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PHR1052
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Simon A Dingsdag et al.
Organic & biomolecular chemistry, 13(1), 98-109 (2014-10-23)
The periodontal pathogen Porphyromonas gingivalis requires porphyrin supplementation for growth. Previously, in order to inhibit P. gingivalis growth, we synthesised very effective 'Trojan horse' ester and amide-linked deuterporphyrin-nitroimidazole (DPIX-Nim) adducts that exploited this requirement to transport metronidazole-derived antibiotics with excellent
Kyu-Hyun Yoon et al.
Journal of Korean medical science, 29(9), 1240-1246 (2014-09-24)
We evaluated the antibiotic resistance rates and eradication rates of clarithromycin based triple therapy from 2005 to 2010 retrospectively. In addition, we investigated the mechanism of clarithromycin resistance in Helicobacter pylori strains isolated from Korean patients. Two hundred and twelve
Horacio Reyes-Vivas et al.
Antimicrobial agents and chemotherapy, 58(12), 7072-7082 (2014-09-17)
Giardiasis is highly prevalent in the developing world, and treatment failures with the standard drugs are common. This work deals with the proposal of omeprazole as a novel antigiardial drug, focusing on a giardial glycolytic enzyme used to follow the
K A Knoop et al.
Mucosal immunology, 8(1), 198-210 (2014-07-10)
The delivery of luminal substances across the intestinal epithelium to the immune system is a critical event in immune surveillance, resulting in tolerance to dietary antigens and immunity to pathogens. How this process is regulated is largely unknown. Recently goblet
C Rodriguez et al.
Veterinary microbiology, 172(1-2), 309-317 (2014-06-05)
Clostridium difficile has been identified as a significant agent of diarrhoea and enterocolitis in both foals and adult horses. Hospitalization, antibiotic therapy or changes in diet may contribute to the development of C. difficile infection. Horses admitted to a care
Shinichiro Morioka et al.
Kekkaku : [Tuberculosis], 88(3), 305-309 (2013-05-16)
We report the case of a patient with pulmonary tuberculosis, whose diagnosis was delayed because of prior treatment with fluoroquinolone and metronidazole. A 35-year-old woman developed productive cough, fever, and back pain, which lasted for 3 weeks before admission to
Claudia M Hemsley et al.
Antimicrobial agents and chemotherapy, 58(10), 5775-5783 (2014-07-23)
Noninherited antibiotic resistance is a phenomenon whereby a subpopulation of genetically identical bacteria displays phenotypic tolerance to antibiotics. We show here that compared to Escherichia coli, the clinically relevant genus Burkholderia displays much higher levels of cells that tolerate ceftazidime.
[Is sequential eradication of Helicobacter pylori effective? Sequential treatment more effective than triple therapy in patients with clarithromycin resistance].
P Malfertheiner
Deutsche medizinische Wochenschrift (1946), 138(13), 628-628 (2013-03-21)
M Catherine McEllistrem et al.
Southern medical journal, 107(9), 597-599 (2014-09-05)
The 2010 Infectious Diseases Society of America/Society for Healthcare Epidemiology of America treatment guidelines for Clostridium difficile infections (CDI) recommend oral metronidazole for mild-to-moderate disease and oral vancomycin for severe disease. Given that disease severity is easily determined by the
T H I Brummer et al.
BJOG : an international journal of obstetrics and gynaecology, 120(10), 1269-1276 (2013-06-22)
To evaluate cefuroxime and metronidazole antibiotic prophylaxis. Observational nonrandomised 1-year prospective cohort study. Fifty-three hospitals in Finland. A total of 5279 women undergoing hysterectomy for benign indications, with cefuroxime given to 4301 and metronidazole given to 2855. Excluding other antibiotics
Simultaneous determination of miconazole nitrate and metronidazole in different pharmaceutical dosage forms by gas chromatography and flame ionization detector (GC-FID).
Ashour S and Kattan N
International Journal of Biomedical Science : IJBS, 6(1), 13-13 (2010)
Fang-Hsuean Liao et al.
Cell & bioscience, 4, 25-25 (2014-06-07)
Protein phosphates 4 (PP4), encoded by the ppp4c gene, is a ubiquitously expressed phosphatase that has been implicated in the regulation of cytokine signaling and lymphocyte survival; recent reports suggest that PP4 may be involved in pre-TCR signaling and B
Muhammad Amin et al.
Molecules (Basel, Switzerland), 18(2), 2135-2149 (2013-02-26)
Different parts of Acacia nilotica (L.) Delile, Calotropis procera (Aiton) W.T. Aiton, Adhatoda vasica Nees, Fagoniaar abica L. and Casuarina equisetifolia L. are traditionally used in folk medicine for the treatment of a variety of common ailments like nausea, cold
Paracetamol or metronidazole?
J Loader et al.
British journal of anaesthesia, 111(2), 301-302 (2013-07-17)
Marin J de Jong et al.
