PHR1052

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显示 1-30 共 157 条结果关于 "PHR1052" 范围论文

The role of antimicrobials in Crohn's disease.

Pramodini B Kale-Pradhan et al.

Expert review of gastroenterology & hepatology, 7(3), 281-288 (2013-03-01)

This review summarizes literature regarding the role of antimicrobials for induction and maintenance of Crohn's disease (CD) remission. PubMed was searched (1966 to October 2012) for controlled trials involving adults and written in English. Five of the 13 identified studies

Comparison of treatment outcomes with vancomycin alone versus combination therapy in severe Clostridium difficile infection.

S N Bass et al.

The Journal of hospital infection, 85(1), 22-27 (2013-07-24)

The recommended treatment for severe Clostridium difficile infection (CDI) is oral vancomycin alone. Combination therapy with metronidazole is only recommended in cases complicated by shock, ileus, or toxic megacolon. However, patients with severe infection are often treated with combination therapy

Clinical manifestations and risk factors of amebic liver abscess in Southeast Taiwan compared with other regions of Taiwan.

Huan-Lin Chen et al.

The American journal of tropical medicine and hygiene, 89(6), 1214-1218 (2013-10-30)

Amebic liver abscess (ALA) had previously been endemic in Taiwan, particularly in the southern region, although its occurrence in the southeastern area was unknown. Thus, we conducted a retrospective study for southeastern Taiwan. We identified 14 patients who were diagnosed

Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.

Anjan Debnath et al.

Antimicrobial agents and chemotherapy, 58(7), 4138-4144 (2014-05-14)

Entamoeba histolytica and Giardia lamblia are anaerobic protozoan parasites that cause amebiasis and giardiasis, two of the most common diarrheal diseases worldwide. Current therapy relies on metronidazole, but resistance has been reported and the drug has significant adverse effects. Therefore

False-negative serologies in amebic liver abscess: report of two cases.

Marie-Pierre Otto et al.

Journal of travel medicine, 20(2), 131-133 (2013-03-08)

Amebiasis, the parasitic disease caused by Entamoeba histolytica, may result in extra-intestinal diseases among which liver abscess is the most common manifestation. We report two cases of amebic liver abscess illustrating the inequal sensitivity of serologic tests detecting anti-amebic antibodies.

Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway.

Qian Li et al.

Microbes and infection, 16(1), 17-27 (2013-10-22)

Pseudomonas aeruginosa is an important opportunistic bacterial pathogen, causing infections of respiratory and other organ systems in immunocompromised hosts that may invade and proliferate in mucosal epithelial cells to induce apoptosis. Previous studies suggest that oral bacteria, especially gram-negative periodontal

Chromatographic methods for simultaneous determination of diiodohydroxyquinoline and metronidazole in their binary mixture.

Nouruddin Wageih Ali et al.

Pakistan journal of pharmaceutical sciences, 26(5), 865-871 (2013-09-17)

Two chromatographic methods were developed for analysis ofdiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, diiodohydroxyquinoline and metronidazole were separated on TLC silica gel 60F254 plate using chloroform: acetone: glacial acetic acid (7.5: 2.5: 0.1, by volume) as mobile

Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine.

Daehee Han et al.

PloS one, 10(2), e0118795-e0118795 (2015-02-18)

We have previously generated a mouse model of spontaneous Th2-associated disease of the small intestine called TRAF6ΔDC, in which dendritic cell (DC)-intrinsic expression of the signaling mediator TRAF6 is ablated. Interestingly, broad-spectrum antibiotic treatment ameliorates TRAF6ΔDC disease, implying a role

Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.

Nitin K Gupta et al.

The American journal of surgical pathology, 37(7), 1109-1113 (2013-05-30)

Cord colitis syndrome (CCS) is a recently described diarrheal illness of uncertain pathogenesis that affects recipients of umbilical cord blood transplant and is associated with negative cultures. CCS exhibits a peculiar histopathologic appearance, as it commonly manifests as granulomatous inflammation

In vitro activity of MCB3681 against Clostridium difficile strains.

Mamun-Ur Rashid et al.

Anaerobe, 28, 216-219 (2014-07-13)

One hundred fourteen Clostridium difficile strains were collected from 67 patients and analyzed for the presence of C. difficile toxin B by the cell cytotoxoicity neutralization assay, genes for toxin A, toxin B, binary toxin and TcdC deletion by PCR. All

Dead bacteria reverse antibiotic-induced host defense impairment in burns.

Lee-Wei Chen et al.

Journal of the American College of Surgeons, 219(4), 606-619 (2014-09-23)

Burn patients can incur high rates of hospital-acquired infections. The mechanism of antibiotic exposure on inducing infection vulnerability has not been determined. This study aimed to examine the effects of antibiotic treatment on host defense mechanisms. First we treated C57/BL6

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes.

Jiajia Xue et al.

Biomaterials, 35(34), 9395-9405 (2014-08-20)

Infection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended

Anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts of five different populations of Hippocratea celastroides collected in Mexico.

Wendy Itzel Escobedo Hinojosa et al.

Journal of ethnopharmacology, 155(2), 1156-1163 (2014-06-28)

The root barks of Hippocratea celastroides have been used for decades in Mexican traditional medicine to treat gastritis and ulcers. To investigate the anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts obtained from the leaves, stems, and root

Characterization of a multidrug resistant C. difficile meat isolate.

Shankumar Mooyottu et al.

International journal of food microbiology, 192, 111-116 (2014-12-03)

Clostridium difficile is a pathogen of significant public health concern causing a life-threatening, toxin-mediated enteric disease in humans. The incidence and severity of the disease associated with C. difficile have increased in the US with the emergence of hypervirulent strains

Innovative use of topical metronidazole.

