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Daniela Sieghart et al.
Journal of cellular and molecular medicine, 19(1), 187-197 (2014-10-15)
Balneotherapy employing sulphurous thermal water is still applied to patients suffering from diseases of musculoskeletal system like osteoarthritis (OA) but evidence for its clinical effectiveness is scarce. Since the gasotransmitter hydrogen sulphide (H2 S) seems to affect cells involved in
Jay Prakash Singh et al.
Cancer letters, 356(2 Pt A), 244-250 (2014-04-29)
The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in
Sreedhar Madishetti et al.
British journal of pharmacology, 171(13), 3328-3337 (2014-03-25)
The μ-opioid receptor has been characterized as the main mediator of opioid signalling in neuronal cells. Opioid-induced pain suppression was originally proposed to be mediated by μ-opioid receptor-induced inhibitory effects on cAMP, which is known to mediate inflammatory hypernociception. Recent
Amy A Boaro et al.
FEMS microbiology ecology, 90(3), 802-815 (2014-10-08)
Integrated 'omics have been used on pure cultures and co-cultures, yet they have not been applied to complex microbial communities to examine questions of perturbation response. In this study, we used integrated 'omics to measure the perturbation response of a
H C Curtius et al.
Journal of chromatography, 112, 523-531 (1975-10-29)
A specific and very sensitive method for the determination of 5-hydroxy-tryptophol (5-HTOL) and 5-methoxytryptophol (5-MTOL) in extracts from human cerebrospinal fluid (CSF) involving the use of mass fragmentography and pentafluoropriopionyl derivatives is described. 5-HTOL and 5-MTOL were determined in human
Catherine E Gleason et al.
The Journal of clinical investigation, 125(1), 117-128 (2014-11-22)
The epithelial Na+ channel (ENaC) is essential for Na+ homeostasis, and dysregulation of this channel underlies many forms of hypertension. Recent studies suggest that mTOR regulates phosphorylation and activation of serum/glucocorticoid regulated kinase 1 (SGK1), which is known to inhibit
Akihiro Sugai et al.
Journal of virology, 88(2), 1140-1149 (2013-11-08)
Measles virus nucleoprotein is the most abundant viral protein and tightly encapsidates viral genomic RNA to support viral transcription and replication. Major phosphorylation sites of nucleoprotein include the serine residues at locations 479 and 510. Minor phosphorylation residues have yet
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Junko Sugatani et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1708-1718 (2014-07-31)
The human pregnane X receptor (hPXR) is recognized as a xenobiotic-sensing nuclear receptor that transcriptionally regulates the gene expression of drug-metabolizing enzymes and transporters. Our study elucidates the mechanism by which the localization of hPXR is regulated through threonine-290. A
Ci-Di Chen et al.
Journal of molecular neuroscience : MN, 55(1), 76-90 (2014-06-09)
Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously
Liang Wang et al.
JAMA neurology, 70(10), 1242-1248 (2013-08-21)
Resting-state functional connectivity magnetic resonance imaging has great potential for characterizing pathophysiological changes during the preclinical phase of Alzheimer disease. To assess the relationship between default mode network integrity and cerebrospinal fluid biomarkers of Alzheimer disease pathology in cognitively normal
Davide Bressanello et al.
Journal of chromatography. A, 1361, 265-276 (2014-08-28)
This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse urine. Samples were obtained from a murine model that mimics a typical unhealthy Western diet featuring
Konstantin I Ivanov et al.
Molecular and cellular biology, 33(19), 3749-3761 (2013-07-24)
One of the key mechanisms linking cell signaling and control of gene expression is reversible phosphorylation of transcription factors. FOXC2 is a forkhead transcription factor that is mutated in the human vascular disease lymphedema-distichiasis and plays an essential role in
E L Wils-Plotz et al.
Poultry science, 92(3), 735-745 (2013-02-26)
Coccidiosis is a major contributor to economic losses in the poultry industry due to its detrimental effects on growth performance and nutrient utilization. We hypothesized that the combined effects of supplemental dietary Thr and purified fiber may modulate the intestinal
Jian-Xu Li et al.
The Biochemical journal, 451(3), 417-426 (2013-02-27)
Most TPSs (terpene synthases) contain plasticity residues that are responsible for diversified terpene products and functional evolution, which provide a potential for improving catalytic efficiency. Artemisinin, a sesquiterpene lactone from Artemisia annua L., is widely used for malaria treatment and
Kun-Chieh Chen et al.
