PHR1219

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关键词:'PHR1219'

显示 1-30 共 980 条结果关于 "PHR1219" 范围论文

NGX6a is degraded through a proteasome-dependent pathway without ubiquitination mediated by ezrin, a cytoskeleton-membrane linker.

Li Wang et al.

The Journal of biological chemistry, 289(52), 35731-35742 (2014-11-08)

Our previous study demonstrated that the NGX6b gene acts as a suppressor in the invasion and migration of nasopharyngeal carcinoma (NPC). Recently, we identified the novel isoform NGX6a, which is longer than NGX6b. In this study, we first found that

Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.

Asuka Yuda et al.

Journal of cellular physiology, 230(1), 150-159 (2014-06-07)

Appropriate mechanical loading during occlusion and mastication play an important role in maintaining the homeostasis of periodontal ligament (PDL) tissue. Connective tissue growth factor (CTGF/CCN2), a matricellular protein, is known to upregulate extracellular matrix production, including collagen in PDL tissue.

Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development.

Zachary Yu-Ching Lin et al.

Developmental biology, 400(1), 43-58 (2015-01-28)

Mammalian spermatogenesis has been investigated extensively in rodents and a strictly controlled developmental process has been defined at cellular and molecular levels. In comparison, primate spermatogenesis has been far less well characterized. However, important differences between primate and rodent spermatogenesis

Kinetics of human sperm acrosomal exocytosis.

C M Sosa et al.

Molecular human reproduction, 21(3), 244-254 (2014-12-03)

The acrosome reaction is a unique event in the lifespan of sperm characterized by the exocytosis of the acrosomal content and the release of hybrid vesicles formed by patches of the outer acrosomal membrane and the plasma membrane. This unique

A method for the efficient cellular uptake and retention of small modified gold nanoparticles for the radiosensitization of cells.

Nina Burger et al.

Nanomedicine : nanotechnology, biology, and medicine, 10(6), 1365-1373 (2014-03-29)

Gold nanoparticles (GNP) enhance the absorbance of photons thereby increasing emission of Auger-/photoelectrons in the nm-μm range. Yet, a major disadvantage is their diameter-dependent cellular uptake with an optimum of ~50 nm which may not offer optimal radiosensitization. A method

An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST.

Francesca Cargnin et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16650-16661 (2014-12-17)

The RE1 Silencing Transcription Factor (REST) acts as a governor of the mature neuronal phenotype by repressing a large consortium of neuronal genes in non-neuronal cells. In the developing nervous system, REST is present in progenitors and downregulated at terminal

On universality of scaling law describing roughness of triple line.

Edward Bormashenko et al.

The European physical journal. E, Soft matter, 38(1), 2-2 (2015-01-27)

The fine structure of the three-phase (triple) line was studied for different liquids, various topographies of micro-rough substrates and various wetting regimes. Wetting of porous and pillar-based micro-scaled polymer surfaces was investigated. The triple line was visualized with the environmental

A micro-QuEChERS method coupled to GC-MS for the quantification of pesticides in specific maternal and fetal tissues.

N Brandhonneur et al.

Journal of pharmaceutical and biomedical analysis, 104, 90-96 (2014-12-17)

The aim of this study was to establish a new QuEChERS (quick, easy, cheap, effective, rugged and safe) method coupled to gas chromatography-mass spectrometry (GC-MS) detection for the evaluation of the pesticide biodistribution in specific maternal and fetal tissues. This

The effects of permethrin on rat ovarian tissue morphology.

Tuğba Kotil et al.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(3), 279-285 (2015-02-11)

All organisms are exposed to chemical agents during their lifetime. One of these agents is a pesticide that is used as fly killer. In this study we investigated the effects of permethrin on rat ovaries using light and electron microscopy.

Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients.

G Blomqvist et al.

American journal of physiology. Endocrinology and metabolism, 283(1), E20-E28 (2002-06-18)

Using R-beta-[1-(11)C]hydroxybutyrate and positron emission tomography, we studied the effect of acute hyperketonemia (range 0.7-1.7 micromol/ml) on cerebral ketone body utilization in six nondiabetic subjects and six insulin-dependent diabetes mellitus (IDDM) patients with average metabolic control (HbA(1c) = 8.1 +/-

Tissue distribution of the Ehrlichia muris-like agent in a tick vector.