Catherine M Zip

Dermatologic clinics, 28(3), 525-534 (2010-06-01)

Metronidazole is a synthetic nitroimidazole derivative with antimicrobial and antiinflammatory properties. It was the first topical therapy approved solely for rosacea and remains a cornerstone of rosacea management. This article reviews the optimal use of topical metronidazole in the treatment

IL-6 stimulates intestinal epithelial proliferation and repair after injury.

Kristine A Kuhn et al.

PloS one, 9(12), e114195-e114195 (2014-12-06)

IL-6 is a pleiotropic cytokine often associated with inflammation. Inhibition of this pathway has led to successful treatment of rheumatoid arthritis, but one unforeseen potential complication of anti-IL-6 therapy is bowel perforation. Within the intestine, IL-6 has been shown to

PAMAM dendrimer generation 5-pluronic F127 nanofilm as a matrix for local metronidazole release.

Tran Huu Dung et al.

Journal of biomedical nanotechnology, 9(7), 1286-1292 (2013-08-06)

A series of dendrimer G5-pluronic F127 nanofilms (at 1:10, 1:20 and 1:30 mole ratios), loaded with various percent of metronidazole hydrochloride, were prepared by the drug deposition with/without gelatin coating. The nanostructural feature of dendrimer G5-pluronic F127 as a matrix

Gingival pain: an unusual side effect of ziprasidone.

Ashwati Raghunath

BMJ case reports, 2013, doi:10-doi:10 (2013-01-04)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyramidal side

Antibiotic prophylaxis for hysterectomy, a prospective cohort study: cefuroxime, metronidazole, or both?

T H I Brummer et al.

BJOG : an international journal of obstetrics and gynaecology, 120(10), 1269-1276 (2013-06-22)

To evaluate cefuroxime and metronidazole antibiotic prophylaxis. Observational nonrandomised 1-year prospective cohort study. Fifty-three hospitals in Finland. A total of 5279 women undergoing hysterectomy for benign indications, with cefuroxime given to 4301 and metronidazole given to 2855. Excluding other antibiotics

High frequency of nonadherence to Clostridium difficile treatment guidelines.

M Catherine McEllistrem et al.

Southern medical journal, 107(9), 597-599 (2014-09-05)

The 2010 Infectious Diseases Society of America/Society for Healthcare Epidemiology of America treatment guidelines for Clostridium difficile infections (CDI) recommend oral metronidazole for mild-to-moderate disease and oral vancomycin for severe disease. Given that disease severity is easily determined by the

Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.

Yasuhiro Horita et al.

Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)

Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated

The clinical effect of scaling and root planing and the concomitant administration of systemic amoxicillin and metronidazole: a systematic review.

Dina Zandbergen et al.

Journal of periodontology, 84(3), 332-351 (2012-05-23)

The treatment of periodontitis frequently begins with a non-surgical phase that includes scaling and root planing (SRP) and, on occasion, the use of systemic antibiotics. The goal of this review is to systematically evaluate the data concerning the effect of

Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection.

Michael Selgrad et al.

World journal of gastroenterology, 20(43), 16245-16251 (2014-12-05)

To assess whether antibiotic resistance varies between the antrum and corpus of the stomach of patients that are either Helicobacter pylori (H. pylori) therapy-naive or pre-treated. H. pylori strains were isolated from antrum and corpus biopsies from 66 patients that

Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections.

Christina M Surawicz et al.

The American journal of gastroenterology, 108(4), 478-498 (2013-02-27)

Clostridium difficile infection (CDI) is a leading cause of hospital-associated gastrointestinal illness and places a high burden on our health-care system. Patients with CDI typically have extended lengths-of-stay in hospitals, and CDI is a frequent cause of large hospital outbreaks

In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria.

Michael D Huband et al.

Antimicrobial agents and chemotherapy, 59(1), 467-474 (2014-11-12)

AZD0914 is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus agalactiae), fastidious Gram-negative (Haemophilus influenzae and Neisseria gonorrhoeae), atypical (Legionella pneumophila), and

A selective antibiotic prophylaxis policy for laparoscopic cholecystectomy is effective in minimising infective complications.

F Yanni et al.

Annals of the Royal College of Surgeons of England, 95(5), 345-348 (2013-07-11)

It has been demonstrated previously that the identification of bactibilia during cholecystectomy is associated with the presence of one or more risk factors: acute cholecystitis, common duct stones, emergency surgery, intraoperative findings and age >70 years. Current evidence-based guidance on

[Acute cholecystitis].

H S Füessl

MMW Fortschritte der Medizin, 155(1), 49-49 (2013-04-12)

Clostridium difficile in retail baskets, trolleys, conveyor belts, and plastic bags in Saudi Arabia.

Mohammed A Alqumber

Saudi medical journal, 35(10), 1274-1277 (2014-10-16)

To determine Clostridium difficile (C. difficile) prevalence on retail surfaces and shoppers plastic bags. From 20 June to 10 August 2011, in a cross-sectional epidemiological study, 17 supermarkets from 2 cities, Albaha and Altaif, Saudi Arabia were sampled. A total

Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants.

Muhammad Amin et al.

Molecules (Basel, Switzerland), 18(2), 2135-2149 (2013-02-26)

Different parts of Acacia nilotica (L.) Delile, Calotropis procera (Aiton) W.T. Aiton, Adhatoda vasica Nees, Fagoniaar abica L. and Casuarina equisetifolia L. are traditionally used in folk medicine for the treatment of a variety of common ailments like nausea, cold

Paracetamol or metronidazole?

J Loader et al.

British journal of anaesthesia, 111(2), 301-302 (2013-07-17)

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