, heart, spleen, liver, kidney, skeletal muscle) and implanted human tumor xenograft
Nafez Abu Tarboush et al.
FEBS letters, 587(12), 1736-1741 (2013-05-15)
MauG catalyzes posttranslational modifications of a methylamine dehydrogenase precursor (preMADH) to complete the biosynthesis of its protein-derived tryptophan tryptophylquinone (TTQ) cofactor. Trp199 is present at the site of interaction between MauG and preMADH and is critical to this process as
Cheuk-Kwan Sun et al.
Journal of pineal research, 58(2), 137-150 (2014-12-11)
Despite high in-hospital mortality associated with acute respiratory distress syndrome (ARDS), there is no effective therapeutic strategy. We tested the hypothesis that combined melatonin-mitochondria treatment ameliorates 100% oxygen-induced ARDS in rats. Adult male Sprague-Dawley rats (n = 40) were equally categorized into
Kan He et al.
Drug metabolism and disposition: the biological fate of chemicals, 32(4), 442-446 (2004-03-25)
Troglitazone (TGZ) was the first glitazone used for the treatment of type II diabetes mellitus. TGZ undergoes an oxidative chroman ring-opening reaction to form a quinone product. Recently, cytochrome P450 (P450) was shown to be able to catalyze the formation
Rajaram Venkatesan et al.
Nature communications, 5, 4805-4805 (2014-09-10)
Mitochondrial fatty acid synthesis (mtFAS) is essential for respiratory growth in yeast and mammalian embryonic survival. The human 3-ketoacyl-acyl carrier protein (ACP) reductase (KAR) of mtFAS is a heterotetrameric α2β2-assembly composed of 17β-hydroxysteroid dehydrogenase type-8 (HSD17B8, α-subunit) and carbonyl reductase
Cheuk-Kwan Sun et al.
American journal of translational research, 7(2), 209-231 (2015-04-23)
This study hypothesized that combined serum-deprived (Sd) and healthy (He) adipose-derived mesenchymal stem cell (ADMSC) therapy is superior to either alone in reducing acute lung ischemia-reperfusion injury (ALIRI). Adult male Sprague-Dawley (SD) rats (n = 30) were equally randomized into
Agustina Manassero et al.
Environmental science and pollution research international, 22(2), 926-937 (2014-03-14)
A kinetic study of the photocatalytic degradation of the pharmaceutical clofibric acid is presented. Experiments were carried out under UV radiation employing titanium dioxide in water suspension. The main reaction intermediates were identified and quantified. Intrinsic expressions to represent the
Yanyan Gong et al.
Journal of hazardous materials, 287, 142-150 (2015-02-07)
This work investigated effects of a popular oil dispersant (Corexit EC9500A) on UV- or sunlight-mediated photodegradation of pyrene (a model polycyclic aromatic hydrocarbon) in seawater. The presence of 18 and 180mg/L of the dispersant increased the first-order photodegradation rate by
Ramona Heinke et al.
Analytical and bioanalytical chemistry, 405(1), 177-189 (2012-10-24)
Liquid chromatography negative ion electrospray ionisation tandem mass spectrometry has been used for characterisation of naturally occurring prenylated fungal metabolites and synthetic derivatives. The fragmentation studies allow an elucidation of the decomposition pathways for these compounds. It could be shown
Organic Chemistry: Aromatic, Alcohols Aldehydes & Acids (2006)
Pu Qian et al.
Biochemistry, 52(43), 7575-7585 (2013-10-18)
Reaction center-light harvesting 1 (RC-LH1) complexes are the fundamental units of bacterial photosynthesis, which use solar energy to power the reduction of quinone to quinol prior to the formation of the proton gradient that drives ATP synthesis. The dimeric RC-LH1-PufX
Quinones and Quinone Enzymes, Part 1 (2004)
Quanjiang Ji et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), 5010-5015 (2013-03-13)
Quinone molecules are intracellular electron-transport carriers, as well as critical intra- and extracellular signals. However, transcriptional regulation of quinone signaling and its molecular basis are poorly understood. Here, we identify a thiol-stress-sensing regulator YodB family transcriptional regulator as a central
W Neumann et al.
Dalton transactions (Cambridge, England : 2003), 44(4), 1748-1753 (2014-12-04)
Carbaboranes are increasingly used as pharmacophores to replace phenyl substituents in established drug molecules. In contrast to traditional organic chemistry, elaborate procedures to introduce functionality frequently fail in the case of carbaboranes and their chemistry is often hampered by degradation
Yohei Yamada et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 29(1), 79-83 (2013-01-11)
We fabricated a thermostable quinoprotein aldose sugar dehydrogenase (tPQQ-ASD derived from a hyperthermophilic archaeon Pyrobaculum aerophilum) immobilized electrode. The electrode was prepared by immobilizing agarose gel mixed with the enzyme and carbon nanofiber (CNF) on a carbon paste (CP) electrode
GuangRong Peh et al.
