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Guan Liu et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 25, 82-87 (2014-05-27)
A Mycobacterium parascrofulaceum strain was isolated from a pneumonia patient-the first such reported case from China. The bacteriological characteristics of the strain were determined. Species identification was performed by homologue gene sequence comparison, then a series of biochemical tests was
A Thabaut et al.
Pathologie-biologie, 42(5), 369-374 (1994-05-01)
The antibacterial activities of pefloxacin (PEF), ofloxacin (OFL), ciprofloxacin (CIP) were measured by agar diffusion (5 micrograms strength disks) against 6370 non duplicate clinical isolates collected in November 1991 in 40 hospitals from various areas in France. The MICs of
Severe hypoglycemia associated with levofloxacin in a healthy older woman.
Sergio Fusco et al.
Journal of the American Geriatrics Society, 61(9), 1637-1638 (2013-09-14)
Direct determination of four fluoroquinolones, enoxacin, norfloxacin, ofloxacin, and ciprofloxacin, in pharmaceuticals and blood serum by HPLC.
Samanidou VF, et al.
Analytical and Bioanalytical Chemistry, 375(5), 623-629 (2003)
K L Simpson et al.
Drugs, 58(3), 509-531 (1999-09-24)
Ofloxacin is a synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Ofloxacin has been formulated as a 0.3% otic solution for the treatment of ear infections. Topical administration of ofloxacin otic solution
Shoichi Onodera et al.
The Japanese journal of antibiotics, 65(6), 399-409 (2013-04-19)
We investigated the efficacy and safety of levofloxacin (LVFX) 500mg once a day in patients with non-gonorrheal urethritis. Men, aged 20 years or older, with urethritis symptoms, and detection of Chlamydia trachomatis (C. trachomatis) or Mycoplasma genitalium (M. genitalium) by
Jennifer Raisch et al.
Laboratory investigation; a journal of technical methods and pathology, 95(3), 296-307 (2014-12-30)
Intestinal dysbiosis has been reported in patients with colorectal cancer, and there is a high prevalence of Escherichia coli belonging to B2 phylogroup and producing a genotoxin, termed colibactin. Macrophages are one of the predominant tumor-infiltrating immune cells supporting key
Saori Uoyama et al.
The Japanese journal of antibiotics, 65(6), 355-363 (2013-04-19)
An in vitro human plasma concentration simulation model with a hollow fiber system was established and used to evaluate the bactericidal effect of levofloxacin (LVFX) 500mg q.d. in combination with meropenem (MEPM) 1000mg t.i.d. against Pseudomonas aeruginosa. Six clinical isolates
Guilian Li et al.
PloS one, 10(2), e0119013-e0119013 (2015-02-20)
Isoniazid (INH) and rifampicin (RIF) are the two most effective drugs in tuberculosis therapy. Understanding the molecular mechanisms of resistance to these two drugs is essential to quickly diagnose multidrug-resistant (MDR) tuberculosis and extensive drug-resistant tuberculosis. Nine clinical Mycobacterium tuberculosis
Deivasigamani Ranjith Kumar et al.
Journal of nanoscience and nanotechnology, 14(7), 5059-5069 (2014-04-25)
Iron oxide (Fe3O4) nanoparticles are prepared by nucleation method using oleylamine (OLA) as the capping agent. The OLA capped Fe3O4 nanoparticles (OLA-Fe3O4) are characterized by Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD) and High Resolution Transmission Electron Microscopic (HRTEM)
Maria Da Graça Souza Cunha et al.
Leprosy review, 83(3), 261-268 (2013-01-30)
Recently antimicrobials of the fluoroquinolone class (pefloxacin and ofloxacin) were found far more effective against Mycobacterium leprae in studies with both mice and patients than dapsone and clofazimine. As multicentre trial participants, we evaluated the therapeutic efficacy, in terms of
Imen Mokdad-Bzeouich et al.
The Journal of antibiotics, 68(3), 148-152 (2014-09-25)
In this particular study, the antibacterial activity of esculin and oligomer fractions was assessed. MIC values of esculin and its oligomer fractions as well as of some antibiotics against Gram-positive and Gram-negative strains and against Escherichia coli multiresistant variants were
Alfred Corey et al.
Toxins, 5(1), 120-138 (2013-01-25)
Inhaled Bacillus anthracis spores germinate and the subsequent vegetative growth results in bacteremia and toxin production. Anthrax toxin is tripartite: the lethal factor and edema factor are enzymatic moieties, while the protective antigen (PA) binds to cell receptors and the
M Baki et al.
Orvosi hetilap, 135(51), 2815-2819 (1994-12-18)
The authors compared the effectivity of doxycyclin or ofloxacin after combined chemotherapy of testicular cancer patients during the leukopenic periods. Between 1988 and 1991 200 patients were randomized and 194 were evaluated. One hundred and fifty two patients had been
Blue-gray pigmentation in trunk and extremities in a 71-year-old man.
Mónica Lorente et al.