Geoffrey E Lynn et al.

PloS one, 10(3), e0122007-e0122007 (2015-03-18)

Human pathogens transmitted by ticks undergo complex life cycles alternating between the arthropod vector and a mammalian host. While the latter has been investigated to a greater extent, examination of the biological interactions between microbes and the ticks that carry

Fabric phase sorptive extraction: a new sorptive microextraction technique for the determination of non-steroidal anti-inflammatory drugs from environmental water samples.

Inés Racamonde et al.

Analytica chimica acta, 865, 22-30 (2015-03-04)

Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of sol-gel hybrid inorganic-organic

VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression.

Niek G J Leus et al.

International journal of pharmaceutics, 469(1), 121-131 (2014-04-22)

In recent years much research in RNA nanotechnology has been directed to develop an efficient and clinically suitable delivery system for short interfering RNA (siRNA). The current study describes the in vivo siRNA delivery using PEGylated antibody-targeted SAINT-based-lipoplexes (referred to

Octylphenol induces changes in glycosylation pattern, calcium level and ultrastructure of bank vole spermatozoa in vitro.

Malgorzata Kotula-Balak et al.

Toxicology in vitro : an international journal published in association with BIBRA, 29(3), 529-537 (2015-01-03)

Our previous studies revealed that in bank vole testicular cells octylphenol (OP) action is related either to its binding to estrogen receptors or increasing cAMP level that modulates spermatozoa motility and acrosome reaction (AR), (Kotula-Balak et al., 2011, 2014). To

Oral administration of Lactobacillus plantarum lysates attenuates the development of atopic dermatitis lesions in mouse models.

Hangeun Kim et al.

Journal of microbiology (Seoul, Korea), 53(1), 47-52 (2014-12-05)

Lactobacillus plantarum is a well-documented probiotic that has been used in clinical trials for the regulation of the immune system and treatment of gastrointestinal diseases. In this study, we evaluated the effects of L. plantarum cell lysates on the immune

A new strategy for specific imaging of neural cells based on peptide-conjugated gold nanoclusters.

Enqi Zhang et al.

International journal of nanomedicine, 10, 2115-2124 (2015-04-04)

Despite the significant progress in molecular imaging technologies that has been made in recent years, the specific detection of neural cells still remains challenging. Here, we suggest the use of gold nanoclusters (AuNCs) modified with a brain-targeting peptide as a

The economics of acetone-butanol fermentation: theoretical and market considerations.

J R Gapes

Journal of molecular microbiology and biotechnology, 2(1), 27-32 (2000-08-11)

Acetone-butanol (AB) fermentation was once run commercially in many countries until these chemicals could be made more cheaply from fossil oil sources. Research into the revitalisation of the process has shown that the process could once again be run economically

Development and validation of one-step ultrasound-assisted extraction for simultaneous determination of multiclass fungicides in soils.

Yared Merdassa et al.

Journal of AOAC International, 98(1), 192-200 (2015-04-11)

A rapid, efficient, and simple one-step ultrasound-assisted extraction (UAE) method was developed for the analysis of seven fungicides (cymoxanil, metalaxyl, mandipropamid, folpet, chlorothalonil, kresoxim-methyl, and famoxadone) in horticultural soils. Analytes in the samples were determined by HPLC with variable wavelength

DOCK2 is critical for CD8(+) TCR(-) graft facilitating cells to enhance engraftment of hematopoietic stem and progenitor cells.

Yujie Wen et al.

Stem cells (Dayton, Ohio), 32(10), 2732-2743 (2014-07-22)

CD8(+) TCR(-) graft facilitating cells (FCs) enhance engraftment of hematopoietic stem cells (HSCs) in allogeneic and syngeneic recipients. The mechanisms by which FCs promote HSC engraftment and tolerance induction have not been fully elucidated. Here, we provide data to support

Exploring potential virulence regulators in Paracoccidioides brasiliensis isolates of varying virulence through quantitative proteomics.

Daniele G Castilho et al.

Journal of proteome research, 13(10), 4259-4271 (2014-08-26)

Few virulence factors have been identified for Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. In this study, we quantitatively evaluated the protein composition of P. brasiliensis in the yeast phase using minimal and rich media to obtain a better understanding of

Upregulation of death receptor 5 and activation of caspase 8/3 play a critical role in ergosterol peroxide induced apoptosis in DU 145 prostate cancer cells.

