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显示 31-60 共 300 条结果 关于 "PHR1033" 范围 论文
Yu-Yun Shao et al.
Oncology, 85(5), 312-316 (2013-11-13)
A germline BIM deletion polymorphism has been proposed to predict a poor treatment efficacy of certain kinase inhibitors. The current study aimed to explore whether the BIM deletion polymorphism predicts the treatment efficacy of sorafenib for advanced hepatocellular carcinoma (HCC).
Liyuan Yang et al.
Zhonghua fu chan ke za zhi, 37(11), 660-662 (2002-12-19)
To investigate the expression of nicotinamide edenine dinucleotide (NADH) dehydrogenase gene in the placenta of patients with pregnancy induced hypertension (PIH) and the role of NADH dehydrogenase in PIH pathogenesis. Using (32)P dATP labeled human NADH dehydrogenase cDNA probe, the
Jose C Paz et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17116-17121 (2014-11-19)
In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions in catecholamine signaling, where it contributes
M Moehler et al.
European journal of cancer (Oxford, England : 1990), 50(18), 3125-3135 (2014-12-03)
Since sorafenib has shown activity in different tumour types and gemcitabine regimens improved the outcome for biliary tract cancer (BTC) patients, we evaluated first-line gemcitabine plus sorafenib in a double-blind phase II study. 102 unresectable or metastatic BTC patients with
Dan Huang et al.
Applied microbiology and biotechnology, 99(3), 1399-1413 (2014-12-10)
Lysine acetylation is a dynamic, reversible posttranslational modification that is known to play an important role in regulating the activity of many key enzymes in bacteria. Acetylproteome studies have been performed on some bacteria. However, until now, there have been
Ruo-Lei Jian et al.
Gene, 562(1), 107-116 (2015-03-01)
Mesenchymal stem cells (MSCs) have been reported to be an attractive source for the generation of transplantable surrogate β cells. A murine embryonic mesenchymal progenitor cell line C3H10T1/2 has been recognized as a model for MSCs, because of its multi-lineage
Mitchell E Horwitz et al.
The Journal of clinical investigation, 124(7), 3121-3128 (2014-06-10)
Delayed hematopoietic recovery is a major drawback of umbilical cord blood (UCB) transplantation. Transplantation of ex vivo-expanded UCB shortens time to hematopoietic recovery, but long-term, robust engraftment by the expanded unit has yet to be demonstrated. We tested the hypothesis
Nian-Cun Qiu et al.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 18(11), 1957-1964 (2014-09-04)
The purpose of this study is to investigate the impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass (RYGB) on the level of fasting and postprandial serum glucagon-like peptide-1 (GLP-1) in type 2 diabetic mellitus rats. Randomized
E V Zinov'ev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(4), 39-44 (2013-06-15)
Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of
Gerardo D Anaya-Eugenio et al.
Journal of ethnopharmacology, 155(1), 416-425 (2014-06-04)
Artemisia ludoviciana, commonly known as "estafiate", plays an important role in contemporary Mexico for treating several diseases including diabetes. To establish the preclinical efficacy of Artemisia ludoviciana as hypoglycemic and/or antihyperglycemic agent using well-known animal models. Acute hypoglycemic as well
Marc Ferrer et al.
Stem cells translational medicine, 3(8), 911-922 (2014-05-31)
There is continuing interest in the development of lineage-specific cells from induced pluripotent stem (iPS) cells for use in cell therapies and drug discovery. Although in most cases differentiated cells show features of the desired lineage, they retain fetal gene
Kengo Nomura et al.
Journal of the American Society of Nephrology : JASN, 25(4), 761-772 (2013-11-23)
Marked hypophosphatemia is common after major hepatic resection, but the pathophysiologic mechanism remains unknown. We used a partial hepatectomy (PH) rat model to investigate the molecular basis of hypophosphatemia. PH rats exhibited hypophosphatemia and hyperphosphaturia. In renal and intestinal brush-border
Sina Bartfeld et al.
Gastroenterology, 148(1), 126-136 (2014-10-14)
We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine and pancreas. Here we describe conditions required for long-term 3-dimensional culture of human gastric stem cells. The technology can be applied
Ivana Cristina Fernandez et al.
Journal of pediatric endocrinology & metabolism : JPEM, 26(3-4), 347-355 (2013-06-07)
Abstract Objectives: The aim was to evaluate the treatment with acetyl-L-carnitine (50 mg/kg/day) and nicotinamide (25 mg/kg/day) in children at risk of type 1 diabetes. This treatment was effective and harmless in experimental type 1 diabetes in mice. Nine out
Sun Young Shin et al.
