PHR1110

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关键词:'PHR1110'

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Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.

D Rating et al.

Journal of neurology, 230(4), 217-225 (1983-01-01)

In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:

Four Cys residues in heterodimeric 2-oxoacid:ferredoxin oxidoreductase are required for CoA-dependent oxidative decarboxylation but not for a non-oxidative decarboxylation.

Zhen Yan et al.

Biochimica et biophysica acta, 1844(4), 736-743 (2014-02-05)

Heterodimeric 2-oxoacid:ferredoxin oxidoreductase (OFOR) from Sulfolobus tokodaii (StOFOR) has only one [4Fe-4S]²⁺ cluster, ligated by 4 Cys residues, C12, C15, C46, and C197. The enzyme has no other Cys. To elucidate the role of these Cys residues in holding of

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.

Aubérie Parent et al.

Nature communications, 6, 5686-5686 (2015-01-20)

Friedreich's ataxia is a severe neurodegenerative disease caused by the decreased expression of frataxin, a mitochondrial protein that stimulates iron-sulfur (Fe-S) cluster biogenesis. In mammals, the primary steps of Fe-S cluster assembly are performed by the NFS1-ISD11-ISCU complex via the

Rebamipide suppresses collagen-induced arthritis through reciprocal regulation of th17/treg cell differentiation and heme oxygenase 1 induction.

Moon SJ, Park JS, Woo YJ, et al.

Arthritis & Rheumatology (Hoboken, N.J.), 66(4), 874-885 (2014)

S81L and G170R mutations causing Primary Hyperoxaluria type I in homozygosis and heterozygosis: an example of positive interallelic complementation.

Riccardo Montioli et al.

Human molecular genetics, 23(22), 5998-6007 (2014-07-06)

Primary Hyperoxaluria type I (PH1) is a rare disease due to the deficit of peroxisomal alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal-5'-phosphate (PLP) enzyme present in humans as major (Ma) and minor (Mi) allele. PH1-causing mutations are mostly missense identified in

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Mark G Jones et al.

Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)

Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is

High concentrations of the melatonin metabolite, N1-acetyl-N2-formyl-5-methoxykynuramine, in cerebrospinal fluid of patients with meningitis: a possible immunomodulatory mechanism.

Sueli de Oliveira Silva et al.

Journal of pineal research, 39(3), 302-306 (2005-09-10)

We evaluated the presence of the melatonin metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), in cerebrospinal fluid (CSF) of patients with viral meningitis (n = 20) and control samples (n = 8) and correlate AFMK levels with inflammatory markers such as cellularity, protein, tumor

Industrial production of L-alanine using immobilized Escherichia coli and Pseudomonas dacunhae.

I Chibata et al.

Microbiological sciences, 1(3), 58-62 (1984-06-01)

Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly.

C T Walsh

The Journal of biological chemistry, 264(5), 2393-2396 (1989-02-15)

Engineering improved T cell receptors using an alanine-scan guided T cell display selection system.

Karolina Malecek et al.

Journal of immunological methods, 392(1-2), 1-11 (2013-03-19)

T cell receptors (TCRs) on T cells recognize peptide-major histocompatibility complex (pMHC) molecules on the surface of antigen presenting cells and this interaction determines the T cell immune response. Due to negative selection, naturally occurring TCRs bind self (tumor) peptides

The c-ring stoichiometry of ATP synthase is adapted to cell physiological requirements of alkaliphilic Bacillus pseudofirmus OF4.

Laura Preiss et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7874-7879 (2013-04-25)

The c-rings of ATP synthases consist of individual c-subunits, all of which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. The c-ring stoichiometry determines the number of ions transferred during enzyme operation and

1H and (13)C NMR spectroscopic analysis of human saliva.

C J L Silwood et al.

Journal of dental research, 81(6), 422-427 (2002-07-05)

We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and

¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure.

Seok-Min Kang et al.

Clinical biochemistry, 44(4), 293-299 (2010-12-21)

We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with

Characterization of a meso-chiral isomer of a hexanuclear Cu(II) cage from racemization of the L-alanine Schiff base.

Chinnaiyan Mahalingam Rajesh et al.

Dalton transactions (Cambridge, England : 2003), 43(34), 12952-12960 (2014-07-16)

We are reporting structural characterization of two new hexanuclear cages (H3O)2[Cu3(μ3-OH)(μ3-NH3)(0.5)(L)3]2·8H2O (1) and (H3O)2[Cu3(μ3-OH)(μ3-H2O)(0.5)(L)3]2·8H2O (1a) where L(2-) is the dianionic form of the Schiff base of L-alanine and salicylaldehyde. The complex 1 has two C3 symmetric hydroxo bridged trinuclear halves

Semagacestat's fall: where next for AD therapies?

Kaj Blennow et al.

Nature medicine, 19(10), 1214-1215 (2013-10-09)

Associations between transports of alanine and cations across cell membrane in rat hepatocytes.

L O Kristensen

The American journal of physiology, 251(5 Pt 1), G575-G584 (1986-11-01)

Alanine transport across the liver cell membrane is a regulated key process in the amino acid metabolism of the body. The majority of alanine influx in hepatocytes is Na+ dependent and is stimulated by intracellular negativity. The molar ratio between

Boundary of the nucleotide-binding domain of Streptococcus ComA based on functional and structural analysis.

