CN
Search Within
PHR1033
应用筛选条件
关键词:'PHR1033'
显示 1-30 共 300 条结果 关于 "PHR1033" 范围 论文
M V Gammons et al.
British journal of cancer, 111(3), 477-485 (2014-07-11)
Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternatively spliced to form two families of isoforms, pro-
Yong-Hui Ding et al.
Drug design, development and therapy, 9, 425-464 (2015-01-28)
Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of
Topical niacinamide and barrier enhancement.
Donald Bissett
Cutis, 70(6 Suppl), 8-12 (2002-12-25)
Involvement of androgen receptor and glucose-regulated protein 78 kDa in human hepatocarcinogenesis.
Xia Jiang et al.
Experimental cell research, 323(2), 326-336 (2014-03-04)
Previous studies demonstrated that androgen receptor (AR) is expressed in human hepatocellular carcinoma (HCC), one of the male-dominant diseases. Glucose-regulated protein 78 kDa (GRP78/Bip), which has a role in cancer development, is one of the androgen response genes in prostate
K Mizrahi et al.
Bone marrow transplantation, 49(7), 942-949 (2014-04-30)
The influence of TNF-α and Fas-ligand (FasL) on viability and function was evaluated in fresh- and expanded-umbilical cord blood (UCB) cells. CD34(+) progenitors and T cells display outstanding survival, whereas ~30% and >50% B lymphocytes and myeloid cells undergo spontaneous
Yong-Hoon Kim et al.
American journal of hypertension, 28(1), 50-57 (2014-06-22)
Endothelial nitric oxide synthase (eNOS) is involved in blood pressure (BP) regulation through the production of nitric oxide. Sirtuin I (SIRT1), an NAD-dependent protein deacetylase, promotes vascular relaxation through deacetylation and activation of eNOS. β-Lapachone (βL) increases the cellular NAD(+)/NADH
Anna Louise Hillberg et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(3), 503-518 (2014-06-12)
Encapsulation of cells in biocompatible polymer matrices represents a powerful tool for cell-based therapies and therapeutic delivery systems. This technology has successfully been used to deliver pancreatic islets to humans for the treatment of Type 1 diabetes. However, the clinical
Nayeli Torres-Ramírez et al.
Life sciences, 93(25-26), 975-985 (2013-11-05)
Excessive energy uptake of dietary carbohydrates results in their storage as fat and requires glucose-6-phosphate dehydrogenase (G6PD)-mediated NADPH production. We sought to assess whether the nicotinamide-induced reduction of G6PD activity might modulate redox balance and lipid accumulation in 3T3-L1 cells.
Chiaki Hiratsuka et al.
Journal of nutritional science and vitaminology, 60(4), 255-260 (2014-10-10)
We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-controlled, crossover
Pilot study of sorafenib in relapsed or refractory peripheral and cutaneous T-cell lymphoma.
Juliet Fraser Gibson et al.
British journal of haematology, 167(1), 141-144 (2014-06-04)
Siyuan Ding et al.
PLoS biology, 12(1), e1001758-e1001758 (2014-01-11)
Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-specific antiviral
Nan-Yuan Teng et al.
Tissue engineering. Part A, 21(7-8), 1444-1454 (2015-01-28)
In vitro differentiation of stem cells into specific cell lineages provides a stable cell supply for cell therapy and tissue engineering. Therefore, understanding the mechanisms underlying such differentiation processes is critical for generating committed lineage-specific cell progenies effectively. We previously
Asghar Ghasemi et al.
Acta physiologica Hungarica, 101(4), 408-420 (2014-12-24)
Diabetes is one of the five leading causes of death in the world, with type 2 diabetes occurring more frequently than type 1. Management of diabetes without side effects is still a challenge and therefore new strategies need to be
I-Chieh Chen et al.
Molecular cancer, 13, 254-254 (2014-11-27)
The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 has been implicated in a variety of physiological processes; however, its
Hiroyuki Yamashita et al.
Pharmaceutical research, 31(8), 1946-1957 (2014-02-14)
The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams
Maria Reig et al.
Best practice & research. Clinical gastroenterology, 28(5), 921-935 (2014-09-28)
In the last years the management of patients with liver cancer has been improved. The BCLC staging/treatment strategy identifies the optimal candidates for each treatment option and sorafenib is the only effective systemic treatment. Others (sunitinib, brivanib, linifanib, everolimus, ramucirumab)
Jun Ni et al.
