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Piret Arukuusk et al.
Biochimica et biophysica acta, 1828(5), 1365-1373 (2013-01-30)
Harnessing of a branched structure is a novel approach in the design of cell-penetrating peptides and it has provided highly efficient transfection reagents for intracellular delivery of nucleic acids. The new stearylated TP10 analogs, NickFects, condense plasmid DNA, splice correcting
Armin Saeedi Vahdat et al.
International journal of pharmaceutics, 454(1), 333-343 (2013-07-04)
The mechanical properties of a solid dosage, defined by its granular micro-structure and geometry, play a key role in its dissolution profile and performance. An ultrasonic method for extracting the viscoelastic material properties and granular structure of drug tablet compacts
Wim Reybroeck et al.
PloS one, 9(5), e98266-e98266 (2014-05-24)
Two Pseudomonas strains, identified as closely related to Pseudomonas tolaasii, were isolated from milk of a farm with frequent false-positive Delvotest results for screening putative antibiotic residues in raw milk executed as part of the regulatory quality programme. Growth at
E Zamora-Rojas et al.
Meat science, 95(3), 503-511 (2013-06-25)
A handheld micro-electro-mechanical system (MEMS) based spectrometer working in the near infrared region (NIR) (1600-2400nm) was evaluated for in-situ and non-destructive prediction of main fatty acids in Iberian pig (IP) carcasses. 110 IP carcasses were measured. Performance of the instrument
Friederike Folttmann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 931-938 (2014-12-03)
A spatial filtering velocimetry (SFV) probe was applied to monitor the increase in particle size during pellet Wurster coating processes in-line. Accuracy of the in-line obtained pellet sizes was proven by at-line performed digital image analysis (DIA). Regarding particle growth
Sindhuri Maddineni et al.
AAPS PharmSciTech, 16(2), 444-454 (2014-11-02)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the
G Hoffmann et al.
Clinical chemistry, 35(4), 587-595 (1989-04-01)
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic
Zulfiqar Ali Mirani et al.
Pakistan journal of pharmaceutical sciences, 26(2), 383-389 (2013-03-05)
In the present study a vancomycin resistant Staphylococcus aureus (S. aureus) (VRSA) (Labeled as CP2) was isolated from the blood of a post-operative cardiac patient is described. It harbors a plasmid which carry vanA gene and exhibited low-level vancomycin resistance
Meng He et al.
ACS applied materials & interfaces, 5(3), 585-591 (2013-01-08)
A novel, highly hydrophobic cellulose composite film (RCS) with biodegradability was fabricated via solvent-vaporized controllable crystallization of stearic acid in the porous structure of cellulose films (RC). The interface structure and properties of the composite films were investigated with wide-angle
Mohamad Navab et al.
Journal of lipid research, 56(4), 871-887 (2015-02-04)
We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null (LDLR(-/-)) mice, and ii) supplementing standard mouse chow with unsaturated (but not saturated) LPA produced dyslipidemia
Stearic acid
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 29(2), 6068-6068 (2018)
P Sanjurjo et al.
Acta paediatrica Scandinavica, 77(2), 202-206 (1988-03-01)
Plasma fatty acids were studied in 20 full-term newborn infants fed human milk and in 17 newborn infants of identical characteristics fed an adapted cow's milk formula. Plasma fatty acids were measured in cord blood and at 7-9 days of
S M Grundy
The American journal of clinical nutrition, 60(6 Suppl), 986S-990S (1994-12-01)
Stearic acid is a long-chain saturated fatty acid. However, in contrast with other saturated fatty acids, stearic acid apparently does not raise serum cholesterol concentrations. Studies carried out three decades ago provided strong suggestive evidence that this was the case.
Mateusz Szalka et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 59, 1-11 (2014-04-22)
HPLC analysis of drug products containing bisoprolol fumarate and lactose revealed the presence of N-formylbisoprolol, which is a final product of the Maillard reaction. Formulations containing secondary amines and reducing carbohydrates are prone to the condensation of amine and carbonyl
A M Turpeinen et al.
