PHR1107

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关键词:'PHR1107'

显示 1-30 共 251 条结果关于 "PHR1107" 范围论文

Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA.

S Ishiwata et al.

The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)

To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The

Intestinal ornithine synthesis from glutamic acid.

Nutrition reviews, 43(4), 119-121 (1985-04-01)

Cholinergic modulation of large-conductance calcium-activated potassium channels regulates synaptic strength and spine calcium in cartwheel cells of the dorsal cochlear nucleus.

Shan He et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(15), 5261-5272 (2014-04-11)

Acetylcholine is a neuromodulatory transmitter that controls synaptic plasticity and sensory processing in many brain regions. The dorsal cochlear nucleus (DCN) is an auditory brainstem nucleus that integrates auditory signals from the cochlea with multisensory inputs from several brainstem nuclei

Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

Wilson I Gonsalves et al.

Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-14)

KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III

Neuroprotective effect of exercise in rat hippocampal slices submitted to in vitro ischemia is promoted by decrease of glutamate release and pro-apoptotic markers.

Flávio Afonso Gonçalves Mourão et al.

Journal of neurochemistry, 131(1), 65-73 (2014-06-07)

The role of physical exercise as a neuroprotective agent against ischemic injury has been extensively discussed. Nevertheless, the mechanisms underlying the effects of physical exercise on cerebral ischemia remain poorly understood. Here, we investigate the hypothesis that physical exercise increases

Cerebral tau is elevated after aneurysmal subarachnoid haemorrhage and associated with brain metabolic distress and poor functional and cognitive long-term outcome.

Raimund Helbok et al.

Journal of neurology, neurosurgery, and psychiatry, 86(1), 79-86 (2014-04-18)

Recent evidence suggests axonal injury after aneurysmal subarachnoid haemorrhage (aSAH). The microtubule-associated protein, tau, has been shown to be elevated in the cerebrospinal fluid after aSAH, however, brain extracellular tau levels and their relation to long-term neurological and cognitive outcomes

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.

Tomoyuki Mashimo et al.

Cell, 159(7), 1603-1614 (2014-12-20)

Glioblastomas and brain metastases are highly proliferative brain tumors with short survival times. Previously, using (13)C-NMR analysis of brain tumors resected from patients during infusion of (13)C-glucose, we demonstrated that there is robust oxidation of glucose in the citric acid

Glutamic acid and gamma-aminobutyric acid neurotransmitters in central control of breathing.

H Kazemi et al.

Journal of applied physiology (Bethesda, Md. : 1985), 70(1), 1-7 (1991-01-01)

We review recent cross-disciplinary experimental and theoretical investigations on metabolism of the amino acid neurotransmitters glutamic acid and gamma-aminobutyric acid (GABA) in the brain during hypoxia and hypercapnia and their possible role in central control of breathing. The roles of

Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions.

Sabine Ruehle et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(25), 10264-10277 (2013-06-21)

A major goal in current neuroscience is to understand the causal links connecting protein functions, neural activity, and behavior. The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. Studies using

X-ray structure of a novel L-ribose isomerase acting on a non-natural sugar L-ribose as its ideal substrate.

Hiromi Yoshida et al.

The FEBS journal, 281(14), 3150-3164 (2014-05-23)

l-Ribose, a pentose, is not known to exist in nature. Although organisms typically do not have a metabolic pathway that uses l-ribose as a carbon source, prokaryotes use various sugars as carbon sources for survival. Acinetobacter sp. DL-28 has been

Specification of spatial identities of cerebellar neuron progenitors by ptf1a and atoh1 for proper production of GABAergic and glutamatergic neurons.

Mayumi Yamada et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4786-4800 (2014-04-04)

In the cerebellum, the bHLH transcription factors Ptf1a and Atoh1 are expressed in distinct neuroepithelial regions, the ventricular zone (VZ) and the rhombic lip (RL), and are required for producing GABAergic and glutamatergic neurons, respectively. However, it is unclear whether

Genetic studies of body mass index yield new insights for obesity biology.

Adam E Locke et al.

Nature, 518(7538), 197-206 (2015-02-13)

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess

Study on dioxygen reduction by mutational modifications of the hydrogen bond network leading from bulk water to the trinuclear copper center in bilirubin oxidase.

Hirotoshi Morishita et al.

Biochemical and biophysical research communications, 450(1), 767-772 (2014-06-22)

The hydrogen bond network leading from bulk water to the trinuclear copper center in bilirubin oxidase is constructed with Glu463 and water molecules to transport protons for the four-electron reduction of dioxygen. Substitutions of Glu463 with Gln or Ala were

Roles of the protruding loop of factor B essential for the localization of lipoproteins (LolB) in the anchoring of bacterial triacylated proteins to the outer membrane.

Yumi Hayashi et al.