Jonghyun Han et al.

Cancer cell international, 14(1), 117-117 (2014-12-17)

Though ergosterol peroxide (EP) derived from Neungyi mushrooms (Sarcodon aspratus) was known to have cytotoxic, apoptotic, anti-inflammatory and antimycobacterial effects, the underlying molecular mechanism of EP still remains unclear. Thus, in the present study, the apoptotic mechanism of EP was

Acetyltransferase p300/CBP associated Factor (PCAF) regulates crosstalk-dependent acetylation of histone H3 by distal site recognition.

James R Kornacki et al.

ACS chemical biology, 10(1), 157-164 (2014-09-10)

Epigenetic regulation is directed, in part, by the correlated placement of histone post-translational modifications, but the mechanisms controlling correlated modifications are incompletely understood. Correlations arise from crosstalk among modifications and are frequently attributed to protein-protein interactions that recruit enzymes to

Occurrence of free estrogens, conjugated estrogens, and bisphenol A in fresh livestock excreta and their removal by composting in North China.

Hui Zhang et al.

Environmental science and pollution research international, 21(16), 9939-9947 (2014-05-16)

An efficient pretreatment and analytical method was developed to investigate the occurrence and fate of four free estrogens (estrone (E1), 17β-estradiol (17β-E2), estriol (E3), and 17α-ethinylestradiol (EE2)), four conjugated estrogens (estrone-3-sulfate sodium salt (E1-3S), 17β-estradiol-3-sulfate sodium salt (E2-3S), estrone-3-glucuronide sodium

Fate and degradation kinetics of nonylphenol compounds in aerobic batch digesters.

Seçil Ömeroğlu et al.

Water research, 64, 1-12 (2014-07-16)

Nonylphenol (NP) compounds are toxic and persistent chemicals that are not fully degraded either in natural or engineered systems. Current knowledge indicates that these compounds concentrate in sewage sludge. Therefore, investigating the degradation patterns and types of metabolites formed during

Plasma amino acid profile on nocturnal hemodialysis.

D S Raj et al.

Blood purification, 18(2), 97-102 (2000-06-06)

The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile. In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD.

Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis.

Catarina L Silva et al.

Talanta, 89, 360-368 (2012-01-31)

A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the

Replication of boid inclusion body disease-associated arenaviruses is temperature sensitive in both boid and mammalian cells.

Jussi Hepojoki et al.

Journal of virology, 89(2), 1119-1128 (2014-11-08)

Boid inclusion body disease (BIDB) is a fatal disease of boid snakes, the etiology of which has only recently been revealed following the identification of several novel arenaviruses in diseased snakes. BIBD-associated arenaviruses (BIBDAV) are genetically divergent from the classical

A cohort study of the effectiveness of insecticide-treated bed nets to prevent malaria in an area of moderate pyrethroid resistance, Malawi.

Kim A Lindblade et al.

Malaria journal, 14, 31-31 (2015-01-30)

Insecticide-treated bed nets (ITNs) are the cornerstone of malaria control in sub-Saharan Africa but their effectiveness may be compromised by the spread of pyrethroid resistance among malaria vectors. The objective of this investigation was to assess the effectiveness of ITNs

Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography-tandem mass spectrometry.

Gilles Provencher et al.

Journal of chromatography. A, 1348, 97-104 (2014-05-20)

Bisphenol A (BPA) and triclosan (TCS) are ubiquitous environmental phenols exhibiting endocrine disrupting activities that may be involved in various health disorders in humans. There is a need to measure separately free forms and conjugated metabolites because only the former

Fast extraction of amphenicols residues from raw milk using novel fabric phase sorptive extraction followed by high-performance liquid chromatography-diode array detection.

Victoria Samanidou et al.

Analytica chimica acta, 855, 41-50 (2014-12-30)

A simple, sensitive, reliable, and fast analytical method was developed for the simultaneous determination of amphenicols residues in raw milk by combining fabric phase sorptive extraction (FPSE) and high-performance liquid chromatography-diode array detection. FPSE, a new generation green sample preparation

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