PHR1101

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关键词:'PHR1101'

显示 1-30 共 661 条结果关于 "PHR1101" 范围论文

Specific expression of apolipoprotein A-IV in the follicle-associated epithelium of the small intestine.

Daisuke Tokuhara et al.

Digestive diseases and sciences, 59(11), 2682-2692 (2014-05-20)

Peyer's patches (PPs), which are covered by specialized follicle-associated epithelium (FAE) including M cells, play a central role in immune induction in the gastrointestinal tract. This study is to investigate a new molecule to characterize PPs. We generated a monoclonal

Inhibition of histone binding by supramolecular hosts.

Hillary F Allen et al.

The Biochemical journal, 459(3), 505-512 (2014-03-01)

The tandem PHD (plant homeodomain) fingers of the CHD4 (chromodomain helicase DNA-binding protein 4) ATPase are epigenetic readers that bind either unmodified histone H3 tails or H3K9me3 (histone H3 trimethylated at Lys⁹). This dual function is necessary for the transcriptional

Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice.

Jin Hwan Lee et al.

Journal of neurotrauma, 31(16), 1417-1430 (2014-04-16)

Preclinical and clinical studies have shown therapeutic potential of mild-to-moderate hypothermia for treatments of stroke and traumatic brain injury (TBI). Physical cooling in humans, however, is usually slow, cumbersome, and necessitates sedation that prevents early application in clinical settings and

The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations.

Christian Schmidl et al.

Blood, 123(17), e68-e78 (2014-03-29)

CD4(+)CD25(+)FOXP3(+) human regulatory T cells (Tregs) are essential for self-tolerance and immune homeostasis. Here, we describe the promoterome of CD4(+)CD25(high)CD45RA(+) naïve and CD4(+)CD25(high)CD45RA(-) memory Tregs and their CD25(-) conventional T-cell (Tconv) counterparts both before and after in vitro expansion by

A pooled analysis evaluating the efficacy and tolerability of tapentadol extended release for chronic, painful diabetic peripheral neuropathy.

Sherwyn Schwartz et al.

Clinical drug investigation, 35(2), 95-108 (2014-12-17)

Data from two similarly designed studies of tapentadol extended release (ER) for managing neuropathic pain associated with diabetic peripheral neuropathy (DPN; NCT00455520, NCT01041859) in adults were pooled for this analysis, allowing a detailed evaluation of efficacy in patient subgroups and

Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice.

Massimiliano Cristofanilli et al.

Experimental neurology, 261, 620-632 (2014-08-12)

Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination and neurodegeneration throughout the CNS, which lead over time to a condition of irreversible functional decline known as progressive MS. Currently, there are no satisfactory treatments for this condition

AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy.

R Thwaite et al.

Gene therapy, 22(2), 196-201 (2014-11-21)

Simian adeno-associated virus (AAV) serotype rh.10 is a promising gene therapy tool, achieving safe, sustained transgene expression in the nervous system, lung, liver and heart in animal models. To date, preexisting immunity in humans has not been confirmed, though exposure

Exogenous 5-aminolevulenic acid promotes seed germination in Elymus nutans against oxidative damage induced by cold stress.

Juanjuan Fu et al.

PloS one, 9(9), e107152-e107152 (2014-09-11)

The protective effects of 5-aminolevulenic acid (ALA) on germination of Elymus nutans Griseb. seeds under cold stress were investigated. Seeds of E. nutans (Damxung, DX and Zhengdao, ZD) were pre-soaked with various concentrations (0, 0.1, 0.5, 1, 5, 10 and

The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates.

Isabella M Guimaraes et al.

Molecular brain, 8, 24-24 (2015-04-18)

The metabotropic glutamate receptor 5 (mGluR5) is involved in various brain functions, including memory, cognition and motor behavior. Regarding locomotor activity, we and others have demonstrated that pharmacological antagonism of mGluR5 promotes hyperkinesia in mice. Moreover, increased locomotor activity can

Inter-cellular transport of ran GTPase.

Deepak Khuperkar et al.

PloS one, 10(4), e0125506-e0125506 (2015-04-22)

Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE). Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of Ran is associated

Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo.

Paula E Beaumont et al.

PloS one, 9(6), e99029-e99029 (2014-06-03)

Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence against infection. In addition to microbicidal potential, these peptides have properties with the capacity to modulate inflammation and immunity. However

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

Lunzhi Dai et al.

Nature chemical biology, 10(5), 365-370 (2014-04-01)

We report the identification of a new type of histone mark, lysine 2-hydroxyisobutyrylation (Khib), and identify the mark at 63 human and mouse histone Khib sites, including 27 unique lysine sites that are not known to be modified by lysine

Biocompatible evaluation of barium titanate foamed ceramic structures for orthopedic applications.

Jordan P Ball et al.

Journal of biomedical materials research. Part A, 102(7), 2089-2095 (2013-07-31)

The potential of barium titanate (BT) to be electrically active makes it a material of interest in regenerative medicine. To enhance the understanding of this material for orthopedic applications, the in vitro biocompatibility of porous BT fabricated using a direct

A highly conserved region between amino acids 221 and 266 of dengue virus non-structural protein 1 is a major epitope region in infected patients.

Magot Diata Omokoko et al.

The American journal of tropical medicine and hygiene, 91(1), 146-155 (2014-04-30)

The immune response to dengue virus (DENV) infection generates high levels of antibodies (Abs) against the DENV non-structural protein 1 (NS1), particularly in cases of secondary infection. Therefore, anti-NS1 Abs may play a role in severe dengue infections, possibly by

Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following traumatic injury?

Amy V Gore et al.