Arteriosclerosis, thrombosis, and vascular biology, 18(2), 316-322 (1998-03-04)
The effects of stearic acid (C18:0) and trans-fatty acids (trans-FAs) on measures of platelet function and prostacyclin (PGI2) production are poorly understood in humans. In this controlled dietary study, platelet function and endothelial PGI2 production were studied in healthy humans
Shao-Ying Hu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(20), 3052-3055 (2013-01-15)
To prepare the sustained release solid dispersion of tripterine, using HPMC-stearic acid with the intention of improving drug dissolution and controlling drug releases moderate, so that the drug performances lower toxicity. Tripterine sustained release solid dispersions was prepared by the
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
E A Emken
The American journal of clinical nutrition, 60(6 Suppl), 1023S-1028S (1994-12-01)
This paper reviews results obtained by stable-isotope-tracer methods for stearic acid (18:0) and palmitic acid (16:0) metabolism and the influence of dietary linoleic acid on the metabolism of these saturated fatty acids in humans subjects. The results, based on stable-isotope-tracer
Talib Hussain et al.
Acta poloniae pharmaceutica, 70(4), 749-757 (2013-08-08)
Gliclazide is an oral hypoglycemic agent, indicated in non insulin dependent diabetes mellitus and in patients with diabetic retinopathy. It has good tolerability and is a short acting sulfonyl urea that requires large dose to maintain the blood glucose level.
Keiko Gotoh et al.
Journal of oleo science, 62(2), 73-79 (2013-02-09)
The soil removal behavior from poly(ethylene terephthalate) (PET) films was investigated using a microscopic image analysis system. Carbon black or stearic acid as a model soil was deposited onto a PET film. The PET film was cleaned in various aqueous
Sarah E E Berry
Nutrition research reviews, 22(1), 3-17 (2009-05-16)
The position of fatty acids in the TAG molecule (sn-1, sn-2 and sn-3) determines the physical properties of the fat, which affects its absorption, metabolism and distribution into tissues, which may have implications for the risk of CHD. The TAG
Laurent Simon et al.
International journal of pharmaceutics, 481(1-2), 64-70 (2015-02-01)
A closed-formed solution of a perforated drug-delivery model was developed. Laplace transforms were applied to the governing equation, which included diffusion through the tubular device and mass transfer across a rectangular cut. A first-order estimate for the fraction of drug
Kaisar Raza et al.
Journal of liposome research, 24(4), 290-296 (2014-04-29)
Capsaicin (CP), a recent FDA-approved drug for the topical treatment of neuropathic pain, is associated with several side effects like irritation, burning sensation, and erythema, resulting in poor patient compliance. The present study is an attempt to study the effect
Dong Chang et al.
Journal of the American College of Nutrition, 33(5), 406-411 (2014-08-01)
To evaluate and compare the levels of free fatty acids between senile cataract patients and normal controls. Fifty consecutive patients with newly diagnosed senile cataract and 50 age- and gender-matched controls were evaluated. Subjects/patients were randomized according to selection criteria.
A Tammaro et al.
Journal of biological regulators and homeostatic agents, 26(4), 783-784 (2012-12-18)
Magnesium stearate is a substance often used as a diluent in the manufacture of medical tablets, capsules and powders. Moreover it is usually found as a food additive or pharmaceutical excipient. We report the first case of a 28 years
Jian You et al.
Biomaterials, 34(18), 4510-4519 (2013-03-21)
It is difficult for most of the drug delivery systems to really display a temporal and spatial release of entrapped drug once the systems are iv administrated. We hypothesized that the photothermal effect, mediated by a near-infrared (NIR) laser and
Clara S Baffoe et al.
The Journal of pharmacy and pharmacology, 67(2), 189-198 (2014-12-17)
To develop and manufacture both immediate and sustained release vaginal tablets containing the anticancer drug disulfiram, which has the potential to be used as a non-invasive treatment for cervical cancer. Disulfiram-loaded vaginal tablets were manufactured at pilot scale using the
M A Denke
The American journal of clinical nutrition, 60(6 Suppl), 1044S-1049S (1994-12-01)
The effects of stearic acid on metabolism must be evaluated for stearic acid as an isolated dietary constituent and for stearic acid as a component of a natural fat. Beef products are the most common source of dietary stearic acid
J P Neoptolemos et al.
Annals of clinical biochemistry, 27 ( Pt 1), 38-43 (1990-01-01)
Erythrocyte fatty acids were measured in 32 patients with colorectal cancer (four with recurrent disease), four patients with large colorectal adenomas, and 42 hospitalised patients without cancer. No significant differences were found with respect to any of the fatty acids
Kristiina Järvinen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 680-688 (2013-01-15)
Continuous manufacturing methods offer economic and quality advantages when compared with batch manufacturing methods. In continuous manufacturing, one requires real time assurance of quality of product via the implementation of PAT tools. This study focuses on an in-line near-infrared (NIR)
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