Seiji Ishii et al.

Biochemistry, 52(15), 2545-2555 (2013-03-29)

The ATP-binding cassette (ABC) transporter ComA is a key molecule essential for the first step of the quorum-sensing system of Streptococcus. The nucleotide binding domains (NBD) of Streptococcus mutans ComA with different N termini, NBD1 (amino acid residues 495-760), NBD2

Involvement of alanine racemase in germination of Bacillus cereus spores lacking an intact exosporium.

Elena Venir et al.

Archives of microbiology, 196(2), 79-85 (2013-12-19)

The L-alanine mediated germination of food isolated Bacillus cereus DSA 1 spores, which lacked an intact exosporium, increased in the presence of D-cycloserine (DCS), which is an alanine racemase (Alr) inhibitor, reflecting the activity of the Alr enzyme, capable of

The cytotoxic and genotoxic effects of metalaxy-M on earthworms (Eisenia fetida).

Tong Liu et al.

Environmental toxicology and chemistry, 33(10), 2344-2350 (2014-07-22)

As the main optical isomer of metalaxyl, metalaxyl-M has been widely used worldwide in recent years because of its notable effect on the prevention and control of crop diseases. Together with the toxicity and degradation of metalaxyl-M, the chemical has

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.

Paul J Kennedy et al.

Psychopharmacology, 232(8), 1357-1371 (2014-10-24)

A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine

The unresolved puzzle why alanine extensions cause disease.

Reno Winter et al.

Biological chemistry, 394(8), 951-963 (2013-04-25)

The prospective increase in life expectancy will be accompanied by a rise in the number of elderly people who suffer from ill health caused by old age. Many diseases caused by aging are protein misfolding diseases. The molecular mechanisms underlying

Plasma free amino acid concentrations in healthy Guatemalan adults and in patients with classic dengue.

P Klassen et al.

The American journal of clinical nutrition, 73(3), 647-652 (2001-03-10)

Plasma free amino acid patterns in health and disease have been reported. However, amino acid concentrations in adult populations in developing countries and in patients with dengue, as a model for an acute infectious viral disease endemic to the tropics

Contaminant-specific targeting of olfactory sensory neuron classes: connecting neuron class impairment with behavioural deficits.

William A Dew et al.

Chemosphere, 112, 519-525 (2014-03-19)

The olfactory system of fish comprises several classes of olfactory sensory neurons (OSNs). The odourants L-alanine and taurocholic acid (TCA) specifically activate microvillous or ciliated OSNs, respectively, in fish. We recorded electro-olfactograms (EOG) in fathead minnows (Pimephales promelas; a laboratory-reared

Hydrolysis of the elastase substrate succinyltrialanine nitroanilide by a metal-dependent enzyme in rheumatoid synovial fluid.

J Saklatvala

The Journal of clinical investigation, 59(5), 794-801 (1977-05-01)

A new type of enzyme hydrolyzing the elastase substrate succinyl-L-alanyl-L-alanine-4-nitroanilide has been found in cell-free rheuma todi synovial fluid. Normal plasma and osteoarthritic synovial fluid contained relatively little enzyme. The pH optimum was 8.0. Unexpectedly, the enzyme activity was not

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

A novel carbon isotope biomarker for dietary sugar.

Dale A Schoeller

The Journal of nutrition, 143(6), 763-765 (2013-04-26)

Light element isotope signatures have been used to study food webs in many ecological niches, including those of ancient humans, but to a far lesser extent in modern humans. A recent paper presented results from a pilot study testing the

A conserved serine residue regulates the stability of Drosophila Salvador and human WW domain-containing adaptor 45 through proteasomal degradation.

Di Wu et al.

Biochemical and biophysical research communications, 433(4), 538-541 (2013-03-26)

The Hippo (Hpo) pathway is a conserved tumor suppressor pathway that controls organ size through the coordinated regulation of apoptosis and proliferation. Drosophila Salvador (Sav), which limits organ size, is a core component of the Hpo pathway. In this study

Protective effects of garlic extract, PMK-S005, against nonsteroidal anti-inflammatory drugs-induced acute gastric damage in rats.

Yoon Jeong Choi et al.

Digestive diseases and sciences, 59(12), 2927-2934 (2014-10-07)

PMK-S005 is synthetic s-allyl-L-cysteine (SAC), a sulfur-containing amino acid, which was initially isolated from garlic. The antioxidant and anti-inflammation activities of SAC have been demonstrated in diverse experimental animal models. The purpose of this study was to investigate the gastroprotective

Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients.

Edyta Reszka et al.

Journal of cancer research and clinical oncology, 140(10), 1723-1731 (2014-06-13)

NRF2 transcription factor is involved in modulation of various antioxidant and metabolic genes and, therefore, may modulate anti-carcinogenic potential. Association between polymorphisms of NRF2 and five NRF2-regulated genes and urinary bladder cancer (BC) risk was analyzed. The study group included

Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment.

C Härnryd et al.

Psychopharmacology, 64(2), 131-134 (1979-08-08)

The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.

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