Archives of disease in childhood, 99(12), 1109-1113 (2014-07-24)
The association between Dientamoeba (D.) fragilis and the aetiology of functional gastrointestinal disorders (FGID) in children is unclear. The aim of this retrospective case-control study is to clarify the clinical relevance of D. fragilis in children with chronic abdominal pain.
Clostridium difficile in retail baskets, trolleys, conveyor belts, and plastic bags in Saudi Arabia.
Mohammed A Alqumber
Saudi medical journal, 35(10), 1274-1277 (2014-10-16)
To determine Clostridium difficile (C. difficile) prevalence on retail surfaces and shoppers plastic bags. From 20 June to 10 August 2011, in a cross-sectional epidemiological study, 17 supermarkets from 2 cities, Albaha and Altaif, Saudi Arabia were sampled. A total
[Acute cholecystitis].
H S Füessl
MMW Fortschritte der Medizin, 155(1), 49-49 (2013-04-12)
Vancomycin-associated neutrophilic dermatitis histologically mimicking Cryptococcus.
Alan S Boyd et al.
Journal of the American Academy of Dermatology, 70(4), e86-e88 (2014-03-19)
Andrey Galkin et al.
The Journal of biological chemistry, 289(15), 10502-10509 (2014-02-22)
Carbamate kinase from Giardia lamblia is an essential enzyme for the survival of the organism. The enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate. We previously reported that disulfiram
Ebola in Freetown area, Sierra Leone--a case study of 581 patients.
Rashid Ansumana et al.
The New England journal of medicine, 372(6), 587-588 (2014-12-30)
Marco Araújo et al.
International journal of pharmaceutics, 469(1), 140-145 (2014-04-29)
This work proposes melanin as a new nanocarrier for pH-responsive drug release. Melanin is an abundant natural polymer that can be easily extracted from cuttlefish as nanoparticles with a suitable size range for drug delivery. However, despite its high potentiality
M B Ellebæk et al.
Techniques in coloproctology, 18(11), 1067-1074 (2014-08-26)
Anastomotic leakage (AL) after rectosigmoid resection is a serious complication associated with high morbidity and mortality. This case-control pilot study investigated the changes in blood concentration of 10 different cytokines and 2 complement factors in relation to symptomatic AL after
Granulomatous lymphangitis.
Gino J Vricella et al.
The Journal of urology, 190(3), 1052-1053 (2013-06-19)
Amber Howerton et al.
The Journal of infectious diseases, 207(10), 1498-1504 (2013-02-20)
Clostridium difficile infection (CDI) is a leading cause of antibiotic-associated diarrhea. The infective form of C. difficile is the spore, but the vegetative bacterium causes the disease. Because C. difficile spore germination is required for symptomatic infection, antigermination approaches could
Ying-Ting Huang et al.
Acta neurologica Taiwanica, 21(2), 74-78 (2012-08-11)
Neurotoxicities resulting from various medications are under diagnosed; Metronidazole-induced encephalopathy is one of them. Here we present two patients with a history of metronidazole use and discuss neuroimaging findings. We report two patients suffering from acute neurological symptoms associated with
Autumn S Downey et al.
The Journal of antimicrobial chemotherapy, 64(4), 751-754 (2009-08-20)
To assess the in vitro activity of the FDA-approved antihelminthic drug pyrvinium pamoate against Entamoeba histolytica and Giardia intestinalis. A head-to-head comparison of a standard radiolabelled thymidine incorporation assay and the SYBR Green I-based fluorescence assay for determination of in
Linda F McElhiney
International journal of pharmaceutical compounding, 17(5), 380-383 (2014-01-28)
Anorectal Crohn's disease is one of the most problematic and debilitating forms of Crohn's disease. Crohn's disease is a type of inflammatory bowel disease that usually affects the intestines but may occur anywhere in the gastrointestinal tract and is frequently
Priscileila Colerato Ferrari et al.
Drug development and industrial pharmacy, 40(8), 1123-1131 (2013-07-03)
Alternating Current Biosusceptometry is a magnetically method used to characterize drug delivery systems. This work presents a system composed by an automated ACB sensor to acquire magnetic images of floating tablets. The purpose of this study was to use an
C G M Jardin et al.
The Journal of hospital infection, 85(1), 28-32 (2013-07-10)
National guidelines recommend oral vancomycin for severe Clostridium difficile infection (CDI) based on results from recent clinical trials demonstrating improved clinical outcomes. However, real-world data to support these clinical trials are scant. To compare treatment patterns and patient outcomes of
Norberto C Chavez-Tapia et al.
The Cochrane database of systematic reviews, (1)(1), CD004886-CD004886 (2009-01-23)
Metronidazole is the standard of care for uncomplicated amoebic liver abscesses (considering that complicated liver abscesses are those localized in left lobe, multiple, and/or pyogenic abscesses). However, a subset of patients with amoebic liver abscesses remain symptomatic, with a significant
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