The Journal of biological chemistry, 289(15), 10530-10539 (2014-02-27)

The Lol system comprising five Lol proteins, LolA through LolE, sorts Escherichia coli lipoproteins to outer membranes. The LolCDE complex, an ATP binding cassette transporter in inner membranes, releases outer membrane-specific lipoproteins in an ATP-dependent manner, causing formation of the

Binding of ArgTX-636 in the NMDA receptor ion channel.

Mette H Poulsen et al.

Journal of molecular biology, 427(1), 176-189 (2014-05-28)

The N-methyl-d-aspartate receptors (NMDARs) constitute an important class of ligand-gated cation channels that are involved in the majority of excitatory neurotransmission in the human brain. Compounds that bind in the NMDAR ion channel and act as blockers are use- and

[Efficacy and safety of poly (gamma-glutamic acid) based nanoparticles (gamma-PGA NPs) as vaccine carrier].

Shinsaku Nakagawa

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 128(11), 1559-1565 (2008-11-05)

Recently, nanoscopic systems that incorporate therapeutic agents, and molecular targeting and diagnostic imaging capabilities are emerging as the next generation of functional nanomedicines to improve the outcome of drug therapeutics. Among the many nanoparticulate systems, micelle-like aggregates or nanoparticles formed

Effect of caries removal techniques on the bond strength of adhesives to caries-affected primary dentin in vitro.

E Yildiz et al.

European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry, 14(3), 209-214 (2013-12-04)

The aim of this in vitro study is to evaluate the effects of three different caries removal techniques on the microtensile bond strength of adhesive materials to caries-affected dentin. Thirty primary molar teeth were used. The teeth were randomly divided

Therapeutics: Negative feedback.

Elie Dolgin

Nature, 508(7494), S10-S11 (2014-04-04)

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

Ultrafine carbon black induces glutamate and ATP release by activating connexin and pannexin hemichannels in cultured astrocytes.

Hongying Wei et al.

Toxicology, 323, 32-41 (2014-06-17)

Ultrafine particles could enter central nervous system and were associated with brain damage. The underlying mechanisms have not been fully elucidated. Glutamate and ATP are important signaling molecules in brain physiology and pathology. We investigated whether ultrafine carbon black (ufCB)

Clinical and pharmacologic study of the epirubicin and paclitaxel combination in women with metastatic breast cancer.

G Grasselli et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 19(8), 2222-2231 (2001-04-17)

A pharmacokinetic interaction may cause increased cardiotoxicity of paclitaxel (PTX) and high cumulative dose of doxorubicin. We tested antitumor activity, tolerability, and pharmacokinetics of the lesser cardiotoxic epirubicin (EPI) and PTX (ET combination). Twenty-seven women with untreated metastatic breast cancer

[Role of glutamate transporters in the pathophysiology of major mental illnesses].

Kohichi Tanaka

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 142(6), 291-296 (2013-12-18)

Regulation of microtubule motors by tubulin isotypes and post-translational modifications.

Minhajuddin Sirajuddin et al.

Nature cell biology, 16(4), 335-344 (2014-03-19)

The 'tubulin-code' hypothesis proposes that different tubulin genes or post-translational modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result in unique interactions with microtubule-associated proteins for specific cellular functions. However, the inability to isolate distinct and homogeneous

Neuronal discharge hypersynchrony and the intracranial water balance in relation to glutamic acid and taurine redistribution: migraine and epilepsy.

N M van Gelder

Progress in clinical and biological research, 351, 1-20 (1990-01-01)

Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease.

Linn Hege Nilsen et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(5), 906-914 (2014-03-07)

Regional hypometabolism of glucose in the brain is a hallmark of Alzheimer's disease (AD). However, little is known about the specific alterations of neuronal and astrocytic metabolism involved in homeostasis of glutamate and GABA in AD. Here, we investigated the

Glutamate/glutamine metabolism coupling between astrocytes and glioma cells: neuroprotection and inhibition of glioma growth.

Pei-Sen Yao et al.

Biochemical and biophysical research communications, 450(1), 295-299 (2014-06-20)

Glioma glutamate release has been shown to promote the growth of glioma cells and induce neuronal injuries from epilepsy to neuronal death. However, potential counteractions from normal astrocytes against glioma glutamate release have not been fully evaluated. In this study

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Takashi Abe et al.

Journal of neuroscience research, 70(3), 447-450 (2002-10-23)

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and

Distribution of glutamate transporters in the human placenta.

C W Noorlander et al.

Placenta, 25(6), 489-495 (2004-05-12)

Glutamate metabolism is known to be important for growth and development of the human fetus. The glutamate transporters EAAT1, EAAT2 and EAAT3 are key components of the glutamate-glutamine cycle and responsible for active transport of glutamate over the cell membrane.

Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.

K J Bär et al.

Neurobiology of aging, 24(2), 333-338 (2002-12-25)

Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of

Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma.

Frederic J Kaye et al.

Journal of the National Cancer Institute, 107(1), 378-378 (2014-12-06)

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