International journal of clinical pharmacology and therapeutics, 51(11), 837-846 (2013-10-01)
The purpose of this study was to identify the correlation of skin toxicity and hypertension with clinical benefit in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib by analyzing medical records retrospectively. Data from medical records was statistically analyzed to
Jun Lu et al.
Biochemical and biophysical research communications, 453(3), 405-410 (2014-10-01)
The direct conversion of one cell type to another without an intermediate pluripotent stage is required for regenerative therapies. The ventral pancreas and liver share a common developmental origin. Recent studies have shown that hepatocytes could be induced to transdifferentiate
Weirong Wang et al.
Experimental cell research, 319(10), 1523-1533 (2013-04-23)
The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, regulates the inflammatory response in adipocytes. However, whether the role of PPARα in inflammation is
Neil M Niren
Cutis, 77(1 Suppl), 11-16 (2006-07-29)
Various skin disorders with an inflammatory component often have been treated with steroids and/or oral antibiotics. However, long-term use of these agents has drawbacks: steroids may induce numerous serious side effects such as hypertension, immunosuppression, and osteoporosis, and overuse of
Kenneth Maiese et al.
Molecules (Basel, Switzerland), 14(9), 3446-3485 (2009-09-29)
Nicotinamide, the amide form of vitamin B(3) (niacin), is changed to its mononucleotide compound with the enzyme nicotinic acide/nicotinamide adenylyltransferase, and participates in the cellular energy metabolism that directly impacts normal physiology. However, nicotinamide also influences oxidative stress and modulates
K Schulpis et al.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 17(5), 443-448 (2004-09-11)
Low folate and vitamin B(12) concentrations during pregnancy are implicated with neural tube defects (NTD) and neurological manifestations in the neonates. To compare serum concentrations of folate and vitamin B(12) in 1025 Greek mothers, 908 immigrant Albanian mothers at delivery
Kristel Hälvin et al.
Analytical and bioanalytical chemistry, 406(28), 7355-7366 (2014-09-10)
The distribution of free and bound forms of B-group vitamins (B1, B2, B3, B5, and B6) was quantified in quinoa seeds using LC-MS-TOF combined with a stable isotope dilution assay. The effectiveness of liberating thiamine, riboflavin, nicotinic acid, pantothenic acid
N Baeza et al.
Diabetes & metabolism, 22(4), 229-234 (1996-07-01)
Beta-cell regeneration in adult pancreas is usually considered to be limited. However, various animal models suggest that this tissue is still capable of regeneration under certain conditions. Reg protein could be responsible for this replicative process. The reg gene codes
Robert T Burns et al.
PloS one, 9(11), e109535-e109535 (2014-11-13)
Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the energetically intensive processes of metamorphosis, post-metamorphic growth, and reproduction, we tested several B vitamins to
Xiaojing Chen et al.
Scientific reports, 4, 7481-7481 (2014-12-17)
SIRT1, a NAD(+) dependent class III deacetylase, takes part in many important biological processes. Previous studies show that SIRT1 is overexpressed in some cancers and plays an essential role in tumorigenesis. However, the association between SIRT1 and colorectal cancer (CRC)
Amanda Rennick et al.
Pharmacotherapy, 33(6), 683-690 (2013-03-26)
Phosphate binders have traditionally been used to treat hyperphosphatemia, a common complication in patients with end stage renal disease (ESRD). New evidence suggests that nicotinic acid and its metabolites may effectively decrease phosphorus absorption in the gastrointestinal tract, thereby reducing
Calin Cainap et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(2), 172-179 (2014-12-10)
This open-label phase III trial evaluated efficacy and tolerability of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC) without prior systemic therapy. Patients were randomly assigned in a 1:1 ratio to linifanib 17.5 mg once daily or sorafenib
I-Chieh Chen et al.
Molecular cancer, 13, 254-254 (2014-11-27)
The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 has been implicated in a variety of physiological processes; however, its
Hiroyuki Yamashita et al.
Pharmaceutical research, 31(8), 1946-1957 (2014-02-14)
The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams
Siyuan Ding et al.
PLoS biology, 12(1), e1001758-e1001758 (2014-01-11)
Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-specific antiviral
Ga Bin Park et al.
Cancer letters, 350(1-2), 5-14 (2014-05-03)
PKCη is involved in proliferation, differentiation, and drug resistance. However, PKCη function in EBV(+) B lymphoma remains poorly understood. Gene silencing of PKCη through siRNA knockdown inhibited cellular proliferation, induced cell cycle arrest in G0/G1 and G2/M phases, and sensitized
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