JAMA dermatology, 149(9), 1111-1112 (2013-07-05)
M Aboubakr
British poultry science, 53(6), 784-789 (2013-02-13)
1. The pharmacokinetics of levofloxacin were investigated in Japanese quails after a single dose of 10 mg/kg BW, given either intravenously or orally. 2. Following intravenous administration, the mean value of distribution at steady state (Vd(ss)), total body clearance (Cl(tot)) and
Koji Toriyama et al.
Cornea, 32(6), 839-841 (2013-02-15)
To report a case of spontaneous bleb formation in a presumed pellucid marginal corneal degeneration with acute hydrops. A 51-year-old man reported sudden ocular pain with a lower conjunctival mass in his left eye. A clinical examination was performed to
Effect of pressure on the chromatographic separation of enantiomers under reversed-phase conditions.
Alexey A Makarov et al.
Journal of chromatography. A, 1352, 87-92 (2014-06-15)
Commercially available ultra high pressure liquid chromatography (UHPLC) equipment offers the ability to explore the influence of backpressure on chromatographic separations. However, the influence of pressure on the chromatographic separation of enantiomers on chiral stationary phases remains largely unexplored. In
Talen K H Wai et al.
Drug safety, 26(6), 405-420 (2003-04-12)
Ofloxacin is a fluoroquinolone antibacterial with potent bactericidal activities and the topical otological preparation of this drug has been clinically utilised since the late 1980s. The rate of eradication with ofloxacin ranges from 83.3% to 100% for all pathogens commonly
Nethaji Ramalingam et al.
Pakistan journal of pharmaceutical sciences, 26(6), 1089-1096 (2013-11-06)
Niosomes are non ionic surfactant vesicles and potential surrogate for liposomes. The aim of the present investigation was to formulate and evaluate niosomes. The formulated ofloxacin niosomes were evaluated for their particle size, zeta potential, surface morphology, entrapment efficiency, in
Célia Lloret-Linares et al.
The Annals of pharmacotherapy, 47(1), e4-e4 (2013-01-18)
To report a case of an overweight man with lymph node tuberculosis due to Mycobacterium bovis, a part of the Mycobacterium tuberculosis complex, treated with fixed-dose combination (FDC) chemotherapy. Following guidelines, according to the patient's weight (92 kg), we prescribed
Feng-Jiao Peng et al.
Environmental toxicology and chemistry, 33(4), 776-783 (2014-01-11)
Soil contamination of antimicrobials has become an increasing concern because of the potential risks to the soil microbial ecosystem and human health. The present study investigated sorption and desorption behaviors of oxytetracycline (OTC) and ofloxacin (OFL) in 3 typical soils
Dan-Dan Zhong et al.
Analytical and bioanalytical chemistry, 405(10), 3205-3214 (2013-02-09)
Frontal polymerization was successfully applied, for the first time, to obtain molecularly imprinted polymers (MIPs). The method provides a solvent-free polymerization mode, and the reaction can be completed in 30 min. By this approach, MIPs were synthesized using a mixture
Yasuhiro Horita et al.
Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)
Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated
Dennis A K Rice et al.
International journal of antimicrobial agents, 41(4), 388-392 (2013-02-16)
An analysis of subjects with concurrent bacteraemia and either nosocomial pneumonia, complicated intra-abdominal infection or complicated urinary tract infection from six phase 3 clinical trials demonstrated similar cure rates and clearance of bacteraemia in patients treated with doripenem and comparator
S V Onrust et al.
Drugs, 56(5), 895-928 (1998-11-26)
Ofloxacin is an established fluoroquinolone agent which achieves good concentrations in genitourinary tract tissues and fluids. It has good in vitro activity against most Enterobacteriaceae, Staphylococcus saprophyticus, methicillin-susceptible S. aureus, Neisseria gonorrhoeae, Chlamydia trachomatis and Haemophilus ducreyi, intermediate activity against
Turan Calhan et al.
Helicobacter, 18(5), 378-383 (2013-04-23)
An ideal second-line therapeutic regimen for the treatment of patients who do not respond to standard triple therapy is currently being investigated. In this study, we aimed to investigate the efficacy of two levofloxacin-containing second-line therapies for Helicobacter pylori (H.
Zohar Habot-Wilner et al.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 232(2), 77-82 (2014-07-12)
To report the long-term outcome of an intravitreal dexamethasone drug delivery system (DEX-DDS) injection for noninfectious uveitic macular edema. This was a retrospective study of 8 eyes (7 patients). The mean follow-up time was 17.3 months. Macular edema resolved in
F Ertas et al.
African health sciences, 12(3), 388-389 (2013-02-06)
Like any other foreign bodies, implanted cardiac devices can become infected. Staphylococcus aureus and coagulase-negative Staphilococci are the most common causes of infections of pacemaker and defibrillator systems. In this case an implantable cardioverter defibrillator pocket infection caused by an
Chhavi Porwal et al.
PloS one, 8(2), e55299-e55299 (2013-02-08)
India with a major burden of multidrug-resistant tuberculosis (MDR-TB) does not have national level data on this hazardous disease. Since 2006, emergence of extensively drug-resistant TB (XDR-TB) is considered a serious threat to global TB control. This study highlights the
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