The journal of trauma and acute care surgery, 78(4), 767-772 (2015-03-26)

One week following unilateral lung contusion (LC), rat lungs demonstrate full histologic recovery. When animals undergo LC plus the addition of chronic restraint stress (CS), wound healing is significantly delayed. Mesenchymal stem cells (MSCs) are pluripotent cells capable of immunomodulation

Development of Recombinant Human Growth Hormone (rhGH) sustained-release microspheres by a low temperature aqueous phase/aqueous phase emulsion method.

Jian Kang et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 141-147 (2014-06-08)

A novel method has been developed to protect Recombinant Human Growth Hormone (rhGH) in poly (lactic-co-glycolic acid) (PLGA) microspheres using an aqueous phase/aqueous phase emulsion and S/O/W multi-emulsion method. This method develops a novel rhGH sustained-release system, which is based

An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.

Jonathan W Astin et al.

Molecular cancer therapeutics, 13(10), 2450-2462 (2014-07-24)

The growth of new lymphatic vessels (lymphangiogenesis) in tumors is an integral step in the metastatic spread of tumor cells, first to the sentinel lymph nodes that surround the tumor and then elsewhere in the body. Currently, no selective agents

Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.

Caroline Camaré et al.

British journal of pharmacology, 172(1), 106-118 (2014-09-02)

Neovascularization occurring in atherosclerotic lesions may promote plaque expansion, intraplaque haemorrhage and rupture. Oxidized LDL (oxLDL) are atherogenic, but their angiogenic effect is controversial; both angiogenic and anti-angiogenic effects have been reported. The angiogenic mechanism of oxLDL is partly understood

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.

Juan Liu et al.

Nature immunology, 15(7), 612-622 (2014-05-27)

Excessive activation of dendritic cells (DCs) leads to the development of autoimmune and inflammatory diseases, which has prompted a search for regulators of DC activation. Here we report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the

Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.

Waseem Kaialy et al.

International journal of pharmaceutics, 477(1-2), 282-293 (2014-12-03)

The purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of xylitol. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic

Lysine partitioning in broiler breeders is not affected by energy or protein intake when fed at current industry levels.

R D Ekmay et al.

Poultry science, 93(7), 1737-1744 (2014-05-28)

A study was conducted to determine the effects of dietary energy and protein intake on the partitioning of lysine in broiler breeder hens. One hundred twenty-six broiler breeders were randomly assigned to 1 of 6 dietary treatments in a 2

The up-regulation of spinal Toll-like receptor 4 in rats with inflammatory pain induced by complete Freund's adjuvant.

Xiao-Hui Zhao et al.

Brain research bulletin, 111, 97-103 (2015-01-17)

Peripheral inflammation induces central sensitization that displays the features by the development of pain hypersensitivity to the stimuli. It has been shown that activation of glia contributes to the development of behavioral hypersensitivity after peripheral inflammation. It has been suggested

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

Xiaole L Chen et al.

Molecular and cellular biology, 34(20), 3855-3866 (2014-08-06)

The Hedgehog (Hh) receptor Patched-1 (PTCH1) opposes the activation of Gli transcription factors and induces cell death through a Gli-independent pathway. Here, we report that the C-terminal domain (CTD) of PTCH1 interacts with and is ubiquitylated on K1413 by the

Supplementary immunocytochemistry of hepatocyte growth factor production in activated macrophages early in muscle regeneration.

Shoko Sawano et al.

Animal science journal = Nihon chikusan Gakkaiho, 85(12), 994-1000 (2014-09-05)

Regenerative intramuscular motor-innervation is thought to reside in the spatiotemporal expression of axon-guidance molecules. Our previous studies showed that resident myogenic stem cells, satellite cells, up-regulate a secreted neural-chemorepellent semaphorin 3A (Sema3A) during the early-differentiation period, in response to hepatocyte

Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography.

Le Ngoc Tran et al.

Journal of chromatography. A, 1356, 289-293 (2014-07-20)

An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 × 10(-3)M of polyethylene glycol

Probing the structure of the S105 hole.

Kam H To et al.

Journal of bacteriology, 196(21), 3683-3689 (2014-08-06)

For most phages, holins control the timing of host lysis. During the morphogenesis period of the infection cycle, canonical holins accumulate harmlessly in the cytoplasmic membrane until they suddenly trigger to form lethal lesions called holes. The holes can be

Development of a new deuterium-deuterium (D-D) neutron generator for prompt gamma-ray neutron activation analysis.

K Bergaoui et al.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 94, 319-327 (2014-10-12)

A new deuterium-deuterium (D-D) neutron generator has been developed by Adelphi Technology for prompt gamma neutron activation analysis (PGNAA), neutron activation analysis (NAA), and fast neutron radiography. The generator makes an excellent fast, intermediate, and thermal neutron source for laboratories

DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation.

Masayuki Okamoto et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2942-2958 (2015-02-24)

Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3β activity. Then, transported Lis1 is retrogradely

Rapid detection of sugar alcohol precursors and corresponding nitrate ester explosives using direct analysis in real time mass spectrometry.

Edward Sisco et al.

The Analyst, 140(8), 2785-2796 (2015-02-27)

This work highlights the rapid detection of nitrate ester explosives and their sugar alcohol precursors by direct analysis in real time mass spectrometry (DART-MS) using an off-axis geometry. Demonstration of the effect of various parameters, such as ion polarity and

LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells.

Huiling Wang et al.

Biochemical and biophysical research communications, 458(1), 201-207 (2015-02-04)

In this study we investigated the antitumor activity of the novel dual dithiocarbamatic acid ester LRD-22 in vitro and in vivo. Several cancer cell lines were employed to determine the effect of LRD-22 on cell growth, and the MTT assay

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