Acta pharmacologica Sinica, 35(9), 1157-1166 (2014-08-05)
To explore the signal transducer and activator of transcription 3 (STAT3) signaling pathway, especially STAT3 acetylation, in angiotensin II (Ang II)-induced pro-fibrotic responses in renal tubular epithelial cells. Rat renal tubular epithelial cell line (NRK-52E) was used. STAT3 acetylation and
Christophe Louandre et al.
Cancer letters, 356(2 Pt B), 971-977 (2014-12-03)
Sorafenib is the treatment of reference for advanced hepatocellular carcinoma (HCC), the most frequent form of primary liver tumour. The loss of function of the retinoblastoma (Rb) protein is an important event during liver carcinogenesis, but it is unclear whether
Shang-Wen Chen et al.
International journal of radiation oncology, biology, physics, 88(5), 1041-1047 (2014-03-26)
This phase 2 study evaluated the efficacy of radiation therapy (RT) with concurrent and sequential sorafenib therapy in patients with unresectable hepatocellular carcinoma (HCC). Forty patients with unresectable HCC unfit for transarterial chemoembolization were treated with RT with concurrent and
Amanda Rennick et al.
Pharmacotherapy, 33(6), 683-690 (2013-03-26)
Phosphate binders have traditionally been used to treat hyperphosphatemia, a common complication in patients with end stage renal disease (ESRD). New evidence suggests that nicotinic acid and its metabolites may effectively decrease phosphorus absorption in the gastrointestinal tract, thereby reducing
Pamela Biondani et al.
Anticancer research, 34(5), 2395-2398 (2014-04-30)
Only scanty data are available to evaluate the impact of sequential TKIs on overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). This retrospective study investigated the efficacy of the sequence sorafenib-sunitinib (SO-SU) and vice versa (SU-SO) in
Katsumi Shibata et al.
Journal of nutritional science and vitaminology, 60(4), 261-268 (2014-10-10)
The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%
Inge M Westra et al.
Toxicology and applied pharmacology, 274(2), 328-338 (2013-12-11)
Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early onset of fibrosis in this model and the effects of
Manisha Sonee et al.
Neurotoxicity research, 4(7-8), 595-599 (2003-04-24)
In previous studies with mice the oxygen radical generating neurotoxin tertiary butylhydroperoxide (t-BuOOH) was used to mimic the oxidative injury that has been implicated in neurodegenerative diseases. In addition, previous studies have shown that the poly (ADP-ribose) polymerase (PARP) inhibitor
Joan Fernando et al.
International journal of cancer, 136(4), E161-E172 (2014-07-24)
The multikinase inhibitor sorafenib is the only effective drug in advanced cases of hepatocellular carcinoma (HCC). However, response differs among patients and effectiveness only implies a delay. We have recently described that sorafenib sensitizes HCC cells to apoptosis. In this
Manuel Chan et al.
Cancer research, 74(21), 5948-5954 (2014-08-26)
GMX1778 and its prodrug GMX1777 represent a new class of cancer drugs that targets nicotinamide phosphoribosyltransferase (NAMPT) as a new strategy to interfere with biosynthesis of the key enzymatic cofactor NAD, which is critical for a number of cell functions
Shin-Ichiro Imai
Current pharmaceutical design, 15(1), 20-28 (2009-01-20)
New interest in NAD biology has recently been revived, and enzymes involved in NAD biosynthetic pathways have been identified and characterized in mammals. Among them, nicotinamide phosphoribosyltransferase (Nampt) has drawn much attention in several different fields, including NAD biology, metabolism
Ion chromatography for the analysis of household consumer products
Murawski D, et al.
Journal of Chromatography A, 546, 351-367 (1991)
Małgorzata Natalia Mojsak et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 29(169), 54-57 (2010-08-18)
Nicotinamide (niacin) is very useful substance in treatment of many kinds of diseases. For the decades the main indications for application of niacin were lipid disorders. There are studies confirming that niacin increases thyroid radiosensitivity to 1-131. The radioiodine therapy
Calin Cainap et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(2), 172-179 (2014-12-10)
This open-label phase III trial evaluated efficacy and tolerability of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC) without prior systemic therapy. Patients were randomly assigned in a 1:1 ratio to linifanib 17.5 mg once daily or sorafenib
1/10