Organic letters, 14(21), 5614-5617 (2012-10-26)
Cyclopropane-substituted allylic ethers react with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form oxocarbenium ions with no competitive ring cleavage. This reaction can be used for the preparation of cyclopropane-substituted tetrahydropyrans. The protocol was used as a key step in the total synthesis of the
Rozbeh Baradaran et al.
Nature, 494(7438), 443-448 (2013-02-19)
Complex I is the first and largest enzyme of the respiratory chain and has a central role in cellular energy production through the coupling of NADH:ubiquinone electron transfer to proton translocation. It is also implicated in many common human neurodegenerative
Sarah Chua et al.
Journal of translational medicine, 12, 357-357 (2014-12-17)
We investigated whether attenuating dipeptidyl peptidase-IV (DPP4) enzyme activity protected rat heart from ischemia-reperfusion (IR) injury (40-min left anterior descending coronary artery ligation followed by 72 h reperfusion). Adult male Fischer 344 rats (n = 24) were equally divided into
P Soucek
Chemico-biological interactions, 121(3), 223-236 (1999-08-26)
Exposure to benzene was recently reported to lower the cytochrome P450 (CYP) content in phenobarbital-pretreated rats in vivo (Gut et al., Environ. Health Perspect. 104 (1996) 1211-1218). This study followed the ability of quinonic benzene metabolites (catechol, hydroquinone, and benzoquinone)
Hong-Quan Duong et al.
International journal of oncology, 44(3), 959-969 (2013-12-25)
We describe the potential benefit of PIK-75 in combination of gemcitabine to treat pancreatic cancer in a preclinical mouse model. The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative
Vandana Bhalla et al.
Dalton transactions (Cambridge, England : 2003), 42(4), 975-980 (2012-11-21)
A pentaquinone based compound 3a has been synthesized which undergoes significant fluorescence enhancement in the presence of Zn(2+) ions with a detection limit up to nanomolar range in THF. Further, the zinc ensemble of 3a is evaluated for its anti-oxidizing
S Patouraux et al.
Cell death & disease, 5, e1208-e1208 (2014-05-09)
Osteopontin (OPN) is a multifunctional protein involved in hepatic steatosis, inflammation, fibrosis and cancer progression. However, its role in hepatic injury induced by ischemia-reperfusion (I-R) has not yet been investigated. We show here that hepatic warm ischemia for 45 min
Xiaoquan Lu et al.
Colloids and surfaces. B, Biointerfaces, 103, 608-614 (2012-12-25)
Photoinduced electron transfer with the electron donor-acceptor linked system of zinc-5,10,15,20-tetraphenylporphyrin (ZnTPP) as donor and benzoquinone (BQ) as acceptor was designed to mimic the electron transfer process in photosynthetic reaction center. Within the framework of the bimolecular electron transfer mechanisms
Libo He et al.
BMC genomics, 16, 184-184 (2015-04-19)
Compensatory growth is accelerated compared with normal growth and occurs when growth-limiting conditions are overcome. Most animals, especially fish, are capable of compensatory growth, but the mechanisms remain unclear. Further investigation of the mechanism of compensatory growth in fish is
Xuejiang Wang et al.
Biosensors & bioelectronics, 41, 557-562 (2012-10-16)
A rapid and reliable p-benzoquinone-mediated amperometric biosensor (ToxTell) incorporated with Psychrobacter sp. to detect toxicities of heavy metal ions has been developed. This ToxTell biosensor relied on the real-time monitoring of inhibition effect for metabolism by toxicant to provide early
Yasunobu Matsuda et al.
International journal of clinical and experimental pathology, 7(5), 2032-2043 (2014-06-27)
Hepatitis B virus X (HBX) protein plays a crucial role in carcinogenesis, but its mechanism is unclear. The involvement of ataxia telangiectasia mutated (ATM) kinase in the enhanced redox system was investigated by examining the phosphorylation level of ATM in
Na Song et al.
Journal of the American Chemical Society, 134(45), 18538-18541 (2012-11-02)
Benzoquinone/hydroquinone redox interconversion by the reversible Os(dmb)(3)(3+/2+) couple over an extended pH range with added acids and bases has revealed the existence of seven discrete pathways. Application of spectrophotometric monitoring with stopped-flow mixing has been used to explore the role
Shuang Feng et al.
FEBS letters, 586(22), 3951-3955 (2012-10-13)
Numerous phenolic compounds have been reported to have an inhibitory role on amyloid formation of proteins. The present study, utilizing lysozyme as a model system, examined the anti-amyloidogenic effects of phenol and three diphenol epimers. The results indicated that catechol
Sabrina Diemert et al.
Water research, 47(5), 1773-1782 (2013-02-06)
Halo-benzoquinones (HBQs) have been previously detected as disinfection by-products in chlorinated drinking water. The current work investigates the link between natural organic matter (NOM) characteristics and HBQ formation during bench-scale coagulation of raw water. Three source waters (Lake Ontario, Otonabee
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