PloS one, 9(5), e97888-e97888 (2014-05-23)
Pemetrexed is approved for first-line and maintenance treatment of patients with advanced or metastatic non-small-cell lung cancer (NSCLC). The protein kinase Akt/protein kinase B is a well-known regulator of cell survival which is activated by pemetrexed, but its role in
Masha M Rosenberg et al.
The Journal of biological chemistry, 288(14), 9779-9789 (2013-02-22)
The motor protein nonmuscle myosin II (NMII) must undergo dynamic oligomerization into filaments to perform its cellular functions. A small nonhelical region at the tail of the long coiled-coil region (tailpiece) is a common feature of all dynamically assembling myosin
Byung Chull An et al.
Biochemistry, 53(49), 7835-7845 (2014-11-18)
Motor activity of myosin III is regulated by autophosphorylation. To investigate the role of the kinase activity on the transporter function of myosin IIIA (Myo3A), we identified the phosphorylation sites of kinase domain (KD), which is responsible for the regulation
Nicolas Paquet et al.
BMC molecular biology, 15, 27-27 (2014-12-17)
Premature aging syndromes recapitulate many aspects of natural aging and provide an insight into this phenomenon at a molecular and cellular level. The progeria syndromes appear to cause rapid aging through disruption of normal nuclear structure. Recently, a coding mutation
Jonel Trebicka et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1393-1402 (2014-06-11)
Patients with cirrhosis display hypocontractility of splanchnic vessels because of dysregulation of vasoactive proteins, such as decreased effect of RhoA/ROCK and increased activity of β-Arrestin-2 and eNOS. However, it is unknown whether the dysregulation of vasoactive proteins is displayed in
Yanmei Si et al.
The Analyst, 139(21), 5466-5471 (2014-09-02)
A simple, rapid, sensitive, selective, and field-deployable detection protocol has been initially proposed for the early warning and diagnosis of exposure to organophosphates (OPs) by electrochemically monitoring the direct biomarkers of free OPs in blood. Phosphorylation-sensitive tyrosine (Tyr), which was
Nahla Elgohary et al.
International journal of oncology, 46(2), 597-606 (2014-11-19)
The mammalian timeless (TIM) protein interacts with proteins of the endogenous clock and essentially contributes to the circadian rhythm. In addition, TIM is involved in maintenance of chromosome integrity, growth control and development. Thus, we hypothesized that TIM may exert
X Li et al.
Journal of internal medicine, 275(4), 418-427 (2013-11-19)
Biochemical changes in the cerebrospinal fluid (CSF) could reflect pathophysiological processes in Alzheimer's disease (AD). However, it is still not clear how these processes correlate with grey matter (GM) volume and microstructural changes in the brain. To assess the relationship
Bo Peng et al.
Molecular bioSystems, 11(1), 105-114 (2014-10-18)
The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of
Colleen R McNamara et al.
PloS one, 8(3), e56576-e56576 (2013-03-08)
Necroptosis is a regulated form of necrotic cell death that has been implicated in the pathogenesis of various diseases including intestinal inflammation and systemic inflammatory response syndrome (SIRS). In this work, we investigated the signaling mechanisms controlled by the necroptosis
HPLC-fluorescence determination of amino acids in pharmaceuticals after pre-column derivatization with phanquinone
Gatti.R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 35(2), 339-348 (2004)
G Alfredsson et al.
Psychopharmacology, 99(3), 322-327 (1989-01-01)
Twenty-four acutely ill schizophrenic patients (DSM-III-R), 18-42 years old, were treated for 6 weeks with sulpiride. Sulpiride was administered in three different daily dosages (starting with 400, 800 or 1200 mg) according to a double blind randomized administration schedule. The
Jesko Koehnke et al.
Chembiochem : a European journal of chemical biology, 14(5), 564-567 (2013-03-14)
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme
Jaesung Jung et al.
Journal of virology, 88(16), 8754-8767 (2014-05-23)
Phosphorylation of serines 157, 164, and 172 within the carboxyl-terminal SPRRR motif of the hepatitis B virus (HBV) core (C) protein modulates HBV replication at multiple stages. Threonine 162 and serines 170 and 178, located within the carboxyl-terminal conserved RRRS/T
Fabien Binamé et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10858-10874 (2013-06-28)
The transmembrane proteoglycan NG2 is expressed by oligodendrocyte precursor cells (OPC), which migrate to axons during developmental myelination and remyelinate in the adult after migration to injured sites. Highly invasive glial tumors also express NG2. Despite the fact that NG2
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